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- Review Article
- Infection
- Etiological and pathophysiological enigmas of severe coronavirus disease 2019, multisystem inflammatory syndrome in children, and Kawasaki disease
- Jung-Woo Rhim, Jin-Han Kang, Kyung-Yil Lee
- Clin Exp Pediatr. 2022;65(4):153-166. Published online November 23, 2021
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· Severe cases of coronavirus disease, Kawasaki disease (KD), and multisystem inflammatory syndrome in children (MIS-C) share similar findings: a protracted clinical course, multiorgan involvement, and similar activated biomarkers.
· Here we propose etiological agents in KD and MIS-C as species in the microbiota and introduce a common pathogenesis through the protein-homeostasis-system hypothesis.
· Early proper dose of corticosteroids and/or intravenous immunoglobulin may help to reduce morbidity and mortality in these diseases.
- Original Article
- Infection
- Febrile urinary tract infection in children: changes in epidemiology, etiology, and antibiotic resistance patterns over a decade
- Woosuck Suh, Bi Na Kim, Hyun Mi Kang, Eun Ae Yang, Jung-Woo Rhim, Kyung-Yil Lee
- Clin Exp Pediatr. 2021;64(6):293-300. Published online October 14, 2020
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Question: How has the antibiotic susceptibility of urinary pathogens changed and what does it imply?
Finding: A yearly increase in multidrug-resistant and extended-spectrum β-lactamase (ESBL)–producing pathogens was observed. A higher recurrence rate was observed in cases of febrile urinary tract infection caused by ESBL producers in patients with underlying vesicoureteral reflux (VUR).
Meaning: The initial empirical antibiotic should reflect the changing susceptibility patterns and underlying VUR status.
- Review Article
- Immunology
- Immunopathogenesis of COVID-19 and early immunomodulators
- Kyung-Yil Lee, Jung-Woo Rhim, Jin-Han Kang
- Clin Exp Pediatr. 2020;63(7):239-250. Published online June 18, 2020
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The novel coronavirus disease 2019 (COVID-19) is spreading globally. Although its etiologic agent is discovered as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there are many unsolved issues in COVID-19 and other infectious diseases. The causes of different clinical phenotypes and incubation periods among individuals, species specificity, and cytokine storm with lymphopenia as well as the mechanism of damage to organ...
- Perspective
- Pulmonology
- Early preemptive immunomodulators (corticosteroids) for severe pneumonia patients infected with SARS-CoV-2
- Kyung-Yil Lee, Jung-Woo Rhim, Jin-Han Kang
- Clin Exp Pediatr. 2020;63(4):117-118. Published online April 8, 2020
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- Editorial
- Pulmonology
- Are alternative antibiotics needed for antibiotic-nonresponsive Mycoplasma pneumoniae pneumonia?
- Eun-Ae Yang, Kyung-Yil Lee
- Clin Exp Pediatr. 2020;63(2):44-45. Published online February 15, 2020
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- Original Article
- Cardiology
- Clinical implications in laboratory parameter values in acute Kawasaki disease for early diagnosis and proper treatment
- Yu-Mi Seo, Hyun-Mi Kang, Sung-Churl Lee, Jae-Won Yu, Hong-Ryang Kil, Jung-Woo Rhim, Ji-Whan Han, Kyung-Yil Lee
- Clin Exp Pediatr. 2018;61(5):160-166. Published online May 28, 2018
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Purpose This study aimed to analyse laboratory values according to fever duration, and evaluate the relationship across these values during the acute phase of Kawasaki disease (KD) to aid in the early diagnosis for early-presenting KD and incomplete KD patients.
Methods Clinical and laboratory data of patients with KD (n=615) were evaluated according to duration of fever at presentation, and were compared between...
- Editorial
- Infection
- Additional corticosteroids or alternative antibiotics for the treatment of macrolide-resistant
Mycoplasma pneumoniae pneumonia - Eun-Ae Yang, Kyung-Yil Lee
- Clin Exp Pediatr. 2017;60(8):245-247. Published online August 14, 2017
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- Original Article
- Epidemiological comparison of three
Mycoplasma pneumoniae pneumonia epidemics in a single hospital over 10 years - Eun-Kyung Kim, You-Sook Youn, Jung-Woo Rhim, Myung-Seok Shin, Jin-Han Kang, Kyung-Yil Lee
- Clin Exp Pediatr. 2015;58(5):172-177. Published online May 22, 2015
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Purpose Mycoplasma pneumoniae (MP) pneumonia epidemics have occurred in 3- to 4-year cycles in Korea. We evaluated the epidemiologic characteristics of MP pneumonia in Daejeon, Korea, from 2003 to 2012.Methods We retrospectively analyzed 779 medical records of children (0-15 years of old) with MP pneumonia admitted to our institution and compared the data from 3 recent epidemics.
Results In 779 patients, the mean age...
- Outbreaks of mumps: an observational study over two decades in a single hospital in Korea
- Ji-Ung Ryu, Eun-Kyung Kim, You-Sook Youn, Jung-Woo Rhim, Kyung-Yil Lee
- Clin Exp Pediatr. 2014;57(9):396-402. Published online September 30, 2014
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Purpose The introduction of the mumps vaccine has dramatically reduced the number of mumps cases, but outbreaks have recently occurred among highly vaccinated populations in developed countries. Epidemiological and clinical characteristics of patients with mumps admitted between 1989 and 2012 in a single hospital in Korea are described in the present study.
Methods We retrospectively evaluated inpatients with mumps between 1989 and 2012...
- Review Article
Mycoplasma pneumoniae pneumonia in children- You-Sook Youn, Kyung-Yil Lee
- Clin Exp Pediatr. 2012;55(2):42-47. Published online February 14, 2012
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Mycoplasma pneumoniae (MP), the smallest self-replicating biological system, is a common cause of upper and lower respiratory tract infections, leading to a wide range of pulmonary and extra-pulmonary manifestations. MP pneumonia has been reported in 10 to 40% of cases of community-acquired pneumonia and shows an even higher proportion during epidemics. MP infection is endemic in larger communities of the...
- Original Article
- Effect of p16 on glucocorticoid response in a B-cell lymphoblast cell line
- Sun-Young Kim, Kyung-Yil Lee, Dae-Chul Jeong, Hak-Ki Kim
- Clin Exp Pediatr. 2010;53(7):753-758. Published online July 31, 2010
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Purpose It has been suggested that p16 has a role in glucocorticoid (GC)-related apoptosis in leukemic cells, but the exact mechanisms have yet to be clarified. We evaluated the relationship between the GC response and p16 expression in a lymphoma cell line.
Methods We used p16 siRNA transfection to construct p16-inactivated cells by using the B-cell lymphoblast cell line NC-37. We compared glucocorticoid...
- The effects of high-dose intravenous immunoglobulin on plasma protein and lipid levels in the patients with Kawasaki disease
- Keun Young Lee, Dong-Un Kim, Hyun Seung Lee, Pil Sang Jang, Young-Hoon Kim, Jin Tack Kim, Hyun Hee Kim, Kyung-Yil Lee, Joon-Sung Lee
- Clin Exp Pediatr. 2006;49(12):1348-1353. Published online December 15, 2006
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Purpose : The reticuloendothelial system is composed of sinusoidal capillaries, through which even large protein molecules are freely movable between plasma and interstitial space, including the lymphatic system. Therefore, high-dose intravenous immunoglobulin (IVIG) would cause a redistribution of proteins between two compartments. To investigate this hypothesis, we measured plasma protein and lipid levels in patients with Kawasaki disease before and... -
- Case Report
- Giant Coronary and Axillary Aneurysms in an Infant with Kawasaki Disease Associated with Thrombocytopenia
- Sei Young Seo, Jin Hee Oh, Jong-Hyun Kim, Ji-Whan Han, Kyung-Yil Lee, Dae Kyun Koh
- Clin Exp Pediatr. 2005;48(8):901-906. Published online August 15, 2005
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Kawasaki disease (KD) is a leading cause of acquired heart disease in children. Yet the etiology of KD is still unknown and diagnosis depends on the exclusion of other diseases and the clinical manifestations meeting the defined criteria. Young infants frequently show atypical clinical courses and are frequently complicated with coronary aneurysms. Some cases show thrombocytopenia, which is known as... -
- Original Article
- Clinico-epidemiologic Study of Henoch-Sch nlein Purpura in Children, 1987 through 2003
- Sun-Mee Choi, Kyung-Yil Lee
- Clin Exp Pediatr. 2005;48(2):174-177. Published online February 15, 2005
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Purpose : We evaluated children with Henoch-Sch nlein purpura(HSP) in terms of epidemiology and clinical characteristics. Methods : A total of 424 medical records of children with HSP admitted to The Catholic University of Korea, Daejeon St. Mary's Hospital, from 1987 to 2003 were retrospectively analyzed. Results : The mean annual number of cases was 25.1?.9 and no one year showed an... -
- Clinico-epidemiologic Study of Mycoplasma pneumoniae Pneumonia(1993 through 2003)
- Seung-Hyun Lee, Suk-Man Noh, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Mi-Hee Lee, Joon-Sung Lee, Byung-Chul Lee
- Clin Exp Pediatr. 2005;48(2):154-157. Published online February 15, 2005
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Purpose : We evaluated the epidemiologic and clinical characteristics of mycoplasma pneumonia. Methods : A total of 559 medical records of children with mycoplasma pneumonia admitted to The Catholic University of Korea, Daejeon St. Mary's Hospital, were retrospectively analyzed. Results : The mean annual number of cases was 51. There was a higher occurrence in autumn (September-November, 41.7%) and in winter(26.7%). Outbreaks... -
- Case Report
- A Case of Meningococcal Meningitis with Complement 9 Deficiency
- Sun-Mee Choi, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Mi-Hee Lee, Byung-Churl Lee
- Clin Exp Pediatr. 2005;48(1):101-103. Published online January 15, 2005
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Meningococcal disease is not rarely associated with abnormalities of the complement system. We experienced a case of C9 deficiency with meningococcal meningitis from a 12-year-old girl. Identification of complement deficiency has implications for management, including family studies, prophylaxis, vaccination, and altered threshold for infection screening and treatment. -
- Original Article
- Epidemiologic Study of Aseptic Meningitis in Daejeon, Korea(1987 through 2003)
- Jung-Hoon You, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Mi-Hee Lee, Byung-Chul Lee
- Clin Exp Pediatr. 2004;47(11):1181-1185. Published online November 15, 2004
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Purpose : To evaluate the epidemiologic characteristics of aseptic meningitis in Daejeon, Korea from 1987 to 2003. Methods : A total of 2201 medical records of children with aseptic meningitis admitted to the Catholic University of Korea, Daejeon St. Mary's Hospital, was retrospectively analyzed. Results : The mean annual number of cases was 129, with a higher rate of occurrence in the... -
- Prediction of Intravenous Immunoglobulin Non-responders in Patients with Kawasaki Disease
- Gi Bum Lee, Ji-Won Lee, Kyung-Yil Lee
- Clin Exp Pediatr. 2004;47(1):90-94. Published online January 15, 2004
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Purpose : We evaluated the effects of intravenous immunoglobulin(IVIG) on the levels of laboratory indices examined serially according to the responsiveness to IVIG therapy in children with Kawasaki disease(KD). Methods : Children with KD(n=63) who had been treated with IVIG at a dosage of 2.0 g/kg were classified into two groups : the IVIG-resistant(consistent fever over 48 hours after initiation... -
- Case Report
- Arthritis in the Subacute Stage of Kawasaki Disease after Responding to Intravenous Immunoglobulin Treatment
- Kyung-Yil Lee, Jin-Hee Oh, Dea-Kyun Koh
- Clin Exp Pediatr. 2003;46(11):1124-1127. Published online November 15, 2003
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We evaluated the clinical and laboratory characteristics of five children with Kawasaki disease who had showed arthritis after responding to intravenous immunoglobulin(IVIG) treatment. Age distribution was between 13 months and six years of age(mean 3.2?.6 years). There were two males and three females. Arthritis occurred when acute symptoms were subsiding, with the average onset on day 5.8?.8 after final IVIG... -
- Original Article
- Causative Organisms in Children with Bacterial Meningitis(1992-2002)
- Hyun-Jung Kim, JI-Won Lee, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Seung-Hoon Hahn, Kyung-Tai Whang
- Clin Exp Pediatr. 2003;46(11):1085-1088. Published online November 15, 2003
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Purpose : This study was performed to assess the difference of organisms causing bacterial meningitis according to time. Methods : We analyzed retrospectively 40 medical records of bacteriologically proven meningitis from 1992 to 2002. We divided them into two groups; neonate's group(14 cases), and children's group(26 cases). The results of the neonate's group were compared with those of previously reported articles... -
- Alteration of Biochemical Profiles after High-Dose Intravenous Immunoglobulin Administration in Kawasaki Disease
- Ji-Won Lee, Kyung-Yil Lee
- Clin Exp Pediatr. 2003;46(8):817-820. Published online August 15, 2003
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Purpose : Intravenous immunoglobulin(IVIG) has been used as an immunomodulatory treatment for several immune-mediated diseases. The early effect of high-dose IVIG on biochemical profiles including lipids and proteins was evaluated in patients with Kawasaki disease(KD). Methods : Twelve children with KD(nine boys) were treated with IVIG of 2 g/kg over 12 hours. Serial sera were collected from the patients four times... -
- Roxithromycin Treatment of Tsutsugamushi Disease (Scrub Typhus) in Children
- Hye-Jin Park, Kyung-Yil Lee
- Clin Exp Pediatr. 2003;46(7):710-713. Published online July 15, 2003
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Purpose : Although chloramphenicol and doxycycline have been used for the treatment of tsutsugamuchi disease, a difficulty exists in determining which drugs to use in treating children because of potential complications such as aplastic anemia or teeth discoloration. We evaluated the effect of roxithromycin, a macrolide antibiotic, on tsutsugamushi disease in children. Methods : A retrospective analysis was conducted on 39... -
- Clinical Significance of C-reactive Protein in Measles
- Sang-Lim Choi, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Kyung-Tai Whang
- Clin Exp Pediatr. 2003;46(5):480-483. Published online May 15, 2003
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Purpose : We evaluated clinical manifestations and laboratory findings in patients with measles according to C-reactive protein(CRP) concentration. Methods : A retrospective analysis was performed using the medical records of patients with measles at The Catholic University of Korea, Daejeon St. Mary's Hospital from October 1999 to May 2000. We divided the patients with measles into four groups according to CRP... -
- Laboratory Values in Patients with Kawasaki Disease after Intravenous Immunoglobulin : Comparison of Patients with Coronary Artery Lesions to those without Coronary Artery Lesions
- Min-Young Park, Kyung-Yil Lee, Ji-Whan Han, Hyung-Shin Lee, Ja-Hyun Hong, Kyung-Tai Whang
- Clin Exp Pediatr. 2003;46(2):162-166. Published online February 15, 2003
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Purpose : We evaluated the effects of intravenous immunoglobulin(IVIG) on level of laboratory parameters examined serially according to the existence of coronary artery lesions in children with Kawasaki disease. Methods : Children with Kawasaki disease(n=63), treated with IVIG at a dose of 2.0 g/kg, were classified as a group with coronary artery lesions(CALs＋ group, n=9) or a group without coronary... -
- A Comparative Study of Measles According to Age
- Eun-Sung Eun, Sang-Lim Choi, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Jin-Han Kang, Kyung-Tai Whang
- Clin Exp Pediatr. 2003;46(1):33-36. Published online January 15, 2003
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Purpose : We evaluated clinical manifestations and laboratory findings in patients with measles according to age distribution. Methods : Retrospective analyses were performed using medical records of patients with measles admitted to The Catholic University of Korea, Daejon St. Mary's Hospital from October 2000 to May 2001. We divided the patients with measles into three age groups, i.e., those who were... -
- An Epidemiologic Study of Kawasaki Disease(1987-2000) : Incidence of Coronary Artery Complication in the Acute Stage
- Kyung-Yil Lee, Min-Young Park, Ji-Whan Han, Hyung-Shin Lee, Jin Choi, Kyung-Tai Whang
- Clin Exp Pediatr. 2002;45(6):783-789. Published online June 15, 2002
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Purpose : We evaluated the epidemiologic characteristics and incidence of coronary artery sequele of children with KD according to treatment. Methods : We retrospectively analyzed 506 medical records of children with KD, who were admitted at Daejeon St. Mary's Hospital from Jan. 1987 to Dec. 2000. Results : The mean annual incidence was 36.1±11.1 cases per year. There was a slightly higher... -
- Radiographic Findings and Atelectasis in Children Admitted to Hospital with Acute Asthma
- Yoo-Jin Jung, Hye-Jin Jung, Kyung-Yil Lee, Won-Bae Lee, Dong-Hurn Yang
- Clin Exp Pediatr. 2002;45(4):519-523. Published online April 15, 2002
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Purpose : We aimed to evaluate the abnormalities of chest radiographs including atelectasis in children who were admitted with bronchial asthma. Methods : We retrospectively analyzed the 357 chest radiographs and the clinical and laboratory features of the 144 children with asthma, who were admitted at Daejoen St. Mary's Hospital from April 1994 to May 1998. Results : Clinical and laboratory... -
- Case Report
- A Case of Acute Renal Failure Following Intravenous Immunoglobulin Therapy in a Child
- Sung-Wook Park, Kyung-Yil Lee, Kyung-Yil Lee, Kye-Nam Yoon, Sang-Won Cha, Dong-Jun Lee, Ji-Whan Han, Kyung-Tai Whang
- Clin Exp Pediatr. 2000;43(5):720-724. Published online May 15, 2000
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Intravenous immunoglobulin(IVIG) therapy is associated with a number of complications, including rare acute renal failure(ARF). Although the cause of IVIG-associated ARF is unknown, it may be related to the stabilizing agent used in IVIG preparations. ARF following IVIG infusion has not been previously described in children. We report a 4-year-old girl with Kawasaki disease who suffered from ARF following IVIG... -
- Original Article
- Clinical Study of Recurrent Parotitis in Children
- Sam-Hwa Yim, Kye-Nam Yoon, Kyung-Yil Lee, Sang-Won Cha, Dong-Jun Lee, Ji-Whan Han, Jin-Han Kang, Kyung-Tai Whang
- Clin Exp Pediatr. 2000;43(5):619-624. Published online May 15, 2000
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Purpose : Recurrent parotitis is defined as a recurrent parotid inflammation, generally associated with sialectasis of the parotid gland. It can often be misdiagnosed as recurrent mumps. We studied the clinical and laboratory features of recurrent parotitis. Methods : Outpatient clinical records of 23 cases were analyzed retrospectively between April 1993 and March 1999. Follow-up after the last outpatient clinic... -
- Case Report
- A Case of Common Variable Immunodeficiency with Autoimmune Hemolytic Anemia
- Kyung-Yil Lee, Yon-Joo Lee, Sang-Won Cha, Dong Joon Lee, Ji-Whan Han, Kyung-Tae Whang, Joong-Gon Kim
- Clin Exp Pediatr. 2000;43(1):117-122. Published online January 15, 2000
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Common variable immunodeficiency(CVID) is a heterogeneous collection of disorders with hypogammaglobulinemia with recurrent bacterial infections and high incidence of autoimmune disorders as its hallmark. We report a 7-year-old girl suffering from CVID with Coombs' test positive hemolytic anemia. She had been relatively well until 23-months old when she was admitted to Taejon St. Mary' s Hospital with pneumonia 5 years ago. Afterwards, she had... -
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