- Review Articles
- Obstructive sleep apnea syndrome in children: Epidemiology, pathophysiology, diagnosis and sequelae
- Sun Jung Chang, Kyu Young Chae
- Clin Exp Pediatr. 2010;53(10):863-871. Published online October 31, 2010
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The prevalence of pediatric obstructive sleep apnea syndrome (OSAS) is approximately 3% in children. Adenotonsillar hypertrophy is the most common cause of OSAS in children, and obesity, hypotonic neuromuscular diseases, and craniofacial anomalies are other major risk factors. Snoring is the most common presenting complaint in children with OSAS, but the clinical presentation varies according to age. Agitated sleep with...
- Treatment of obstructive sleep apnea in children
- Young Min Ahn
- Clin Exp Pediatr. 2010;53(10):872-879. Published online October 31, 2010
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Obstructive sleep apnea (OSA) in children is a frequent disease for which optimal diagnostic methods are still being defined. Treatment of OSA in children should include providing space, improving craniofacial growth, resolving all symptoms, and preventing the development of the disease in the adult years. Adenotonsillectomy (T&A) has been the treatment of choice and thought to solve young patient's OSA...
- Original Articles
- Multiple births conceived by assisted reproductive technology in Korea
- Young Sil Park, Sun Hee Choi, Kye Shik Shim, Ji Young Chang, Won Ho Hahn, Yong Sung Choi, Chong-Woo Bae
- Clin Exp Pediatr. 2010;53(10):880-885. Published online October 31, 2010
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Purpose The recent trends of multiple births (MBs) conceived by assisted reproductive technology (ART) in Korea were analyzed as well as the relationship with maternal age, especially advanced maternal age.
Methods Data were obtained from the Korean Statistical Information Service and annual ART reports from the ART committee of the Korean Society of Obstetrics and Gynecology.
Results MBs increased from the early 1990s; there was...
- Clinical characteristics of children with 2009 pandemic influenza A (H1N1) admitted in a single institution
- Sang In Park, Min Ji Kim, Ho Yeon Hwang, Chi Eun Oh, Jung Hyun Lee, Jae Sun Park
- Clin Exp Pediatr. 2010;53(10):886-891. Published online October 31, 2010
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Purpose This study aims to investigate the clinical characteristics of children diagnosed with the novel influenza A (H1N1) in the winter of 2009 at a single medical institution.
Methods Out of 545 confirmed cases of influenza A (H1N1) in children, using the real time RT-PCR method at Kosin University Gospel Hospital from September to December of 2009, 149 patients and their medical records...
- Prevalence and risk factors of the metabolic syndrome in young adults with childhood-onset hypopituitary growth hormone deficiency
- Han Hyuk Lim, Min Jae Kang, In Suk Yun, Young Ah Lee, Choong Ho Shin, Sei Won Yang
- Clin Exp Pediatr. 2010;53(10):892-897. Published online October 31, 2010
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Purpose This study evaluated the prevalence of the metabolic syndrome (MetS) and risk factors for metabolic derangement in young adults with childhood-onset hypopituitary growth hormone deficiency (ACOHGHD).
Methods Thirty patients with ACOHGHD who were treated with hormone-replacement therapy, aged 18 to 29 years, who visited the Seoul National University Children's Hospital between September 2009 and February 2010 were enrolled. Height, weight, waist circumference,...
- The neuroprotective effect of recombinant human erythropoietin via an antiapoptotic mechanism on hypoxic-ischemic brain injury in neonatal rats
- Moon Sun Kim, Yoo Kyung Seo, Hye Jin Park, Kye Hyang Lee, Kyung Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Woo Taek Kim
- Clin Exp Pediatr. 2010;53(10):898-908. Published online October 31, 2010
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Purpose The neuroprotective effects of erythropoietin (EPO) have been recently shown in many animal models of brain injury, including hypoxic-ischemic (HI) encephalopathy, trauma, and excitotoxicity; however, limited data are available for such effects during the neonatal periods. Therefore, we investigated whether recombinant human EPO (rHuEPO) can protect against perinatal HI brain injury via an antiapoptotic mechanism.
Methods The left carotid artery was ligated...
- Case Reports
- An atypical phenotype of hypokalemic periodic paralysis caused by a mutation in the sodium channel gene
SCN4A - Yang Hee Park, June Bum Kim
- Clin Exp Pediatr. 2010;53(10):909-912. Published online October 31, 2010
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Familial hypokalemic periodic paralysis is an autosomal-dominant channelopathy characterized by episodic muscle weakness with hypokalemia. The respiratory and cardiac muscles typically remain unaffected, but we report an atypical case of a family with hypokalemic periodic paralysis in which the affected members presented with frequent respiratory insufficiency during severe attacks. Molecular analysis revealed a heterozygous c.664 C>T transition in the sodium...
- A case of intracranial hemorrhage in a neonate with congenital factor VII deficiency
- Won Seok Lee, Young Sil Park
- Clin Exp Pediatr. 2010;53(10):913-916. Published online October 31, 2010
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Congenital factor VII deficiency is a rare autosomal-recessive bleeding disorder. Bleeding manifestations and clinical findings vary widely, ranging from asymptomatic subjects to patients with hemorrhages that may cause significant handicaps. Treatment has traditionally involved factor VII(FVII) replacement therapy using fresh frozen plasma, prothrombin complex concentrates or plasma-derived FVII concentrates. Recombinant activated FVII (NovoSeven®) is currently considered the first-line treatment for...
- Bloody nipple discharge in an infant
- Ji Yeon Seo, Sang Jeong Kim, Soon Joo Lee, Eun Song Song, Young Jong Woo, Young Youn Choi
- Clin Exp Pediatr. 2010;53(10):917-920. Published online October 31, 2010
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Although milky nipple discharge appears frequently in infants, bloody nipple discharge is a very rare finding. We experienced a 4-month-old, breast-fed infant who showed bilateral bloody nipple discharge with no signs of infection, engorgement, or hypertrophy. The infant's hormonal examination and coagulation tests were normal, and an ultrasound examination revealed mammary duct ectasia. The symptoms resolved spontaneously within 6 weeks...
