- Review Article
- Nephrology (Genitourinary)
- Renal replacement therapy in neonates with an inborn error of metabolism
- Heeyeon Cho
- Clin Exp Pediatr. 2019;62(2):43-47. Published online November 7, 2018
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Hyperammonemia can be caused by several genetic inborn errors of metabolism including urea cycle defects, organic acidemias, fatty acid oxidation defects, and certain disorders of amino acid metabolism. High levels of ammonia are extremely neurotoxic, leading to astrocyte swelling, brain edema, coma, severe disability, and even death. Thus, emergency treatment for hyperammonemia must be initiated before a precise diagnosis is...
- Original Articles
- Adolescence Medicine
- Serum alanine aminotransferase levels are closely associated with metabolic disturbances in apparently healthy young adolescents independent of obesity
- Ki Eun Kim, Kyung Suk Baek, Sol Han, Jung Hyun Kim, Youn Ho Shin
- Clin Exp Pediatr. 2019;62(2):48-54. Published online November 23, 2018
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Purpose: Liver metabolism plays a pivotal role in the development of metabolic disorders. We aimed to investigate the clinical and laboratory risk factors associated with alanine aminotransferase (ALT) levels in young adolescents from an urban population in Korea. Methods: A population of 120 apparently healthy adolescents aged 12–13 years was included in the cross-sectional design study; 58 were overweight or obese...
- Neurology
- Genotype-phenotype correlations in pediatric patients with myotonic dystrophy type 1
- Hyeong Jung Kim, Ji-Hoon Na, Young-Mock Lee
- Clin Exp Pediatr. 2019;62(2):55-61. Published online September 23, 2018
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Purpose: Myotonic dystrophy, also known as dystrophia myotonica (DM), is an autosomal dominant disorder with 2 genetically distinct forms. DM type 1 (DM1) is the more common form and is caused by abnormal expansion of cytosine/thymine/guanine (CTG) repeats in the DM protein kinase (DMPK ) gene. Our study aimed to determine whether the age of onset is correlated with CTG...
- Hematology and Oncology
- Lymphocyte-monocyte ratio at day 14 of first cisplatin-doxorubicin chemotherapy is associated with treatment outcome of pediatric patients with localized osteosarcoma
- Jun Ah Lee, Hea Lin Oh, Dong Ho Kim, Jung Sub Lim
- Clin Exp Pediatr. 2019;62(2):62-67. Published online October 1, 2018
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Purpose: We aimed to determine the prognostic significance of lymphocyte counts and the lymphocytemonocyte ratio (LMR) in pediatric patients with osteosarcoma. Methods: We retrospectively reviewed the medical records of 27 pediatric patients with localized extremity osteosarcoma, treated at the Korea Cancer Center Hospital between May 2002 and March 2016. Leukocyte counts and LMR before treatment and on day 14 (LMR14) of...
- Neonatology (Perinatology)
- Dorsal midline cutaneous stigmata associated with occult spinal dysraphism in pediatric patients
- Hyun Jung Sung, Hyun-Seung Lee
- Clin Exp Pediatr. 2019;62(2):68-74. Published online October 1, 2018
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Purpose: To investigate the prevalence of occult spinal dysraphism (OSD) and subsequent neurosurgery in pediatric patients with isolated or combined dorsal midline cutaneous stigmata with or without other congenital malformations. Methods: We carried out a retrospective review of patients who underwent sonography or magnetic resonance imaging (MRI) for OSD because of suspicion of dorsal midline cutaneous stigmata (presumed to be a...
- Case Report
- Allergy
- Drug eruption by antihistamine mistaken for chronic urticaria in a child
- Gun Moo Lee, Shou-Yu Chu, Sung Yeon Kang, Hyo-Bin Kim, Jin-Sung Park, Ja Kyoung Kim
- Clin Exp Pediatr. 2019;62(2):75-78. Published online October 30, 2018
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Although rare, antihistamines can cause adverse effects, including drug-induced eruptions or anaphylaxis. A 4-year-old child visited the pediatric department of a hospital for skin eruptions after administration of antihistamines, (e.g., ucerax [hydroxyzine] or leptizine [levocetirizine]), for cholinergic rashes; he did not have pruritus. Skin prick, intradermal, and drug provocation tests were performed to determine the relationship between the antihistamines and...
