- Perspective
- Other
- Role of the Korea National Institute of Health in the children’s health effect study of particulate matter
- Young Youl Kim
- Clin Exp Pediatr. 2021;64(4):139-140. Published online November 17, 2020
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Particulate matter (PM) adversely affects children’s lungs and cognitive development, and an early exposure to it can lead to chronic metabolic diseases. The Korea National Institute of Health convened a Task Force on the Health Impact of PM to produce scientific evidence and promote technological developments to prevent PM-induced health effects.
- Review articles
- Immunology
- Systematic review of literature and analysis of big data from the National Health Insurance System on primary immunodeficiencies in Korea
- Sohee Son, Ji-Man Kang, Younsoo Hahn, Kangmo Ahn, Yae-Jean Kim
- Clin Exp Pediatr. 2021;64(4):141-148. Published online July 13, 2020
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In this article, a systematic review of reported primary immunodeficiency disease (PID) cases in Korea was performed and we attempted to estimate the number of PID patients and healthcare costs for the first time in Korea. Our review revealed that Korean PID cases are greatly underreported in the literature based on health insurance. Physicians in the field and health care policymakers should be aware of the disease burden of PID.
- Review Articles
- Genetics and Metabolism
- Neurofibromatosis type I: points to be considered by general pediatricians
- Eungu Kang, Hee Mang Yoon, Beom Hee Lee
- Clin Exp Pediatr. 2021;64(4):149-156. Published online July 15, 2020
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Neurofibromatosis type 1 (NF1), a prevalent genetic disease that is transmitted in an autosomal dominant manner, is characterized by multiple cutaneous café-au-lait spots and neurofibromas as well as various degrees of neurological, skeletal, and neoplastic manifestations. The clinical features of NF1 increase in frequency with age, while the clinical diagnosis can remain undetermined in some pediatric patients. Importantly, affected patients...
- Neonatology (Perinatology)
- Clinical implications of coronavirus disease 2019 in neonates
- Do-Hyun Kim
- Clin Exp Pediatr. 2021;64(4):157-164. Published online February 4, 2021
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• Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) was detected in approximately 3% of neonates of mothers with coronavirus disease 2019 (COVID-19).
• Neonatal COVID-19 is relatively benign with 16%–22.4% cases asymptomatic.
• Neonates with pre-existing medical conditions and preterm infants are at a higher risk of severe COVID-19.
• Requirement for neonatal mechanical ventilation is 20%–22.4% (vs. 4% in children)
• Low birth weight (13.9%) and premature birth (22.2%) affect neonates of mothers with COVID-19.
- Editorials
- Genetics and Metabolism
- Improving the lives of children with neurofibromatosis type 1
- Yoo-Mi Kim
- Clin Exp Pediatr. 2021;64(4):165-166. Published online September 18, 2020
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· The early diagnosis of neurofibromatosis type 1 (NF1) could be supported by molecular testing in sporadic NF1 patients and would benefit their health.
· The well-planned surveillance and introduction of newly developed drugs targeting molecular pathways could improve the lives of pediatric NF1 patients.
- Neonatology (Perinatology)
- Fluconazole prophylaxis for prevention of invasive candidiasis in extremely preterm infants
- Chun Soo Kim
- Clin Exp Pediatr. 2021;64(4):167-168. Published online July 17, 2020
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- Which factors predict outcomes of neonates with hypoxic-ischemic encephalopathy following therapeutic hypothermia?
- Gyu Hong Shim
- Clin Exp Pediatr. 2021;64(4):169-171. Published online December 11, 2020
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Determining the therapeutic hypothermia and predict long-term prognosis quickly and accurately in infants with moderate to severe hypoxic-ischemic encephalopathy requires a thorough history taking, physical examination, amplitude-integrated electroencephalography, brain magnetic resonance imaging with diffusion-weighted imaging and proton magnetic resonance spectroscopy, heart evaluation (cardiac enzymes, electrocardiography, and echocardiography), and several other biomarkers.
- Original Articles
- Neonatology (Perinatology)
- Fluconazole prophylaxis against invasive candidiasis in very low and extremely low birth weight preterm neonates: a systematic review and meta-analysis
- Mahmoud Robati Anaraki, Masoud Nouri-Vaskeh, Shahram Abdoli Oskoei
- Clin Exp Pediatr. 2021;64(4):172-179. Published online May 14, 2020
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· Mortality is decreased significantly in meta-analysis of studies in different regimen of fluconazole prophylaxis.
· Significant decrease was seen in incidence of invasive candidiasis-associated mortality in extremely low birth weight infants in same schedules of prophylaxis.
· More studies required to relief the concerns.
- Predictive factors of death in neonates with hypoxic-ischemic encephalopathy receiving selective head cooling
- Behnaz Basiri, Mohammadkazem Sabzehei, Mohammadmahdi sabahi
- Clin Exp Pediatr. 2021;64(4):180-187. Published online August 27, 2020
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Question: What is the most important factor that increases mortality in infants with hypoxic-ischemic encephalopathy (HIE) who receive selective head cooling?
Finding: All cases of neonatal mortality were severe HIE (stage 3), and a severely abnormal amplitude-integrated electroencephalography and mortality were increased with the need for advanced neonatal resuscitation upon delivery.
Meaning: Advanced neonatal resuscitation affects HIE outcomes, and medical personnel should be prepared to provide the best intervention.
