- Review Articles
- Neurology
- Cerebral organoid research for pediatric patients with neurological disorders
- Jin Eun, Jung Eun Lee, Seung Ho Yang
- Clin Exp Pediatr. 2025;68(4):269-277. Published online November 28, 2024
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Cerebral organoids obtained from human induced pluripotent stem cells are transforming the study of pediatric neurological diseases by providing more accurate models of human brain development and pathology. These advancements have improved pathology modeling and the potential for novel therapeutic approaches despite existing challenges such as reproducibility and vascularization.
- Cardiology
- Lifelong impact of elevated blood pressure from childhood to adulthood
- Junhyun Kwon, Eunji Kim
- Clin Exp Pediatr. 2025;68(4):278-286. Published online November 28, 2024
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· Childhood blood pressure (BP) is significantly associated with adult hypertension and cardiovascular disease.
· Despite ongoing debate regarding the need for regular BP screening and early pharmacotherapy in children, the benefits of optimizing BP throughout childhood are clear.
· Childhood presents a critical window for normalizing BP through lifestyle modifications such as reducing sodium intake and increasing physical activity to promote lifelong cardiovascular health and prevent longterm complications.
- Neonatology (Perinatology)
- Recent advances in understanding pathophysiology of non-nutritional stunting in very preterm infants
- Eduardo Cuestas, Alina Rizzotti
- Clin Exp Pediatr. 2025;68(4):287-297. Published online December 23, 2024
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· Previous reviews of extrauterine growth restriction focused mainly on weight growth restriction caused by nutritional factors or pathological conditions.
· This review summarizes recent developments in the pathophysiology of nonnutritional length growth restriction in very preterm infants with focus on the impact of sustained neonatal inflammation on their short- and long-term outcomes.
· Further research is needed to investigate optimal strategies to improve length growth restriction in very preterm infants.
- Editorials
- Neonatology (Perinatology)
- Advancements and challenges in neonatal resuscitation: embracing laryngeal mask airways for improved outcomes
- Jang Hoon Lee
- Clin Exp Pediatr. 2025;68(4):298-299. Published online November 28, 2024
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Positive pressure ventilation (PPV) is the most critical intervention provided during delivery room resuscitation. In the new guidelines, this recommendation has been expanded to suggest the use of laryngeal mask airyway (LMA) versus face masks for PPV. Evidence-based information and hands-on training related to this practice will help more healthcare providers become familiar with and appropriately use LMA during delivery room resuscitations.
- General Pediatrics
- Global breastfeeding efforts: a long way to go
- Hye-Jung Shin
- Clin Exp Pediatr. 2025;68(4):300-302. Published online November 13, 2024
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· Despite much effort, breastfeeding practices remain unsatisfactory worldwide.
· Effective breastfeeding-promoting interventions are needed that are appropriate for age, culture, and social environment.
· Interventions can promote breastfeeding, especially in younger populations such as adolescent mothers.
- Original Articles
- Neurology
- Occurrence of stroke in children and young adults in Indonesia: a multicenter private hospital study
- Jeanne Leman, Veli Sungono, Yosua Timotius Haryono, Muhammad Adam Mudzakir, Dewi Lestari Rahmawati, Callistus Bruce Henfry Sulay, Gilbert Sterling Octavius
- Clin Exp Pediatr. 2025;68(4):303-310. Published online November 13, 2024
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Question: What is the occurrence of pediatric stroke in Indonesia?
Finding: This multicenter study identified 1,074 stroke cases, predominantly hemorrhagic (83.4%), with males and older children at higher risk. Accidents were the primary cause (73.2%).
Meaning: Pediatric stroke in Indonesia shows critical epidemiological trends, highlighting the need for targeted prevention efforts, particularly for high-risk groups like males and accident victims.
- Nephrology (Genitourinary)
- C3 glomerulopathy in children: experience at a resource-limited center
- Soumya Reddy, Abhishek Ghante, Mahesha Vankalakunti, Anil Vasudevan
- Clin Exp Pediatr. 2025;68(4):311-318. Published online November 28, 2024
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Question: What are the clinicopathological features and outcomes of pediatric C3 glomerulopathy (C3G) in resource-limited settings?
Finding: Children with C3G in resource-limited settings have significant morbidities, and most experience kidney sequelae despite treatment. Electron microscopy was performed in only 50% of our patients, while none received complement assays or genetic testing.
Meaning: Pediatric C3G presentation, management, and kidney outcomes vary. Its thorough evaluation and management are challenging in resource-limited settings.
- Pulmonology
- Impact of obesity on pulmonary function of preschool children: an impulse oscillometry study
- Anuvat Klubdaeng, Kanokporn Udomittipong, Apinya Palamit, Pawinee Charoensittisup, Khunphon Mahoran
- Clin Exp Pediatr. 2025;68(4):319-325. Published online November 13, 2024
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Question: Does obesity in preschool children affect lung function, and which obesity indices can predict such alterations?
Finding: Preschool children with obesity exhibit impaired lung function characterized by elevated total and peripheral airway resistance. Waist-to-height ratio was the strongest predictor of such changes.
Meaning: Early obesity prevention and treatment are needed. Monitoring waist-to-height ratio, body weight, and body mass index may help identify children at risk of altered lung function.
- Perspective
- Other
- Telemedicine in pediatrics: things to consider
- Sandhya J. Kadam, Archana Reddy Bongurala
- Clin Exp Pediatr. 2025;68(4):326-328. Published online February 3, 2025
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This article highlights the benefits, challenges, and current significance of telemedicine. Future research is needed, primarily to address the challenges of optimizing the implementation of telehealth. To use telemedicine effectively and efficiently for the timely diagnosis and management of patients, an evaluation of current telemedicine practice is needed. Analysis of shortcomings and advantages can help enhance healthcare delivery to pediatric patients, making it more accessible for future use.
