- Review Articles
- Lung interstitial cells during alveolarization
- Chang Won Choi
- Clin Exp Pediatr. 2010;53(12):979-984. Published online December 31, 2010
-
Recent progress in neonatal medicine has enabled survival of many extremely low-birth-weight infants. Prenatal steroids, surfactants, and non-invasive ventilation have helped reduce the incidence of the classical form of bronchopulmonary dysplasia characterized by marked fibrosis and emphysema. However, a new form of bronchopulmonary dysplasia marked by arrest of alveolarization remains a complication in the postnatal course of extremely low-birth-weight infants....
- Neonatal innate immunity and Toll-like receptor
- Hye Sun Yoon
- Clin Exp Pediatr. 2010;53(12):985-988. Published online December 31, 2010
-
The innate immune response is the first line of defense against microbial infections. Innate immunity is made up of the surface barrier, cellular immunity and humoral immunity. In newborn, immunologic function and demands are different to adults. Neonatal innate immunity specifically suppresses Th1-type immune responses, and not Th2-type immune responses, which are enhanced. And the impaired response of macrophages is...
Ureaplasma infections in pre-term infants: Recent information regarding the role ofUreaplasma species as neonatal pathogens- Tae-Jung Sung
- Clin Exp Pediatr. 2010;53(12):989-993. Published online December 31, 2010
-
Although numerous clinical observational studies have been conducted over a period of over 30 years, the clinical significance of
Ureaplasma infection is still under debate. TheUreaplasma speices. is a commensal in the female genital tract and considered to have of low virulence; however,Ureaplasma colonization has been associated with infertility, stillbirth, preterm delivery, histologic chorioamnionitis, and neonatal morbidities, including...
- Original Articles
- Risk factors of ocular involvement in children with mitochondrial respiratory chain complex defect
- Jung Hyun Chae, Jung Hun Lee, Kyo Ryung Kim, Suk Ho Byeon, Young Mock Lee, Hoon Chul Kang, Joon Soo Lee, Heung Dong Kim
- Clin Exp Pediatr. 2010;53(12):994-999. Published online December 31, 2010
-
Purpose Mitochondrial dysfunction can present with various symptoms depending on the organ it has affected. This research tried to analyze the ophthalmologic symptoms and ophthalmologic examination (OE) results in patients with mitochondrial disease (MD).
Methods Seventy-four patients diagnosed with mitochondrial respiratory chain complex defect with biochemical enzyme assay were included in the study. They were divided into 2 groups based on the OE...
- Therapeutic monitoring of vancomycin according to initial dosing regimen in pediatric patients
- Dae Il Kim, Mi Sun Im, Jin Hyoung Choi, Jina Lee, Eun Hwa Choi, Hoan Jong Lee
- Clin Exp Pediatr. 2010;53(12):1000-1005. Published online December 31, 2010
-
Purpose This study aimed to determine the optimal initial vancomycin dose to achieve appropriate trough levels in pediatric patients.
Methods We analyzed clinical data for 309 children treated with intravenous vancomycin between 2004 and 2009 at 2 different hospitals in South Korea. The patients were 1-16 years old and exhibited normal renal function. Patient data, including reason for treatment and initial dosing regimen,...
- What is the 'objective' differential factor of diarrhea in infancy?: Normal state versus diarrheal illness in infants with chronic frequent and loose stool
- Jin-Bok Hwang, Kyung Ji Kang, Jung Jeung Lee, Ae Suk Kim
- Clin Exp Pediatr. 2010;53(12):1006-1011. Published online December 31, 2010
-
Purpose This study aimed to identify 'objective' differential factors for normal frequent loose stool (NFLS) and diarrheal illness with dehydration and nutritional deficiency (DIDN) among infants with chronic frequent loose stool (CFLS).
Methods Data were analyzed from infants under 2 years of age with CFLS who had been transferred from general pediatricians. These 46 patients were divided into 2 groups (NFLS versus DIDN)....
- Clinical outcome of transcatheter closure of patent ductus arteriosus in small children weighing 10 kg or less
- Young A Park, Nam Kyun Kim, Su-Jin Park, Bong Sic Yun, Jae Young Choi, Jun Hee Sul
- Clin Exp Pediatr. 2010;53(12):1012-1017. Published online December 31, 2010
-
Purpose Transcatheter closure has become an effective therapy in most patients with patent ductus arteriosus (PDA). However, there are difficulties in transcatheter closure of PDA in small children. We reviewed clinical outcomes of transcatheter closure of PDA in children weighing less than 10 kg in a single center.
Methods Between January 2003 and December 2009, 314 patients with PDA underwent transcatheter closure in...
- Case Reports
- A family with Townes-Brocks syndrome with congenital hypothyroidism and a novel mutation of the
SALL1 gene - Won Ik Choi, Ji Hye Kim, Han Wook Yoo, Sung Hee Oh
- Clin Exp Pediatr. 2010;53(12):1018-1021. Published online December 31, 2010
-
Townes-Brocks syndrome (TBS) is a rare autosomal dominant congenital disorder caused by mutations in the
SALL1 gene. Its signs and symptoms overlap with other genetic syndromes, including VACTERL association, Pendred syndrome, Baller-Gerold syndrome, and cat eye syndrome. Structural vertebral abnormalities, hypoplasia of the thumb, and radial bone abnormalities, which are not usually associated with TBS, help in the differential diagnosis...
- A case of thanatophoric dysplasia type I with an R248C mutation in the
FGFR3 gene - Eun Jung Noe, Han Wook Yoo, Kwang Nam Kim, So Yeon Lee
- Clin Exp Pediatr. 2010;53(12):1022-1025. Published online December 31, 2010
-
Thanatophoric dysplasia (TD) is a short-limb neonatal dwarfism syndrome that is usually lethal in the perinatal period. It is characterized by shortening of the limbs, severely small thorax, large head with a prominent forehead, macrocephaly, curved femur, and flattened vertebral bodies. These malformations result from the mutation in fibroblast growth factor receptor 3 (FGFR-3) gene which is located on the...
