- Review Article
- Endocrinology
- Management issues of congenital adrenal hyperplasia during the transition from pediatric to adult care
- Jin-Ho Choi, Han-Wook Yoo
- Clin Exp Pediatr. 2017;60(2):31-37. Published online February 27, 2017
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Steroid 21-hydroxylase deficiency is the most prevalent form of congenital adrenal hyperplasia (CAH), accounting for approximately 95% of cases. With the advent of newborn screening and hormone replacement therapy, most children with CAH survive into adulthood. Adolescents and adults with CAH experience a number of complications, including short stature, obesity, infertility, tumor, osteoporosis, and reduced quality of life. Transition from...
- Original Articles
- Cardiology
- Relationship between serum sodium level and coronary artery abnormality in Kawasaki disease
- Sora Park, Lucy Youngmin Eun, Ji Hong Kim
- Clin Exp Pediatr. 2017;60(2):38-44. Published online February 27, 2017
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Purpose Kawasaki disease (KD) is an immune-related multisystemic vasculitis that occurs in children, especially ensuing from a coronary artery abnormality. Sodium level is known to be related to vascular injury, which could affect the progress of KD. The purpose of this study was to determine the serum sodium levels that could predict the occurrence of cardiac and coronary artery events in...
- Endocrinology
- The serum level of 25-hydroxyvitamin D for maximal suppression of parathyroid hormone in children: the relationship between 25-hydroxyvitamin D and parathyroid hormone
- Jung In Kang, Yoon Suk Lee, Ye Jin Han, Kyoung Ae Kong, Hae Soon Kim
- Clin Exp Pediatr. 2017;60(2):45-49. Published online February 27, 2017
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Purpose Serum level of 25-hydroxyvitamin D (25-OHD) is considered as the most appropriate marker of vitamin D status. However, only a few studies have investigated the relationship between 25-OHD and parathyroid hormone (PTH) in children. To this end, this study was aimed at evaluating the lowest 25-OHD level that suppresses the production of parathyroid hormone in children.
Methods A retrospective record review was...
- Neonatology (Perinatology)
- Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures
- Jae Won Shin, Yun Seob Jung, Kyungsoo Park, Soon Min Lee, Ho Seon Eun, Min Soo Park, Kook In Park, Ran Namgung
- Clin Exp Pediatr. 2017;60(2):50-54. Published online February 27, 2017
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Purpose The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software NONMEM.
Methods A retrospective analysis of 18 neonatal patients with seizures, who were treated with LEV, including 151 serum samples, was performed. The mean loading dose was 20 mg/kg, followed by...