The neurodevelopmental risks of very preterm infants have been well recognized; however, studies of the neurodevelopmental outcomes of MLPT infants have been reported over the last two decades [2-4].

The fetal brain weight at 34-week gestation is only 65% of the weight at 40-week gestation [5]. Thus, the last few weeks of gestation are important for brain maturation. The brain of the preterm infant has to grow, mature, and adapt to the extrauterine environment after birth, and the interruption of this natural process may affect the infant’s neurodevelopment.

In recent issue of Clinical and Experimental Pediatrics, Jin et al. [6] reported on the long-term outcomes of MLPT infants at school age. Of their MLPT population, 24.3% had a borderline intelligence function and memory quotient, 32.4% had a borderline executive quotient, 13.5% had internalizing problems, and 66.7% had an abnormal score for at least one variable for attention deficit hyperactivity disorder.

Vohr [2] and Natarajan and Shankaran [3] reviewed studies of the long-term neurodevelopmental outcomes of MLPT infants at school age. They reported that MLPT children were at an increased risk of developmental, language, and cognitive delays at school age, showed poorer school performance, and were more likely to need special education for behavioral problems. A meta-analysis of cognitive development and behavioral problems indicated an increased incidence of internalizing or externalizing behavior and a higher prevalence of attention problems in MLPT children [7].

Bogičević et al. [8] reported that Weschler Full Scale and Verbal Intelligence Quotient scores of 6-year-old MLPT children were lower than those of their full-term peers, a phenomenon that can be predicted by a toddler’s skills at 24 months of age.

Putnick et al. [9] assessed language performance from 5 months to 8 years of age and reported that MLPT children had poorer performance than that of their full-term peers, a difference that was stable from 20 months to 8 years. They suggested that language performance at the end of the second year is highly predictive of later language performance and claimed that physicians must refer MLPT infants for early intervention whenever they recognize language delays.

As Vohr [2] suggested, the close surveillance of MLPT children’s neurodevelopmental status and early referral of those demonstrating a neurodevelopmental delay is important.

The study of Jin et al. [6] had some limitation. Specifically, it lacked a full-term peer control group and included only neonatal intensive care unit graduates, who had medical complications and were at higher risk than their counterparts who did not require intensive care were in. However, it called attention to the importance of surveillance of the neurobehavioral development of MLPT children.

MLPT births comprised 90.1% of total preterm births in Korea in 2018 [1]. The need for long-term follow-up for MLPT infants increases the burden on medical facilities. As Favrais and Saliba [4] suggested, we must determine the selection criteria for long-term follow-up of MLPT infants or a screening policy that identifies the targeted population using developmental screening tests based on parental response. In Korea, infants and children 4–71 months of age have been screened annually since 2007 through the National Health Screening Program for Infants and Children. As part of the health screening program, neurodevelopmental screening is performed annually from 9 months of age until a child’s sixth birthday. Infants and children born between 2008 and 2009 were screened with the Korean version of the Ages and Stages Questionnaire, a neurodevelopmental screening test, through the national health screening program. As higher refer rates were consistently observed in prematurely born children (Table 1), they were at a higher risk of developmental delay than were their full-term peers.

In 2015, a new developmental screening test based on parental response, the Korean Developmental Screening Test for Infants and Children (K-DST), was developed and launched in the National Health Screening Program for Infants and Children [10]. About 75% of infants and children who were born in Korea, including preterm infants, have since been screened annually by the K-DST as a part of the national health screening program. All children are provided with annual screening opportunities by the K-DST; furthermore, MLPT children must be evaluated and monitored by pediatric neurologists or psychiatrists according to a standardized protocol if they show any signs of developmental delay or behavioral problems.

The proper analysis of the neurodevelopmental evaluation data of MLPT referred cases will provide the basis for selection criteria for the further evaluation of and early intervention for MLPT infants and children.