Assessing pain in newborns is challenging because of the infants’ inability to communicate with the health care providers [3]. Therefore, neonatal intensive care units must adopt effective pain assessment tools that consider multiple factors (gestational age and physiological and behavioral responses to pain).

Thus, health care professionals face the dilemma of balancing the need for proper monitoring, testing, and treatment with the need to minimize patient pain and stress. Certain nonpharmacological methods can efficiently decrease pain and discomfort due to routine care measures and minor procedures (e.g., heel stick and phlebotomy) in preterm and term neonates [4]. These methods include breastfeeding, nonnutritive sucking, swaddling, or facilitated tucking (gently maintaining the arms and legs in a flexed position), skin-to-skin contact (e.g., kangaroo care), and sensorial saturation through massage, touch, voice, and smell.

Pharmacological therapies for neonatal pain control include oral sucrose and other sweet liquids, local analgesia including topical anesthetics and lidocaine, and systematic analgesia including opioid therapy (morphine and fentanyl) [5]. When sucrose is used, it should be prescribed and tracked as a medication, and the neonate should be monitored for changes in vital signs as well as any clinical signs of aspiration. Whenever pharmacological therapy—especially systematic analgesia—is used, the balance between the benefits and the adverse effects of the intervention must be considered. Opioid therapy, in particular, can have numerous adverse effects including respiratory depression, hypotension, urinary retention, and reduced gut motility [5].

Kumar et al. [6] investigated and compared the effectiveness of various nonpharmacological methods of analgesia in newborns in a prospective study conducted at a tertiary care hospital. Three hundred healthy term neonates were divided into 6 groups of 50 newborns each. Groups 1–5, the intervention groups, received one of 5 nonpharmacological interventions (breastfeeding, nonnutritive sucking, rocking, 25% sucrose, or distilled water), while group 6, the control group, received no intervention. All patients subsequently received an intramuscular hepatitis B vaccine injection. Interestingly, in contrast to most other studies, Kumar et al. [6] considered sucrose a nonpharmacological method of intervention, reporting that when breastfeeding is unavailable, other methods such as 25% sucrose or nonnutritive sucking can be employed in the pain management of newborns.

Preventing pain is an important goal of pain management. Further, it is considerably more difficult to control pain once it has started. A thorough understanding of the pain mechanism is necessary for pain management in newborns. Therefore, every neonatal intensive care unit should adopt an effective pain prevention protocol that includes plans for reducing the number of painful procedures performed as well as a pain assessment and management plan that includes routine pain assessment and pharmacological and nonpharmacological options for minimizing pain.