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"Most viewed" Articles are from the articles published in 2024 during the last six month.
- Editorial
- Infection
- Preventing bloodstream infections in children after liver transplantation
(1,902 times)
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Young June Choe
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Clin Exp Pediatr. 2024;67(11):599-600. Published online April 18, 2024
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Liver transplantation (LT) is crucial for children with end-stage liver diseases, yet bloodstream infections (BSI) pose significant risks, despite medical advancements. Immunosuppressants, essential for preventing organ rejection, heighten infection susceptibility. Understanding BSI organisms is vital due to antimicrobial resistance. Pediatric LT recipients have unique risk factors, demanding tailored preventive measures. This systematic review on bacterial BSI emphasizes the urgency of effective prevention strategies, considering the high incidence and distinct organism profile. Further research is vital for optimizing antibiotic management and improving outcomes for this vulnerable population. |
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- Original Article
- Nephrology (Genitourinary)
- Serum metabolomic profile in children with sepsis-associated acute kidney injury
(1,764 times)
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Nisha Chaudhary, Praveen Singh, Abhijeet Saha, Shantanu Sengupta
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Clin Exp Pediatr. 2026;69(7):545-554. Published online April 15, 2026
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Question: Can the potential metabolites/pathways involved in the pathogenesis of sepsis-associated acute kidney injury (SA-AKI) be identified using metabolomics?
Finding: We identified 18 novel metabolites involved in the pathogenesis of SA-AKI as well as 31 metabolites that were altered in severe AKI. Linoleic acid, linolenic acid, and phospholipid pathways were altered in SA-AKI.
Meaning: Once validated, these markers may be used to diagnose SA-AKI at an early stage before sufficient kidney injury occurs. |
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- Editorial
- Neonatology (Perinatology)
- Impacts of maternal COVID-19 during pregnancy on neonatal health and epidemiology
(1,758 times)
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Jae Woo Lim
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Clin Exp Pediatr. 2024;67(3):149-151. Published online December 28, 2023
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Newborns born to mothers infected with coronavirus disease 2019 (COVID-19) should be closely monitored for respiratory disorders, such as transient tachypnea of the newborn, regardless of their COVID-19 test results. Further research is required of the development of infants born to mothers with COVID-19. The trends in Korea's birth rate and infant mortality rates have not been significantly affected by COVID-19. |
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- Editorial
- Critical Care Medicine
- Is it possible to provide palliative care to pediatric patients with neurological diseases?
(1,626 times)
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Young-Hoon Kim
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Clin Exp Pediatr. 2024;67(8):403-404. Published online February 15, 2024
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· Patients with neurological diseases often require external mechanical support to maintain mechanical ventilation or supply.
· Little has been done to help the families of affected children make difficult decisions that carry significant physical and psychological consequences.
· The establishment of a department that provides pediatric palliative care for neurological patients should be considered. |
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- Erratum: Authour correciton
- Author correction: Bifidobacterium animalis subsp. lactis BLa80 for preventing allergic, respiratory, and gastrointestinal diseases in young children in China: a randomized double-blind placebo-controlled trial
(1,625 times)
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Ke Chen, Xi Zhang, Kaihong Zeng, Jiayi Zhong, Shanshan Jin, Yang Nie, Ping Yang, Nianyang He, Haixia Chen, Yanmei Cao, Yunrong Fu, Ziji Fang, Wei Jiang, Changqi Lium
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Clin Exp Pediatr. 2026;69(5):455-455. Published online April 28, 2026
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- Original Article
- Other
- Did government subsidy program improve quality of care for children with complex chronic conditions in children’s hospitals? A quasi-experimental study in South Korea
(1,452 times)
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Riyoung Na, Myoung-Hee Kim, Seok-Jun Yoon
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Clin Exp Pediatr. 2026;69(7):582-592. Published online May 28, 2026
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Question: Do government-funded Specialized Public Medical Centers for Children (SPMCCs) improve the quality of care for pediatric patients requiring complex and intensive medical care?
Finding: The SPMCC hospital designation reduced 30-day readmission rates among pediatric patients with severe conditions.
Meaning: Government investments are associated with improved quality of care for children with complex chronic conditions. Therefore, sustained government funding is essential to enhancing pediatric care quality. |
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- Hematology
- Peripheral blood cell counts of prematurely born, small for gestational age neonates
(1,370 times)
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Mara O. Zuiderwijk, Sophie Groene, Enrico Lopriore, Vincent Bekker, Michiel H.D. Schoenaker
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Clin Exp Pediatr. 2026;69(7):572-581. Published online May 12, 2026
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Question: As small for gestational age (SGA) neonates are more susceptible to infections, we hypothesized that their complete blood count and leukocyte differentiation might be affected.
Finding: The counts of multiple blood cells of extreme SGA neonates were affected as illustrated by multivariate analyses, which showed significant decreases in neutrophil, monocyte, lymphocyte, and thrombocyte counts.
Meaning: The mechanisms underlying this phenomenon and its clinical effects require further elucidation. |
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- Editorial
- Cardiology
- Beyond morphometry: the atrial septal defect pressure gradient as a dynamic predictor of mitral valve growth in borderline left hearts
(1,345 times)
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Han Ki Park
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Clin Exp Pediatr. 2026;69(6):484-485. Published online May 27, 2026
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Traditional morphometric scores often fail to predict the success of biventricular repair of borderline left hearts. Wang et al. demonstrated that a low atrial septal defect (ASD) pressure gradient is a critical functional predictor of mitral valve growth. By integrating ASD hemodynamics with anatomical data, clinicians can better identify candidates for biventricular repair, proving that the "grey zone" is narrower than previously thought and improving outcomes for vulnerable neonates. |
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- Original Article
- Gastroenterology
- Distinct age-dependent phenotypes of abnormal liver function tests derived from national Emergency Department data
(1,326 times)
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Dong-Uk Kim, Shinjie Choi, Yeji Kim, Lia Kim, Jung Ok Shim, Jin Soo Moon, Jong Woo Hahn, Hye Ran Yang, Ju Young Chang, Jae Sung Ko
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Clin Exp Pediatr. 2026;69(7):563-571. Published online May 14, 2026
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Question: What are the clinical phenotypes and pathogen associations of pediatric and adult Emergency Department visits for abnormal liver function tests?
Finding: Pediatric visits showed fever-predominant profiles with temporal correlations with respiratory viruses, whereas adult visits revealed population-level temporal associations between enteric pathogens and infectious gastroenteritis, upper gastrointestinal disorders, and metabolic comorbidity clustering.
Meaning: These findings provide novel population-level evidence of age-specific pathogen associations and support distinct age-stratified clinical diagnostics. |
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- Neonatology (Perinatology)
- Association between base excess levels and clinical outcomes among very low birth weight infants: a multicenter birth cohort study in South Korea
(1,309 times)
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Ji Yoo Kim, Hyeon Jin Kim, Heeyoon Choi, Minji Kim, Jinseok Lee, Yong Sung Choi, Dong Keon Yon
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Clin Exp Pediatr. 2026;69(7):555-562. Published online May 21, 2026
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Question: Is metabolic acidosis at birth in very low birth weight infants (VLBWIs) associated with long-term clinical outcomes?
Finding: Metabolic acidosis at birth was associated with increased mortality, adverse respiratory outcomes, neurological morbidities, and infection-related and gastrointestinal outcomes.
Meaning: VLBWIs with metabolic acidosis are at high risk of systemic complications. This finding emphasizes the need for close monitoring and comprehensive care. |
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- Pulmonology
- Telomere biology disorders associated with childhood interstitial lung disease
(943 times)
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Maria Greiner-Mai, Christina Katharina Rapp, Katrin Knoflach, Daniel Gräfe, Franz Wolfgang Hirsch, Julia Ley-Zaporozhan, Simone Reu-Hofer, Julia Hentschel, Stefan Zielen, Monika Helena Tedy, Heymut Omran, Ernst Rietschel, Tuğba Sismanlar Eyuboglu, Ayse Tana-Aslan, Nagehan Emiralioglu, Nicola Ullmann, Samuele Naviglio, Massimo Maschio, Fabian Beier, Tuğba Ramaslı Gürsoy, Matthias Griese, Freerk Prenzel
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Clin Exp Pediatr. 2026;69(7):593-603. Published online June 18, 2026
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Question: What are the pulmonary manifestations and clinical characteristics of telomere biology disorders in children with interstitial lung disease?
Finding: Telomere biology disorders are an important but often underrecognized cause of childhood interstitial lung disease and are associated with variable pulmonary, radiologic, and histopathologic findings, frequent multisystem involvement, and often severe disease progression.
Meaning: Early genetic testing and multidisciplinary evaluation are essential for timely diagnosis, optimized management, and improved outcomes in affected children. |
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- Editorial
- Pulmonology
- Telomere biology disorders in childhood interstitial lung disease: new insights from the chILD-EU cohort
(522 times)
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Andrew Courtwright
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Clin Exp Pediatr. 2026;69(7):542-544. Published online June 30, 2026
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Greiner-Mai et al. expand recognition of telomere biology disorder (TBD)-associated interstitial lung disease (ILD) in children, demonstrating heterogenous radiographic and ILD subtypes in combination with variable extrapulmonary phenotypes, even in the absence of ultrashort peripheral blood telomere length (TL). While their findings highlight some of the limitations of current TL testing methods, they introduce critical questions regarding family screening and the role of antifibrotic and telomere-directed therapies in children with TBD-related ILD. |
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