Clinical and Experimental Pediatrics

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Original Article

Assessment of natural killer cell subpopulations in pediatric patients with transfusion-dependent β-thalassemia major

Fathia Elbassal, Mohamed Soliman, Nourhan Mohamed, Mai El-Hamid, Hanan El-Sheity

Background: Iron overload is a hallmark complication in patients with transfusion-dependent β-thalassemia major, primarily resulting from ineffective erythropoiesis, repeated blood transfusions, and increased gastrointestinal iron absorption. This iron accumulation, reflected in elevated serum ferritin levels, has been implicated in immune dysregulation. Natural killer (NK) cells are a pivotal component of the innate immune system, known for their cytotoxic activity and...

DOI: https://doi.org/10.3345/cep.2025.01046 [Accepted]

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