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Original Article
Infection
Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis
Farhad Sarrafzadeh, Seyed Mojtaba Sohrevardi, Hamid Abousaidi, Hossein Mirzaei
Clin Exp Pediatr. 2021;64(8):415-421.   Published online November 20, 2020
The pooled prevalence of methicillin-resistant Staphylococcus aureus (MRSA) was 42% among culture-positive cases of S. aureus, 51% in hospitalized children, and 14% in healthy children. The high prevalence of MRSA in Iranian children may be due to insufficient infection control measures in hospitals, inappropriate use of methicillin, inadequate staff training, and over-prescription of antibiotics in Iran.
Case Report
Neonatology (Perinatology)
Successfully treated infective endocarditis caused by methicillin-resistant Staphylococcus Aureus in extremely low birth weight infant
Sehwa Jung, Kyung Uk Jeong, Jang Hoon Lee, Jo Won Jung, Moon Sung Park
Clin Exp Pediatr. 2016;59(2):96-99.   Published online February 29, 2016

Survival rates of preterm infants have improved in the past few decades, and central venous catheters play an important role in the intensive medical treatment of these neonates. Unfortunately, these indwelling catheters increase the risk of intracardiac thrombosis, and they provide a nidus for microorganisms during the course of septicemia. Herein, we report a case of persistent bacteremia due to...

Retropharyngeal abscess coinfected with Staphylococcus aureus and Mycobacterium tuberculosis after rhinoviral infection in a 1-month-old infant
Jeong Hee Shin, Se In Sung, Jin Kyu Kim, Ji Mi Jung, Eun Sun Kim, Soo Han Choi, Yae Jean Kim, Kang Mo Ahn, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2013;56(2):86-89.   Published online February 25, 2013

A retropharyngeal abscess is a rare disease entity in young infants but can develop after nasopharyngeal viral infection. Group B Streptococcus and Staphylococcus aureus are the most common pathogens in young infants, however, Mycobacterium tuberculosis is very rare. We report the case of retropharyngeal abscess and coinfection with S. aureus and M. tuberculosis in a very young infant presenting with...

Original Article
Regional outbreak of staphylococcal scalded skin syndrome in healthy children
Hyun Jeong Do, Eun Sil Park, Jae Young Lim, Chan Hoo Park, Hyang Ok Woo, Hee Shang Youn, Ji Hyun Seo
Clin Exp Pediatr. 2010;53(1):48-55.   Published online January 15, 2010
Purpose : Staphylococcal scalded skin syndrome (SSSS) is a relatively uncommon superficial blistering skin disease that is due to Staphylococcus aureus. We had experienced a regional outbreak of SSSS over 3 years in healthy children. Methods : We retrospectively reviewed the medical records of those patients diagnosed as SSSS. Most of neonatal cases were nosocomial infections and excluded from the...
Review Article
Regionalization of neonatal care and neonatal transport system
Jong Beom Sin
Clin Exp Pediatr. 2007;50(1):1-6.   Published online January 15, 2007
In the United States, The concept of designation for hospital facilities that care for newborn infants according to the level of complexity of care provided was first proposed in 1976. The extent of perinatal health care regionalization varies widely from one area to the other. facilities that provide hospital care for newborn are classified into three categories on the basis...
Original Article
Clinical characteristics and risk factors for staphylococcal infections in neonatal intensive care unit
Min Kook Chung, Jeong Ho Choi, Jin Keun Chang, Sung Hoon Chung, Chong Woo Bae, Sung Ho Cha
Clin Exp Pediatr. 2006;49(12):1287-1295.   Published online December 15, 2006
Purpose : The importance of staphylococcal infections in NICU has been emphasized in terms of increased resistant strains and increased incidence of morbidity and mortality. In this study, we inrestignted the clinical characteristics and risk factors for staphylococcal infections, and looked into sensitivity trends of antibiotics in the era of a high rate of methicillin-resistant staphylococcus aureus (MRSA) in our...
Epidemiology of central venous catheter related blood stream infections in pediatric patients
Jung Hyun Kim, Ho Sun Eun, Kyung Min Choi, Dong Soo Kim, Dong Eun Young
Clin Exp Pediatr. 2006;49(2):157-161.   Published online February 15, 2006
Purpose : The purpose of this study is to investigate the pathogens of central venous catheter-related blood stream infections and search for the association among the insertion site, the duration and the underlying conditions with the prevalence of central venous catheter-related blood stream infections under 15 years old. Methods : A retrospective study was performed from Jan, 2003 to Dec, 2003...
Clinical Entities and Etiology of Invasive Bacterial Infections in Apparently Healthy Children
Joon Ho Lee, Eun Kyoung Song, Jin A Lee, Nam Hee Kim, Dong Ho Kim, Ki Won Park, Eun Hwa Choi, Hoan Jong Lee
Clin Exp Pediatr. 2005;48(11):1193-1200.   Published online November 15, 2005
ilus influenzae has been declined to 4% each from 23% and 14%, respectively, compared to previous study. S. agalactiae was the most common isolate in the infants ≤3 months. Among the infants and children aged 3 months to 2 years and children of 2-5 years, S. pneumoniae(57%, 52%, respectively, in each group) was the most common isolates followed by S....
Case Report
A Case of Pyomyositis and Toxic Shock Syndrome Caused by Methicillin Resistant Staphylococcus aureus
Yang Kyong Kim, Dal Hyon Kim, Soon Ki Kim, Byong Kwan Son, Young Jin Hong
Clin Exp Pediatr. 2005;48(1):88-92.   Published online January 15, 2005
Pyomysitis is a primary acute bacterial infection of large skeletal muscule, usually occuring in the absence of specific cause of infection. Pyomyositis has been reported mainly in tropical countries and was rare in temperate climates. but it has been recognized with increasing frequency. Toxic shock syndrome(TSS) is an acute mutisystemic disease characterized by high fever, hypotension, multisystem dysfunction and erythematous...
Original Article
Associated-Genes and Virulence Factors of Staphylococcus aureus Isolated from Nasal Cavity of Neonates
Yung Bu Kim, Ji Young Moon, Jae Hong Park
Clin Exp Pediatr. 2003;46(1):24-32.   Published online January 15, 2003
Purpose : Nosocomial infection with Staphylococcus aureus, especially methicillin resistant S. aureus, has become a serious concern in the neonatal intensive care unit. The aim of this study is to investigate the virulence factors, and the relationship between the antibiotic resistance and the associated genes of Staphylococcus aureus isolated from nasal cavity of neonates. Methods : Fifty one isolates of S....
Isolation of Causative Microorganism and Antimicrobial Susceptibility Test in Impetigo Developed in the Past Four Years
Hyun Jeong Lee, Sang Jung Lee, Seog Jun Ha, Chang Kyu Oh, Jin Wou Kim
Clin Exp Pediatr. 2000;43(5):632-637.   Published online May 15, 2000
Purpose : Recently, Staphylococcus aureus has been reported as the principal microorganism isolated from impetigo, showing variable degrees of antimicrobial resistance. The aim of this work was to study the causative organism of impetigo the their antimicrobial susceptibility developed in impetigo in the past four years. Methods : We performed bacterial cultures and antimicrobial susceptibility tests in 73 patients with impetigo...
Clinical Study of Multiple Intestinal Ulcerations and Perforations Caused by Methicillin-Resistant Staphylococcus aureus in Infants
Seok Joo Han, Poong Man Jung, Jai-Eok Kim, Jeong Hong, Hoguen Kim, Inwha Seong, Eui Ho Hwang
Clin Exp Pediatr. 1999;42(1):77-87.   Published online January 15, 1999
Purpose : In recent years, the authors experienced a distinctive clinical entity of multiple intestinal ulcerations and perforations in infants. The purpose of this study was to describe the clinical characteristics of this entity, examine th possible pathogenesis and the effective treatment. Methods : Seven infants underwent abdominal exploration under suspicion of surgical abdomen and were noted to have multiple intestinal...
Interaction of the mec Regulator Genes in Methicillin Resistant Staphylococcus
Young Choi, In Seok Lim, Tae Sub Shim, Mi Kyung Lee, Ae Ja Park
Clin Exp Pediatr. 1998;41(9):1224-1233.   Published online September 15, 1998
Purpose : Low-affinity penicillin-binding protein PBP 2a encoded by mecA is closely related to methicillin resistance in staphylococci, and the expression of PBP 2a is controlled by regulator elements encoded by mecR1 and mecI. Deletion or mutation which occurred in mecI is considered to be associated with constitutive production of PBP 2a. We investigated the distribution of mec regulator genes...
Rapid Identification of Mycoplasma Pneumoniae, Mycobacterium Tuberculosis and Staphylococcus Aureus in Pleural Fluid by PCR
Chang Wan Kim, Byung Moon Ahn, Eun Ryoung Kim, Il Su Kim, Yung Seuk Pak, Sang Chul Sung
Clin Exp Pediatr. 1997;40(9):1232-1241.   Published online September 15, 1997
Purpose : Pleural effusions may develop during the course of bacterial pneumonia. The aim of this study was to evaluate the significance of the polymerase chain reaction(PCR) method for detection of M ycoplasma pneumoniae, M ycobaterium tuberculosis and Staphylococcus aureus from pleural fluid. Methods : Total 12 samples were obtained from pleural fluid; 2 samples from children with Mycoplasma pneumonia, 5 samples from adults with...
Case Report
Toxic Shock Syndrome in a 13 Year Old Boy
Ji Hye Kim, Sung Hee Oh
Clin Exp Pediatr. 1995;38(12):1706-1712.   Published online December 15, 1995
Toxic Shock Syndrome(TSS), known to be mediated by toxins produced by Staphy¡ⓒlococcus aureus, is a potentially fatal multisystemic illness unless treated properly. Although the reported cases of TSS were primarily among menstruating women, more cases of TSS among children, nonmenstruating women and male adults have been reported recently. In Korea, however, TSS has not drawn much attention yet, and no...
Original Article
MIC and MBC of Oral Antimicrobial Agents Against Staphylococcus aureus
Min Hang Kim, Jin Won Park, Yun Joo Chung, Kyung Sik Ryoo, Myung Woong Chang
Clin Exp Pediatr. 1992;35(5):659-666.   Published online May 15, 1992
Antimicrobial susceptibility for 25 stranis of methicillin senitive Staphylococcus (MSSA) and 25 strains of methicillin resistant Staphylococcus aureus (MRSA), isolated from in-patients at Kosin Medical Center from January, 1989 to July, 1990, were tested by the tube dilution method. 1) For MSSA, sensitivity tests showed 21% was sensitive to cefadroxil. Seventy one percent was intermediate and 8% was resistant. 2) 96% of...
A statistical analysis of methicillin-resistant staphylococcus aureus.
Yong Woon Paik, Ji Suk Kim, Yun Joo Cheung, Suk Ja Park, Hung Kim
Clin Exp Pediatr. 1991;34(5):645-653.   Published online May 31, 1991
A comparative study was retrospectively performed with 1220 strains of staphylococcus aureus isolated from out-patients and in-patients at Kosin Medical Center from Jan. 1986 to Aug. 1989, in oder to find annual prevalence of MRSA and susceptibilities to several antibiotics. The following results were observed; 1) overall annual prevalence of MRSA were 18.9% in 1986, 29.4% in 1987, 46% in 1989 and the yearly increasing tendency...
A Clinical Study of Staphylococcus Aureus Infection in Children.
Yong Joon Shin, Young Pyo Chang, Dong Kyu Jin, Byung Kiu Park, Hoan Jong Lee, Hyung Ro Moon
Clin Exp Pediatr. 1990;33(1):35-41.   Published online January 31, 1990
We reviewed 113 patients with Staphylococcus aureus infection and 219 strains of Staphylococcus aureus isolated from pediatric patients of Seoul National University Hospital from Jan. 1, 1987 to Dec. 31, 1987. The results were as follows: 1) The proportion of MSSA was 50.2% of total Staphylococcus aureus isolated and that of MRSA was 49.8%. Staphylococcus aureus were isolated from pus (33.8%), urine (16.9%), ear discharge (8. 2%),...
A Clinical Study of Methicillin Resistant Staphylococcus Aureus.
Young Mok Hwang, Jae Youn Kim, Soon Wha Kim, Myoung Ik Lee, Keun Chan Sohn, Kyeung Eun Jung
Clin Exp Pediatr. 1989;32(12):1661-1668.   Published online December 31, 1989
We studied about antimicrobial susceptibilities of MRSA and isolation rate of MRSA according to culture site among 656 Staphylococcus aureuses which were isolated from various specimens of admitted patients and out-patients in pediatric departmet of National Medical Center during the period from July, 1983 to June, 1988, and clinical observation of 32 invasive infections caused by either MSSA or MRSA was performed. The results were...
Facial and Submandibular Cellulitis due to Staphylococcus Aureus.
Young Suk Song, Moon Ho Chung, Gwi Jong Choi, Soo Jee Moon, Chong Moo Park
Clin Exp Pediatr. 1983;26(7):663-666.   Published online July 31, 1983
A retrospective study was done on 20 cases of facial and submandibular cellulitis, who had been admitted to our institution from August 1978 to August 1982. The following results were obtained. 1) There were no differences in sexual incidence. 2) In age incidence, 14 cases(70%) were before 2 years old. 3) The most frequent site of facial and submandibular cellulitis was left submandibular area, which was 11...
Shigelle, and Salmonella.
NamSu Kim, Jae Ho Lee, Chang Yee Hong
Clin Exp Pediatr. 1982;25(11):1106-1119.   Published online November 30, 1982
1. A total of 3,178 strains of Staphylococcus aureus, 278 strains of Shegella and 506 strains of Salmonella were isolated and tested for sensitivity against antimicrobial agents at Seoul National University Hospital from January 1971 to December 1980. Clinical study was made on children under 15 years old. 2. Sensitive strains to antimicrobial agents were more frequently isolated in children than adult. But the pa竹ern of sensitivity...
Case Report
A Case of Staphylococcal Scalded Skin Syndrome.
Jung Sook Moon, Soo Ok Lee, Dong Hwan Lee, Sang Jhoo Lee
Clin Exp Pediatr. 1981;24(2):169-172.   Published online February 15, 1981
The authors experienced a case of staphylococcal scalded skin syndrome in 6 month old male infant and reported with brief review of literatures. His chief complaints on admission were fever, vomiting, and watery diarrhea for one day. On the fourth hospitalization day, generalized erythema was developed which was followed by generalized skin exfoliation and methicillin therapy was started. On the...