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Original Article
Gastroenterology
Association between Body Mass Index and Hepatitis B antibody seropositivity in children
Yoowon Kwon, Su Jin Jeong
Clin Exp Pediatr. 2019;62(11):416-421.   Published online August 12, 2019
Background: The seropositivity rate of hepatitis B surface antigen (anti-HBs) antibodies is known to be ≥95% after hepatitis B virus vaccination during infancy. However, a low level or absence of anti-HBs in healthy children is discovered in many cases. Recent studies in adults reported that a reduced anti-HBs production rate is related to obesity.
Purpose: To investigate whether body mass index...
Comparison of the seroconversion rate after primary hepatitis B vaccination and after revaccination of non-responders in full-term infants according to mother's HBsAg seropositivity
Jang Hee Kang, Jae Won Moon, Seung Hyun Kong, Kwang Su Hwang, Ji Sun Mok, Hyeon Jung Lee
Clin Exp Pediatr. 2008;51(11):1165-1171.   Published online November 15, 2008
Purpose : This study aimed to identify the true extent of non-responsiveness in full-term infants born from HBsAg-negative or HBsAg-positive mothers and vaccinated against hepatitis B virus (HBV) at 0, 1, and 6 months of age and to evaluate the effect of revaccination among non-responders. Methods : The study included 716 full-term infants born in 2004-2007. Of 716, 662 infants...
The effect of Lantus on glycemic control in children and adolescents with type 1 diabetes mellitus
Young Jun Rhie, Hyun Wook Chae, Ho Seong Kim, Duk Hee Kim
Clin Exp Pediatr. 2007;50(6):565-569.   Published online June 15, 2007
Purpose : With a duration of action of approximately 24 hours and peakless levels, Lantus is a more physiologic basal insulin analogue compared with NPH. The aim of this study was to compare the glycemic control of Lantus plus Humalog with that of premixed insulin in children and adolescents with type 1 diabetes mellitus. Methods : The subjects consisted of...
The outcome of perinatal prophylaxis for HBeAg positive mothers according to the maternal HBV-DNA levels at the delivery time
On Jeong, Jong-Hyun Kim
Clin Exp Pediatr. 2007;50(4):347-354.   Published online April 15, 2007
Purpose : Perinatal hepatitis B viral infection is decreasing; however, 10% of babies to HBeAg positive mothers still become chronic carriers despite perinatal prophylaxis. Although, the cause of prophylaxis failure is still unclear, an importance of maternal HBV-DNA level at the delivery time has been suggested. This study was established to certify if it would be a useful predictable factor...
A study and the growth and the development of microvascular complications in patients with type 1 diabetes mellitus
Young Ah Lee, Kyong-Ah Yun, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2007;50(2):190-197.   Published online February 15, 2007
Purpose : Reduced growth and microvascular complications have been recognized as consequences of type 1 diabetes mellitus (T1DM). We assessed the effect of T1DM on growth and factors associated with the development of microvascular complications. Methods : We conducted a retrospective longitudinal evaluation of 154 patients above 16 years of age. We analyzed factors which affect final height standard deviation scores...
Immune responses of hepatitis B vaccination among very low birth weight infant
Young-Deuk Kim, Myung-Ki Han, Ai-Rhan E. Kim, Ki-Soo Kim, Soo-Young Pi
Clin Exp Pediatr. 2006;49(8):857-863.   Published online August 15, 2006
Purpose : To evaluate the immunogenicity of hepatitis B vaccine among very low birth weight infants(VLBWI) who were vaccinated at 0, 1, 6 months of chronological age and to determine the factors associated with antibody formations. Methods : A total of 243 VLBWI admitted to Seoul and Gangneung Asan Medical Center neonatal intensive care units from 1997 to 2004 were...
Medical Lecture Course
Perinatal Hepatitis B Virus Infection - Viral Factors in the Mechanism of Perinatal Immunoprophylaxis Failure -
Jong-Hyun Kim
Clin Exp Pediatr. 2004;47(2):123-130.   Published online February 15, 2004
Perinatal hepatitis B virus(HBV) infection may occur despite combined immunoprophylaxis with hepatitis B immunoglobulin and vaccines. Although the mechanism of perinatal prophylaxis still has been obscure, it could be due to : in utero infection; host factors as the personal immunological differences of HLA or cytokine gene; viral factors as a high maternal HBV-DNA level or the presence of surface...
Original Article
Sequential Analysis of Hepatitis Be Antigen Status in Infants Born to Hepatitis Be Antigen-Positive Mothers
Eun Sook Park, Hae Kyung Lee, Chang Hee Oh, Sung Ku Kim, Hae Sun Yun, Won Keun Song, Young Ah Lee
Clin Exp Pediatr. 2002;45(6):727-731.   Published online June 15, 2002
Purpose : The objectives of this study are to evaluate the significance of HBeAg positivity in infants born to HBeAg and HBsAg positive mothers. Methods : The HBeAg status of 22 HBeAg positive, HBsAg negative infants born to HBeAg and HBsAg positive mothers from December 1996 to March 1999 were evaluated by enzyme immunoassay. Results : The number of HBsAg positive...
Case Report
A Case of Dominantly Inherited β Thalassemia Due to Hb Dieppe
You Kyoung Choi, Hong Jin Lee, Won Il Park, Kyung Ja Lee, Sung Ha Kang, Ji Yeon Kim, Sung Sup Park
Clin Exp Pediatr. 2002;45(5):659-663.   Published online May 15, 2002
β thalassemias are usually transmitted as autosomal recessive traits. However, some dominant forms of β thalassemia have been identified in individuals who have inherited a single copy of an abnormal β globin gene. Thalassemia intermedia with mild anemia, jaundice, and splenomegaly has been observed in these patients. Electrophoresis has shown elevated Hemoglobin(Hb) A2 and Hb F levels. In particular, there...
Original Article
Effects of Hepatitis B Revaccination in Nonresponsive Children
Ui Chong Chong, Mi Ran Kim, Chong Young Park
Clin Exp Pediatr. 1999;42(6):778-782.   Published online June 15, 1999
Purpose : Hepatitis B virus infection is prevalent in Korea. Active immunization of Hepatitis B has been proceeded extensively for the last decade. This study was performed to estimate the negative rate of anti-HBs after immunization and to evaluate the effect of revaccination among Korean children between 1995 and 1997, as well as to determine a proper revaccination schedule. Methods :...
Immune Responses and Efficacy of Hepatitis B Vaccine in Neonates Born from Hepatitis B Carrier Mothers : Focus on HBV-DNA
Jong-Hyun Kim, Jin-Han Kang, Chang-Kyu Oh
Clin Exp Pediatr. 1998;41(11):1498-1508.   Published online November 15, 1998
Purpose : The aim of this study was to elucidate the pathogenesis of vertical transmission of hepatitis B virus(HBV), and to study the protective efficacy of the vaccine and hepatitis B immune globulin(HBIG). Methods : Eighty-two infants born from HBV carrier mothers were studied. HBV plasma-derived vaccine and HBIG were administered to their neonates. Then, changes of viral markers, anti-preS2...
The Change of Anti-HBs Titer after Injection of HBIG and HBV in Newborn Delivered from HBsAg Carrier Mothers
Qoae Suk Roh, Jin Young Jung
Clin Exp Pediatr. 1997;40(8):1141-1148.   Published online August 15, 1997
Purpose : We studied prevention effects of vertical transmission of Hepatitis B with follow-up, through the change of Anti-HBs titers during 9 months after injection of Hepatitis B immunoglobulin(HBIG) and Hepatitis B vaccine(HBV) at birth in newborn delivered from Hepatitis antigen carrier mothers. Methods : This study was performed on newborn delivered from HBsAg carrier mothers at Hae Sung Hospital from Feb. 1995 to May...
Recent Changesin Prevalence of Hepatitis B Viral Markers in Preschool Children in Seoul,1995
Yon Ho Choe, Jeong Kee Seo, Jeong Hwan Yun, Hyo Seok Lee
Clin Exp Pediatr. 1996;39(9):1254-1259.   Published online September 15, 1996
Purpose : A nationwide hepatitis B vaccination publicity campaign and program was launched in 1988 in Korea. This survey was designed to evaluate the recent changes of the positive rates of hepatitis B surface antigen and antibody in sampled preschool children living in Seoul, 1995. Methods : Study population consisted of 218 preschool children aged 2 to 5 years. Most of them had been...
Serial Changes of Blood Glucose Levelsin IDDM Patients Using Intermediate-acting Insulin only Therapy
Ye Sik Kim, Mi Jung Park, Duk Hi Kim
Clin Exp Pediatr. 1996;39(4):552-557.   Published online April 15, 1996
Purpose : We investigated the clinical characteristics of IDDM patients, treated with NPH only, and evaluated current problems by measurement of serial blood glucose, insulin, C-peptide for 12 hours after administration of intermediate-acting insulin. Methods : We studied 19 IDDM patients who had been diagnosed and followed up on a regular basis at Severance hospital. They were assigned into 2 groups, one(HbA1c...
Prevalence and Its Changes of Hepatitis B Viral Markers from 1988 to 1993 in Korean Children
Jae Geon Sim, Jeong Kee Seo, Seong Jae Suh
Clin Exp Pediatr. 1995;38(11):1535-1539.   Published online November 15, 1995
Purpose : Hepatitis B infection is prevalent in Korea and active immunization of Hepatitis B has been proceeded intensively during the last decade. This study was designed to evaluate the changes of the prevalence of hepatitis B surface antigen (HBsAg) and that of antibody (HBsAb) in Korean children from 1988 to 1993. We can estimate the prevalence and tendency of...
Immunogenicity of a Recombinant Hepatitis B Virus Vaccine Compared With a Plasma-derived Hepatitis B Vaccin~ and of Vaccination Schedules in Neonates
Ae Sil Kang, Jong Sin Kim, Jae Won Huh, Chang Youn Lee, Hyun Gi Jung, Jae Sun Park, Kwang Soo Hwang
Clin Exp Pediatr. 1995;38(11):1525-1534.   Published online November 15, 1995
Purpose : Hepatitis B virus (HBV) vaccine was developed against HBV infection, and used widely in the world. The plasma-derived HBV vaccine was prepared from the plasma of chronic hepatitis B virus carrier. But, the plasma-derived HBV vaccine had many kinds of problems, such as the limitation of source, expensiveness, and the possibility of infection which spread through blood. To avoid these...
The Growth Hormone-Binding Proteins in Human Serum: Partial characterization and Regulation
Ji Young Suh, Bu Hun Lee, Jeh Hoon Shin, Hang Lee, Seong Ryul Jang
Clin Exp Pediatr. 1994;37(10):1427-1436.   Published online October 15, 1994
We assessed abotu growth homone binding proteins(GHP|BP) activity which was measured eluted biotin GH fraction with alkaline phosphatase-streptavidine in children with insulin dependent diabetes mellitus(IDDM), short stature due to growth hormone deficiency(GHD), chronic renal failure, short stature due to nutritional deficiency. Hypothyroidism, and noraml control groups using high pressure liquid chromatography protein pak 300 sw column. The following results are observed: 1)...
Hepatitis with Positive HBsAg in 3 Generations in 3 Families.
Dong Hak Shin
Clin Exp Pediatr. 1987;30(11):1265-1273.   Published online November 30, 1987
Since Jolly reported multiple occurences of cryptogenic cirrhosis in children in a family members in 1892, there had been sporadic cases reported and this familial liver cirrhosis was called as familial juvenile cirrhosis by Gunn. In 1960, numer of family pedigree of chronic liver diseases (such as chronic hepatitis, liver cirrhosis and liver cell carcinoma) in adult was more numerous than that of in...
The Effect of Hepatitis B Vaccination on Newborns of Hepatitis B Carrier Mothers.
Ho Taek Kom, Pyung Kil Kim, Chang Ho Hong, Chul Lee
Clin Exp Pediatr. 1987;30(11):1228-1235.   Published online November 30, 1987
The transmission of hepatitis B virus (HBV) from carrier mothers to their infants is a serious problem in many countries and the transmission rate is reported to be as high as 60%. The best preventive method of perinatal transmission is hepatitis B immune globulin (HBIG) which confers a passive immunity and HB vaccine which confers an active immunity. However, the exact dosage and the...
The Influence of Hepatitis B Virus to Neonates.
Dong Hak Shin, Rac Kyun Ro, Sung Do Yoon
Clin Exp Pediatr. 1986;29(1):51-57.   Published online January 31, 1986
To evaluate the influence of HBV to fetus, authors studied 817 pregnant women and neonates who were admitted to delivery room of Keimyung University Dongsan medical center from 1882 to 1984. The results were as follows; 1) Percent of HBsAg positive mother was 6.8% (50/817) and child bearing age was 7.8% (72/917). Percent of Anti-HBs positive was 33.9% and...
A Clinical Study of Viral Hepatitis in Childhood.
Ju Kyeong Lee, Chan Yong Kim
Clin Exp Pediatr. 1984;27(11):1078-1087.   Published online November 30, 1984
A clinical study has been made on 158 children with viral hepatitis who had been admitted to the pediatric department of Busan Maryknoll Hospital during a 472 year period from January 1979 to June 1983. The following results were obtained. 1) Viral hepatitis was 1.61% of all the pediatric inpatients. Positive rate of HBsAg was 25.9% of viral hepatitis. 2) Age incidence showed even distribution after...
Case Report
Four Cases of Gianotti-Crosti Syndrome.
Yong Gab Kwon, Ki Sup Chung, Kir Yong Kim
Clin Exp Pediatr. 1984;27(8):820-826.   Published online August 31, 1984
The Gianotti-Crosti syndrome, papular acrodermatitis of childhood(PAC), is an infrequently recognized disorder with distinctive characteristics. At present hepatitis B virus is thought to be an etiologic gent. The disease is very rare in Korea, in spite of the high frequency of hepatitis B surface antigen(HBsAg) in the general population. It is known that subtype ayw of the HBsAg may influence...
Original Article
Clinical Study of 20 Pediatric Cases of HBs Antigenemia Associated Membranous Nephropathy.
Jae Seung Lee, Jung Hye Choi, Young Cherl Lee, Duk Jin Yun
Clin Exp Pediatr. 1984;27(8):760-765.   Published online August 31, 1984
A clinical study was done in 20 cases of HBs antigenemia associated membranous nephropathy admitted to the Department of Pediatrics, Yonsei University, College of Medicine, Severance hospital from Jan. 1979 to May 1984. The results are as follows; 1)The age distribution was from 2 years and 5 months to 14 years, and the mean age was 7 years and 10...
The Frequency of HBsAg and HBsAb Positive in Hospitalized Children and Preschool Children in Kindegarten From Busan Area.
Kew Keun Hwang, Won Kyung Kim, Kyung Tae Kim, Jung Hee Lee
Clin Exp Pediatr. 1984;27(1):61-67.   Published online January 31, 1984
The authors evaluated HBsAg and Anti-HBs on 434 cases who were admitted to pediatric ward of St. Benedict Hospital and HBsAg on 656 cases of 6 kindegartens in Busan area from January to April in 1983. The results were as follows. 1)Among 434 cases of hospitalized children (male; 256, female; 178), 24(5.53%) were HBsAg positive and 13(2.98%) were HBsAb positive. 2)Among...
Clinical Assessment of Extrahepatic Biliary Atresia and Neonatal Hepatitis.
Chong Ku Yun, Eue Cho Yang
Clin Exp Pediatr. 1984;27(1):33-42.   Published online January 31, 1984
A clinical assessment was carried out in 37 cases with Extrahepatic biliary atresia (EHBA) and 35 cases with Neonatal hepatitis (NH), who were admitted to the Dept, of Pediatrics and Pediatric Surgery, Seoul National University Hospital, during the 30 months from January 1980 to June 1982. The following results were obtained; 1)By sex distribution, 40% of EHBA and 69% of NH...
Case Report
Two Case of Ginaotti-Crosti Syndrome.
Jae Ho Lee, Soon Ung Kang, Jeong Kee Seo, Hyo Seop Ahn, Kwng Wook Ko, Won Suk Kim
Clin Exp Pediatr. 1982;25(12):1289-1294.   Published online December 31, 1982
The Gianotti-Crosti syndrome is an. infrequently recognized disorder with distinctive clinical features. We have experienced two cases of Gianotti-Crosti syndrome diagnosed by clinical manifestation, laboratory data and histopathologic finding of skin. Case one; An 18-month-old girl was admitted to the pediatric ward with the chief complaint of erythematous rash. Its onset was preceded by an. upper respiratory tract infection. She had a wide spread erythematous...
Original Article
Clinical Observation of Viral Hepatitis.
Han Ku Moon, Chang Moo Lee, Myung Hi Shin, Jee Sub Oh
Clin Exp Pediatr. 1982;25(11):1097-1105.   Published online November 30, 1982
We observed 197 cases of viral hepatitis who were admitted to the dept, of pediatrics in WMBH, Busan, from July ’78 to June ’81 and the following results were obtained. 1. Of 197 cases of viral hepatitis, 52(24.6%) were positive for HBsAg. 2. On admission, increased ESR was found in 58.6% of HBsAg negative group, and the mean value was 20.3+13.7 mm/hr. In HBsAg positive group...
Prevalence of Australia Antigen and Antibody in Pediatric Age Group.
Kwang Woo Kim, Su Young Kim, Jung Joo Kim, Dong Hak Shin
Clin Exp Pediatr. 1982;25(5):445-452.   Published online May 31, 1982
Research study of Hepatitis B infection has been much advanced recently and the incidence of the Hepatitis B infection, such as acute viral hepatitis, chronic active hepatitis, chronic persistant hepatitis, acute fulminating hepatitis and carrier states are increasing significantly. The authors evaluated HBsAg and AntiHBs in the child age group and the results are summarized as follows: Of 271 children...
A Study on the Normal Value of Red Blood Cell of Korean Primary School Children.
Shin Chung Jee, Chang Soo Ra
Clin Exp Pediatr. 1981;24(8):743-751.   Published online August 15, 1981
This study was undertaken on 120 healthy primary school children (male 60, female 60), who live in a fishing village, Geo-Mun island, Chulla-Namdo, in order to investigate normal value of red blood cell. Ages of the children were ranged from six years to twelve years. The author cheked the number of red blood cell, hemoglobin level, hematcrit, mean corpuscular volume(MCV),...
The Incidence of HBs Antigenemia in Glomerular Desease and Control Group in Children.
Yong Choi, Whan Jong Lee, Jeong Kee Seo, Kwang Wook Ko
Clin Exp Pediatr. 1981;24(2):122-127.   Published online February 15, 1981
HBsAg, HBcAb and HBsAb were examined with radio-immunoassay in 265 patients with glomerular disease, who were admitted to wards or visited to outpatient clinics of department of pediatrics, Seoul National University Hospital, from Jan., 78 to Oct. 80, and in 576 control group, with other than liver disease and without history of transfusion. The incidence in glomerular disease was 10.2%(27...