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Original Article

IGF-I on the Expression of Gene Associated with Hypoxic Ischemic Brain Injury in the Neonatal Rats

Hyung-Shin Lee, Sang-Hyun Byun, Ren Zhe Ann, Kyu-Sang Song, Young-Ik Lee, Yoo-Jung Hahn, Yong-Hun Chung

Clin Exp Pediatr. 2001;44(7):796-807. Published online July 15, 2001

Purpose : To investigate the effect of intraperitoneal injection of IGF-I after hypoxic ischemic brain injury on neuronal cell necrosis, apoptosis and expression of proapoptotic and antiapoptotic proteins bax and bcl-2, respectively. Methods : The right carotid artery was cut between the double ligation. Then allowed to recover for 30 minutes followed by exposure to 8% oxygen at 37℃ for...

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