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Original Article

Synergistic Cytotoxicity of Arsenic Trioxide and Sulindac Against Neuroblastoma

Du Young Choi

Clin Exp Pediatr. 2004;47(9):1002-1007. Published online September 15, 2004

Purpose : Recent clinical studies have shown that arsenic trioxide(As2O3) at low concentrations induces complete remission without significant toxicity in patients with refractory acute promyelocytic leukemia(APL). Like APL cells, neuroblastoma(NB) cells are thought to be arrested at an early stage of differentiation, and can respond with retinoic acid treatment. Sulindac, a nonsteroidal antiinflammatory drug, was reported to induce antitumor activity...

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