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Original Article
The association between serum IGF-1 and neonatal growth and disease in a NICU
Jung Ok Kim, Hae Ri Lim, Heng Mi Kim
Clin Exp Pediatr. 2009;52(2):176-180.   Published online February 15, 2009
Purpose : The objective of this study was to establish the serum IGF-1 level in newborn infants, and investigate its association with growth and diseases. Methods : In a retrospective study, serum IGF-1 levels were measured for newborn infants admitted to NICU at Kyungpook University Hospital from March 2007 to July 2007. Birth data, disease history, and hospital course were...
Case Report
Epidural hematoma treated by aspiration of accompanying cephalhematoma in a newborn infant
Ki Won Oh, Heng Mi Kim
Clin Exp Pediatr. 2007;50(11):1125-1128.   Published online November 15, 2007
Epidural hematoma is relatively rare in newborn infants and frequently associated with instrumental deliveries or other complications during labor and delivery. Although surgical evacuation has been the most common therapy, many other procedures have been described. Although many epidural hematomas require surgical evacuation rather than nonsurgical management, conservative or aspiration of hematoma have been attempted. In the case of EDH...
Original Article
Diagnostic limitation and usefulness of 99mTc-DISIDA hepatobiliary scanning on neonatal cholestasis
Jung Mi Kim, Byung-Ho Choi, You Cheol Jang, Ki Won Oh, Min Hyun Cho, Kyung Hee Lee, Jin-Young Park, Heng Mi Kim
Clin Exp Pediatr. 2006;49(7):737-744.   Published online July 15, 2006
Purpose : To assess the usefulness of 99mTc-DISIDA scanning in the early evaluation of neonatal cholestasis and to verify the diagnostic value of this test in the differential diagnosis of biliary atresia. Methods : DISIDA scannings were performed and analyzed in 87 children(58 males and 29 females; age, 18-139 days, mean, 59.1 days) with neonatal cholestasis. Five groups according to the...
The Relationship between Developmental Quotient in Children with Delayed Language Development and Later Intellectual Quotient
So Yeon Kim, Yeon Kyung Jung, Hai Lee Jung, Woo Taek Kim, Im Hee Shin, Jung Han Park, Heng Mi Kim, Jin Kyung Kim
Clin Exp Pediatr. 2004;47(5):496-504.   Published online May 15, 2004
Purpose : The objective of this study was to test the predictive validity of developmental test for later intellectual development in young children with delayed language development. Methods : The study subjects were 66 children who had presented delayed language development and had an initial developmental test and a follow-up intelligence test. The mean age at initial test was 34.2 months(17-48...
Clinical Characteristics and Prognosis of Neonatal Seizures
Chang Wu Kim, Chang Hwan Jang, Heng Mi Kim, Byung Ho Choe, Soon Hak Kwon
Clin Exp Pediatr. 2003;46(12):1253-1259.   Published online December 15, 2003
Backgroud : Seizures in the neonate are relatively common and their clinical features are different from those in children and adults. The study aimed to provide the clinical profiles of neonatal seizure in our hospital. Methods : A total of 41 newborns with seizures were enrolled in this study over a period of three years. They were evaluated with special reference...
The Effect of Postnatal Dexamethasone Treatment on Hypoxic-Ischemic Brain Injury in Neonatal Rats
Chang Ro Park, Kyung Pil Park, Heng Mi Kim, Yoon Kyung Sohn
Clin Exp Pediatr. 2003;46(10):989-995.   Published online October 15, 2003
Purpose : Dexamethasone is frequently administered to prevent or treat chronic lung disease in human neonates who are also prone to hypoxic-ischemic(HI) insults. Recently, meta-analysis of the follow-up studies reveals a significantly increased odd ratio for the occurrence of cerebral palsy or an abnormal neurologic outcome, and there is conflicting evidence regarding the impact of dexamethasone exposure on HI brain...
Changes of Neutrophil Count in Peripheral Blood of the Neonate with Periventricular Leukomalacia
Hwan Seok Lee, Kyung Pil Park, Heng Mi Kim
Clin Exp Pediatr. 2003;46(10):966-971.   Published online October 15, 2003
Purpose : It is now well established that infection and inflammation play an important role in the pathogenesis of ischemic brain damage. The loss of neutrophils from systemic circulation is an associated finding in injury mediated by granulocyte. Periventricular leukomalacia(PVL) caused by ischemia is the principal form of brain injury in premature infants. This study was conducted to evaluate whether...
Total Parenteral Nutrition-associated Cholestasis in Premature Infants
Kyung Pil Park, Se Young Kim, Heng Mi Kim
Clin Exp Pediatr. 2003;46(1):17-23.   Published online January 15, 2003
Purpose : Cholestasis is a major complication in prolonged use of TPN, especially in the neonatal period, but there are few long-term reviews examining the clinical course in premature infants. Thus, in this study, we reviewed premature infants with TPN-associated cholestasis(TPNAC) to determine the incidence, clinical courses and possible risk factors. Methods : Retrospective review of 66 premature infants less than...
A Clinical Characteristics of Systemic Candidiasis in Neonatal Intensive Care Unit : Comparison with Systemic Bacterial Infection
Jung Hwa Lim, Kyung Pil Park, Jin Kyung Kim, Heng Mi Kim
Clin Exp Pediatr. 2002;45(7):847-854.   Published online July 15, 2002
Purpose : Long term hospitalized infants in neonatal intensive care units(NICUs) are prone to systemic infection. It is important to differentiate systemic candidiasis from systemic bacterial infection early in the course. Thus, in this study, we have compared clinical characteristics of systemic candidiasis and systemic bacterial infection, in premature low birth weight infants. Methods : Retrospective chart review of the medical...
Case Report
A Case of Hypernatremic Dehydration in an Exclusively Breast-Fed Newborn Infant
Kyung Pil Park, Jin Kyung Kim, Heng Mi Kim
Clin Exp Pediatr. 2002;45(6):790-795.   Published online June 15, 2002
Sporadic reports of hypernatremic dehydration in breastfed newborn infants have appeared in medical literature for at least 3 decades. We report the first case of hypernatremic dehydration resulting from inadequate breast-feeding in Korea. A 14-day old baby, born to a mentally retarded mother, was transferred to our hospital with a body weight loss of 460 g since birth(17%) and a...
Original Article
Effect of Hypoxia-ischemia on c-fos Expression in the Neonatal Rat Brain
Wang Bock Lee, Sun Hak Kwon, Heng Mi Kim
Clin Exp Pediatr. 2000;43(3):386-394.   Published online March 15, 2000
Purpose : Brain damage resulting from a combination of hypoxia and ischemia in the newborn infant remains a major cause of perinatal death, cerebral palsy, mental retardation and epilepsy. Metabolic stress, including ischemia, hypoxia and seizures, induces the expression of a variety of stress proteins including nuclear proto-oncogene c-fos. The induction of c-fos can be considered a biomarker of events...
Changes in Arterial Blood Gas in Crying Neonates
Yeo Hyang Kim, Heng Mi Kim
Clin Exp Pediatr. 1999;42(11):1496-1501.   Published online November 15, 1999
Purpose : Arterial blood gas and pH measurements are the standard by which adequacy of oxygenation and ventilation are assessed. The major problem with arterial punctures is that they can rarely be done without disturbing the neonates. Crying during arterial puncture usually results in change in respiratory patten and thus may result in significant changes in blood gas values Methods :...
Pain Reduction Effects of Continuous Fentanyl Infusion to Intensive Care Neonates
Wi Kyung Hwang, Heng Mi Kim
Clin Exp Pediatr. 1999;42(5):657-665.   Published online May 15, 1999
Purpose : To determine whether pain control using fentanyl would effectively reduce behavioral distress, physiologic and hormonal responses to postoperative pain and mechanical ventilation in neonates. Methods : Neonates who were admitted to the NICU(neonate intensive care unit) of Kyungpook University Hospital, requiring surgery or mechanical ventilation were evaluated. Twelve neonates undergoing operation were randomised into two groups. After operation, one...
Analgetic Effect of Chloral Hydrate in Pain Induced by Spinal Tap in Neonates
Eun Jin Choi, Heng Mi Kim
Clin Exp Pediatr. 1997;40(7):925-930.   Published online July 15, 1997
Purpose : The need for analgesia in neonates during and after surgery has been widely accepted in the past decade. Pain relief and sedation are still rarely used during minor treatment procedures in the neonatal intensive care units. However, many diagnostic and treatment procedures in the neonatal intensive care unit are noxious and often painful, and highly stressful for sick neonates. Methods : A prospective...
Packed Red Cell Transfusion in Neonate : Effects of Age of Red Cells on Serum Laboratory Values and Readjustment of Hematocrit Values after Transfusion
Dong Ha Lee, Jin Kyung Kim, Heng Mi Kim
Clin Exp Pediatr. 1994;37(4):452-456.   Published online April 15, 1994
Sick neonates often require periodic small volume transfusion(10mg/kg) to replace blood draw for laboratory monitoring during their hospital stay. The effect of packed red cell transfusion on the hematocrit, potassium, ionized calcium, acid base status, glucose and indirect bilirubin was investigated in 25 transfusions. Analysis of transfused blood by the age of the red cells, older red cells (more than...
Case Report
Transient Methemoglobinemia with Acidosis in Newborn
Heng Mi Kim
Clin Exp Pediatr. 1994;37(3):416-421.   Published online March 15, 1994
methemoglobinemia is an uncommon clinicl problem generally caused by inherited disorders of hemoglobin metabolism or environmental toxicity from oxidizing agents. Since methemoglobin has no oxigen carrying capacity, patient with severe methemoglobinemia may have dangerous hypoxia even when arterial oxygen tension is normal. Degree of exposure to oxidants which are benign for older individuals may produce severe methemoglobinemia in newborns. Acidosis without...
Original Article
Postnatal Changes of Cretine Kinase and Isoenzyme Activities in Normal and Asphyxiated Newborns
Ki Young Koo, Nam Geun Heo, Heng Mi Kim
Clin Exp Pediatr. 1993;36(9):1219-1226.   Published online September 15, 1993
This study was conducted to evaluate the postnatal changes of serum creatine kinase (CK)and its isoenzymes in normal and asphyxiated newborns. In normal newborns total CK, CK-MM and CK-MB reached a plateau between 2 and 24 hr after birth whereas the serum CK-BB remained stable after birth. CK-MM, CK-MB and CK-BB respectivily composed 90~94%, 5~7% and 1~5%...
Postnatal change of Atrial natriuretic peptide in newborn Infants
Eun Sook Kim, Heng Mi Kim
Clin Exp Pediatr. 1992;35(9):1193-1197.   Published online September 15, 1992
Atrial natriuretic peptide(ANP)has been described as a part of the regulatory system of volume homeostasis. The role of ANP in postnatal volume hmestasis was investigated in 27 normal newborn infants during the early postnatal period. Plasma Mean plasma concentration of plasma ANP was 24.7¡¾13.8 pg/13.8pg/ml on the 1st day, 56.2¡¾60.0pg/ml on the 3-5th day and 35.0¡¾22.0pg/ml on the 7th day....
A Comparison of Reagent Test Strip-photometer and Laboratory Plasma Glucose Values in Newborns
Jin Kyung Kim, Myung Chul Hyun, Sang Bum Lee, Heng Mi Kim
Clin Exp Pediatr. 1992;35(8):1501-1058.   Published online August 15, 1992
Although reagent test strip-photometer method is frequently used to estimate plasma glucose values in nurseries, the accuracy in newborns have not been evaluated previously. In this study values of 44 samples of laboratory glucose were compared with values simultaneously obtained by reagent test strip-photometer. Laboratory values were determined by glucose oxidase method using veous plasma. Reagent test strip-photometer values were determined...
Serum ionized Ca measured with new ion-selected electrode and Q-oTc interval in newborn infants.
Beom Joo Kim, Chang Hee Han, Heng Mi Kim, Doo Hong Ahn
Clin Exp Pediatr. 1991;34(3):303-310.   Published online March 31, 1991
The reliability of electrocardiographic detection of serum ionized Ca level was studied in 13 preterm and 32 full term infants. The concentration of ionized Ca was measured with a new ion-selected electrode, NOVA SP4 (NOVA Biomedical, Waltham, MA USA). The Q-oTc interval correlated with total Ca (r=o.553, p<0.01) and ionized Ca (r= -0.435, p< 0.01) but the Q-Tc interval did not correlate with total and...
Blood Level of Phenobarbital in Treatment of Seizure After Neonatal Asphyxia.
Ji Yean Lee, Heng Mi Kim, Doo Hong Ahn
Clin Exp Pediatr. 1989;32(9):1265-1272.   Published online September 30, 1989
In this study, we attempted to determine an optimal first dose of phenobarbital for the treatment of seizures in the asphyxiated full term neonates. Blood samples were obtained 2 to 48 hours after the administration of final effective loading dose and plasma levels were determined by the EMIT system. Four groups of neonates were studied. Six neonates (Group 1) received an intravenous loading dose of...
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