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Original Article
Salmonellosis in children: Analysis of 72 Salmonella-positive culture cases during the last 10 years
Sung Hoon Noh, Ka Young Yu, Jung Soo Kim, Pyoung Han Hwang, Dae Sun Jo
Clin Exp Pediatr. 2009;52(7):791-797.   Published online July 15, 2009
Purpose : We aimed to investigate the clinical manifestations of and antibiotic resistance in culture-proven childhood salmonellosis. Methods : Clinical manifestations and laboratory data of and antibiotic use in subjects with culture-proven childhood salmonellosis, who were treated at the Chonbuk National University Hospital between September 1998 and August 2008, were analyzed retrospectively. Patients with underlying diseases or concomitant illnesses were excluded. Results...
The societal cost of rotavirus infection in South Korea
Bong Min Yang, Dae Sun Jo, Youn Hee Kim, Ji Min Hong, Jung Soo Kim
Clin Exp Pediatr. 2008;51(9):977-986.   Published online September 15, 2008
Purpose : This study aims to estimate the financial cost of rotavirus infection in Korea in the year of 2005. Methods : The incidence rates used were from the epidemiological profile at Jeoungeub District (5.8 cases/1,000 children <5 years old for inpatients, and 22.65 cases/1,000 children <5 years old for outpatients, per year). The health care cost per capita of rotavirus...
Capsaicin induced apoptosis and the enhanced anticancer effect of anticancer drugs in cancer cells
Sun Young Kim, You Jin Lee, Eun Hye Park, Ho Keun Yi, Dae Sun Jo, Jung Soo Kim, Pyoung Han Hwang
Clin Exp Pediatr. 2008;51(3):307-314.   Published online March 15, 2008
Purpose : Capsaicin, the major pungent ingredient in red pepper, has long been used in spices and food additives. It has been recently shown to induce apoptosis in several cell lines through a not well known mechanism. The aim of this study was to investigate the apoptosis-inducing effect of capsaicin on gastric cancer cells, and to provide valuable information concerning...
Immunogenicity and safety of enhanced-inactivated poliovaccine(eIPV) in healthy Korean infants
Jung Soo Kim, Young Jin Hong, Jong Duk Kim, Young Taek Jang, Jin Han Kang
Clin Exp Pediatr. 2006;49(8):864-869.   Published online August 15, 2006
Purpose : We evaluated the immunogenicity and safety of eIPV(Imovax PolioⓇ) in a group of healthy Korean infants on a three-dose primary vaccination. Methods : Eighty one healthy infants aged 8-10 weeks were enrolled, and 79(male 42, female 37) completed the study. Three doses of eIPV were injected intramuscularly at 2, 4 and 6 months of age as of primary...
The effect of local rifampicin instillation on the treatment of suppurative BCG lymphadenitis
Min Son Kim, Dae Sun Jo, Kang Mi Kyung, Sang Jae Kim, Jung Soo Kim
Clin Exp Pediatr. 2006;49(1):40-45.   Published online January 15, 2006
Purpose : The purpose of this study was to evaluate the types of lymphadenitis after BCG vaccination and the effect of local rifampicin instillation on the treatment of suppurative BCG lymphadenitis. Methods : A total of 32 otherwise healthy infants with suppurative BCG lymphadenitis, who visited the Department of Pediatrics of Chonbuk National University Hospital, from March 2002 through June 2004,...
Pediatrician Perspectives on the Evaluation and Treatment of Acute Gastrointestinal Infections, Jeonbuk, South Korea, 2002
So Hee Lim, Yang Sim Koe, Dae Sun Jo, Sin Jae Lee, Pyoung Han Hwang, P. Kilgore, B. Nyhambat, Jung Soo Kim
Clin Exp Pediatr. 2003;46(12):1217-1223.   Published online December 15, 2003
Purpose : This study was conducted to assess clinical practices related to the evaluation and treatment of patients with acute gastrointestinal infection(AGI) in infants and children. This survey also evaluated the current opinion regarding the use of rotavirus vaccine. Methods : This survey was conducted using a self-administered questionnaire provided to 82 pediatricians in private clinics of Jeonbuk province. From April...
Alteration of Growth Factor Expression after Acute Ischemic Renal Injury
Yang Sim Koe, Soo Yeon Lee, Won Kim, Soo Chul Cho, Pyoung Han Hwang, Jung Soo Kim, Dae-Yeol Lee
Clin Exp Pediatr. 2003;46(7):687-694.   Published online July 15, 2003
Purpose : Regeneration and repair after ischemic renal injury appears to be modulated by circulating or locally produced growth factors. This study examined the changes of serum insulin like growth factor(IGF-I) and renal expression of IGF-I and II, vascular endothelial growth factor(VEGF), transforming growth factor-β(TGF-β), and connective tissue growth factor(CTGF) during the active regeneration period after acute ischemic injury. Methods :...
The Findings and Significances of Brain SPECT in Acute Mealses Encephalitis
Jung Chul Kim, Ju Mi Choung, So Hee Eun, Dae-Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 2002;45(11):1373-1380.   Published online November 15, 2002
Purpose : Acute measles encephalitis(ME) is characterized by an abrupt onset of fever and obtundation, frequently accompanied by seizures and multifocal neurological signs. The aim of this study was to clarify the clinical manifestation, progression and the brain SPECT patterns in patients with acute ME. Methods : This study included 11 children with acute ME admitted to Chonbuk National University Hospital. Ten patients received a...
Study on Vaccination State in Children : Jeonbuk Province, 2000
Ju Mi Choung, Jung Chul Kim, So Hee Eun, Pyoung Han Hwang, B. Nyhambat, P. Kilgore, Jung Soo Kim
Clin Exp Pediatr. 2002;45(10):1234-1240.   Published online October 15, 2002
Purpose : This study was carried out to obtain the vaccination rate and age appropriateness of vaccination in children under five years of age in Jeonbuk province. Methods : Eight hundred and fifty infants and children were enrolled in this study. Vaccination rate(Number of vaccinees/Number of subjects), places of vaccination, age appropriateness of vacination were examined by either vaccine record review or interview with...
Anti-angiogenesis and Anti-metastasis Characteristics of the Novel Tumor Suppressor Gene PTEN
Pyoung Han Hwang, Ho Keun Yi, Myoung Hee Han, Dae Yeol Lee, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 2001;44(6):654-663.   Published online June 15, 2001
Purpose : The tumor suppressor gene PTEN/MMAC1 is mutated in a variety of advanced and metastatic cancers, strongly suggesting that PTEN/MMAC1 alterations may be involved in tumor progression and the formation of metastases. However, the roles of PTEN in tumor growth and metastasis and its functional mechanisms are not fully understood. We evaluated the tumor suppressor function of PTEN/MMAC1 gene...
Studies on Functional Differentiation of Small Intestinal Epithelial Cells
Ho Keun Yi, Su Mi Oh, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang
Clin Exp Pediatr. 2001;44(5):523-532.   Published online May 15, 2001
Purpose : We investigated compounds from food sources given to children that may induce the differentiation of small intestinal epithelial cells in order to signal pathways that induce the proliferation and differentiation of small intestinal epithelial cells. Methods : We analyzed small intestinal epithelial cell differentiation using in vitro IEC-6 cells model. The growth curve of IEC-6 cells was obtained...
Effectiveness of Preoperative Transcatheter Arterial Chemoembolization in Hepatoblastoma
Pyoung Han Hwang, Dae Sun Jo, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 2000;43(8):1098-1105.   Published online August 15, 2000
Purpose : To evaluate the effectiveness of transcatheter arterial chemoembolization(TACE) as a preoperative treatment for initially unresectable hepatoblastomas. Methods : From January 1995 to July 1999, we identified two boys and three girls(age range : 5- 27 months; mean age : 12 months) with pathologically-confirmed hepatoblastoma. To assess response to treatment, we utilized an identical TACE procedure for all the patients....
Induction of Apoptosis of Ewing`s Sarcoma Cells by Regulating Fusion Protein Expression
Ho Keun Yi, Ran Ju Kim, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang
Clin Exp Pediatr. 2000;43(7):942-951.   Published online July 15, 2000
Purpose : Fusion genes(EWS-Fli-1 and EWS-erg ) function as transcription activators and are essential for maintaining tumorigenic properties in Ewing`s sarcoma cells. Several reports have noted that Ets family transcription factors bind with CBP(CREB binding protein) in vitro. To understand the interaction of fusion proteins and CBP, we studied the CBP protein in TC135 cells expressing the EWS-Fli-1 gene. We...
Comparative Reactivity of 2 TU and 5 TU PPD Skin Tests
Dae Sun Jo, Kyeong Mee Lee, Dae-Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 2000;43(5):638-643.   Published online May 15, 2000
Purpose : These days 5 TU purified protein derivative(PPD) is substituted with 2 TU PPD for the tuberculin skin test, a test essential in the diagnosis of tuberculosis in pediatric population. However, there had been no adequate criteria for the positivity of 2 TU PPD skin test. This study was performed to clarify the criteria of positive reactivity of 2...
The Relation between Antibiotic Use and Changes of Antimicrobial Resistance of Gram Negative Bacilli Isolated in Chonbuk National University Hospital(1993-1997)
Min Ki Chang, Jung Min Chu, Hae Soo Lee, Jung Soo Kim
Clin Exp Pediatr. 2000;43(5):625-631.   Published online May 15, 2000
Purpose : Antimicrobial resistance has become a major medical and public health problem. This study was performed to evaluate the changes in antimicrobial susceptibility patterns. Methods : The susceptibility of 8,224 recent clinical isolates during a 5-year period from 1993 to 1997 were tested against 8 antimicrobial agents. Antimicrobial susceptibility test was performed by disc diffusion method. Results : E. coli...
Effects of Cefodizime on Phagocytosis of COS-1 Ccells
Pyoung Han Hwang, Sang Yun Nam, Ho Keun Yi, Min Ho Kim, Kong Soo Kim, Jung Soo Kim
Clin Exp Pediatr. 1998;41(12):1632-1638.   Published online December 15, 1998
Purpose : Cefodizime is a new third-generation cephalosporin which has a structure and immunomodutation properties similar to cefotaxime. Various studies on cefodizime have demonstrated the direct eradication of bacteria in cooperation with the host defense mechanism, particularly with phagocytosis. We evaluated the effects of cefodizime on the phagocytosis of COS-1 cells transfected with FcγRI/γγ or FcγRIIA cDNA. Methods : Phagocytosis was...
Type I Vitamin D Dependent Rickets
Soo Ja Hwang, Jung Soo Kim, Hae Il Cheong, Yong Choi
Clin Exp Pediatr. 1998;41(7):877-882.   Published online July 15, 1998
Purpose : Vitamin D dependent rickets(VDDR) is a rare, autosomal recessively transmitted disorder characterized by hypocalcemia, hypophosphatemia, increased alkaline phosphatase, secondary hyperparathyroidism and many other clinical features. Type Ⅰ VDDR arises from primary deficiency in the renal 1α-hydroxylase that produces 1,25(OH)2D3. So patients with type I VDDR require life long administration of vitamin D. Methods : There had been 6 children(4...
The Study of Transplacental Transfer of Immunoglobulin G in Premature Infants
Sung Soo Moon, Yoon Ki Kang, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1998;41(6):747-753.   Published online June 15, 1998
Purpose : Premature infants have low serum immunoglobulin G(IgG) levels because IgG is transplacentally acquired, primarily after 32-34 weeks of gestational age. We studied the transplacental transfer of serum IgG in preterm infants. Methods : The IgG levels in the sera were measured by radial immunodiffusion method(Behring nephelometer, Germany). Results : There was a significant difference between IgG concentration and gestational age; the IgG concentration increased...
Changes of Anti-H.influenzae Type b IgG in the Sera of Korean Infants and Children after Birt
Jong Man Park, Keoung Hie Moon, Kyung Mee Lee, Sun Jun Kim, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1997;40(2):181-188.   Published online February 15, 1997
Purpose : Most of invasive Haemophilus influenzae diseases occur in children under 5 years of age, and are due almost exclusively to type b strain. Although antibodies to several surface antigens of H.influenzae play a role in conferring immunity, antibody to the type b capsular polysaccharide appeared to have the most important protective functions. However, the antibody response to vaccines or natural...
Placental Transfer of Anti-H. influenzae Type b Specific IgG and IgG Subclasses
Soo Hee Chang, Moon Hwan Lee, Pyoung Han Hwang, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1995;38(12):1638-1644.   Published online December 15, 1995
Purpose : Haemophilus injluenzae type b (Hib) is one of the most important causes of invasive bacterial diseases in infants and children. In Korea, however, the proportion occupied by Hib as a cause of pediatric pathogen seems to be less compared to those of western countries. This study was performed to provide the epidemiologic and immunologic basis of H influenzae type...
Effects of Cyclosporine on the Renal Sympathetic Nerve Activity and Baroreflex Function in Rabbits
Chan Uhng Joo, Tae Hee Park, Moon Hwan Lee, Jung Soo Kim
Clin Exp Pediatr. 1995;38(7):955-962.   Published online July 15, 1995
Purpose : The immunosuppresive drug cyclosporine(CS) is a novel agent that has greatly enhanced long-term survival after organ transplantation and has proved beneficial in the treat-ment of many autoimmune diseases. However, CS has emerged as a new cause of hypertens-ion. Although the causes of the hypertension are undoubtedly multifactorial, there are evidenc-es to suggest that sympathetic overactivity is involved. We...
The Effect of Milk on the Bioavailability of 6-mercaptopurine
Sun Kyu Park, Ran Ju Kim, Pyoung Ha Hwang, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1994;37(12):1732-1737.   Published online December 15, 1994
The purine antimetabolite 6-Mercaptopurine (6-MP) has been in clinical use for over 30 years and is still a widely used agent in the treatment of childhood acute lymphoglastic leukemia. The bioavailibility, clinical effecacy and toxicity of 6-MP administered orally for maintenance therapy of children with acute lymphoblastic leukemia are highly variable in many studies, as well as at different times...
Case Report
A Case of Wiskott-Aldrich Syndrome
Byoung Geun Lee, Soo Hee Chang, Soo Young Cho, Pyoung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1994;37(11):1615-1619.   Published online November 15, 1994
Wiskott-Aldrich Syndrome is an X-linked disorder characterized by recurrent infection, thrombocytopenia and eczema. Various defects in cell-mediated immunity and deficient antibody response to carbohydrate antigens have been described. We experienced a case of Wiskott-Aldrich Syndrome of 28 months old male patient. He has been suffered from multiple petechiae with bleeding, recurrent pyogenic infections and generalized eczema since 3 months of...
Original Article
Analysis of Platelet Membrane Glycoprotein Ⅱb-Ⅲa complex in Whole Blood of Glanzmann's Thrombasthenia by Flow Cytometry
Byoung Geun Lee, Man Choon Kang, Jong Man Park, Pyung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1994;37(11):1540-1547.   Published online November 15, 1994
Glanzmann's thrompasthenia is a rare autosomal recessive hemorrhagic disorder characterized by prolonged bleeding time, and deficient or absent clot retraction in the presence of normal platelet count. The major underlying abnormality in this disease is grossly defective first-phase aggregation of platelet, which are unresponsive to ADP or other platelet agonists such as epinephrine, collagen, thrombin in any concentration. This disability...
Comparison of Anticancer Drug Efficacy Using the Short-Term Microplate Culture and MTT Dye Reduction Assa
Nam Ki Kim, Kwang Rae Lee, Pyoung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1993;36(10):1426-1433.   Published online October 15, 1993
Individual tumors, even those of the same histologic type, show varying sensitivity to specific cytotoxic agent. Therefore, sensitivity testing assume an increasingly important as an orientational aid in planning chemotherapy. In the past decade there have been many attempts to develop a chemosensitivity test that would predict the clinical effectiveness of various chemosherapeutic agents against human neoplasms. In the United States...
Changes of IgG Subclasses in the Sera of the Children with Kawasaki Disease
Seog Beom Cho, Sun Kyu Park, Pyoung Han Hwang, Jung Soo Kim, Sa Hyoung Choi
Clin Exp Pediatr. 1993;36(9):1197-1202.   Published online September 15, 1993
Kawasaki disease is an acute vasculitis of infancy and early childhood characterized by high fever, rash, mucositis, lymphadenopathy and coronary artery damage. The failure to indentify a causative organism using convetional culture and serological techniques, and the lack of response to antibiotics indicate that the disorder is probably not due to any known bacterial or viral pathogens. During...
Case Report
Changes of Serum IgG4 in Allergic Patients
Soo Young Cho, Sun Kyu Park, Pyoung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1993;36(3):403-408.   Published online March 15, 1993
This study ws performed to evaluate the changes of serum IgG4 level in children with allergic diseases. Serum IgE, IgG and IgG4 level were measured using enyzme immunoassay(IgE) and radial immunodiffusion method (IgG and IgG4) in 21 children with bronchial asthma, allergic rhinitis or urticaria. Eosinophil counts in peripheral blood and the values fo serum IgE were significantly increased in allergic...
Original Article
Systolic Pressure Amplification of the Aortic Pressure in Children with Congenital Heart Disease
Chan Uhng Joo, Byoung Geun Lee, Sun Jun Kim, Jung Soo Kim
Clin Exp Pediatr. 1993;36(2):232-238.   Published online February 15, 1993
Direct intraarterial measurement of blood pressure is an important diagnostic procedure in critical patients and premature baby care. Direct measurement was more accepted and confident method in physician than the indirect methods. But the presence of a significant amplification of systolic pressure in peripheral artery may lead to important error. So we have investigated the degree of the systolic pressure...
Case Report
Hutchinson-Gilford Progeria Syndrome
Moon Whan Lee, Byoung Geun Lee, Pyung Han Hwang, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1992;35(7):971-977.   Published online July 15, 1992
Hutchinson-Gilford Progeria Syndrome is an extremely rare condition that was initially reported by Jonathan Hutchinson in 1886 and further described by Hastings Gilford in 1904. Clinical manifestations are evident by the first or second year of life with the physical characteris-tics of the elderly. Progeric patients ordinarily develop atherosclerosis and die of cardiac or cerebral vascular disease between 7 and 27...
Original Article
A Clinical Study on Cardiovascular Disease of Children Taken Cardiac Catheterization and Cineangiography
Gi Yeon Song, Seog Beom Cho, Pyoung Han Hwang, Chan Uhng Joo, Jung Soo Kim
Clin Exp Pediatr. 1992;35(7):949-956.   Published online July 15, 1992
A clinical study was made on 533 patients with cardiovascular disease who were admitted to pediatric department of Chonbuk National University Hospital and performed cardiac catheterization and cineangiography from February 1984 to August 1991. The results were as follows; 1) The ratio of male to female was about 0.81:1; among 533 cases, male 283cases, male 283cases, female 295cases. 2)The age distribution of the...
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