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Case Report
Methemoglobinemia development after ingestion of a chinese herbal medicine: A case report
Se Eun Hyun, Pil Joo Hwang, Kyung Pil Nam, Eun Gyong Yoo, Man Yong Han
Clin Exp Pediatr. 2008;52(3):385-388.   Published online March 15, 2009
An 8-year-old girl visited the emergency room with perioral cyanosis and dyspnea, which had developed 20 hrs prior to the hospital visit. She had taken a Chinese herbal medication for 3 days prior to the onset of the symptoms. A co-oximeter examination revealed a methemoglobin level of 23.7%. An intravenous infusion of methylene blue was administered. Chemical analysis of the...
Original Article
Variation of parameters according to cardiac cycle length, evaluated by TDI in children
Chang-Hyun Lee, Jae-Kwang Kim, Hyun-Seung Jin, Kie-Young Park, Bong-Seong Kim, Myung-Ki Han
Clin Exp Pediatr. 2009;52(3):339-345.   Published online March 15, 2009
Purpose : This study aimed to determine the variation in parameters according to cardiac cycle length (CL; time interval between the QRS peaks on ECG) in children by using the conventional pulsed Doppler and tissue Doppler imaging echocardiography. Methods : Eighteen children with an anatomically normal heart were enrolled for the study. All children were examined by conventional and pulsed...
Epidemiologic and clinical features in children with acute lower respiratory tract infection caused by human metapneumovirus in 2006-2007
Gwi Ok Park, Ji Hyun Kim, Jae Hee Lee, Jung Ju Lee, Sin Weon Yun, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byoung Hoon Yoo,, Mi Kyung Lee, Soo Ahn Chae
Clin Exp Pediatr. 2009;52(3):330-338.   Published online March 15, 2009
Purpose : The causes of acute lower respiratory tract infection (ALRTI) are mostly attributable to viral infection, including respiratory syncytial virus (RSV), parainfluenza virus (PIV), influenza virus A/B (IFV A/B), or adenovirus (ADV). Several Korean studies reported human metapneumovirus (hMPV) as a common pathogen of ALRTI. However, studies on seasonal distribution and clinical differences relative to other viruses are insufficient,...
Nationwide surveillance of acute interstitial pneumonia in Korea
Byoung-Ju Kim, Han A Kim, Young-Hwa Song, Jinho Yu, Seonguk Kim, Seong Jong Park, Kyung Won Kim, Kyu-Earn Kim, Dong Soo Kim, June Dong Park, Kang Mo Ahn, Hyo-Bin Kim, Hyang-Min Jung, Chun Kang, Soo-Jong Hong
Clin Exp Pediatr. 2009;52(3):324-329.   Published online March 15, 2009
Purpose : Acute interstitial pneumonia (AIP) is a rare disease, but its prognosis is fatal because of lack of efficient treatment modality. Recently, it has been reported that there was epidemic AIP in Korea. This study aims to investigate the past and current status of AIP in Korea. Methods : We performed a nationwide survey and a prospective study. From August...
The usefulness of diagnostic tests in children with language delay
Seung Taek Oh, Eun Sil Lee, Han Ku Moon
Clin Exp Pediatr. 2009;52(3):289-294.   Published online March 15, 2009
Purpose : To assess the usefulness of magnetic resonance imaging (MRI), karyotyping, brainstem auditory evoked potential (BAEP), electroencephalogram (EEG), tandem mass screening test, and newborn metabolic screening test in children with language delay for diagnosing underlying diseases. Methods : From January 2000 to June 2007, a retrospective chart review was performed for 122 children with language delay who visited the...
Review Article
Mycoplasma and chlamydia infection in Korea
Kyung Won Kim, Kyu-Earn Kim
Clin Exp Pediatr. 2009;52(3):277-282.   Published online March 15, 2009
Pneumonia, which usually requires hospitalization for children, is caused by various pathogens. According to recent surveys, the prevalence of atypical pneumonia caused by Mycoplasma or Chlamydia has increased, especially in preschool children. Also, the evidence has been accumulated that Mycoplasma or Chlamydia infection is associated with asthma including both inception and exacerbation. Therefore, it is important to consider how the...
Acute viral lower respiratory tract infections in children
Joon Soo Park
Clin Exp Pediatr. 2009;52(3):269-276.   Published online March 15, 2009
Viruses are the most common cause of lower respiratory tract infections (LRTIs) in infants and young children and are a major public health problem in this age group. Viruses were identified in 54.9-70.4% of hospitalized infants and children with LRTIs in Korea. The viral pathogens identified included respiratory syncytial virus (RSV) A and RSV B, influenza (Inf) A, Inf B,...
Original Article
Factors for persistent growth hormone deficiency in young adults with childhood onset growth hormone deficiency
Young Ah Lee, Hye Rim Chung, Se Min Lee, Jae Hyun Kim, Ji Hyun Kim, Sun Hee Lee, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2009;52(2):227-233.   Published online February 15, 2009
Purpose : Growth hormone (GH) replacement after retesting is necessary because impairment of body composition and cardiovascular health has been more severe in adult patients with persistent GH deficiency (GHD) from childhood to adulthood. This study aimed to investigate the factors for persistent GHD and define a highly probable group of persistent GHD in young adults with childhood-onset GHD. Methods :...
The effectiveness of biochemical indexes for evaluating the nutrition states of children
Jae Kwang Kim, Hyun Seong Jin, Myung Ki Han, Bong Seong Kim, Choong Hwan Cha, Kie Young Park
Clin Exp Pediatr. 2009;52(2):167-175.   Published online February 15, 2009
Purpose : This study has been conducted to analyze whether the biochemical nutrition indexes might be useful and effective for evaluating the nutrition states of children. Methods : We evaluated 269 children, aged 3-9 years old, who had visited Gangneung Asan Hospital for elective surgery from January 2006 to December 2007, and examined their anthropometric and preoperative laboratory data with...
Complex febrile convulsions: A clinical study
Jeong Sic Kang, Sa-Ra Kim, Dong Wook Kim, Tae Won Song, Nam Hee Kim, Jong Hee Hwang, Jin Soo Moon, Chong Guk Lee
Clin Exp Pediatr. 2009;52(1):81-86.   Published online January 15, 2009
Purpose : Febrile convulsions are classified into simple or complex types, the latter being characterized by increased risk of recurrence and progression to epilepsy. This study aimed to delineate the clinical characteristics of complex febrile convulsions. Methods : Between January 2003 and December 2006, 550 children were diagnosed with febrile convulsions at the Department of Pediatrics, Ilsan Paik Hospital. Their...
Changes in platelet counts caused by valproate in children with epilepsy
Ju Hee We, Young Mi Kim, Sang Ook Nam
Clin Exp Pediatr. 2009;52(1):75-80.   Published online January 15, 2009
Purpose : In adults, valproate (VPA) has been reported to be associated with thrombocytopenia. However, few studies have investigated this association in children, and the factors affecting platelet counts remain controversial. This study was undertaken to investigate changes in platelet counts following VPA therapy and related factors in children with epilepsy. Methods : Our subjects comprised 75 epileptic children who...
Drug resistance of Mycobacterium tuberculosis in children
Soo Jin Lee, Young Min Ahn, Hee Jin Kim
Clin Exp Pediatr. 2009;52(1):61-67.   Published online January 15, 2009
Purpose : The rate of drug-resistant tuberculosis (DR-TB) in children is an indicator of the effectiveness of TB control programs in the community. This study aimed to assess the prevalence of DR-TB in children and evaluate TB management. Methods : Between January 1999 and July 2007, drug susceptibility tests for anti-TB drugs were employed for patients aged less than 19...
Erratum
Ethical considerations for clinical trials performed in children
Myungho Oh
Clin Exp Pediatr. 2009;52(1):1-5.   Published online January 15, 2009
Children are not small adults and there is a need to carry out specific trials that cannot be performed in adults. In general, children (minors) are unable to consent but their assent should be obtained using age appropriate information. Institutional Review Board (IRB) need paediatric expertise to balance the benefits and risks of research in children. The lack of consent...
Original Article
Prevalence of obesity, hypertension, and hyperlipidemia in Gunpo children of low economic status
Kyung Hee Yi
Clin Exp Pediatr. 2008;51(12):1310-1314.   Published online December 15, 2008
Purpose : This study aimed to assess the prevalence of obesity, hypertension, and hyperlipidemia in children from low-income families in Gunpo and to evaluate whether economic status affects the prevalence of obesity. Methods : Between October 2007 and March 2008, 341 children (167 girls and 174 boys; age, 6 to 13 years) were enrolled in this study. All these children came...
Review Article
Neuromuscular disorders in children : Diagnosis and treatment
Jong Hee Chae
Clin Exp Pediatr. 2008;51(12):1295-1299.   Published online December 15, 2008
Inherited muscle diseases are heterogeneous with varying genetic etiologies and present with common symptoms and signs, including weakness, motor developmental delay, and hypotonia. To diagnose these various diseases, a meticulous family and clinical history, physical and neurological examinations, laboratory findings with electromyography, muscle biopsy, and genetic testing are needed. Here, I review several inherited muscle diseases, with a focus on...
Pediatric cerebrovascular disease
Ji Hoon Phi, Kyu-Chang Wang, Byung-Kyu Cho, Seung-Ki Kim
Clin Exp Pediatr. 2008;51(12):1282-1289.   Published online December 15, 2008
Recently, accumulated clinical experience and advanced neuroradiological techniques have led to a better understanding of pediatric cerebrovascular disease (CVD), which was once considered rare. Approximately 10% of pediatric neurosurgical patients have CVD; therefore, it is no longer uncommon to pediatricians and pediatric neurosurgeons. Furthermore, children with CVD tend to recover better than adults after stroke because the immature brain is...
Case Report
Congenital hernia of the lung through the azygoesophageal recess
Young Seok Choi, Young Jun Son, Si Young Bae, Kyung Sun Min, Young Kuk Cho, Woo Yeon Choi, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang
Clin Exp Pediatr. 2008;51(10):1123-1126.   Published online October 15, 2008
A lung hernia, defined as the protrusion of pulmonary tissue and pleural membranes through a defect in the thoracic wall, is a rare event. It can be congenital or acquired, and cervical, thoracic, or diaphragmatic in location. We report the rare occurrence of a congenital atraumatic lung herniation through the azygoesophageal recess. An 8-month-old male infant, who was born...
Coronary artery fistula associated with single coronary artery
Seong Man Kim, Min Seob Song, Kwang Hyun Cho, Chul Ho Kim
Clin Exp Pediatr. 2008;51(10):1118-1122.   Published online October 15, 2008
A case of a single coronary artery complicated with a coronary artery fistula (CAF) to the right ventricle is extremely rare, and its management strategy and prognosis are not clear. A 5-year-old boy was hospitalized for evaluation of a continuous heart murmur. Transthoracic echocardiography suggested a CAF to the right ventricle, with an enlarged left coronary artery. Cardiac catheterization...
Original Article
The long-term follow-up of height in children with epilepsy
Ju Hee We, Sang Ook Nam
Clin Exp Pediatr. 2008;51(10):1090-1095.   Published online October 15, 2008
Purpose : To assess the height growth of children with epilepsy receiving antiepileptic drugs (AEDs) and the related factors. Methods : The subjects were 148 children diagnosed with epilepsy at Pusan National University Hospital between January 1996 and December 2003, who received AEDs for more than 3 y. We measured height at the initiation of AED medication and at the...
Intraosseous line insertion education effectiveness for pediatric and emergency medicine residents
Jung Woo Lee, Jun Seok Seo, Do Kyun Kim, Ji Sook Lee, Seonguk Kim, Jeong-Min Ryu, Young Ho Kwak
Clin Exp Pediatr. 2008;51(10):1058-1064.   Published online October 15, 2008
Purpose : This study aimed to assess current knowledge of and training experiences with the intraosseous (IO) line among emergency medicine (EM) and pediatric residents who care for critically ill children and to evaluate the educational effectiveness of the IO line workshop. Methods : During May and June 2008, a workshops on IO line insertion was held for EM and...
The relationships among perception of physique, self-esteem, sociality, and behavioral characteristics in children
Min-Ja Jung, Kyung-Lim Yoon, Kye-Shik Shim
Clin Exp Pediatr. 2008;51(10):1052-1057.   Published online October 15, 2008
This study was to examine the relations of perception of physique with self-esteem, sociality and problematic behaviors in children. Methods: Four hundred sixty five (231 boys and 234 girls) children were divided into three groups according to their height or body mass index according to the physical growth standard table had been presented in 2007 by the Korean Pediatric Society. The...
Study of sedation according to neurologic and non-neurologic pediatric patients
Jeong Hwa Kim, Min Seon Kim, Dae-Yeol Lee, Sun Jun Kim
Clin Exp Pediatr. 2008;51(10):1047-1051.   Published online October 15, 2008
Purpose : This study aims to evaluate the efficacy and safety of sedatives for pediatric patients using noninvasive procedures. Methods : We performed a prospective study in 446 (aged 1 month-21 y) consecutive pediatric patients undergoing sedation to study noninvasive sedation techniques from February to August 2007. We reviewed demographic data, sedative drugs, dosage, complications, and successful rates of sedation...
Review Article
The use of fluoroquinolone in children
Jae Kyun Hur
Clin Exp Pediatr. 2008;51(10):1042-1046.   Published online October 15, 2008
The fluoroquinolones are an important group of antibiotics widely used in the treatment of various infectious diseases in adults, as a result of an excellent spectrum of activity, good tissue penetration and convenient ways of administration. In recent decades, there has been extensive development, clinical investigation, licensure and use of fluoroquinolone antibiotics. However, the use of fluoroquinolones in children has...
Once daily dosing of aminoglycoside in children
Seon Hee Shin
Clin Exp Pediatr. 2008;51(10):1038-1041.   Published online October 15, 2008
Aminoglycosides are frequently used antibiotics in children. The multiple daily dosing (MDD) in infants and children is twice or three times daily depending on age. Recent studies in adults have shown that once daily dosing (ODD) maximizes the bactericidal activity and might minimize the toxicity of antibiotics. So, I reviewed many studies about efficacy, toxicity and cost effectiveness of ODD...
Case Report
A case of testicular adrenal rest tumor in a male child with congenital adrenal hyperplasia
Joo Hwa Kim, Kyong Ah Yun, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2008;51(9):1018-1022.   Published online September 15, 2008
Testicular adrenal rest tumors are a well-known complication in male patients with congenital adrenal hyperplasia. Corticosteroid suppressive therapy usually results in the regression of these tumors. We describe a patient with 21-hydroxylase deficiency who developed bilateral testicular masses. Despite steroid suppressive therapy, the tumors did not regress and hormonal control was poor. Consequently, bilateral partial orchiectomies were performed.
Original Article
Clinical significance of the mechanical properties of the abdominal aorta in Kawasaki disease
Mi Jin Kim, Mi Jin Kim, Sang Yun Lee, Sang Yun Lee, Yong Bum Kim, Yong Bum Kim, Hong Ryang Kil, Hong Ryang Kil
Clin Exp Pediatr. 2008;51(9):1012-1017.   Published online September 15, 2008
Purpose : This study aimed to assess the mechanical properties of the abdominal aorta in school-aged patients treated for Kawasaki disease and in normal, healthy children. Methods : This study examined 28 children with Kawasaki disease who had been followed up on and 30 healthy subjects of the same age and gender. We recorded systolic (Ps) and diastolic (Pd) blood pressure...
Normal blood pressure values and percentile curves measured by oscillometric method in children under 6 years of age
Jin A Sohn, Hee Sook Lee, Kyoung Aha Lim, So Young Yoon, Jo Won Jung, Nam Su Kim, Chung Il Noh, Soon Young Lee, Young Mi Hong
Clin Exp Pediatr. 2008;51(9):998-1006.   Published online September 15, 2008
Purpose : Hypertension is defined as average systolic blood pressure and/or diastolic blood pressure that is ≥95th percentile for gender, age, and height on ≥three occasions. Knowing that blood pressure values increase in children as they grow older, the purposes of this study were to measure blood pressure by an oscillometric device and to determine normal values and percentile curves...
Evaluating and managing hypertension in children: a survey of Korean cardiologists and nephrologists
Eun Hee Lee, Hyung Eun Yim, Gi Young Jang, Kee Hwan Yoo, Chang Sung Son, Young Sook Hong, Joo Won Lee
Clin Exp Pediatr. 2008;51(9):992-997.   Published online September 15, 2008
Purpose : Hypertension (HTN) is no longer an exclusively adult disease; the prevalence of pediatric HTN is increasing. To understand the evaluation and treatment of childhood HTN in Korea, we investigated, via a questionnaire, how hypertensive children are currently assessed and managed by pediatric cardiologists (CA) and nephrologists (NE). Methods : We surveyed 82 pediatric CA and 77 NE, regarding...
Comparison of a whole blood Interferon-γ assay and A tuberculin skin test for detecting latent tuberculosis infection in children
Jin-Kyong Chun, Jin-Kyong Chun, Chang Ki Kim, Chang Ki Kim, Hyun Sook Kim, Hyun Sook Kim, Ghee Young Jung, Ghee Young Jung, John A. Linton, John A. Linton, Ki Hwan Kim, Ki Hwan Kim, Taek Jin Lee, Taek Jin Lee, Ji Hyun Jeon, Ji Hyun Jeon, Dong Soo Kim, Dong Soo Kim
Clin Exp Pediatr. 2008;51(9):971-976.   Published online September 15, 2008
Purpose : Surveillance for detecting and managing latent tuberculosis infection (LTBI) is a key component of tuberculosis control. The classic surveillance tool, the tuberculin skin test (TST), may have some limitations when used in the Bacillus Calmette-Guérin (BCG)-vaccinated population. The object was to perform a blood test QuantiFERON®-TB Gold In Tube (QFT-G IT) based on the detection of interferon-γ (IFN-γ)...
Prevalence and trends in obesity among Korean children and adolescents in 1997 and 2005
Kyungwon Oh, Myoung Jin Jang, Na Yeoun Lee, Jin Soo Moon, Chong Guk Lee, Myung Hwan Yoo, Young Taek Kim
Clin Exp Pediatr. 2008;51(9):950-955.   Published online September 15, 2008
Purpose : The objective of this study was to provide current estimates of the prevalence and examine trends of overweight and obesity in children and adolescents. Methods : Height and weight measurements from 183,159 (112,974 in 1997, 70,185 in 2005) children and adolescents aged 2 to 18 years were obtained via the 1997 and 2005 National Growth Survey. Obesity among...


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