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Original Article
Safety and efficacy of the ultra-rush immunotherapy with extracts of Dermatophagoides pteronyssinus in children
Sei Eun Hyun, Hyoung Yun Kim, Ji Hee Kwak, Youn Ho Shin, Ji Yeong Seo, Man Yong Han
Clin Exp Pediatr. 2008;51(8):868-873.   Published online August 15, 2008
Purpose : Immunotherapy is accepted as the only treatment of allergic disease that can modify the natural course of the disease and ameliorate symptoms. This study aimed to evaluate the safety and efficacy of ultra-rush therapy using Dermatophagoides extracts in children. Methods : Of children older than four years who had visited Bundang CHA Pediatric Allergy Clinic, those showing positive...
A comparison between impulse oscillometry system and spirometry for spirometry for detecting airway obstruction in children
Hae Young Hur, Ji Hee Kwak, Hyoung Yun Kim, Da Wun Jung, Yoon Ho Shin, Man Yong Han
Clin Exp Pediatr. 2008;51(8):842-847.   Published online August 15, 2008
Purpose : Measurement of forced expiratory volume in 1 second (FEV1) is usually difficult to obtain in children under six years of age because it requires active cooperation. This study evaluates the sensitivity of impulse oscillometry system (IOS) parameters for detecting airway obstruction in comparison with FEV1. Methods : We studied 174 children who performed the lung function and methacholine challenge...
Detection and clinical manifestations of twelve respiratory viruses in hospitalized children with acute lower respiratory tract infections : Focus on human metapneumovirus, human rhinovirus and human coronavirus
Kum Hyang Kim, Jung Ho Lee, Dong Shin Sun, Dong Shin Sun, Young Jin Choi, Joon Soo Park, Chang Jin Kim, Dong Jun Jung
Clin Exp Pediatr. 2008;51(8):834-341.   Published online August 15, 2008
Purpose : This study was perfomed to analyze in detail the viral etiology of acute lower respiratory tract infections (ALRI) in Cheunan, Korea by multiplex RT-PCR, including human rhinovirus (hRV) and newly identified viruses such as human metapneumovirus (hMPV) and human coronavirus (HCoV-OC43, HCoV-229E/NL63). Method : Nasopharyngeal aspirates (NPA) were collected from 863 hospitalized children with ALRI on the first day...
Infantile risk factors for obesity in preschool children
Sun Ju Park, Jae Won Moon, Hyun Ji Kim, Min Jung Cho
Clin Exp Pediatr. 2008;51(8):804-811.   Published online August 15, 2008
Purpose : Childhood obesity is a problem that places a child at great risk for becoming an obese adult. To prevent obesity, it is important to focus on early life risk factors that may contribute to childhood obesity. The aim of this study is to find obesity-causing infantile risk factors in preschool children. Methods : A total of 223 children aged...
Review Article
Lymphadenopathy
Nack-Gyun Chung
Clin Exp Pediatr. 2008;51(8):797-803.   Published online August 15, 2008
Lymphadenopathy is a common problem in children and adolescents. A wide variety of diseases and conditions may present as lymphadenopathy and an understanding of these conditions is essential to determine the most appropriate diagnostic work-up for each patient. A detailed history and physical examination with careful attention to the anatomical regions drained by the involved lymph node or mass often...
Malignancies in children who present with bone pain
Jun Ah Lee
Clin Exp Pediatr. 2008;51(8):792-796.   Published online August 15, 2008
Bone pain in a child could be associated with cancer as an initial manifestation of the disease. The childhood malignancies that frequently present bone pain are leukemia, neuroblastoma, and primary bone tumors such as osteosarcoma and Ewing sarcoma. Persistent bone or joint pain associated with swelling, mass, or limitation of motion implies underlying serious causes. Systemic manifestations such as lymphadenopathy,...
The epidemiology and present status of chronic hepatitis B in Korean children
Byung-Ho Choe
Clin Exp Pediatr. 2008;51(7):696-703.   Published online July 15, 2008
Korea is now classified as an area of intermediate endemicity for hepatitis B virus (HBV), due to the implementation of universal HBV vaccination and national preventive programs for HBV infection. A national program of HBV vaccination was launched in Korea in 1988 for school-going children and was listed on a vaccination guideline in 1991. In 1995, universal vaccination for newborn...
Erratum
\Improving women's and children's health in DPRK\" project funded by the Republic of Korea"
Young-Jeon Shin
Accepted January 1, 1970  
The economic recession of North Korea has been prolonged, the need for humanitarian assistance for the women and children of DPRK has been raised. In March 2006, South Korean government signed MOU with World Health Organization (WHO) to financially support "Improving Women's and Children's Health in DPRK (IWCH)" project. The assistance projects through UNICEF and the non-government organizations of South...
Original Article
Coronary artery diameter of normal children aged 3 months to 6 years
Jeong Jin Yu, Suk Kyung Cho, Yong-Mean Park, Ran Lee, Sochung Chung, Sun Hwan Bae
Clin Exp Pediatr. 2008;51(6):629-633.   Published online June 15, 2008
Purpose : This study was designed to investigate normal domestic values for the diameter of the left main coronary artery (LCA), the left anterior descending coronary artery (LAD) and the right coronary artery (RCA). These data are necessary to define dilatation of coronary arteries in Kawasaki disease cases. Methods : Study subjects were 43 normal healthy children whose ages ranged from...
The utility of ambulatory blood pressure monitoring in obese children
Myung Jin Kim, Jin Young Song
Clin Exp Pediatr. 2008;51(6):604-609.   Published online June 15, 2008
Purpose : Obesity in children and adolescence is highly correlated with adult obesity, which can provoke hypertension. Therefore, it is important to evaluate the blood pressure of obese children regularly. In this study, the results of ambulatory blood pressure monitoring (ABPM) in obese children and adolescents were evaluated. Methods : ABPM was conducted for selected patients who visited Handong University...
Erratum
Assessment of modifiable lifestyle factors for obese children and adolescents through questionnaires
Jeong Wan Seo, Ji A Jung, Hye Sook Park, Jae Sung Ko, Yong Joo Kim, Jae Young Kim, Eell Ryoo, Sun Hwan Bae, Jae Geon Sim, Hye Ran Yang, Byung Ho Choe, Ky Young Cho
Clin Exp Pediatr. 2008;51(6):576-583.   Published online June 15, 2008
Purpose : The identification of specific behaviors conducive to overeating or inactivity is the cornerstone of obesity management. The Committee on Nutrition of the Korean Pediatric Society developed parent and self-reporting questionnaires about eating behavior and physical activity in 2006. The aim of this study was to evaluate the usefulness of the questionnaires in assessing modifiable lifestyle factors related to...
Review Article
Epidemiologic characteristics of type 1 diabetes in children aged 14 years or under in Korea, 1985-2000
Choong Ho Shin
Clin Exp Pediatr. 2008;51(6):569-575.   Published online June 15, 2008
Type 1 diabetes mellitus (T1DM) develops in genetically susceptible individuals as a result of progressive autoimmune destruction of beta cells. There is a large global variation in incidence among children aged 0-14 years. The incidence of T1DM in Korea is very low. The latest survey in Korea was conducted in 2001 by the Korean Society of Pediatrics to analyze ...
Epidemiology of the metabolic syndrome among Korean children and adolescents
Mi Jung Park
Clin Exp Pediatr. 2008;51(6):564-568.   Published online June 15, 2008
The prevalence of obesity in Korean children is estimated to be around 10%, and has increased significantly over the past 20 years. Metabolic syndrome, which includes central obesity, glucose intolerance, insulin resistance, dyslipidemia, and hypertension, is a well documented risk factor for cardiovascular diseases, but there is no general consensus concerning its definition for children. In this study, ablut 30-40%...
Original Article
The characteristics of neurocardiogenic syncope in children
Kyung Yeon Lee, Jin Young Lee, Myoung Hyun Kim, Jeong Eun Lee, Yong Dae Kim, Eun Ju Lee, Young Su Lim, Won Seop Kim
Clin Exp Pediatr. 2008;51(5):512-517.   Published online May 15, 2008
Purpose : Syncope is relatively common in children and adolescents. Among the etiologies of syncope, neurocardiogenical syncope is the most common, but it is often confounded with seizure. We investigated the clinical features of patients under the age of 15 with neurocardiogenical syncope, compared to patients with neurologic disorders including epilepsy. Methods : Among the children who visited the...
Clinical features of transient small bowel intussusception in children
Ji Seung Heo, Eun Min Seo, Eun Jung Shim, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo, Kwan Seop Lee
Clin Exp Pediatr. 2008;51(5):500-505.   Published online May 15, 2008
Purpose : We analyzed the clinical features, management and outcome of small bowel intussusception in children compared with ileocolic intussusception. Methods : We retrospectively reviewed the records of 210 children with documented intussusception, in whom intussusception was initially diagnosed by ultrasonography during the four-year period of 2002 to 2005. Results : A total of 191 children were diagnosed with ileocolic intussusception and...
Gastric mucosal immune response of Helicobacter pylori-infected children
Hye Won Yom, Jeong Wan Seo
Clin Exp Pediatr. 2008;51(5):492-499.   Published online May 15, 2008
Purpose : Helicobacter pylori infection is one of the most common gastrointestinal infections worldwide; it almost invariably causes chronic gastritis. Pediatric studies may provide important insights into the mucosal immune response of H. pylori-infection, as children are not submitted to environmental factors such as alcohol, tobacco and anti-inflammatory medication. The aim of the present study was to investigate the mucosal...
Increased vascular endothelial growth factor in children with acute Mycoplasma pneumoniae pneumonia and wheezing
Young Seo, Byung Keun Yu, Yeon Joung Oh, Yoon Lee, Young Yoo, Ji Tae Choung, Young Yull Koh
Clin Exp Pediatr. 2008;51(5):487-491.   Published online May 15, 2008
Purpose : Although Mycoplasma pneumoniae (M. pneumoniae) infection can cause wheezing in non-asthmatic children, the mechanisms of this symptom remain unclear. Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis and vascular permeability, and is also known to be elevated in cases of chronic pulmonary disease such as asthma. We hypothesized that VEGF may increase in children with...
Use of herbal medicine in epileptic children
Jee Yeon Lee, Wook Sun Choi, So-Hee Eun, Baik-Lin Eun, Young Sook Hong, Joo Won Lee
Clin Exp Pediatr. 2008;51(4):415-419.   Published online April 15, 2008
Purpose : Herbal medicine is thought to be widely used by children with epilepsy, but there have been few studies. This study aimed to investigate the perceptions and the actual conditions of usage of herbal medicine by children with epilepsy. Methods : From July to August 2007, three hundred seventy eight questionnaires were completed by parents of epileptic children who visited...
Efficacy and safety of electrolytes-free polyethylene glycol (PEG) 4000 for disimpaction in children with chronic functional constipation
Jeong Hee Lee, Ran Lee, Sun Hwan Bae
Clin Exp Pediatr. 2008;51(4):391-395.   Published online April 15, 2008
Purpose : This study was performed evaluate optimal dose for disimpaction, efficacy and safety of PEG 4000 in children with chronic functional constipation. Methods : Eighty six children with chronic functional constipation were enrolled in this prospective study at Konkuk university hospital March, 2003 through August, 2006. Success in disimpaction with PEG 4000 was defined as meeting at least two out...
Review Article
The prevalences of asthma and allergic diseases in Korean children
Soo-Jong Hong, Kang-Mo Ahn, Soo-Young Lee, Kyu-Earn Kim
Clin Exp Pediatr. 2008;51(4):343-350.   Published online April 15, 2008
Asthma and allergic diseases are one of the most common disorders in children. Due to its increased prevalence, as well as the increased morbidity and mortality from these diseases, asthma and allergic diseases have come to be recognized as a major worldwide public health issue. In addition, socioeconomic burden of asthma and allergic diseases has increased in Korea also. The...
A suggestion of health insurance for children
Baik-Lin Eun
Clin Exp Pediatr. 2008;51(4):339-342.   Published online April 15, 2008
The Korean Health Insurance (KHI) has been introduced since 1977 and it took only 12 years that KHI had accomplished the total coverage of Korean population. The remarkable success of KHI can be compared with other OECD countries which had taken some 30 years to over 100 years to establish the total coverage of the population. Life expectancy at birth...
Original Article
Therapeutic response of cyclosporine and outcome in steroid resistant nephrotic syndrome
Hyung Soon Choi, Joo Hoon Lee, Young Seo Park
Clin Exp Pediatr. 2008;51(3):293-298.   Published online March 15, 2008
Purpose : The aim of our study was to evaluate the therapeutic response to cyclosporine, time to remission and side effects in steroid resistant nephrotic syndrome (SRNS). Methods : This study included 22 children with idiopathic SRNS who were treated with cyclosporine between June 1989 and August 2006. Medical records were reviewed retrospectively. Results : The mean age of patients at diagnosis...
The relationship between leptin adiponectin ratio and insulin resistance in healthy children
Gae-Hyun Ahn, Shin-Hye Kim, Eun-Gyong Yoo
Clin Exp Pediatr. 2008;51(3):256-261.   Published online March 15, 2008
Purpose : Leptin and adiponectin are two representative adipocytokines. Leptin increases, but adiponectin decreases, with obesity and insulin resistance. We aimed to study the relationship between the leptin/adiponectin ratio and insulin resistance in healthy children. Methods : Seventy-seven healthy children (36 boys and 41 girls) were enrolled in this study. Anthropometric measurements were performed, and the percentage of weight for...
Review Article
Overview of the national health screening program for infant and children
Baik-Lin Eun, Seong Woo Kim, Young Key Kim, Jung Wook Kim, Jin Soo Moon, Su Kyung Park, In Kyung Sung, Son Moon Shin, Sun Mi Yoo, So Hee Eun, Hea Kyoung Lee, Hyun Taek Lim, Hee Jung Chung
Clin Exp Pediatr. 2008;51(3):225-232.   Published online March 15, 2008
The mission of National Health Screening Program for Infant and Children is to promote and improve the health, education, and well-being of infants, children, families, and communities. Although the term 'diagnosis' usually relates to pathology, a similar diagnostic approach applies to the child seen primarily for health supervision. In the case of health, diagnosis determines the selection of appropriate health...
Original Article
Effects of an intensive asthma education program on asthmatic children and their caregivers
Kang Jin Seo, Gun Ha Kim, Byung Keun Yu, Yun Ku Yeo, Jong Hoon Kim, Eu Ddeum Shim, Mi Ri Yoon, Young Yoo, Ji Tae Choung
Clin Exp Pediatr. 2008;51(2):188-203.   Published online February 15, 2008
Purpose : Asthma is one of the most common chronic childhood disease. Education of asthmatic children and their families about asthma and its management may improve disease control, reduce symptoms, and improve school performance. The aim of the study was to evaluate the effects of an intensive asthma education program in asthmatic children and their families on outcome measure...
Relationship between exhaled nitric oxide and pulmonary function test in children with asthma
Han-Seok Ko, Sung-Hoon Chung, Yong-Sung Choi, Sun-Hee Choi, Yeong-Ho Rha
Clin Exp Pediatr. 2008;51(2):181-187.   Published online February 15, 2008
Purpose : Asthma is characterized by reversible airway obstruction and bronchial hyperresponsiveness result from airway inflammation. Fraction of nitric oxide in expired air (FeNO) has recently been investigated as a noninvasive measure of airway inflammation. FeNO has been reported to correlate with induced sputum eosinophilia and methacholine challenge test that it is represent severity of asthma. The purpose of this...
Efficacy and safety of oxcarbazepine in epileptic children
Hye Kyung Shin, Yoon Lee, Jee-Yeon Lee, Wooksun Choi, So-Hee Eun, Baik-Lin Eun, Young Sook Hong, Joo Won Lee
Clin Exp Pediatr. 2008;51(2):162-169.   Published online February 15, 2008
Purpose : Oxcabarzepine (OXC), newly recommended antiepileptic drug, has been prescribed for patients with partial seizures and generalized tonic clonic seizures in Korea from 1999. There are limited reports about an efficacy of OXC therapy in epileptic children in Korea. This study evaluated the efficacy and safety of OXC in the light of our experience. Methods : The patients, who had...
Review Article
Clinical aspects of injury and acute poisoning in Korean pediatric patients
Joon Seok Park, Mi Jin Lee
Clin Exp Pediatr. 2008;51(2):116-121.   Published online February 15, 2008
Unintentional injuries are the most important cause of morbidity and mortality in the pediatric population, and the home is the most common site of injury for children in Korea. The most common cause of injury was slip down. Fall down and burn were frequent in infant/toddlers group, automobile and bicycle accident more frequent in preschool children. Findings from the survey...
Case Report
Primary leiomyosarcoma of the chest wall in a child : a case report
Jae Hyuk Choi, David Chanwook Chung, Mee Jeong Lee
Clin Exp Pediatr. 2008;51(1):98-101.   Published online January 15, 2008
Leiomyosarcoma is an uncommon soft tissue sarcoma of mesenchymal cell origin, which shows smooth muscle differentiation. Leiomyosarcoma is seldom found in the pediatric population, and accounts for fewer than 2% of all soft tissue sarcomas. Leiomyosarcoma of the chest wall is extremely rare in children. We report here a case of an 8-year-old boy with a primary leiomyosarcoma that was...
Original Article
Maintenance dose of electrolyte free polyethylene glycol (PEG) 4000 in Korean children with chronic functional constipation
So Hee Lee, Sun Hwan Bae
Clin Exp Pediatr. 2007;50(12):1212-1216.   Published online December 15, 2007
Purpose : To determine optimal maintenance dose and to evaluation the efficacy and safety of polyethylene glycol 4000 (PEG4000) in children with chronic functional constipation. Methods : This study enrolled 41 children with chronic functional constipation at the Konkuk university hospital August 2005, then June, 2007. Effective maintenance dose was designed as initial amount of PEG4000 that improved frequency, bowel movement,...
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