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Case Report
A Case of WDHA(Watery Diarrhea Hypokalemia Achiorhydria) Syndrome
Nam Seon Beck, Jun Jai Kim, Beom Soo Park, Jeong Kee Seo, Hyo Seop Ahn, Hyung Ro Moon, Je Geun Chi
Clin Exp Pediatr. 1992;35(4):575-580.   Published online April 15, 1992
VIP secreting tumors are rare in children but they produce a dramatic clinical picture, the most prominent feature of which is profuse, watery diarrhea and hypokalemia. A 5-year-old girl was brought to Seoul National University Children's Hospital for evaluation of profuse watery diarrhea. She presented with watery diarrhea, hypokalemia, and stunted growth, and had experienced these problems for four years...
Three Cases of Brain Tumors with Bone Metastasis
Eun Joo Kim, Kyung Duk Park, Eun Sil Dong, Hye Jung Park, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Je Geun Chi
Clin Exp Pediatr. 1992;35(3):381-389.   Published online March 15, 1992
Medulloblastoma and primitive neuroectodermal tumor(PNET) are relatively common intracranial neoplasms in childhood. Their extracranial metastasis were thought to be rare occurrences. But they are more frequent compared to other intracranial tumors. The most frequent site of metastasis deposits in medulloblastoma is bone, and metastasis to lymph node, peritoneum, liver or lung have been reported infrequently. The authors experienced three cases...
Original Article
Clinical Considerations of the Mediastinal Tumors in Children
Eun Joo Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1992;35(1):98-107.   Published online January 15, 1992
Mediastinal tumors of children constitute a heterogeneous group of malignant and benign neoplasms because they originated from a variety of structures. But they show some characteristics in type of tumor according to location, relative frequency of masses, clinical manifestations. Management and long-term reusult. We observed 82 patients less than 16 years of age who were evaluated and treated for a...
Incidence Estimation of Leukemia among Korean Children
Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Yoon-Ok Ahn
Clin Exp Pediatr. 1992;35(1):80-87.   Published online January 15, 1992
Leukemia is a neoplasm arising from the malignant transformation of hematopoietic cells. The incidence data of leukemia have not been available for Korean as a whole. The present study was therefore undertaken in order to estimate the incidence of childhood leukemia among Korean. The study population of this investigation was the beneficiaries of the Korea Medical Insurance Corporation(KMIC) during the period...
Immune response induced by live attenuated varicella vaccine(Biken@) in children with acute lymphoblastic leukemia.
Hyo Seop Ahn, Joong Gon Kim
Clin Exp Pediatr. 1991;34(9):1255-1260.   Published online September 30, 1991
To determine the safety and efficacy of varicella vaccine, we studied 10 healthy children and 12 children in remission from acute lymphoblastic leukemia. They were immunized with the Oka strain of live attenuated varicella vaccine (Biken®). All the healthy children and 6 children with leukemia received the vaccine of 1,000 plaque-forming units (PFU), and 6 leukemic children received the vaccine of 500 PFU. The...
A case of bone marrow necrosis in acute lymphoblastic leukemia.
Mee Ran Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(8):1163-1168.   Published online August 31, 1991
Bone marrow necrosis is a rare complication most commonly encountered in patients with leuke- mia, metastatic tumor in marrow, sickle cell disease, DIC and severe infections. Recently it is regarded as a more common finding frequently overlooked and carrying not so poor prognosis. We reported here a boy with ALL who showed marrow necrosis on biopsy at the time of diagnosis and achieved complete...
A case of pancytopenia associated with mycoplasmal pneumonia.
Young Mee Yoo, Beom Soo Park, In Sang Jeon, Hee Young Shin, Hyo Seop Ahn, Se Jung Sohn
Clin Exp Pediatr. 1991;34(6):826-831.   Published online June 30, 1991
Mycoplasma pneumoniae infection is manifestated as pneumonia and extra-pulmonary symptoms such as hematologic, neurologic, gastrointestinal, musculoskeletal, dermatologic and cardiac manifes- tations. Among the hematologic changes, hemolytic anemia is most frequently seen. Throm- bocytopenic purpura, lymphocytosis or rarely lymphopenia, elevated erythrocyte sedimentation rate, positive direct Coombs test, reticulocytosis and DIC are known hematologic features. This 12 years old female patient was presented with pneumonia and pancytopenia....
A case of acute lymphoblastic leukemia complicating neuroblastoma in remission.
Dong Woo Son, Bum Soo Park, Jun Jae Kim, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(5):720-729.   Published online May 31, 1991
As childhood cancer survivors are now increasing in number owing to the improvements in diagnosis, staging, and treatment, concerns have been raised regarding the quality of survival of these patients. One of the limitation to quality and length of survival has been the development of second malignant neoplasm (SMN). In Korea, only one case of SMN has been reported. However, one can expect that...
Two cases of nasopharyngeal carcinoma in children.
Tae Sun Ha, Chul Ho Jang, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(4):587-593.   Published online April 30, 1991
Nasopharyngeal carcinoma is a primary malignancy of nasopharyngeal epithelium, firstly de- scribed as a separate entity by Regaud and Schmincke in 1921. Although it is a rare tumor, reprsent- ing less than 1% of pediatric malignancies, it accounts for 9% of the nasopharyngeal neoplasms of childhood, and has not been reported in Korean child. We experienced two cases of nasopharyngeal carcinoma in a 10...
Malignant Schwannomas in children.
Joon Jai Kim, Dong Joo Shin, Dong Won Son, Hong Hoe Koo, In Sang Jeon, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(4):525-531.   Published online April 30, 1991
Six pediatric patients who were diagnosed as malignant Schwannoma and treated at Seoul National University Children’s Hospital from Aug. 1981 to Jun. 1990 were reviewed. Mean age was 11 years and 1 month and all cases except one were over 10 years old. Of six cases, three (50%) were associated with von Recklinghausen’s disease. Overall male to female ratio was 1 : 2. In...
Clinical study of Kasabach-Merritt syndrome.
Eun Jung Bae, Young Ah Lee, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(3):371-379.   Published online March 31, 1991
A retrospective analysis of clinical findings in 20 patients with Kasabach-Merritt syndrome who visited Department of Pediatrics, Seoul National University Hospital from January, 1979 to June, 1990 was performed. The average age of occurrence was 6.4 month and male to female ratio was 1: 1.2. The mean size of hemangioma was 11.0x8.5 cm and the locations were cutanous in 18 (extrem- ities 5, trunk...
Clinical considerations of acute leukemia or transient myeloprolifo- rative disorder in Down syndrome.
Eun Sil Dong, Sung Hee Jang, Hong Hoe Koo, Hye Lim Jung, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(1):74-82.   Published online January 31, 1991
Children with Down syndrome have an increased incidence of acute leukemia. Infants with Down syndrome are also at risk of developing a transient myeloproliferative disorder indistinguishable from acute nonlymphocytic leukemia (ANLL) except by its eventual clinical recovery. We observed 11 patients with acute leukemia or transient myeloproliferative disorder in Down syndrome who had admitted to the Departmetn of Pediatrics, Seoul National University Children’s Hospital,...
Cardiac Tumor in Children.
Eun Jung Bae, Young Hwue Kim, Jung Yun Choi, Yong Seung Hwang, Hyo Seop Ahn, Yong Soo Yun
Clin Exp Pediatr. 1990;33(11):1540-1547.   Published online November 30, 1990
Primary cardiac tumor is very rare and has been a medical curiosity but is potentially curable by current management with improvements of the imaging apparatus and the surgical technique. Metastatic cardiac tumor is also very rare and is more difficult to diagnose than primary ones because of lack of specific symptoms. Twelve cases of cardiac tumor, collected from 1978 to 1989 at the Department...
Whole Cow's milk Related iron Deficiency Anemia in Early Childhood.
In Sang Jeon, Heon Seok Han, Hyo Seop Ahn, Jin Q Kim
Clin Exp Pediatr. 1990;33(10):1374-1379.   Published online October 31, 1990
To study the relationship between large amount of whole cow’s milk (WCM) intake and iron deficiency anemia (IDA) in early childhood, we carried out the study on 9 children with IDA, who were fed WCM, about 1,000 ml over 3 months, experienced at the department of Pediatrics, Seoul National University Hospital, during 5 months from March 1989 to July 1989. The results were as...
A Clinical Study of Childhood Non-Hodgkin's Lymphoma.
In Sang Jeon, Hyo Seop Ahn, Chong Ku Yun
Clin Exp Pediatr. 1990;33(6):807-820.   Published online June 30, 1990
To study the clinical characteristics and treatment result of childhood NHL, the retrospective study was performed on 82 children with NHL, experienced at the department of Pediatrics, Seoul National University Hospital, during 10 years from January 1979 to December 1988. The results were as follows; 1) The sex ratio of male to female was 2.4:1. 2) The age of patients ranged from 8 months to 15 years,...
A case of Second Malignant Neoplasm Complicating Hodgkin's Disease in Remission.
Hong Hoe Koo, Jong Woon Choi, Sang Oh Na, Il Soo Ha, Hee Young Shin, Hyo Seop Ahn, Yeon Lim Suh, Chul Woo Kim, Je Geun Chi
Clin Exp Pediatr. 1990;33(4):564-572.   Published online April 30, 1990
Recent advances in the treatment of cancer have resulted in increased survival and possible cure for many malignant disorders, particularly childhood cancers. There has been a marked improvement in the treatment of childhood Hodgkin’s disease, and five-year survival rates for even advanced stages of Hodgkin’s disease approach or exceed more than 75% with modern treatment policies. However, successful therapy in childhood cancer is frequently...
A case of congenital dyserythropoietic Anemia.
Sang Oh Na, Seong Hoon Ha, Hong Hoe Koo, Hee Young Shin, Il Soo Ha, Hyo Seop Ahn, Doek Ja Oh, Myoung Hee Park
Clin Exp Pediatr. 1990;33(3):410-415.   Published online March 31, 1990
The congenital dyserythropoietic anemia refers to a group of hereditary disorders of erythropoiesis characterized by ineffective erythropoiesis, multinuclearity of erythroblasts, and secondary hemo- chromatosis. The authors report a case of anemia in a 4 month-old girl whose bone marrow showed dyserythropoietic features. A brief review of referential literatures was made.
A Case of Mucinous Cystadenocarcinoma in a Premenarchal Girl.
Hong Hoe Koo, Sang Oh Na, In Sang Jeon, Hyo Seop Ahn, Wan Suk Park, Suk Koo Lee, Kwi Won Park, Chong Jai Kim, Je Geun Chi
Clin Exp Pediatr. 1990;33(1):124-128.   Published online January 31, 1990
In childhood, cancer of the ovary is highly unusual. It is responsible for only 1—2% of cancers found in patients under the age of 17. The frequency with which the various histologic types of ovarian neoplasm occur in childhood differs from that in adults. Epithelial tumors account for 70% to 80% of ovarian neoplasms in adults but only 20% in patients less than...
A Case of Bilateral Wilms' Tumor.
Hyun Jun Cho, In Sang Jeon, Hyo Seop Ahn, Hwang Choi
Clin Exp Pediatr. 1990;33(1):117-123.   Published online January 31, 1990
Bilateral Wilms’ tumor is a relatively uncommon disease. We experienced a case of bilateral Wilms’ tumor in a 3 year 9 month-old boy. He had favorable histology on the both sides with pulmonary metastasis. Chemotherapy and radiation therapy on the lung and left renal bed were performed after left radical nephrectomy with biopsy on the right tumor. There was a good response to chemotherapy...
A clinical study on histiocytosis X.
Sang Oh Na, Joong Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 1989;32(11):1510-1519.   Published online November 30, 1989
We made a clinical study on 31 cases of histiocytosis X who had been admitted to the Dept, of Ped. of S.N.U.C.H. from Jan. 1981 to Dec. 1987. Among 31 cases, 28 patients received chemotherapy to include prednisolone, vinblastine, methotrex- ate and cyclophosphamide as induction therapy, and 6-mercaptopurine, methotrexate and cyclophos- phamide as maintenance therapy. The results obtained were as follows. 1) The sex incidence revealed male...
Three Cases of Typhlitis during Treatment for Acute Myelocytic Leukemia in Children.
Soon Mee Park, Il Soo Ha, Hoan Jong Lee, Jeong Kee Seo, Hyo Seop Ahn, Kyung Mo Yeon
Clin Exp Pediatr. 1989;32(10):1455-1462.   Published online October 31, 1989
Typhlitis is a rare necrotizing colitis in which inflammation is confined to cecum. It occurs during chemotherapy for malignancies, in terminal stage of aplastic anemia, in transplant patients. The pathogenesis of typhlitis has included leukemic infiltration of the bowel, thrombocytopenia, direct toxic effects of chemotherapy, steroid, bacterial invasion of the bowel wall secondary to neutropenia and alteration of the bowel flora by broad-spectrum antibiotics....
Angiolymphoid Hyperplasia with Eosinophilial: Kiruma's disease.
Choong Won Lee, Young Sik Kim, Soon Ki Kim, Il Soo Ha, Hyo Seop Ahn, Je Geun Chi, Il Han Kim
Clin Exp Pediatr. 1989;32(10):1416-1421.   Published online October 31, 1989
Kimura’s disease is a rare, benign disease characterized by single or multiple subcutaneous nodules, eosinophilia and distinctive histopathologic features. Seven cases of Kimura’s disease under 15 yeaps of age who were admitted to the Dept, of Pediatrics, Seoul National University Hospital from Apr. 1983 to July 1987 were reviewed. The results were as follows: 1) The lesions were noted between the ages of 28 months and...
Cyclophosphamide-Induced Hemorrhagic Cystitis in Acute Lymphocytic Leukemia and Non-Hodgkin Lymphoma.
Young Seo Park, Il Soo Ha, Soon Ki Kim, Hae Il Jung, Yong Choi, Hyo Seop Ahn
Clin Exp Pediatr. 1989;32(5):665-669.   Published online May 31, 1989
We studied the cyclophosphamide-induced hemorrhagic cystitis in 72 cases of acute lymphocytic leukemia or Non-Hodgkin lymphoma, which had been treated at Seoul National University Children' s Hospital from June, 1985 to May, 1988 1) Among 72 cases treated with cyclophosphamide, 6 cases(12.8%) developed hemorrhagic cystitis in 47 cases of acute lymphocytic leukemia and 2 cases(8.0%) in 25 cases of Non-Hodgkin lymphoma. 2) The development of...
Infections in Childhood Leukemia.
Choong Won Lee, Young Sik Kim, Byung Kyu Park, Soon Ki Kim, Il Soo Ha, Hoan Jong Lee, Hyo Seop Ahn
Clin Exp Pediatr. 1989;32(5):659-664.   Published online May 31, 1989
A retrospective study was performed on twenty-nine children, who had experienced infection one or more times, among the thirty-eight children diagnosed as leukemia at the Department of Pediatrics, Seoul National University Hospital, between January, 1984 and June, 1985, and followed up for more than three years. The results were as follows; 1) The age of patients ranged from I year 5 months to 14 years...
High-Dose Cytosine Arabinoside (HD Ara-C) Therapy for Refractory Acute Leukemia in Children.
Il Soo Ha, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1988;31(10):1328-1337.   Published online October 31, 1988
Eleven children with refractory acute leukemia were treated with high dose cytosine arabinoside (HD Ara-C), given at a dosage of 3 gm/m2 intravenously over about one hour every 12 hours for four to eight doses. The antileukemic effects were evaluable in nine of the patients, two with ALL, seven with ANLL. Six of the seven patients with ANLL attained complete remission, while neither...
Treatment of Acute Myelogenous Leukemia in Children: Remission Induction with Adriamycin and Cytosine Arabinoside, and Postremission Maintenance Chemotherapy with Adriamycin, Cytosine Arabinoside and 6-thioguanine.
Soon Ki Kim, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1988;31(7):850-862.   Published online July 31, 1988
The authers assessed the effectiveness of chemotherapy in 40 children with AML, experienced at Seoul National University Children’s Hospital during 8 years 5 months from April 1979 to August 1987. Remission induction treatment included adriamycin 30 mg/m2/day IV on days 1-3 and cytosine arabinoside 75 mg/m2/day continuous IV infusion on days 1-5. This regimen was repeated, if necessary, for one or two more courses. After...
A Clinical Observation on the Incidence of Childhood Leukemia.
Hyo Seop Ahn, Il Soo Ha, Soon Ki Kim, Hoan Jong Lee, Chang Yee Hong
Clin Exp Pediatr. 1988;31(7):841-849.   Published online July 31, 1988
We have analysed the type, age, sex, initial hematologic values and cell markers in 295 children, who had been diagnosed as leukemia at the department of pediatrics, Seoul National University Hospital, from Jan. 1983 to Dec. 1987. The patients were composed of 197 cases (66.8%) of ALL, 82 cases (27.7%) of ANLL and 16 cases (5.5%) of CML. FAB subclassification have been done in...
Endodermal Sinus Tumor in Children.
Jae Sun Jung, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1988;31(6):772-778.   Published online June 30, 1988
Thirty-three cases of endodermal sinus tumor were reviewed. They were diagnosed at Seoul National University Hospital over the last 9 years. Sixteen were testicular, 12 were sacrococcygeal and the others were mediastinal, vaginal, ovarian, retrovesical and tongue endodermal sinus tumor. Endodermal sinus tumor of the tongue was the first reported case in the world. Serum 公-fetoprotein of 32 cases was elevated at diagnosis and...
Burkitt Lymphoma in Children.
Soo Jong Hong, Dong Kyu Jin, Hee Young Shin, Hyo Seop Ahn, Chang Yee Hong, Je G Chi
Clin Exp Pediatr. 1988;31(4):482-491.   Published online April 30, 1988
Seventeen cases of Burkitt lymphoma under 15 years of age who were admitted to Dept, of Ped., Seoul National University Hospital from Jan. 1979 to Dec. 1986 were reviewed and analysed. One hundred and six cases of non-Hodgkin lymphoma were seen during the same period. 1) Burkitt lymphoma accounted for 16% of non-Hodgkin lymphoma. 2) The age ranged from 10/12 year to 15 5/12 years, with...
Acute Tumor Lysis Syndrome in Burkitt Lymphoma.
Dong Kyu Jin, Soo Jong Hong, Il Soo Ha, Hyo Seop Ahn, Yong Choi, Chang Yee Hong
Clin Exp Pediatr. 1988;31(3):362-369.   Published online March 31, 1988
To assess the tumor lysis syndrome in Burkitt lymphoma, we analyzed the clinical and laboratory findings of 17 patients with Burkitt lymphoma who were admitted to the Department of Pediatrics, Seoul National University Hospital from January 1979 to December 1986. The acute tumor lysis syndrome was diagnosed when two of the five following metabolic abnormal- ities were met: ① hyperuricemia (≥8.0mg/dl), ② hyperphosphatemia (≥5.5 mg/dl),...
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