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Original Article
Clinical predictors of chest radiographic abnormalities in young children hospitalized with bronchiolitis: a single center study
Ga Ram Kim, Min Sun Na, Kyung Suk Baek, Seung Jin Lee, Kyung Suk Lee, Young Ho Jung, Hye Mi Jee, Tae Hee Kwon, Man Yong Han, Youn Ho Sheen
Clin Exp Pediatr. 2016;59(12):471-476.   Published online December 31, 2016

Chest radiography is often performed on patients hospitalized with typical clinical manifestations of bronchiolitis. We aimed to determine the proportion of subjects with pathologic chest radiographic findings and the clinical predictors associated with pathologic chest radiographic findings in young children admitted with the typical presentation of bronchiolitis.


We obtained the following data at admission: sex, age, neonatal history, past history of...

Review Article
Postinfectious bronchiolitis obliterans in children: lessons from bronchiolitis obliterans after lung transplantation and hematopoietic stem cell transplantation
Jinho Yu
Clin Exp Pediatr. 2015;58(12):459-465.   Published online December 22, 2015

Postinfectious bronchiolitis obliterans (PIBO) is an irreversible obstructive lung disease characterized by subepithelial inflammation and fibrotic narrowing of the bronchioles after lower respiratory tract infection during childhood, especially early childhood. Although diagnosis of PIBO should be confirmed by histopathology, it is generally based on history and clinical findings. Irreversible airway obstruction is demonstrated by decreased forced expiratory volume in 1...

Original Article
Respiratory syncytial virus infection cases in congenital heart disease patients
Woo Sup Shim, Jae Yeong Lee, Jin Yong Song, Soo Jin Kim, Sung Hye Kim, So Ick Jang, Eun Yong Choi
Clin Exp Pediatr. 2010;53(3):380-391.   Published online March 15, 2010
Purpose : Respiratory syncytial virus (RSV) is one of the main pathogens causing lower respiratory infections (LRI) in young children, usually of limited severity. However, in congenital heart disease (CHD) patients, one of the high-risk groups for RSV infection, RSV can cause serious illnesses and fatal results. To elucidate the effects of RSV infection in CHD patients, we observed RSV...
Clinical characteristics of severe respiratory syncytial virus infection requiring mechanical ventilation in neonatal period and early infancy
Seung Han Shin, Jae Ri Kim, Jin-A Lee, Chang Won Choi, Ee-Kyung Kim, Eun Hwa Choi, Han-Suk Kim, Beyong Il Kim, Hoan Jong Lee, Jung-Hwan Choi
Clin Exp Pediatr. 2008;51(4):372-376.   Published online April 15, 2008
Purpose : To identify clinical characteristics of severe respiratory syncytial virus (RSV) in neonatal period and early infancy and provide information in clinical practice. Methods : Twelve neonates and young infants (<6 months) who were infected by respiratory syncytial virus and required mechanical ventilation between March 2005 and July 2007 were enrolled. Diagnosis of RSV infection was made based on the...
The evaluation of risk for aspiration using lipid-laden macrophage index in infants with bronchiolitis
Ji Yeon Koh, Hee Kang, Ju Young Chung, Tae Hee Han, Chang Keun Kim
Clin Exp Pediatr. 2006;49(7):763-768.   Published online July 15, 2006
Purpose : We investigated the risk of aspiration using the lipid-laden macrophage index(LLMI) from laryngeal lavages in infants with bronchiolitis. Methods : Laryngeal lavages from 22 infants with acute bronchiolitis caused by respiratory syncytial virus(RSV) were evaluated during the acute stage. Repeat studies were performed at 3 to 4 weeks after the initial study(remission stage). Lavage cell counts and differentials were...
Lower respiratory tract infection of positive antigen test for respiratory syncytial virus on children under 2 years of age
Jea Heon Jeong, Kyoung Hee Moon, Chang Woo Lee, Du Young Choi, Yeun Geun Oh, Hyang Suk Yoon, Ji Hyun Cho, Jong Duck Kim
Clin Exp Pediatr. 2006;49(4):394-400.   Published online April 15, 2006
Purpose : This study was design and performed for evaluations of resent clinical pattern of bronchiolitis caused by RSV infection with children under 2 year of age for 5 years, who were admitted to pediatric ward. Methods : The inclusion criteria of the patients were children under 24 month-of-age, clinical manifestations of lower respiratory tract infection, and RSV antigen that...
The Efficacy of Nebulized 3 Percent Hypertonic Saline Solution and Fenoterol in Infants with Bronchiolitis
Joon Young Park, Young Mi Jeong, Soo Jin Jeong, Son Sang Seo
Clin Exp Pediatr. 2005;48(5):518-522.   Published online May 15, 2005
Purpose : To evaluate the effect of inhaled hypertonic saline solution in hospitalized infants with bronchiolitis. Methods : A randomized double blind trial was performed from October 2003 to May 2004. A total of eighty patients <1 year of age with a clinical diagnosis of acute viral bronchiolitis were enrolled and assigned to receive either of the following : inhalation of...
Case Report
A Case of Diffuse Panbronchiolitis Developing in Childhood
Jung Hoon You, Hyung Shin Lee, Kyung Yil Lee, Ja Hyun Hong, Mi Hee Lee, Byung Cheol Lee
Clin Exp Pediatr. 2005;48(1):97-100.   Published online January 15, 2005
Diffuse panbronchiolitis(DPB) is a chronic inflammatory airway disease predominantly affecting respiratory bronchioles, with distinct clinicopathological profiles. It was first described in 1966 by Yamanaka et al. The etiology of DPB is not yet clear, and the natural history of the disease is respiratory failure leading to cor pulmonale and ultimately death. But the long-term use of low-dose macrolide has proven...
Original Article
The Efficacy of Nebulized Epinephrine Versus Fenoterol in Hospitalized Infants with Acute Bronchiolitis
Sang Hee Lee, Kyung Ah Nam, Ji Youn Choi, Meen Jung Kim, Son Sang Seo
Clin Exp Pediatr. 2004;47(9):953-958.   Published online September 15, 2004
Purpose : Acute bronchiolitis is a lower respiratory tract disease, resulting from inflammatory obstruction of the small airway. The main treatment of acute bronchiolitis is supportive but, numerous investigators have examined the efficacy of beta agonist as bronchodilators. In acute bronchiolitis, mucosal edema in the bronchioles may be an important cause of airway obstruction therefore, an alpha and beta agonist...
Case Report
Bronchiolitis Obliterans Associated with Stevens-Johnson Syndrome
Ko Un Chun, Soo Yun, Byung Ho Cha, Hae Yong Lee
Clin Exp Pediatr. 2004;47(7):803-806.   Published online July 15, 2004
Bronchiolitis Obliterans(BO) is one of the rare inflammatory lung disease that primarily affects bronchi and bronchioles, followed by partial or complete obstruction. In children, the etiology of BO has been under consideration, but infections and toxic inhalation, connective tissue diseases, lung transplantation, congestive pulmonary edema, etc., may be causes of BO. Even though steroid therapy was reported as an effective...
Original Article
Serum ECP, RANTES and Eotaxin Levels in Infants with Bronchiolitis
Jong Seo Yoon, Mi Hee Lee, Joon Sung Lee
Clin Exp Pediatr. 2004;47(2):170-176.   Published online February 15, 2004
Purpose : Viral respiratory infection, especially respiratory syncytial(RS) virus, can predispose sufferers to the development of asthma by mechanisms that are presently undetermined. The role of inflammatory mediators in pathogenesis of asthma and RS virus disease is not well-understood. We investigated the performance of serum eosinophil cationic protein(ECP), regulated on activation normal T-cell expressed and secreted(RANTES) and eotaxin levels on...
The Significances of Chest X-ray Findings and Serum IFN-γ, IL-5, ECP as Predictors of Prognosis of Bronchiolitis and Bronchopneumonia in Infants
Su Hyun Cho, Hyun Seung Lee, Mi Hee Lee, Joon Sung Lee
Clin Exp Pediatr. 2003;46(3):230-235.   Published online March 15, 2003
Purpose : Lower respiratory tract infections in infant and young children are often due to a virus, especially the Respiratory syncytial(RS) virus. Chest X-ray findings in bronchiolitis and bronchopneumonia are different. The radiographic hallmark of bronchiolitis is pulmonary hyperinflation and similar to that of bronchial asthma. Bronchiolitis is predisposed to later development of bronchial asthma. To evaluate the difference of...
Case Report
A Case of Diffuse Aspiration Bronchiolitis in a Dysphagic Infant
Ok Ja Choi, Bong Seong Kim, ung Hye Park, Soo-Jong Hong
Clin Exp Pediatr. 2000;43(6):842-845.   Published online June 15, 2000
Diffuse aspiration bronchiolitis is defined as a clinical entity characterized by a chronic inflammation of bronchioles caused by recurrent aspiration of foreign particles. Clinical symptoms are bronchorrhea, bronchospasm, and dyspnea, and chest radiographs show the presence of regional or disseminated small nodular shadows and hyperlucency. Chest CT should help in detecting diffuse nodular shadows of bronchiolitis. Pathologic findings of diffuse...
Original Article
Arterial Oxygen Desaturation after Salbutamol Nebulization in Wheezy Infants and Children
Eun Sun Yoo, Jung Won Seo, Seung Joo Lee
Clin Exp Pediatr. 1996;39(7):953-961.   Published online July 15, 1996
Purpose : Nebulized selective β2-adrenoreceptor agonists have been widely used in acute asthma and selectively in acute bronchiolitis. However, nebulized salbutamol have been reported to cause arterial oxygen desaturation in some of the acute bronchiolitis and severe asthma patients. This may be the results of a paradoxical bronchoconstriction linked to acidic and hyper-osmolar nebulized salbutamol solution and etc. We assessed the changes in arterial...
Case Report
One Case of Bronchiolitis Obliterans Associated with Stevens-Johnson Syndrome due to Mycoplasma pneumoniae In fection
Soo Kyung Lee, Joon Soo Lee, Soo Young Lee, Byung Ju Jeoung, Kyu Earn Kim, Ki Young Lee
Clin Exp Pediatr. 1993;36(10):1441-1446.   Published online October 15, 1993
Bronchiolitis obliterans is an infrequent disorder characterized by partial or complete obstruction of bronchi and bronchioles by fibrous tissue following an insult to the lower respiratory tract. In the pediatric population, Bronchiolitis obliterans has most frequently been preceded by respiratory tract infection by adenovirus, influenza, measles. But it may occur in young adults after mycoplasma infection. We experienced the case...
Original Article
Clinical and Epidemiologic Features of Respiratory Syncytial Virus Infection
Hoan Jong Lee, Seong Hee Jang
Clin Exp Pediatr. 1992;35(10):1389-1401.   Published online October 15, 1992
Although lower respiratory tract infection is a major cause of childhood morbidity in Korea and respiratory viruses are presumed to be important pathogens, there have been few studies available. We diagnosed RSV infection by virus isolation and immunofluorescence in children with lower respiratory tract infection, seen at Seoul National University Children's Hospital from Nov. 1990 to Jul. 1991. The results were...
A Study on the Growth Pattern, History of Respiratory Illness and Family History in Acute Bronchiolitis.
Dong Won Choi, Byung Ju Jung, Kyu Earn Kim, Ki Young Lee
Clin Exp Pediatr. 1990;33(5):623-631.   Published online May 31, 1990
The authors evaluated the growth pattern, history of frequent respiratory illness and family history in 111 infants who were admitted to the Department of Pediatrics, Yonsei University Hospital with the diagnosis of acute bronchiolitis from Sept. 1986 to Jun. 1988. The results of the study were as follows: 1) The sex incidence of bronchiolitis was higher in males compared with the sex incidence of the total...
Serum IgE Levels in Bronchiolitis Patients.
Seong Hee Choi, Keun Lee
Clin Exp Pediatr. 1989;32(6):749-755.   Published online June 30, 1989
Bronchiolitis is a virus.caused lower respiratory disease resulting from inflammatory obstruction of the small airways. The condition may develop to asthma anddifferential diagnosis is not clearcut between two diseases during infancy. Measurement of the serum IgE concentration has been used as an aid in the differential diagnosis. The purpose of this study is to compare the serum IgE levels between control groups and bronchiolitis patients,...
A Clinical Observation on Acute Bronchiolitis.
Jong Man Lee, Won Ik Lee, Jong Seung Kim, Chang Kyu Oh
Clin Exp Pediatr. 1982;25(12):1218-1224.   Published online December 31, 1982
A clincial study of 289 cases of acute bronchiolitis, which were admitted to the pediatric department of St. Paul’s Hospital during the period of 6 years from January 1975 to December 1980 was reviewed. The results were as follows: 1. Male was predominant, and male to female ratio was 2.3 : 1. 2. The highest incidence (72.3%) was in infants below the age of 6 months and...
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