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Review Article
General Pediatrics
A new perspective on cholesterol in pediatric health: association of vitamin D metabolism, respiratory diseases, and mental health problems
Jeana Hong
Clin Exp Pediatr. 2022;65(2):65-72.   Published online December 9, 2021
∙ Pediatric dyslipidemia is associated with several health problems besides cardiovascular diseases.
∙ There is a direct association between pediatric dyslipidemia and low serum vitamin D levels, asthma, and mental health problems regardless of body mass index.
∙ More large-scale nationally representative studies are needed to establish the appropriate cutoff points for the definition of dyslipidemia that is a prerequisite for further epidemiological studies in the Korean pediatric population.
Original Article
Endocrinology
Lipid accumulation product is a predictor of nonalcoholic fatty liver disease in childhood obesity
Bahar Özcabı, Salih Demirhan, Mesut Akyol, Hatice Öztürkmen Akay, Ayla Güven
Clin Exp Pediatr. 2019;62(12):450-455.   Published online October 28, 2019
Background: Lipid accumulation product (LAP) is associated with the presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults.
Purpose: Here we evaluated the ability of LAP to predict NAFLD in obese children. Methods: Eighty obese children (38 girls; age 6–18 years) were included. Anthropometric measurements and biochemical values were obtained from the patients’ medical records. LAP was calculated as [waist...
Gastroenterology
Nonalcoholic fatty liver disease in obese and nonobese pediatric patients
Eun Jeong Kim, Hyun Jin Kim
Clin Exp Pediatr. 2019;62(1):30-35.   Published online September 17, 2018

Purpose: Obesity is risk factor for nonalcoholic fatty liver disease (NAFLD). However, nonobese patients are also increasingly susceptible to NAFLD. The aim of this study was to compare the clinical characteristics of obese and nonobese pediatric patients with NAFLD. Methods: We retrospectively studied 68 patients who were diagnosed with NAFLD between January 2010 and October 2016 at 10–18 years of age....
Case Report
A case of Smith-Lemli-Opitz syndrome diagnosed by identification of mutations in the 7-dehydrocholesterol reductase (DHCR7) gene
Mee Rim Park, Jung Min Ko, Chong-Keun Cheon, Gu-Hwan Kim, Han-Wook Yoo
Clin Exp Pediatr. 2008;51(11):1236-1240.   Published online November 15, 2008
Smith-Lemli-Opitz syndrome (SLOS) is a rare, autosomal recessive disease caused by an inborn error in cholesterol synthesis. Patients with this disease suffer from multiple malformations due to reduced activity of 7-dehydrocholesterol reductase (DHCR7), which increases 7-dehydrocholesterol (7DHC) and 8-dehydrocholesterol (8DHC) concentrations and decreases cholesterol concentration in body fluids and tissue. The SLOS phenotypic spectrum ranges from a mild disorder with...
Original Article
Changes of Lipid and Lipoprotein Compositions in Kawasaki Disease and its Impact on Cardiac Complications
Sin Weon Yun, Ho Seok Lee, Dong Woon Kim, Kang Won Rhee, Young Soo Jung
Clin Exp Pediatr. 2005;48(12):1370-1377.   Published online December 15, 2005
Purpose : Delineation of serum lipid and lipoprotein values in children after Kawasaki disease(KD) is important because of the predilection of this disease for the coronary arteries. Methods : The KD group was composed of 51 patients who were hospitalized from Jan. 2002 to Dec. 2003. Control was 25 patients with non-KD febrile illness. The levels of total lipid, phospholipid,...
The Prevalence of Childhood and Adolescent Obesity in Jeju and Clinical Characteristics according to the Degree of Obesity
Jung Ho Seo
Clin Exp Pediatr. 2004;47(4):362-367.   Published online April 15, 2004
Purpose : Recently, childhood obesity has increased and became a major health concern in Korea. The aim of this study is to examine the prevalence of childhood and adolescent obesity in Jeju and to analyze clinical characteristics according to the degree of obesity. Methods : A total of 3,643 students from April 2002 to August 2002 were studied. To examine the...
Alteration of Biochemical Profiles after High-Dose Intravenous Immunoglobulin Administration in Kawasaki Disease
Ji-Won Lee, Kyung-Yil Lee
Clin Exp Pediatr. 2003;46(8):817-820.   Published online August 15, 2003
Purpose : Intravenous immunoglobulin(IVIG) has been used as an immunomodulatory treatment for several immune-mediated diseases. The early effect of high-dose IVIG on biochemical profiles including lipids and proteins was evaluated in patients with Kawasaki disease(KD). Methods : Twelve children with KD(nine boys) were treated with IVIG of 2 g/kg over 12 hours. Serial sera were collected from the patients four times...
The Prevalent Rates of Abnormal Serum Aminotransferase Levels and Total Cholesterol Levels among Adolescents with Obesity
Hyun Oh Jang, Chong Guk Lee, Yun Ju Kang
Clin Exp Pediatr. 2002;45(12):1484-1490.   Published online December 15, 2002
Purpose : The purpose of this study was to look at prevalences of abnormal serum aminotransferase levels and abnormal serum total cholesterol levels among adolescents with obesity in Seoul area. Methods : Body mass index[BMI(kg/m2)], serum aspartate aminotransferase(AST) alanine aminotransferase(ALT), and total cholesterol levels were measured in 26,876 adolescents(male : 13,287, female : 13,589) of first grade of high school in...
The Prevalence of Obesity and Underweight in Adolescents in Incheon Area and the Relationship between Serum Cholesterol Level and Obesity
Myung Hyun Kim, Tae Wan Kim, Young Jin Hong, Byong Kwan Son, Soo Hwan Pai, Kyung Ja Chang, Soon Ki Kim
Clin Exp Pediatr. 2002;45(2):174-182.   Published online February 15, 2002
Purpose : The purpose of this study was to investigate the prevalence of obese and underweight adolescents in Incheon area and to examine the relationship between serum cholesterol level and obesity, then to assess the nutritional condition of adolescents. Methods : With a questionnaire regarding their demographic characteristics, blood samples were obtained from apparently healthy students aged 12 to 24 years...
Erratum
Reference Values of Hematologic and Biochemical Parameters of Nutrition around Weaning Period
Seung Joo Lee, Jeong Wan Seo, Jae Ock Park, Jae Hoon Shin, Hae Ran Lee, Ji Tae Chung, Hae Il Chung
Clin Exp Pediatr. 1999;42(1):6-14.   Published online January 15, 1999
Purpose : To determine the reference values of hematologic and biochemical parameters of nutrition around the weaning period. Methods : From February 1996 to March 1997, several nutritional laboratory values were evaluated in 130 healthy babies and 120 inpatients in the recovery stage of acute illness at six general hospitals. Results : Reference values in 9-month-old healthy babies(range : 6-12 months) were...
Case Report
A Case of Familial Hypercholesterolemia with Diabetes Mellitus
Yong Kyu Sohn, Kee Young Chang, Kee Hyoung Lee, Young Chang Tockgo
Clin Exp Pediatr. 1997;40(6):862-866.   Published online June 15, 1997
Familial Hypercholesterolemia is the most common hyperlipoproteinemia during the childhood, which occurs from the mutation of genes that regulates low-density lipoproteins(LDL), and is classified into two types, the homozygote presented abnormal genes from both parents and the heterozygote presented an abnormal gene from each parent. Type IIa familial hypercholesterolemia is characterized by, especially, increased level of LDL which is common type and normal level...
Original Article
Lipid Profile and Its Association with Coronary Aneurysm in Kawasaki Disease
Ju Sik Choi, Suk Min Choi, Kyu Hyung Lee
Clin Exp Pediatr. 1997;40(6):835-840.   Published online June 15, 1997
Purpose : The value of serum lipid in children after recovery of Kawasaki disease may be important because of the predilection of this disease for the coronary artery. Methods : We measured serum high density lipoprotein(HDL)-cholesterol, total cholesterol, triglycerides in 22 patients (mean age 38months, range 6 to 93 months) with Kawasaki disease during 10 days or less after onset and 2 months later...
The Change of Serum Cholesterol level in Children with Fever
Mi Ja Park, Jae Yoon Kim, Jae Wook Ko, Don Hee Ahn
Clin Exp Pediatr. 1996;39(7):908-914.   Published online July 15, 1996
Purpose : This study was undertaken to assess the change of the serum cholesterol level according to the duration of fever in children. Methods : A retrospective study presents data on fasting serum cholesterol assessed 346 children aged from 3 to 14 years, admitted to National Medical Center from Jan. 1992 to Jun. 1994 due to febrile disease. These patients were divided into three...
A Study on Nutritional Status of Iron and Lipids in Infants
Kwang-Hea Choi, Son Moon Shin, Kee-Hwa Oh, Jung Sook Seo, Kwang-Soo Kim, Yung-Sun Choi
Clin Exp Pediatr. 1995;38(3):297-305.   Published online March 15, 1995
Purpose : This study was conducted to get baseline data to establish a guideline for the infant nutrition by observing the feeding practice and nutritional intake during infancy and evaluationg the nutritional status of iron and lipids at 12-month-old infants. Methods : This survery was cnducted from July to November, 1992. Subjects were healthy infants who were brought to Yeungnam University...
Serum Total Cholesterol and HDL Levels in Healthy Korean School Children: Do They Correlate with Obesity?
Jae Geon Sim, Mi Za Chun, Moses Whang
Clin Exp Pediatr. 1994;37(11):1579-1585.   Published online November 15, 1994
Purpose : The cut-off value for hypercholesterolemia and normal HDL levels for Korean children are still not established despite increasing hypercholesterolemia with recent socioeconomic change. One of the aims of this study its to screen the serum total cholesterol and HDL levels in normal Korean school children, and another is to evaluate the relationships between serum lipid levels and obesity. Methods...
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