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Review Article
Neurology
Neonatal seizures: diagnostic updates based on new definition and classification
Eun-Hee Kim, Jeongmin Shin, Byoung Kook Lee
Clin Exp Pediatr. 2022;65(8):387-397.   Published online April 4, 2022
· Neonatal seizures are often electrographic-only seizures without clinical signs; therefore, the identification of electrical seizure activity on electroencephalography is the gold standard for diagnosis.
· Clinical signs of neonatal seizures are divided into motor or nonmotor seizures, and motor seizures are mostly focal or multifocal.
· Most neonatal seizures are caused by acute symptomatic etiologies, but in cases of intractable seizures, structural, genetic, or metabolic etiologies should be investigated.
General Pediatrics
Association between maternal smoking during pregnancy and risk of bone fractures in offspring: a systematic review and meta-analysis
Erfan Ayubi, Saeid Safiri, Kamyar Mansori
Clin Exp Pediatr. 2021;64(3):96-102.   Published online February 5, 2020
Question: What is the effect of maternal smoking during pregnancy (MSDP) on the risk of bone fractures in the offspring?
Finding: After the adjustment for misclassification, MSDP may be associated with a 27% increased risk of bone fracture in the offspring (pooled odds ratio, 1.27; 95% confidence interval, 1.00–1.62; I2=0%; P=0.537)
Meaning: Preventive measures and health education programs should be designed and implemented to encourage women to stop smoking, especially during.
Febrile seizures
Sajun Chung
Clin Exp Pediatr. 2014;57(9):384-395.   Published online September 30, 2014

Febrile seizure (FS) is the most common seizure disorder of childhood, and occurs in an age-related manner. FS are classified into simple and complex. FS has a multifactorial inheritance, suggesting that both genetic and environmental factors are causative. Various animal models have elucidated the pathophysiological mechanisms of FS. Risk factors for a first FS are a family history of the...

The diagnosis of pediatric sinusitis
Chang-Keun Kim
Clin Exp Pediatr. 2007;50(4):323-327.   Published online April 15, 2007
Although most clinicians now agree that sinusitis can afflict children of all ages, appropriate diagnosis remain controversial. Sinusitis is one of the most challenging diagnoses for a clinician, because there is a lack of validated diagnostic criteria for acute rhinosinusitis. Symptoms generally include nasal congestion, purulent nasal discharge, and cough .The physical examination is often unsuccessful in confirming the diagnosis....
Original Article
Study on the Correlation between Clinical Classification according to Hemorrhagic Symptoms and Platelet Counts in Childhood Idiopathic Thrombocytopenic Purpura
Ho Il Bang, Sae Ron Shin, Du Young Choi
Clin Exp Pediatr. 2004;47(4):412-416.   Published online April 15, 2004
Purpose : Idiopathic thrombocytopenic purpura(ITP) is a relatively common hematologic disease in children. The optimal strategy for treating ITP during childhood is a matter of controversy. In general, platelet count has been the primary, if not the sole measure, on which treatment decisions have been made and outcomes determined. In this study, we tried to find out the correlation between...
Characteristics of Pulmonary Atresia and Ventricular Septal Defect According to Morphologic Classification and Changes of Pulmonary Artery after Modified B-T Shunt
Kise Nam, Jeong Hoon Kim, Jae Young Choi, Jun Hee Sul, Sung Kue Lee, Young Hwan Park
Clin Exp Pediatr. 2004;47(3):304-309.   Published online March 15, 2004
Purpose : The purpose of this study is to help determine the optimal time and method for operation of pulmonary atresia(PA) with ventricular septal defect(VSD). Methods : Seventy patients who were diagnosed as PA with VSD in the Pediatric Department of Cardiology, Severance Hospital between May, 1991 and April, 1995, were included in our study. Subjects were divided into two groups...
A Clinical Study on Childhood Hemolytic Anemia According to Etiological Classification
Hae-Sik Kwon, Jung-Chul Kang, Sung-Chul Won, Seung-Hwan Oh, Chuhl-Joo Lyu
Clin Exp Pediatr. 2003;46(9):883-888.   Published online September 15, 2003
Purpose : The etiology of hemolytic anemia can be classified as either cellular or extracellular defects of red blood cells. The aim of this study was to investigate the clinical and laboratory findings of hemolytic anemia concerning its etiological classification. Methods : Clinical and laboratory findings of the patients with hemolytic anemia treated from January 1987 to May 2002 at Severance...
Electrocardiographic and Echocardiographic Characterisitics of Wolff-Parkinson-White Syndrome in Preschool Children
Jeoung Min Chu, Hyun Sup Sim, Soo Chul Cho, Chan Uhng Joo
Clin Exp Pediatr. 2002;45(9):1097-1105.   Published online September 15, 2002
Purpose : This study was conducted to estabilish the prevalence, clinical features and relationship between ECG findings and echocardiographic findings of Wolff-Parkinsion-White(WPW) syndrome in asymptomatic preschool children. Methods : An electrocardiographic screening study was performed on 77,824 preschool children in Jeonbuk province from April, 1999 to August, 2001. Patients with WPW syndrome underwent echocardiographic study. Results : Twenty three patients with WPW...
The Clinical Types and Characteristics of Diabetes Mellitus in Korean Children
Eun Gyong Yoo, Hye Jung Shin, Duk Hi Kim
Clin Exp Pediatr. 2000;43(12):1591-1598.   Published online December 15, 2000
Purpose : Diabetic children should be classified into type 1 or 2 for adequate diabetic control. However, there is a shortage of information of the appropriate criteria in Korea. This study is desinged to discover the clinical types and characteristics of diabetes mellitus(DM) in Korean children. Methods : We studied the clinical characteristics and laboratory findings of 177 diabetic children. Classification...
Clinical Profiles and Anatomic Classification of Intestinal Malrotation
Jung A Kim, Jae Seong Ko, Jeong Kee Seo, Kwi Won Park, Woo Sun Kim, In One Kim
Clin Exp Pediatr. 1999;42(4):526-534.   Published online April 15, 1999
Purpose : Intestinal malrotation is a developmental anomaly and may be complicated by volvulus and intestinal necrosis. We performed anatomic classification and compared clinical profiles to understand their relationship. Methods : Twenty-eight children were diagnosed as intestinal malrotation at Seoul National University Children's Hospital between Jan. 1980 to Dec. 1995. The patients were classified into 4 groups by age at...
A Clinical Study on the Liver Cirrhosis in Children: Review of 40 Cases
Je Woo Kim, Ki Sup Chung, Chan Il Park
Clin Exp Pediatr. 1995;38(11):1506-1514.   Published online November 15, 1995
Purpose : Liver cirrhosis is relatively uncommon disease in childhood, but the overall prevalence rate and etiology of the liver cirrhosis in children were uncertain in Korea. This clinical study was undertaken to help pediatricians manage the patients properly by investigating the etiology, clinical findings and the outcome on 40 pediatric patients with liver cirrhosis. Methods : This study was conducted...
Cystic Kidney Disease According to Potter's Classification
Kee Hyuck Kim, Sung Chul Shin, Soon Il Lee, Je Geun Chi
Clin Exp Pediatr. 1995;38(1):91-98.   Published online January 15, 1995
The cystic disease of the kidney include a heterogeneous group of developmental, hereditary, and acquired disorders. Based on extensive microdissection studies, Potter concluded all renal cystic diseases could be categorized into four types. We have experienced 5 cases of cystic kidney disease which were confirmed by aoutopsy and classified as Type I, Type II, Type III, Boderline between types II and...
Analysis of the Morphological Characteristics of Double Outlet Right Ventricle and Comparative Study of Operative Methods
Jun Hee Sul, Jong-Kyun Lee, Jo Won Jung, Sung Kyu Lee, Bum Koo Cho
Clin Exp Pediatr. 1993;36(12):1721-1731.   Published online December 15, 1993
Double outlet right ventricle, a complex of congenital cardiac anomalies in which both great arteries arise wholly or in large part from the morphologic right ventricle presents diverse clinical manifestations according to the morphological characteristics. Eighty cases with DORV were diagnosed and operated at Yonsei Cardiovascular Center from 1988 to 1992. The analysis of the morphological characteristics of this anomaly and...
Tricuspid Atresia : A Re-evaluation and Classification
Jun Hee Sul, Jong Kyun Lee, Seok Min Choi, Sung Kyu Lee
Clin Exp Pediatr. 1993;36(12):1716-1720.   Published online December 15, 1993
Morphological evaluations accounting the associated anomalies were performed in the 60 cases of tricuspid atresia, diagnosed at Divsion of Pediatric Cardiology. The following results were obtained. 1) Twenty one out of the 6 cases had transposition of the great vessels, among which 8 cases were in complete A-transposition. 2) Seven cases were associated with pulmonany atresia, in 1 case, aorts arise from...
Studies on Type of Ventricular Septal Defect of Tetralogy of Fallot and its Clinical Significance.
Myung Kul Yum, Hee Shang Youn, Heung Jae Lee
Clin Exp Pediatr. 1989;32(3):359-365.   Published online March 31, 1989
To assess the VSD type of TOF and relationship between VSD type of TOF and pulmonary valve stenosis, small pulmonary valve annulus, and pulmonary artery anomaly, we analyzed 256 cases of surgically confirmed TOF patients. The summary of observation is as follows; 1) Four tytes of VSDs were found. The most frequent is perimembranous (PM) VSD of which incidence is 75.7% (159/210), second most...
A Clinical Observation on the Incidence of Childhood Leukemia.
Hyo Seop Ahn, Il Soo Ha, Soon Ki Kim, Hoan Jong Lee, Chang Yee Hong
Clin Exp Pediatr. 1988;31(7):841-849.   Published online July 31, 1988
We have analysed the type, age, sex, initial hematologic values and cell markers in 295 children, who had been diagnosed as leukemia at the department of pediatrics, Seoul National University Hospital, from Jan. 1983 to Dec. 1987. The patients were composed of 197 cases (66.8%) of ALL, 82 cases (27.7%) of ANLL and 16 cases (5.5%) of CML. FAB subclassification have been done in...
Burkitt Lymphoma in Children.
Soo Jong Hong, Dong Kyu Jin, Hee Young Shin, Hyo Seop Ahn, Chang Yee Hong, Je G Chi
Clin Exp Pediatr. 1988;31(4):482-491.   Published online April 30, 1988
Seventeen cases of Burkitt lymphoma under 15 years of age who were admitted to Dept, of Ped., Seoul National University Hospital from Jan. 1979 to Dec. 1986 were reviewed and analysed. One hundred and six cases of non-Hodgkin lymphoma were seen during the same period. 1) Burkitt lymphoma accounted for 16% of non-Hodgkin lymphoma. 2) The age ranged from 10/12 year to 15 5/12 years, with...
Clinical and Statistical Obervation of Sick Babies in SCBU.
Kyung Tae Kim, Dae Sik Hong, Kew Taek Kim
Clin Exp Pediatr. 1981;24(1):24-35.   Published online January 15, 1981
Clinical and statistical analysis were performed on 573 cases of neonates who were admitted in the special care baby unit, St. Benedict Hospital, from January 1978 to June 1979. The results were as following: 1) Sex ratio of male to female was 1.04:1. 2) According to the route of admission, The ratio of "non-referred patients" to "referred patients was 1.86:1....
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