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Original Article
Infection
Evolving treatment strategies for invasive Streptococcus pyogenes in children in the postpandemic era
Laura Buricchi, Giuseppe Indolfi, Marco Renni, Elisabetta Venturini, Luisa Galli, Elena Chiappini
Clin Exp Pediatr. 2025;68(11):921-931.   Published online August 11, 2025
Question: What are the roles of linezolid, intravenous immunoglobulin (IVIG), and corticosteroids in pediatric invasive group A streptococcal infection (iGAS)? Can any improve outcomes beyond beta-lactams and clindamycin?
Finding: Two of 46 patients with iGAS died. Nearly all received beta-lactams plus clindamycin. Linezolid was effective in refractory cases. IVIG and corticosteroids had variable efficacies.
Meaning: Linezolid may be valuable in refractory cases. IVIG may be considered in severe presentations. The role of corticosteroids remains less clearly defined.
A case of babesiosis in an eight year old Korean boy.
Jae Geon Sim, Hyun Seung Park, Don Hee Ahn, Weon Gyu Kho, Jong Yil Chai
Clin Exp Pediatr. 1991;34(10):1417-1421.   Published online October 31, 1991
Authors experienced a case of babesiosis in an eight year old boy just returned from Advijan, Ivory coast, Africa, where he had been for three years. Parasites were identified from blood smears. He was treated with clindamycin and quinine for ten days with good recovery. Brief review followed.
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