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Review Article
Pathophysiology and management of disorders in water metabolism
Dong Un Kim
Clin Exp Pediatr. 2007;50(5):430-435.   Published online May 15, 2007
Even though we drink and excrete water without recognition, the amount and the composition of body fluid remain constant everyday. Maintenance of a normal osmolality is under the control of water balance which is regulated by vasopressin despite sodium concentration is the dominant determinant of plasma osmolality. The increased plasma osmolality (hypernatremia) can be normalized by the concentration of urine,...
Medical Lecture Course
Renal Transport Proteins Involved in Urinary Concentrating Mechanism
Dong Un Kim
Clin Exp Pediatr. 2004;47(5):480-484.   Published online May 15, 2004
Renal tubule and vasa recta are arranged in complex but specific anatomic relationships and the production of a concentrated urine is achieved by countercurrent multiplication mechanism in the renal medulla. This model requires that the ascending thin limb is highly permeable to NaCl but impermeable to water, while the descending thin limb is impermeable to NaCl but highly permeable to...
Original Article
Pharmacokinetics of Cyclosporine A and Its Therapeutic Effect in Children with Renal Diseases
Woo Sung Chun, Min-Soo Park, Jae Seung Lee, Juyun Yu, Moon Sung Park, Ki-Soo Pa
Clin Exp Pediatr. 2004;47(2):193-203.   Published online February 15, 2004
Purpose : To know the body handling properties and anti-proteinuric effect of cyclosporine A(CsA) in children with renal diseases, 34 patients with nephrotic syndrome or glomerular diseases were included to treatment trials and evaluated. Methods : Microemulsion formula CsA, 5 mg/kg/day was administered orally in two divided doses for 9.3?.6 months. Pharmacokinetic studies of CsA were done twice at beginning and...
Mean Corpuscular Hemoglobin Concentration as a Discriminating Tool between Hereditary Spherocytosis and Intravascular Hemolysis
Hae Young Park, Hwang Min Kim, Kyoung Ah Lee, Dong Il Won, Sei Myeng Park, Seok Won Park, Baek Keun Lim, Kil Young Kim
Clin Exp Pediatr. 2001;44(6):664-668.   Published online June 15, 2001
Purpose : The purposes of this study were to elucidate the diagnostic significance of mean corpuscular hemoglobin concentration(MCHC) for various kinds of hemolytic anemia, the mechanism of elevated MCHC in hereditary spherocytosis(HS). Methods : The subjects consisted of 39 cases of HS(group 1), 31 cases of intravascular hemolysis (IH) such as DIC, snake bite or hemolytic uremic syndrome(group 3), and sex...
Zinc and Copper Concentrations and Their Correlation with Protien in Cerebrospinal Fluid of Children with Neurologic Disorders
Myung Joon Cha, Young Joon Kim, Ha Joo Choi, Woo Kap Chung
Clin Exp Pediatr. 1997;40(8):1062-1070.   Published online August 15, 1997
Purpose : The importance of trace elements in their effect on the physiology and pathology of the central nervous system is well recognized. Changes in the concentrations of these elements in the brain could take place in pathological states. Recently, a greater emphasis has been given to the role of trace elements in the function of the nervous system both in normal and pathological...
Plasma Amino Acid Patterns in Reye's Syndrome.
Han Wook Yoo, Hee Shang Youn
Clin Exp Pediatr. 1989;32(10):1377-1383.   Published online October 31, 1989
The metabolic disturbances of Reye’s syndrome are many and involve carbohydrates, amino acids, free fatty acids, proteins, ammonia and acid-base balance. It has been suggested that the derangement of mitochondrial integrity by an agent or agents unknown leads to a loss of enzyme activity in many metabolic pathways in which t노e mitochondria are involoved. Of primary interests in this study is the abnormalities regarding...
A Study on the Change of Plasma Renin Activity(PRA) and Aldosterone Concentration(PAC) before and after Heart Operation in Children with Congenital Heart Disease.
Jae Hong You, Jae Ho Lee
Clin Exp Pediatr. 1989;32(9):1232-1239.   Published online September 30, 1989
Thes is a study on changes of plasma renin activity (PRA) and aldosterone concentration (PAC) which was obtained before and after heart operation in 26 normotensive children with congenital heart diseases without renal disease admitted in Chungnam National University Hospital for cardiac catheterization with angiogram and heart operation from Apr. 1988 to Aug. 1988 to confirm any differences of PRA and PAC between groups...
The Effect of Intravenous Dextrose Water Given to Mother During Labor on Sodium Concentration of Maternal and Cord Serum.
Soo Kyung Chung, Dong Suk Suh, Seung Joo Lee, Keun Lee
Clin Exp Pediatr. 1986;29(8):840-844.   Published online August 31, 1986
We studied the influence of intravenous electrolyte-free dextrose solution given to the mother during labor on the change of maternal and cord serum concentrations and the incidence of hyponatremia in 109 mothers and their newborns. 1) Na+ concentrations of maternal and cord serum in study group given intravenous electrolyte free dextrose solutions were 134.57土2.43 and 134.54±2.95, which was significantly lower,...
Calcium, Phosphorus, and Magnesium contents of Breast Milk.
In Bock Lee, Kwang Rhun Koo, Chang Soo Ra
Clin Exp Pediatr. 1985;28(12):1216-1220.   Published online December 31, 1985
In order to determine the concentration of Ca, P, and Mg of breast mik and the alterations of their concentrations during the period of lactation, the authors studied the concentrations of Ca, P, and Mg of breast milk from 68 Korean healthy nursing mothers who delivered at term. Ca, P, and Mg concentration of breast milk were measured by calorimetric...
The Influence of Phototherapy on the Concentration of Serum Calcium.
Hyun Sook Lee, Hung Bae Park
Clin Exp Pediatr. 1984;27(9):865-871.   Published online September 30, 1984
Since the report of Dr. Cremer in the 1950s the effectiveness of phototherapy in the treatment of neonatal hyperbilirubinemia has been demonstrated in many clinical trials and now become widely accepted as a routine therapeutic measure in most pediatric clinics. Considering the relatively high incidence of prematurity and neonatal jaundice especially in Asian countries, it is of great concern to...
Study of Bilirubin Concentration on The Neonatal Jaundice.
Seung Kwon Kim, Woo Sik Chung, Byung Do Nam, Kew Taek Kim
Clin Exp Pediatr. 1982;25(11):1089-1096.   Published online November 30, 1982
W« studied the guidelines on the serum bilirubin concentration of 15 mg% for the management of neonatal jaundice and compared the group of serum bilirubin concentration below 15 mg% ■and the group of serum bilirubin concentration above 15 mg%. 83 cased of icteric infants without any risk factors for kernicterus, ahove 12 m.g% in serum bilirubin concentration, were born at the St. Benedict hospital...
Clinical Study on Acute Glomerulonephritis in Children.
Jae Sook Ma, Suk Jung Chang, Hyung Suck Byun, Chull Sohn
Clin Exp Pediatr. 1982;25(1):19-28.   Published online January 31, 1982
A clinical study was done on 199 cases of Acute Glomerulonehritis, who had been admitted to the department of Pediatrics, Chonnam National University Hospital during the five years period from January 1976 to December 1980. The following results were obtained. 1) Males were affected more frequently than females by a 2:1 ratio, and the highest incidence was noted in children...
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