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Original Article

Production of Interleukin-1α and Tumor Necrosis Factor-α by Human Cord and Adult Blood Mononuclear Cells Stimulated by TSST-1 and LPS

Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim

Clin Exp Pediatr. 1997;40(5):690-700. Published online May 15, 1997

Purpose : Immature immunological defens mechanism in the neonate may contribute to the high susceptibility to overwhelming sepsis. S. aureus TSST-1 and E. coli LPS known as one of the important pathogens of septic shock or toxic shock induce massive release of various cytokines, such as tumor necrosis factor-alpha(TNF-α) and interleukin-1α(IL-1α) produced from peripheral blood mononuclear cells(PBMC). In contrast, limited...

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