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- Review Article
- Infection
- COVID-19 among infants: key clinical features and remaining controversies
- Nevio Cimolai
- Clin Exp Pediatr. 2024;67(1):1-16. Published online November 27, 2023
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· Clinical studies of coronavirus disease 2019 (COVID-19) in infants should be supported by rigorous laboratory diagnostic criteria.
· Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads to infants similarly to other viral respiratory infections.
· Among infants ≤1 year of age beyond the immediate postpartum period, COVID-19 is relatively mild, but even the low risk of severe disease requires prevention.
· Comorbidities increase infection vulnerability and complications in infants.
· Clinical and laboratory data do not sufficiently distinguish COVID-19 from other respiratory viral infections.
· Coinfection with SARS-CoV-2 is uncommon among infants.
· Unique infection sequelae, including multi-inflammatory syndrome in children and neonates and long COVID require further study and refinement of diagnostic criteria.
· Infection control standards applied to mother-infant dyads should be tempered by standard preventive strategies, maternal input, accommodation potential, and overall safety.
· Maternal vaccination prevents disease in early infancy.
- Pulmonology
- Epidemiology and surveillance implications of community-acquired pneumonia in children
- Eui Jeong Roh, Jung Yeon Shim, Eun Hee Chung
- Clin Exp Pediatr. 2022;65(12):563-573. Published online October 17, 2022
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The identification of the causative pathogens of community-acquired pneumonia and appropriate treatment and prevention can reduce mortality and the socioeconomic burden by reducing the medical expenses. The world has been in the coronavirus disease 2019 pandemic since 2020, and there is always a risk of continuous emergence and epidemic of new respiratory infectious diseases. Therefore, it is important to sustain a monitoring system for respiratory infectious diseases including pneumonia.
- Review article
- Immunology
- Systematic review of literature and analysis of big data from the National Health Insurance System on primary immunodeficiencies in Korea
- Sohee Son, Ji-Man Kang, Younsoo Hahn, Kangmo Ahn, Yae-Jean Kim
- Clin Exp Pediatr. 2021;64(4):141-148. Published online July 13, 2020
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In this article, a systematic review of reported primary immunodeficiency disease (PID) cases in Korea was performed and we attempted to estimate the number of PID patients and healthcare costs for the first time in Korea. Our review revealed that Korean PID cases are greatly underreported in the literature based on health insurance. Physicians in the field and health care policymakers should be aware of the disease burden of PID.
- Review Article
- Cardiology
- Reality of Kawasaki disease epidemiology
- Gi Beom Kim
- Clin Exp Pediatr. 2019;62(8):292-296. Published online July 9, 2019
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Epidemiologic studies of Kawasaki disease (KD) have shown a new pattern or change of its occurrence suggestive of its pathophysiology or risk factors from the first patient with KD reported in 1961. The incidence of KD in Northeast Asian countries including Japan, South Korea, China, and Taiwan is 10–30 times higher than that in the United States and Europe. Knowing...
- Original Article
- Infection
- Clinical and laboratory profiles of hospitalized children with acute respiratory virus infection
- Eunjin Choi, Kee-Soo Ha, Dae Jin Song, Jung Hwa Lee, Kwang Chul Lee
- Clin Exp Pediatr. 2018;61(6):180-186. Published online June 25, 2018
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Purpose Despite the availability of molecular methods, identification of the causative virus in children with acute respiratory infections (ARIs) has proven difficult as the same viruses are often detected in asymptomatic children.
Methods Multiplex reverse transcription polymerase chain reaction assays were performed to detect 15 common respiratory viruses in children under 15 years of age who were hospitalized with ARI between January 2013...
- Gastroenterology
- Characteristics and prognosis of hepatic cytomegalovirus infection in children: 10 years of experience at a university hospital in Korea
- Chae-Yeon Min, Joo Young Song, Su Jin Jeong
- Clin Exp Pediatr. 2017;60(8):261-265. Published online August 14, 2017
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Purpose Studies on cytomegalovirus (CMV) infections in immunocompetent children are lacking, and minimal information is available in the medical literature on hepatic manifestations and complications of CMV. The aims of this study were to evaluate the clinical characteristics, laboratory data, and prognosis of children with CMV hepatitis, and to investigate its prevalence at a single medical center in Korea over a...
- Epidemiological comparison of three
Mycoplasma pneumoniae pneumonia epidemics in a single hospital over 10 years - Eun-Kyung Kim, You-Sook Youn, Jung-Woo Rhim, Myung-Seok Shin, Jin-Han Kang, Kyung-Yil Lee
- Clin Exp Pediatr. 2015;58(5):172-177. Published online May 22, 2015
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Purpose Mycoplasma pneumoniae (MP) pneumonia epidemics have occurred in 3- to 4-year cycles in Korea. We evaluated the epidemiologic characteristics of MP pneumonia in Daejeon, Korea, from 2003 to 2012.Methods We retrospectively analyzed 779 medical records of children (0-15 years of old) with MP pneumonia admitted to our institution and compared the data from 3 recent epidemics.
Results In 779 patients, the mean age...
- Changes of clinical characteristics and outcomes in patients with Kawasaki disease over the past 7 years in a single center study
- Hye Jin Kang, Gee Na Kim, Hong Ryang Kil
- Clin Exp Pediatr. 2013;56(9):389-395. Published online September 30, 2013
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Purpose This single-center study was conducted to assess the changes in epidemiological and clinical characteristics and outcomes of patients with Kawasaki disease (KD) over the past 7 years.
Methods This retrospective study included 135 children with KD, admitted to Chungnam National University Hospital, Daejeon, between 2004 and 2005 (group A, n=53) and between 2011 and 2012 (group B, n=82). Medical records were reviewed...
- Review Article
- Current status of measles in the Republic of Korea: an overview of case-based and seroepidemiological surveillance scheme
- Young June Choe, Geun-Ryang Bae
- Clin Exp Pediatr. 2012;55(12):455-461. Published online December 20, 2012
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Following the Five Year Measles Elimination Program, measles has been declared eliminated from the Republic of Korea since 2006. However, there remain challenges related to the surveillance of measles in the postelimination phase. Even though the routine surveillance system has revealed a gradual decrease in the number of reported cases since 2002, 4 resurgences have occurred, notably due to outbreaks....
- Original Article
- Birth statistics of high birth weight infants (macrosomia) in Korea
- Byung-Ho Kang, Joo-Young Moon, Sung-Hoon Chung, Yong-Sung Choi, Kyung-Suk Lee, Ji-Young Chang, Chong-Woo Bae
- Clin Exp Pediatr. 2012;55(8):280-285. Published online August 23, 2012
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Purpose The authors analyzed the trend from the birth-related statistics of high birth weight infants (HBWIs) over 50 years in Korea from 1960 to 2010.
Methods We used 2 data sources, namely, the hospital units (1960's to 1990's) and Statistics Korea (1993 to 2010). The analyses include the incidence of HBWIs, birth weight distribution, sex ratio, and the relationship of HBWI to maternal...
- Epidemiology of Kawasaki disease in infants 3 months of age and younger
- Eun Jung Lee, Yong Won Park, Young Mi Hong, Joon Sung Lee, Ji Whan Han
- Clin Exp Pediatr. 2012;55(6):202-205. Published online June 21, 2012
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Purpose This study investigated the epidemiology of Kawasaki disease (KD) in infants ≤3-month-old.
Methods To study the epidemiology of KD in Korea, data for 27,851 KD patients were collected on a 3-year basis between 2000 and 2008 in a retrospective survey. From this, data for 609 KD patients ≤3-month-old were analyzed and compared with the data for KD patients >3-month-old.
Results The 609 KD patients...
- Review Article
- Epidemiology of astrovirus infection in children
- Hye Sook Jeong, Ahyong Jeong, Doo-Sung Cheon
- Clin Exp Pediatr. 2012;55(3):77-82. Published online March 16, 2012
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Human astrovirus (HAstV) is a major cause of acute diarrhea among children, resulting in outbreaks of diarrhea and occasionally hospitalization. Improved surveillance and application of sensitive molecular diagnostics have further defined the impact of HAstV infections in children. These studies have shown that HAstV infections are clinically milder (diarrhea, vomiting, fever) than infections with other enteric agents. Among the 8...
- Changes in the neonatal and infant mortality rate and the causes of death in Korea
- Sung-Hoon Chung, Yong-Sung Choi, Chong-Woo Bae
- Clin Exp Pediatr. 2011;54(11):443-455. Published online November 30, 2011
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Neonatal mortality rate (NMR) or infant mortality rate (IMR) are the rate of deaths per 1,000 live births at which babies of either less than four weeks or of one year of age die, respectively. The NMR and IMR are commonly accepted as a measure of the general health and wellbeing of a population. Korea's NMR and IMR fell significantly...
- Original Article
- Multiple births conceived by assisted reproductive technology in Korea
- Young Sil Park, Sun Hee Choi, Kye Shik Shim, Ji Young Chang, Won Ho Hahn, Yong Sung Choi, Chong-Woo Bae
- Clin Exp Pediatr. 2010;53(10):880-885. Published online October 31, 2010
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Purpose The recent trends of multiple births (MBs) conceived by assisted reproductive technology (ART) in Korea were analyzed as well as the relationship with maternal age, especially advanced maternal age.
Methods Data were obtained from the Korean Statistical Information Service and annual ART reports from the ART committee of the Korean Society of Obstetrics and Gynecology.
Results MBs increased from the early 1990s; there was...
- Review Article
- Obstructive sleep apnea syndrome in children: Epidemiology, pathophysiology, diagnosis and sequelae
- Sun Jung Chang, Kyu Young Chae
- Clin Exp Pediatr. 2010;53(10):863-871. Published online October 31, 2010
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The prevalence of pediatric obstructive sleep apnea syndrome (OSAS) is approximately 3% in children. Adenotonsillar hypertrophy is the most common cause of OSAS in children, and obesity, hypotonic neuromuscular diseases, and craniofacial anomalies are other major risk factors. Snoring is the most common presenting complaint in children with OSAS, but the clinical presentation varies according to age. Agitated sleep with...
- Recent progress in the understanding of clinical characteristics, epidemiology, and pathogenesis of new bronchopulmonary dysplasia
- Beyong Il Kim
- Clin Exp Pediatr. 2009;52(1):6-13. Published online January 15, 2009
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Recent advances in perinatal care have resulted in improved survival of extremely low birth weight infants (ELBWI). However, bronchopulmonary dysplasia (BPD) remains one of the major complications in ELBWI. BPD was originally described over 40 years ago; the clinical characteristics, epidemiology, and pathogenesis of BPD have changed markedly through this period. In this article, I have reviewed recent progress in... -
- Original Article
- Epidemiologic study of Kawasaki disease in 6 months old and younger infants
- Yong Won Park, Ji Whan Han, In Sook Park, Chang Hwi Kim, Sung Ho Cha, Jae Sook Ma, Joon Sung Lee, Tae Chan Kwon, Sang Bum Lee, Chul Ho Kim, Heung Jae Lee, Yong Soo Yun
- Clin Exp Pediatr. 2008;51(12):1320-1323. Published online December 15, 2008
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Purpose : The aim of this study was to investigate the epidemiologic status of Kawasaki disease (KD) in infants ≤6 months of age. Methods : For the epidemiologic study of KD in Korea, data from 22,674 KD patients were collected from 1997 to 2005 on a 3-year basis by a retrospective survey. From this survey, data of 1,739 KD patients ≤6... -
- Incidence of congenital heart disease in the western part of Gyeongnam Province in Korea
- Sun Hwa Jang, Jae Hui Kim, Jung Sook Yeom, Eun Sil Park, Ji Hyun Seo, Jae Young Lim, Chan Hoo Park, Hyang Ok Woo, Hee Shang Youn
- Clin Exp Pediatr. 2008;51(8):848-855. Published online August 15, 2008
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Purpose : The objective of this study was to ascertain the incidence of congenital heart disease in the western part of Gyeongnam Province in Korea. Methods : We enrolled 849 children (M:F=390:459) who were diagnosed with congenital heart disease (CHD) and received echocardiography during January 1997 to December 2005 in Gyeongsang National University Hospital. The subjects were limited to patients born... -
- Review Article
- The epidemiology and present status of chronic hepatitis B in Korean children
- Byung-Ho Choe
- Clin Exp Pediatr. 2008;51(7):696-703. Published online July 15, 2008
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Korea is now classified as an area of intermediate endemicity for hepatitis B virus (HBV), due to the implementation of universal HBV vaccination and national preventive programs for HBV infection. A national program of HBV vaccination was launched in Korea in 1988 for school-going children and was listed on a vaccination guideline in 1991. In 1995, universal vaccination for newborn... -
- Current status of hepatitis A virus infections in Korea
- Hee-Shang Youn
- Clin Exp Pediatr. 2008;51(7):690-695. Published online July 15, 2008
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The age-specific anti-hepatitis A virus (HAV) seroprevalence rates in South Korea have changed markedly since the last 2030 years with an improvement in the socio-economic, housing, and environmental-sanitation conditions. These changes are characterized by very low anti-HAV seropositive rates among individuals less than 30 years of age; however, nowadays, most adolescents and young adults at an increased risk of developing... -
- Original Article
- An epidemiological study on enuresis in children of two elementary schools in Suwon
- Hyun Jung Lee, Kang Gyoon Lee, Eun Jin Kim, Ki-Soo Pai, Sang Don Lee
- Clin Exp Pediatr. 2008;51(5):518-522. Published online May 15, 2008
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Purpose : The purpose of this study was to investigate the prevalence of enuresis in association with voiding habits and socioeconomic status in elementary school children. Methods : A dynamic survey was done of 1,514 students from two elementary schools in Suwon, Korea in December 2006. Data regarding gender, age, height and weight, voiding habits, and monthly family incomes were... -
- Review Article
- Epidemiology of Kawasaki disease in Korea
- Yong Won Park
- Clin Exp Pediatr. 2008;51(5):452-456. Published online May 15, 2008
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Kawasaki disease (KD) is an acute, self-limited vasculitis of unknown etiology that occurs predominantly in infants and young children. Initially described in 1967 by Dr. Tomisaku Kawasaki, it is now the most common cause of acquired heart disease among children in developed nations. Although KD has been reported across all racial and ethnic groups, the incidence of KD is more... -
- Original Article
- Clinical and Epidemiologic Study of Kawasaki Disease in Children 8 Years of Age and Older
- Yong Won Park, Ji Whan Han, In Sook Park, Chang Hwi Kim, Sung Ho Cha, Jae Sook Ma, Tae Chan Kwon, Sang Bum Lee, Chul Ho Kim, Heung Jae Lee, Yong Soo Yun
- Clin Exp Pediatr. 2005;48(10):1139-1142. Published online October 15, 2005
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Purpose : The aim of this study was to investigate the epidemiologic and clinical profiles of Kawasaki disease(KD) in children 8 years of age and older. Methods : For the epidemiologic study of KD in Korea, data of total 15,692 KD patients were collected from 1994 to 2002 on a 3 year basis, by the retrospective survey. Among them, data of... -
- Clinico-epidemiologic Study of Henoch-Sch nlein Purpura in Children, 1987 through 2003
- Sun-Mee Choi, Kyung-Yil Lee
- Clin Exp Pediatr. 2005;48(2):174-177. Published online February 15, 2005
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Purpose : We evaluated children with Henoch-Sch nlein purpura(HSP) in terms of epidemiology and clinical characteristics. Methods : A total of 424 medical records of children with HSP admitted to The Catholic University of Korea, Daejeon St. Mary's Hospital, from 1987 to 2003 were retrospectively analyzed. Results : The mean annual number of cases was 25.1?.9 and no one year showed an... -
- Clinico-epidemiologic Study of Mycoplasma pneumoniae Pneumonia(1993 through 2003)
- Seung-Hyun Lee, Suk-Man Noh, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Mi-Hee Lee, Joon-Sung Lee, Byung-Chul Lee
- Clin Exp Pediatr. 2005;48(2):154-157. Published online February 15, 2005
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Purpose : We evaluated the epidemiologic and clinical characteristics of mycoplasma pneumonia. Methods : A total of 559 medical records of children with mycoplasma pneumonia admitted to The Catholic University of Korea, Daejeon St. Mary's Hospital, were retrospectively analyzed. Results : The mean annual number of cases was 51. There was a higher occurrence in autumn (September-November, 41.7%) and in winter(26.7%). Outbreaks... -
- Prevalence of Antibodies against Adenoviruses in Korean Children and Adults
- Hyun Oh Jang, Jin A Lee, Nam Hee Kim, Eun Hee Chung, Hoan Jong Lee
- Clin Exp Pediatr. 2004;47(12):1300-1305. Published online December 15, 2004
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Purpose : Adenoviruses(Ads) are responsible for approximately 10 percent of lower respiratory tract infections(LRTIs) in children. The purpose of this study is to evaluate the prevalence of antibodies (Abs) against common serotypes of Ads in Korean children and adults. Methods : The sera were tested for neutralizing Abs against Ad serotypes 1 through 7 and 21 with a colorimetric microneutralization assay... -
- Epidemiologic Study of Aseptic Meningitis in Daejeon, Korea(1987 through 2003)
- Jung-Hoon You, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Mi-Hee Lee, Byung-Chul Lee
- Clin Exp Pediatr. 2004;47(11):1181-1185. Published online November 15, 2004
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Purpose : To evaluate the epidemiologic characteristics of aseptic meningitis in Daejeon, Korea from 1987 to 2003. Methods : A total of 2201 medical records of children with aseptic meningitis admitted to the Catholic University of Korea, Daejeon St. Mary's Hospital, was retrospectively analyzed. Results : The mean annual number of cases was 129, with a higher rate of occurrence in the... -
- An Epidemiological Study on Refractory Enterobiasis
- Hyea Sook Ryue, Jo-Won Jung, Ki-Soo Pai
- Clin Exp Pediatr. 2004;47(2):177-182. Published online February 15, 2004
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Purpose : In order to render substantial solutions to control the refractory enterobiasis, factors were evaluated which were associated with treatment failure in Enterobius vermicularis infestation. Methods : An epidemiological study was done in 20 patients with refractory entrobiasis and in 107 preschoolers as a control. The possible symptoms and hygienic habits which may associated with entrobiasis were surveyed by questionnaires. Results... -
- A Five-year Epidemiologic Study of Childhood Leukemia in Busan City, 1996 to 2000
- Jae Hoon Moon, Soon Yong Lee, Jong Beom Sinn, Jae Sun Park, Young Ho Lee, Young Tak Lim, Su Eun Park
- Clin Exp Pediatr. 2003;46(10):972-976. Published online October 15, 2003
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Purpose : For the control of childhood leukemia, of which the mortality is still high, the basic data for the incidence has a great importance. The authors analyzed the data from 133 new patients with childhood leukemia between 1996-2000 in Busan, Korea. Methods : The data were obtained from 133 new cases(87 males and 46 females from 0 to 15 years... -
- Epidemiological Study of Kawasaki Disease in Kyung Nam Area
- Jeong Soo Yang, Eun Young Cho, Hae Sung Jung, Ji Young Hwang, Dong-Jin Lee, Eun Suk No, Myoung-Bum Choi, Chan-Hoo Park, Hee-Shang Youn, Hyang-Ok Woo
- Clin Exp Pediatr. 2002;45(7):896-901. Published online July 15, 2002
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Purpose : The aim of this study was to determine the epidemiology of Kawasaki disease in the Kyung Nam area and to evaluate whether the results of this epidemiological study could support infectious etiology. Methods : We sent a questionnaire to three training hospitals in the Kyung Nam area and retrospectively reviewed their medical records of Kawasaki disease from Jun.... -
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Impact Factor4.2
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6.52022CiteScore92nd percentilePowered by
