Clinical and Experimental Pediatrics

Review Article

Gastroenterology

Balancing therapeutic benefits and hidden risks of proton pump inhibitors in pediatric practice: a narrative review and update

Maria Rogalidou, Alexandra Papadopoulou

Clin Exp Pediatr. 2026;69(3):186-196. Published online February 25, 2026

Proton pump inhibitors (PPIs) effectively treat acid-related disorders, including gastroesophageal reflux disease, eosinophilic esophagitis, peptic ulcers, and Zollinger-Ellison syndrome. Long-term use, particularly in children, may lead to microbiome alterations, nutrient deficiencies, infections, renal injury, osteoporosis, fractures, and other gastrointestinal changes. PPI therapy should be guided by clear clinical indications, prescribed at the lowest effective dose for the shortest necessary duration, and regularly reassessed to minimize risks in young children.

DOI: https://doi.org/10.3345/cep.2025.02761

Original Article

Percutaneous endoscopic gastrostomy in children

Jye Hae Park, SeonKyeong Rhie, Su Jin Jeong

Clin Exp Pediatr. 2011;54(1):17-21. Published online January 31, 2011

Crossref 10

Purpose

Percutaneous endoscopic gastrostomy (PEG) can improve nutritional status and reduce the amount of time needed to feed neurologically impaired children. We evaluated the characteristics, complications, and outcomes of neurologically impaired children treated with PEG.

Methods

We retrospectively reviewed the records of 32 neurologically impaired children who underwent PEG between March 2002 and August 2008 at our medical center. Forty-two PEG procedures comprising...

DOI: https://doi.org/10.3345/kjp.2011.54.1.17

The Etiologic Diseases and Diagnostic Usefulness of Color Doppler Ultrasonography in Children with Chronic Coughs

Sun Young Park, Joon Sung Lee

Clin Exp Pediatr. 2002;45(4):489-497. Published online April 15, 2002

Purpose : The objectives of this study were to investigate the causes of chronic cough and to establish the appropriate diagnostic approach to chronic cough in children. Methods : One hundred and thirty two cases of chronic cough were prospectively evaluated. They visitors to pediatric chronic cough clinics at Kang-nam saint Mary's Hospital of Catholic University from August 2000 to...

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Gastroesophageal Reflux Disease in Children with Chronic Cough

Pan Joo Lim, Jae Ock Park, Dong Hwan Lee, Sang Mann Shin, Dong Won Kim

Clin Exp Pediatr. 1998;41(9):1234-1242. Published online September 15, 1998

Purpose : We investigated the incidence of gastroesophageal reflux disease(GERD) by 24-hour esophageal pH monitoring in patients who had chronic cough for more than 3 weeks. Methods : From January 1995 to August 1996, 33 patients with chronic cough which had lasted for more than 3 weeks were enrolled in the 24-hour esophageal pH monitoring. The result was interpreted with the...

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