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Review Article
The genes associated with gonadotropin-releasing hormone-dependent precocious puberty
Jin Soon Hwang
Clin Exp Pediatr. 2012;55(1):6-10.   Published online January 31, 2012

Human puberty is a complex, coordinated biological process with multiple levels of regulations. The timing of puberty varies greatly in children and is influenced by both environmental and genetic factors. The key genes of pubertal onset, KISS1, GPR54, GNRH1 and GNRHR, may be major causal factors underlying gonadotropin-releasing hormone-dependent precocious puberty (GDPP). Two gain-of-function mutations in KISS1 and GPR54 have...

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