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- Original Article
- Neonatology (Perinatology)
- Effectiveness of various nonpharmacological analgesic methods in newborns
- Pancham Kumar, Rakesh Sharma, Sukhdev Rathour, Sunidhi Karol, Mohit Karol
- Clin Exp Pediatr. 2020;63(1):25-29. Published online August 16, 2019
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Question: Can nonpharmacological methods be used for neonatal pain management.
Finding: Nonpharmacological methods like Sucrose, breastfeeding etc have shown to significantly reduce the pain caused by intramuscular hepatitis B vaccination.
Meaning: Nonpharmacological methods are the safe and cheap potential modalities of analgesia which can be used during mild to moderate pain in newborns.
- Gastroenterology
- Association between Body Mass Index and Hepatitis B antibody seropositivity in children
- Yoowon Kwon, Su Jin Jeong
- Clin Exp Pediatr. 2019;62(11):416-421. Published online August 12, 2019
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Background: The seropositivity rate of hepatitis B surface antigen (anti-HBs) antibodies is known to be ≥95% after hepatitis B virus vaccination during infancy. However, a low level or absence of anti-HBs in healthy children is discovered in many cases. Recent studies in adults reported that a reduced anti-HBs production rate is related to obesity.
Purpose: To investigate whether body mass index...
- Comparison of the seroconversion rate after primary hepatitis B vaccination and after revaccination of non-responders in full-term infants according to mother's HBsAg seropositivity
- Jang Hee Kang, Jae Won Moon, Seung Hyun Kong, Kwang Su Hwang, Ji Sun Mok, Hyeon Jung Lee
- Clin Exp Pediatr. 2008;51(11):1165-1171. Published online November 15, 2008
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Purpose : This study aimed to identify the true extent of non-responsiveness in full-term infants born from HBsAg-negative or HBsAg-positive mothers and vaccinated against hepatitis B virus (HBV) at 0, 1, and 6 months of age and to evaluate the effect of revaccination among non-responders. Methods : The study included 716 full-term infants born in 2004-2007. Of 716, 662 infants... -
- Review Article
- The epidemiology and present status of chronic hepatitis B in Korean children
- Byung-Ho Choe
- Clin Exp Pediatr. 2008;51(7):696-703. Published online July 15, 2008
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Korea is now classified as an area of intermediate endemicity for hepatitis B virus (HBV), due to the implementation of universal HBV vaccination and national preventive programs for HBV infection. A national program of HBV vaccination was launched in Korea in 1988 for school-going children and was listed on a vaccination guideline in 1991. In 1995, universal vaccination for newborn... -
- The management and treatment of chronic hepatitis B in Korean children
- Byung-Ho Choe
- Clin Exp Pediatr. 2007;50(9):823-834. Published online September 15, 2007
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Interferon (IFN) alpha has been the first line therapy of chronic hepatitis B in children, but HBeAg seroconversion occurred in 26% of treated children compared to 11% of controls in multinational randomized controlled study. Recently, lamivudine was shown to be a potent inhibitor of Hepatitis B virus (HBV) reproduction both in HBeAg positive and in HBeAg negative (the pre-core mutant... -
- Original Article
- The outcome of perinatal prophylaxis for HBeAg positive mothers according to the maternal HBV-DNA levels at the delivery time
- On Jeong, Jong-Hyun Kim
- Clin Exp Pediatr. 2007;50(4):347-354. Published online April 15, 2007
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Purpose : Perinatal hepatitis B viral infection is decreasing; however, 10% of babies to HBeAg positive mothers still become chronic carriers despite perinatal prophylaxis. Although, the cause of prophylaxis failure is still unclear, an importance of maternal HBV-DNA level at the delivery time has been suggested. This study was established to certify if it would be a useful predictable factor... -
- A study of the current(2003-2005) prevalence of anti-HBs and immunologic memory of hepatitis B vaccine in children from the central area of Korea
- Young Won An, Eun Hee Chung, Insoo Rheem
- Clin Exp Pediatr. 2006;49(6):630-634. Published online June 15, 2006
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Purpose : This study was conducted to assess the current(2003-2005) prevalence of anti-HBs and immunologic memory for Hepatitis B vaccine in children from the central area of Korea. Methods : Subjects were chosen from children and adolescents who received tests for hepatitis B surface antigen(HBsAg) and anti-HBs at Dankook University Hospital from March 2003 to May 2005. Among these, antibodies to... -
- Comparison of Therapeutic Efficacy between Lamivudine and Alpha-Interferon in Korean Children with Chronic Hepatitis B at Two Years after the Initiation of Treatment
- Byung-Ho Choe, You Cheol Jang, Chang Hwan Jang, Ki Won Oh, Jun Hwa Lee, Cheol Woo Ko
- Clin Exp Pediatr. 2005;48(1):55-62. Published online January 15, 2005
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Purpose : We compared the therapeutic efficacy of lamivudine and alpha-interferon in children with chronic hepatitis B two years after the initiation of treatment, so that we could verify the safety and long term efficacy of lamivudine in children. Methods : We prospectively studied 44 children(32 male and 12 female; age, 1-18 years, mean, 9 years) treated for chronic hepatitis B... -
- Medical Lecture Course
- Impact of Host Genetics on Susceptibility and Outcome of Viral Infections
- Eun Hwa Choi
- Clin Exp Pediatr. 2004;47(8):815-820. Published online August 15, 2004
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The generation of a draft sequence of the human genome has lead to an opportunity to characterize human diversity, including the differences in host response to numerous pathogens. Host responses upon exposure to a pathogen can determine the wide spectrum of illness from subclinical or mild to severe diseases. Host factors, particularly genetic backgrounds, influence the pathogenesis of infectious diseases.... -
- Original Article
- Natural History of Chronic Hepatitis B in Children
- Yuria Kim, Seoung Yeon Baek, Ji Hyun Eom, Ki Sup Chung
- Clin Exp Pediatr. 2004;47(3):282-289. Published online March 15, 2004
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Purpose : We investigated the spontaneous seroconversion rate of hepatitis B viral markers and predictive factors affecting seroconversion in children with chronic hepatitis B. Methods : The study population included 214 children diagnosed as chronic hepatitis B, with positive HBsAg, HBeAg and HBVDNA over six months, and all patients had a family history of chronic Hepatitis B. They were followed between... -
- Medical Lecture Course
- Perinatal Hepatitis B Virus Infection - Viral Factors in the Mechanism of Perinatal Immunoprophylaxis Failure -
- Jong-Hyun Kim
- Clin Exp Pediatr. 2004;47(2):123-130. Published online February 15, 2004
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Perinatal hepatitis B virus(HBV) infection may occur despite combined immunoprophylaxis with hepatitis B immunoglobulin and vaccines. Although the mechanism of perinatal prophylaxis still has been obscure, it could be due to : in utero infection; host factors as the personal immunological differences of HLA or cytokine gene; viral factors as a high maternal HBV-DNA level or the presence of surface... -
- Original Article
- Study on Hepatitis B Virus Pre-S/S Gene Mutations in Children with Chronic Hepatitis B Infection
- Byeong Hee Son, Yeong Hong Park, Woo Yeong Chung
- Clin Exp Pediatr. 2001;44(7):741-751. Published online July 15, 2001
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Purpose : Hepatitis B virus(HBV) with various mutations has been reported. The aims of this study were to investigate the frequency and manifestation of HBV pre-S/S mutations in children with chronic hepatitis B infection. Methods : Sera from 17 children with chronic hepatitis B infection were analyzed by direct sequencing of polymerase chain reaction amplification of HBV DNA. Results : Seventeen... -
- Hepatitis B Virus Pre-S Gene Mutations in Children with Chronic Hepatitis B Infection
- Jae Young Kim, Woo Yeong Chung, Chul Ho Kim
- Clin Exp Pediatr. 2000;43(9):1232-1240. Published online September 15, 2000
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Purpose : The envelope of HBV consists of three polypeptides which are encoded in pre-S/S open reading frame. Three translation initiation sites are present within this pre-S/S open reading frame, i.e. pre-S1, pre-S2, and S, allowing the expression of large, middle and small HBs proteins. The pre-S1 is thought to carry the receptor binding site for viral entry into hepatocyte... -
- Mutations in Hepatitis B Virus Precore and Core Promotor in Children with Chronic Hepatitis B Infection - Comparison Between Vertical and Non-vertical Transmission -
- Jin Kuk Kim, Yeong Hong Park, Woo Yeong Chung, Chul Ho Kim
- Clin Exp Pediatr. 2000;43(6):779-791. Published online June 15, 2000
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Purpose : The aims of this study were to investigate the frequencies and role of hepatitis B virus(HBV) precore and core promotor mutations in children with chronic hepatitis B infection. Methods : Sera from 46 children with chronic hepatitis B infection were analyzed by direct sequencing of polymerase chain reaction product of HBV DNA. In this study, the patients were divided... -
- Factors Predictive of Response to Interferon-α Therapy in Children with Chronic Hepatitis B
- Hong Kwon Kim, Bo Hwa Choi, Kyung Mo Kim, Kyung Hoon Kang, In Seok Lim, Eung Sang Choi
- Clin Exp Pediatr. 2000;43(4):514-519. Published online April 15, 2000
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Purpose : The efficacy and safety of interferon-alpha(IFN-α) therapy in children with chronic hepatitis B(CHB) is similar to that of adults. However, little information is available about the predictive factors of response to this therapy in children. The aim of this study was to determine the predictive factors for responsiveness to IFN-α therapy in children with CHB. Methods : The basal... -
- Hepatitis B Virus Precore and Core Promotor Mutations in Children with Chronic Hepatitis B Infection
- Woo Yeong Chung, Jin Kuk Kim, Yeong Hoon Kim, Yeong Hong Park, Chul Ho Kim
- Clin Exp Pediatr. 1999;42(10):1392-1402. Published online October 15, 1999
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Purpose : The aims of this study were to investigate the frequencies and role of hepatitis B virus(HBV) precore and core promotor mutations in children with chronic hepatitis B infection. Methods : Sera from 31 children with chronic HBV infection were analyzed by direct sequencing of polymerase chain reaction amplification of HBV DNA. Results : Twenty-nine adr type were analyzed. The mutations... -
- Effects of Hepatitis B Revaccination in Nonresponsive Children
- Ui Chong Chong, Mi Ran Kim, Chong Young Park
- Clin Exp Pediatr. 1999;42(6):778-782. Published online June 15, 1999
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Purpose : Hepatitis B virus infection is prevalent in Korea. Active immunization of Hepatitis B has been proceeded extensively for the last decade. This study was performed to estimate the negative rate of anti-HBs after immunization and to evaluate the effect of revaccination among Korean children between 1995 and 1997, as well as to determine a proper revaccination schedule. Methods :... -
- Immune Responses and Efficacy of Hepatitis B Vaccine in Neonates Born from Hepatitis B Carrier Mothers : Focus on HBV-DNA
- Jong-Hyun Kim, Jin-Han Kang, Chang-Kyu Oh
- Clin Exp Pediatr. 1998;41(11):1498-1508. Published online November 15, 1998
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Purpose : The aim of this study was to elucidate the pathogenesis of vertical transmission of hepatitis B virus(HBV), and to study the protective efficacy of the vaccine and hepatitis B immune globulin(HBIG). Methods : Eighty-two infants born from HBV carrier mothers were studied. HBV plasma-derived vaccine and HBIG were administered to their neonates. Then, changes of viral markers, anti-preS2... -
- Effect of Simultaneous Administration of Hepatitis B Vaccine with DPT and Oral Polio Vaccine
- Hyo Geun Ju, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang
- Clin Exp Pediatr. 1998;41(4):451-455. Published online April 15, 1998
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Purpose : The universal vaccination against hepatitis B during early infancy is the only effective way to control hepatitis B infection in highly endemic areas in Korea. The purpose of this study was to assess the effectiveness of simultaneous hepatitis B vaccination with DPT and oral polio at 2, 4, 6 months of age in babies of HBs antigen negative mothers. Methods : One... -
- The Change of Anti-HBs Titer after Injection of HBIG and HBV in Newborn Delivered from HBsAg Carrier Mothers
- Qoae Suk Roh, Jin Young Jung
- Clin Exp Pediatr. 1997;40(8):1141-1148. Published online August 15, 1997
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Purpose : We studied prevention effects of vertical transmission of Hepatitis B with follow-up, through the change of Anti-HBs titers during 9 months after injection of Hepatitis B immunoglobulin(HBIG) and Hepatitis B vaccine(HBV) at birth in newborn delivered from Hepatitis antigen carrier mothers. Methods : This study was performed on newborn delivered from HBsAg carrier mothers at Hae Sung Hospital from Feb. 1995 to May... -
- The Therapeutic Effect of Interferon-alpha Treatment in Children with Chronic Hepatitis B
- Il Sang Jeong, Ki Sup Chung
- Clin Exp Pediatr. 1997;40(7):955-964. Published online July 15, 1997
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Purpose : The prevalance rate of chronic hepatitis B viral infection in children is high in our contry. We performed a prospective study to evaluate the effectiveness of and the factors predictive of response to interferon-alpha therapy in children with chronic hepatitis B. Methods : Thirty-two children with chronic hepatitis B werew admitted to the Department of Pediatrics, Yonsei University College of Medicine from... -
- Recent Changesin Prevalence of Hepatitis B Viral Markers in Preschool Children in Seoul,1995
- Yon Ho Choe, Jeong Kee Seo, Jeong Hwan Yun, Hyo Seok Lee
- Clin Exp Pediatr. 1996;39(9):1254-1259. Published online September 15, 1996
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Purpose : A nationwide hepatitis B vaccination publicity campaign and program was launched in 1988 in Korea. This survey was designed to evaluate the recent changes of the positive rates of hepatitis B surface antigen and antibody in sampled preschool children living in Seoul, 1995. Methods : Study population consisted of 218 preschool children aged 2 to 5 years. Most of them had been... -
- Clinical and Histologic Changes in Children with Chronic Hepatitis B Virus Infection after Alpha Interferon Therapy
- Kyung Mo Kim, Soo Jong Hong, Young Seo Park, Hyung Nam Moon, Chang Yee Hong, Joo Ryoung Huh
- Clin Exp Pediatr. 1995;38(9):1232-1241. Published online September 15, 1995
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Purpose : Several trials in children for chronic hepatitis B have shown the efficacy of alpha interferon in eliminating hepatitis B virus replication, accompanied by an improvement in the liver cell damage. But reports about the alpha interferon therapy are rare in Korean children and there is no report about histologic changes even with adult. So we tried to... -
- A Clinical Study on Chronic Hepatitis b in the Children
- Bon Su Koo, Han Sang Joo, Yung Tak Lim, Hee Ju Park
- Clin Exp Pediatr. 1994;37(6):767-775. Published online June 15, 1994
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The author observed clinical study and response of -interferon treatment of 43 cases of chronic hepatitis who were admitted to Department of Pediatrics Pusan National University College of Medicine during the period of 4 year 6 months from Jenuary, 1988 to Jun, 1992. The results were as follows: 1) Of 43 patients with chronic hepatitis CPH was 17 cases (39.5%) and CAH... -
- Transmission of Hepatitis B Virus from Asymptomatic Carrier Mothers to Their Offspring Using the Polymerase Chain Reaction Technique
- Jin Sook Kim, Young Ran Yoon, Mi Kyung Kim, Hye Kyung Han, Mi Ryung Um, Kyung Hoon Choi, Mi Na Lee, In Keol Moon, In Kweon Han
- Clin Exp Pediatr. 1994;37(2):231-239. Published online February 15, 1994
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Total 8,341 pregnant women who visited Obstetric clinic Cheil General Hospital from January 1991 to July 1992 were screened for HBsAg. Sixty five women with positive HbsAg who delivered healthy babies during that period and their infants are included in the study. HBsAg, Anti-HBs, Anti-HBc, HBeAg and Anti-HBe were tested by radioimmunoassay and hepatitis B virus DNA were studied by polymerase... -
- The Effect of Prolonged Treatment in Children with Chronic Hepatitis B with Combination of Alpha-Interferon and Acyclovir
- Jeong Ok Hah, Kyoung A Lee
- Clin Exp Pediatr. 1993;36(12):1701-1706. Published online December 15, 1993
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This study was conducted to evaluate the effect of prolonged treatment in children with chronic hepatitis B will combination of alpha-interferon and acyclovir. The study population consisited of & patients with chronic hepatitis B who showed histological findings compatible with chronic active hepatitis (4 cases) or chronic persistent hepatitis (3 cases) on liver biopsy and had elevated AST and ALT with... -
- The Change of Anti-HBs Titer after Hepatitis B Vaccination in Newborn According to Dosage and Time
- Joon Young Lee, Yong Sik MIn, Chang hwi Kim, Sang Jhoo Lee
- Clin Exp Pediatr. 1993;36(5):656-663. Published online May 15, 1993
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We studied anti-HBs titer, positive and effective rate in relation to dosages(5, 10) and time interval after third vaccination in 23 infants born to HBsAg negative mother. The babies were divided into two groups. In one group(n=12), 5 of Hepavax was administered intramusculary at 1 month, 2 months and 6 months age, in other group (n=11), 10 of Hepavax at... -
- A case of primary hepatocellular carcinoma following vertical transmission of hepatitis B virus in a child.
- Soo Kyoung Lee, Ki Sup Chung, Sun Won Hong, Chan Il Park
- Clin Exp Pediatr. 1991;34(11):1573-1580. Published online November 30, 1991
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Authors experienced a case of primary hepatocellular carcinoma in a 7 year 9 month old male patient, who was admitted to our hospital due to abdominal pain on right upper quadrant and anorexia during last two months. On family history, his mother was HBs Ag and HBe Ag carrier. On past history, he was admitted to a hospital due to persistant jaundice at... -
- A comparison between remission and nonremission groups of hepatitis B virus-associated membranous nephropathy in children.
- Kang Yong Park, Hye Won Park, Yon Ho Choe, Tae Sun Ha, Il Soo Ha, Yong Choi, Kwang Wook Ko, Hyun Soon Lee, Yong Il Kim
- Clin Exp Pediatr. 1991;34(11):1512-1518. Published online November 30, 1991
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We analyzed medical records of 35 patients with Hepatitis B virus-associated Membranous Nephropathy proven by kidney biopsy at SNUCH from Jan. 1975 to Jun. 1990. Clinical presentation, laboratory and pathologic findings were compared between remission group (who are free of proteinuria and edema in current status) and nonremission group (who have either proteinuria or edema). Age at onset was younger in remission group (4.51 ±2.93... -
- Prevalence of hepatitis B surface antigen in pediatric in patients.
- Kyung Hee Kim, Myung Ik Lee, Young Jin Hong, Keun Chan Sohn
- Clin Exp Pediatr. 1991;34(3):355-362. Published online March 31, 1991
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Thirty three from 689 children (4.79%) who were screened among hospitalized patients from July, 1986 to June, 1988, were positive for hepatitis B surface antigen in their serum sample tested by radioimmunoassay. The positive rate of hepatitis B surface antigen was 3.04% when the hepatitis patients were excluded. The incidence of hepatitis B surface antigen was higher (5.18%) in male than in famale (4.17%)... -
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Impact Factor4.2
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6.52022CiteScore92nd percentilePowered by
