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Original Article
The corrected QT (QTc) prolongation in hyperthyroidism and the association of thyroid hormone with the QTc interval
Ye Seung Lee, Joong Wan Choi, Eun Ju Bae, Won Il Park, Hong Jin Lee, Phil Soo Oh
Clin Exp Pediatr. 2015;58(7):263-266.   Published online July 22, 2015

Ventricular repolarization is assessed using the QT interval corrected by the heart rate (QTc) via an electrocardiogram (ECG). Prolonged QTc is associated with an increased risk of arrhythmias and cardiac mortality. As there have been few reports regarding the effects of hyperthyroidism on ventricular repolarization, we studied the association between serum free thyroxine (free T4 [fT4]) and thyroid stimulating hormone...

Case Report
Two adolescent patients with coexistent Graves' disease and Moyamoya disease in Korea
Chong Kun Cheon, Su Yung Kim, Jae-Ho Yoo
Clin Exp Pediatr. 2014;57(6):287-291.   Published online June 30, 2014

Moyamoya disease is a cerebrovascular condition that results in the narrowing of the vessels of the circle of Willis and collateral vessel formation at the base of the brain. Although relationships between Graves' disease and cerebrovascular accidents in Moyamoya disease are obscure, the coexistence of the two diseases is noteworthy. Moyamoya disease has been rarely reported in adolescent patients with...

Hyperthyroidism Caused by a Mutation in the Thyrotropin Receptor Gene in Two Brothers
Jae Hyun Kim, Sung Soo Lee, Jung Sub Lim, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2005;48(3):337-341.   Published online March 15, 2005
Thyrotropin receptor(TSHR) mutations must be considered when congenital hyperthyroidism has persisted, but there has been no evidence for autoimmunity. TSHR mutations leading to constitutive activation of the thyroid gland were identified as the molecular cause of autosomal dominant nonautoimmune hyperthyroidism and sporadic congenital hyperthyroidism. We report two cases of hyperthyroidism caused by germline TSHR mutation who presented with exessive sweating...
Original Article
Changes of Bone Metabolism Markers and Bone Mineral Density with Improvement of Thyroid Function in Children and Adolescents with Hyperthyroidism
Min Ho Jung, Choong Ho Shin, Sei Won Yang, Byung Churl Lee
Clin Exp Pediatr. 2002;45(6):743-753.   Published online June 15, 2002
Purpose : Dynamics of bone mineral density(BMD) and bone metabolism in children and adolescents with hyperthyroidism have not been thoroughly investigated. The aim of this study was to study how the improvement of thyroid function with antithyroid treatment influenced bone metabolism and BMD in children and adolescents with hyperthyroidism. Methods : Serum levels of osteocalcin(OC), bone-specific alkaline phosphatase(b-ALP), and carboxyterminal telopeptide...
Case Report
A Case of Neonatal Hyperthyroidism with Unilateral Ear Anomaly
Kwang Ok Chung, Na Yeon Kim, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 1998;41(6):845-849.   Published online June 15, 1998
Neonatal hyperthyroidism is a very rare disorder occurring typically in the offspring of patients with Graves' disease or chronic thyroiditis. It is caused by the transplacental passage of thyroid stimulating antibodies(TSAb) from the mother to the fetus. There has been few reports of neonatal hyperthyroidism associated with congenital anomalies. We experienced a case of neonatal hyperthyroidism with unilateral microtia and agenesis of external auditory canal...
Original Article
Study on the Thyroid Function of Neonate Born to Mother with Hyperthyroidism
Choong Ho Shin, Se Young Kim, Sei Won Yang, Jung Hwan Choi, Chong Ku Park
Clin Exp Pediatr. 1996;39(1):106-114.   Published online January 15, 1996
Purpose : In newborns from mothers with Graves' disease, neonatal transient hyperthyroidism or hypothyroidism may develop early in life. We evaluated the incidence and prognosis of neonatal thyroid dysfunction in neonates born to mothers with hyperthyroidism during pregnancy. Methods : We measured blood T4, T3, TSH levels and TSH-R-Ab titer in 48 hyperthyroid mothers and their babies between 1988 and 1994. Results :...
Case Report
A Case of Hyperthyroidism Following Primary Hypotyroidism
Han Sung Cho, Hwang Jae Yoo, Sang Ook Park, Jae Hong Park, Su Young Kim
Clin Exp Pediatr. 1995;38(6):863-866.   Published online June 15, 1995
A 9-year-old girl presented with primary hypothroidism have been followed by the development of hyperthyroidism. The diagnosis of primary hypothyroidism had been made by clinical manifestation, elavated serum thyroid-stimulating hormone level, antithyroglobulin antibody and antimicrosome antibody. Five and a quarter years later, the diagnosis of hyperthyroidism had been made by clinical maifestation such as enlargemetn of thyroid gland, tahcycardia, increased...
A Case Report of McCune Albright Syndrome.
Kei Hag Son, Un Ki Yoon, Soon Ok Byun, Ji Sub Oh
Clin Exp Pediatr. 1986;29(12):1366-1371.   Published online December 31, 1986
A case of McCune Albright syndrome in a 8 year old girl was presented. Examination revealed polyostotic fibrous dysplasia, cutaneous pigmentation, sexual precocity and hyperthyroidism. Recently, she has suffered from craniofacial deformity and thyroid gland enlargement. The diagnosis was confirmed by characteristic clinical feature, radiologic evidence,biochemical assay and radioisotopic assay. A review of the literature was made briefly.
Original Article
A Clinical Study on Thyroid Disease in Childhood.
Shin Chul Jun, Chan Yung Kim
Clin Exp Pediatr. 1984;27(6):592-602.   Published online June 30, 1984
The author summarized 287 cases of children who were diagnosed as having thyroid disease at Pediatric O.P.D. of the B.N.U. Hospital from Jan. 1973 to Aug. 1983. The children were grouped according to their thyroid function tests and the observed clinical data are as follows: 1)The ratio between male and female patients was 1 : 9.3. Age distribution was puberty,...
Case Report
A Case of Hyperthyroidism.
Cheol Woon Beak, Seung Geun Hong, Sang Geel Lee, Im Joo Kang
Clin Exp Pediatr. 1983;26(10):1033-1038.   Published online October 31, 1983
We experienced a case of congenital hyperthyroidism in a male neonate with tachycardia- and tachypnea, who was the 2nd. full-term product of 28-year-old mother with hyperthyroidism. On physical examination, there was exophthalmos, goiter and hepatosplenom egaly. Bone age was accelerated to about one year of age and thyroid function test was abnormal data reflecting hyperthyroidism. The review of the related literature was made briefly. This is...
A Case of Neonatal Hyperthyroidism.
Gui Hee Jun, Yeon Sang Lee, Jung Ju Kim, Dong Hak Shin
Clin Exp Pediatr. 1983;26(9):939-944.   Published online September 30, 1983
The pathogenesis of neonatal hyperthyroidism has been known to be related with LATS,LATS-P, TSI and cell mediated immunity. The authors studied a case of neonatal hyperthyroidism born to a mother having a history of hyperthyroidism and diagnosed it through clinical symptoms of tremor, exophthalmos, tachycardia, excessive activity, nervousness and the thyroid function tests of T3, T4, RAI uptake and TSH. This case has...
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