Clinical and Experimental Pediatrics

Original Article

Neonatology (Perinatology)

Effects of carnosine and hypothermia combination therapy on hypoxic-ischemic brain injury in neonatal rats

Jun Chul Byun, Seong Ryong Lee, Chun Soo Kim

Clin Exp Pediatr. 2021;64(8):422-428. Published online February 24, 2021

Question: How can we further improve the neuroprotective effects of hypothermia in newborns with hypoxic-ischemic (HI) brain injury?
Finding: Combination carnosine and hypothermia therapy effectively reduced brain damage in neonatal rats. The in situ zymography, terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay, and immunofluorescence study results showed that neuroprotective effects were achieved with combination therapy only.
Meaning: Carnosine and hypothermia have synergistic neuroprotective effects against brain damage following HI injury

DOI: https://doi.org/10.3345/cep.2020.01837

Predictive factors of death in neonates with hypoxic-ischemic encephalopathy receiving selective head cooling

Behnaz Basiri, Mohammadkazem Sabzehei, Mohammadmahdi sabahi

Clin Exp Pediatr. 2021;64(4):180-187. Published online August 27, 2020

Web of Science 3 Crossref 3

Question: What is the most important factor that increases mortality in infants with hypoxic-ischemic encephalopathy (HIE) who receive selective head cooling?
Finding: All cases of neonatal mortality were severe HIE (stage 3), and a severely abnormal amplitude-integrated electroencephalography and mortality were increased with the need for advanced neonatal resuscitation upon delivery.
Meaning: Advanced neonatal resuscitation affects HIE outcomes, and medical personnel should be prepared to provide the best intervention.

DOI: https://doi.org/10.3345/cep.2019.01382

Clinical impact of admission hypothermia in very low birth weight infants: results from Korean Neonatal Network

Na Hyun Lee, Soo Kyung Nam, Juyoung Lee, Yong Hoon Jun

Clin Exp Pediatr. 2019;62(10):386-394. Published online May 22, 2019

Crossref 13

Background: Preterm infants have difficulty maintaining body temperature after birth. However, clinical guidelines advocate that neonatal body temperature should be maintained at 36.5°C–37.5°C.
Purpose: We aimed to investigate the incidence of admission hypothermia in very low birth weight (VLBW) infants and to determine the association of admission temperature with in-hospital mortality and morbidities. Methods: A cohort study using prospectively collected data involving...

DOI: https://doi.org/10.3345/kjp.2019.00206

The impact of a quality improvement effort in reducing admission hypothermia in preterm infants following delivery

Han Saem Choi, Soon Min Lee, Hoseon Eun, Minsoo Park, Kook-In Park, Ran Namgung

Clin Exp Pediatr. 2018;61(8):239-244. Published online August 15, 2018

Crossref 14

Purpose: Hypothermia at admission is associated with increased mortality and morbidity in preterm infants. We performed a quality improvement (QI) effort to determine the impact of a decrease in admission hypothermia in preterm infants. Methods: The study enrolled very low birth weight (VLBW) infants born at Gangnam Severance Hospital between January 2013 and December 2016. This multidisciplinary QI effort included the...

DOI: https://doi.org/10.3345/kjp.2018.61.8.239

Outcome of inflammatory response after normothermia during cardiopulmonary bypass surgery in infants with isolated ventricular septal defect

Dong Sub Kim, Sang In Lee, Sang Bum Lee, Myung Chul Hyun, Joon Yong Cho, Young Ok Lee

Clin Exp Pediatr. 2014;57(5):222-225. Published online May 31, 2014

Crossref 4

Purpose

A recent study analyzing several cytokines reported that long cardiopulmonary bypass (CPB) time and long aortic cross clamp (ACC) time were accompanied by enhanced postoperative inflammation, which contrasted with the modest influence of the degree of hypothermia. In this present study, we aimed to examine the effect of CPB temperature on the clinical outcome in infants undergoing repair of isolated...

DOI: https://doi.org/10.3345/kjp.2014.57.5.222

Susceptibility of rat hippocampal neurons to hypothermia during development

Kyung Ah Seo, Sehhyun Kim, Na Mi Lee, Soo Ahn Chae

Clin Exp Pediatr. 2013;56(10):446-450. Published online October 31, 2013

Crossref 2

Purpose

This study evaluated the extent of damage due to hypothermia in the mature and immature brain.

Methods

Hippocampal tissue cultures at 7 and 14 days in vitro (DIV) were used to represent the immature and mature brain, respectively. The cultures were exposed at 25℃ for 0, 10, 30, and 60 minutes (n=30 in each subgroup). Propidium iodide fluorescent images were captured 24...

DOI: https://doi.org/10.3345/kjp.2013.56.10.446

Cited By 22	Retinopathy of prematurity: a review of epidemiology and current treatment strategies
Cited By 19	Genetic factors in precocious puberty
Cited By 18	Global relationship between parent and child obesity: a systematic review and meta-analysis
Cited By 14	Gross motor dysfunction and balance impairments in children and adolescents with Down syndrome: a systematic review
Cited By 13	Etiological and pathophysiological enigmas of severe coronavirus disease 2019, multisystem inflammatory syndrome in children, and Kawasaki disease

Search