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Original Article
Association of Toll-like receptor 2-positive monocytes with coronary artery lesions and treatment nonresponse in Kawasaki disease
Soo Jung Kang, Nam Su Kim
Clin Exp Pediatr. 2017;60(7):208-215.   Published online July 31, 2017

Activation of Toll-like receptor 2 (TLR2) present on circulating monocytes in patients with Kawasaki disease (KD) can lead to the production of proinflammatory cytokines and interleukin-10 (IL-10). We aimed to determine the association of the frequency of circulating TLR2+/CD14+ monocytes (FTLR2%) with the outcomes of KD, as well as to compare FTLR2% to the usefulness of sIL-10.


The FTLR2% in patients...

Prediction of unresponsiveness to second intravenous immunoglobulin treatment in patients with Kawasaki disease refractory to initial treatment
Euri Seo, Jeong Jin Yu, Hyun Ok Jun, Eun Jung Shin, Jae Suk Baek, Young-Hwue Kim, Jae-Kon Ko
Clin Exp Pediatr. 2016;59(10):408-413.   Published online October 17, 2016

This study investigated predictors of unresponsiveness to second-line intravenous immunoglobulin (IVIG) treatment for Kawasaki disease (KD).


This was a single-center analysis of the medical records of 588 patients with KD who had been admitted to Asan Medical Center between 2006 and 2014. Related clinical and laboratory data were analyzed by univariate and multivariate logistic regression analyses.


Eighty (13.6%) of the 588 patients...

Prediction of nonresponsiveness to medium-dose intravenous immunoglobulin (1 g/kg) treatment: an effective and safe schedule of acute treatment for Kawasaki disease
Kyung Pil Moon, Beom Joon Kim, Kyu Jin Lee, Jin Hee Oh, Ji Whan Han, Kyung Yil Lee, Soon Ju Lee
Clin Exp Pediatr. 2016;59(4):178-182.   Published online April 30, 2016

Medium-dose (1 g/kg) intravenous immunoglobulin (IVIG) is effective in the majority of patients with Kawasaki disease (KD) but some patients who do not respond to medium-dose IVIG are at high risk for the development of coronary artery lesions (CALs). The purpose of this study was to identify the clinical predictors associated with unresponsiveness to medium-dose IVIG and the development of...

Meta-analysis of factors predicting resistance to intravenous immunoglobulin treatment in patients with Kawasaki disease
Jin-Young Baek, Min Seob Song
Clin Exp Pediatr. 2016;59(2):80-90.   Published online February 29, 2016

Studies have been conducted to identify predictive factors of resistance to intravenous immunoglobulin (IVIG) for Kawasaki disease (KD). However, the results are conflicting. This study aimed to identify laboratory factors predictive of resistance to high-dose IVIG for KD by performing meta-analysis of available studies using statistical techniques.


All relevant scientific publications from 2006 to 2014 were identified through PubMed searches. For...

Case Report
Pulmonary hemorrhage in pediatric lupus anticoagulant hypoprothrombinemia syndrome
Ji Soo Kim, Min Jae Kim, E Young Bae, Dae Chul Jeong
Clin Exp Pediatr. 2014;57(4):202-205.   Published online April 30, 2014

Lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS), a very rare disease that is caused by the presence of antifactor II antibodies, is usually counterbalanced by the prothrombotic effect of lupus anticoagulant (LAC). Patients with LAHPS are treated using fresh frozen plasma, steroids, immunosuppressive agents, and immunoglobulins for managing the disease and controlling hemorrhages. Notably, steroids are the important treatment for treating hypoprothrombinemia and...

Original Article
Statistical Analysis of 1,000 Cases of Kawasaki Disease Patients Diagnosed at a Single Institute
Dae Hwan Hwang, Kyoung Mi Sin, Kyong Min Choi, Jae Young Choi, Jun Hee Sul, Dong Soo Kim
Clin Exp Pediatr. 2005;48(4):416-424.   Published online April 15, 2005
Purpose : To find the risk factors associated with coronory artery lesions, non-responsiveness to intravenous immunoglobulin(IVIG) treatment, and recurrences in Kawasaki disease patients. Methods : We retrospectively analyzed 1,000 Kawasaki disease patients who were admitted to Yonsei University Medical Center from September 1990 to December 2003. We compared between responder and non-responder groups to IVIG treatment as well as between relapsed...
Case Report
A Case of Mycoplasma pneumoniae Pneumonia Complicated with Guillain-Barr Syndrome and Encephalitis
Soon Bum Lee, Hee Jung, Yong Seok Lee, Bum Sun Kwon, Jeesuk Yu
Clin Exp Pediatr. 2004;47(12):1338-1348.   Published online December 15, 2004
The most common pathogen of respiratory tract infection among school-age children and adolescents is Mycoplasma pneumoniae, which causes clinical manifestations of pneumonia, acute asthmatic attack, pharygitis, and tonsilitis. It can also cause extrapulmonary infections that involves skin, the nervous system, the digestive system, the cardiovascular system, and the hematopoietic system. It is reported that the central nervous system symptoms may...
Original Article
Aseptic Meningitis Secondary to High-Dose Intravenous Immunoglobulin Therapy in Kawasaki Disease
Ae Ra Cho, Jee Yoon Park, Kyung Hyo Kim, Young Mi Hong
Clin Exp Pediatr. 2004;47(5):561-566.   Published online May 15, 2004
Purpose : Kawasaki disease is a multisystemic inflammatory vasculitis and associated with neurologic features such as aseptic meningitis. High-dose intravenous immunoglobulin(IVIG) is used to treat Kawasaki disease and generally considered to be safe, but rare cases of aseptic meningitis with unknown etiology have been reported. The aseptic meningitis associated with Kawasaki disease was compared with meningitis as the adverse reaction...
A study on the immune reaction to the milk protein antigens in the postpartum mother, newborn baby, and children.
Soo chul Cho, Ju Hyung Kim, Hong Ro Lee, Jong San Lee, Pyoung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1991;34(11):1547-1558.   Published online November 30, 1991
There is continuing interest in the isotype response of human serum antibodies reactive with dietary proteins. This study was performed to clarify the humoral immune responses against cow’s milk proteins, 分-lactoglobulin and a-lactalbumin. Milk protein specific IgG, IgA, IgM, and IgG subclasses were measured using ELISA in the blood of various groups of age. The results were as follows: 1) Milk protein specific immunoglobulins were higher...
Changes of PPD-Specific Immunoglobulin in Pulmonary Tuberculosis After Treatment.
Ja Young Kim, Mun Hwan Lee, Pyoung Han Hwang, Chan Uhng Joo, Jung Soo Kim
Clin Exp Pediatr. 1990;33(12):1647-1655.   Published online December 31, 1990
The definite diagnosis and precise assessment of response to therapy is still a problem in childhood tuberculosis because these patients rarely produce sputum and if obtained it may be negative. For this reason, diagnosis rely largely on the clinical and X-ray examination, which have a low specificity and high proportion of false positive results. Recently immunologic diagnosis of tuberculosis using enzyme-linked immunosorbent assay (ELISA) was...
Changes of beta-lactoglobulin Specific Immunoglobulins According to the Age and the Onset of Cow's Milk Feeding.
Jong San Lee, Soo Young Cho, Pyoung Han Hwang, Soo Cheol Cho, Jung Soo Kim
Clin Exp Pediatr. 1990;33(12):1639-1646.   Published online December 31, 1990
It is not yet possible to explain in detail the pathogenesis of the diverse types of food allergy encountered clinically. This generalization applies to milk allergy in spite of the large number of studies reporting the immune responses to cow’s milk proteins, both in healthy subjects and in milk sensitive patients. This study was performed to define the changes of circulating immunoglobulins against milk protein...
Clinical Study of Acute Glomerulonephritis in Children.
Kyeong Rae Moon, Choon Ho Park, Sang Kie Kim, Jin Heon Kim, Chang Soo Ra
Clin Exp Pediatr. 1986;29(2):178-185.   Published online February 28, 1986
From January 1979 to June 1984, 96 cases of acute glomerulonephritis were clinically investigated at the Department of Pediatrics, Chosun University Hospital, and following results were obtained: 1) Male to female ratio was 1.7 : 1, and the age incidence was highest in children from 7 to 9 years (35.4%), with a seasonal peak in Autumn and Winter (66.8%). 2) The most common...
A Study on Serum Immuoglobulins and Complements in Newborn Infants.
Song Soo Moon, Chang Soo Ra
Clin Exp Pediatr. 1986;29(1):58-71.   Published online January 31, 1986
The author investigated serum immunoglobulins (IgG, IgA, and IgM) and complements (C3and C4) of cord blood in 29 cases of normal fullterm infants, 14 cases of low birth weight infants (8 cases of premature infants) and 43 cases of their mothers at delivery. Serum immunoglobulin and complement levels were measured by the single radial immuno diffusion method (NISSUI, Japan). The...
Quantitative Determination of Immunologlobulins in Breast Milk During the Period of Lactation.
Sung Ee Kim, Chang Soo Ra
Clin Exp Pediatr. 1982;25(12):1203-1209.   Published online December 31, 1982
It has been established by many investigations that immunoglobulins in breast milk, par- ticularly secretory IgA, are important in. protecting the infant, not only through the colostrum but through milk from birth to the early months of life. In order to determine the levels of immunoglobulins in breast milk and the alterations of levels of immunoglobulins during the period of lactation, the authors studied...
A prospective study on immunoglobulins and ESR in acute viral hepatitis patients.
Jong Wie Choi, Sung Seek Lee, Ki Sup Chung
Clin Exp Pediatr. 1982;25(9):914-921.   Published online September 30, 1982
This study was carried out in 78 subjects of both sexes who were affected by acute viral hepatitis and admitted to Severance Hospital attached to Yonsei Medical College from Oct. 1980 to June. 1981. Hepatitis B markers, serum immunoglobulins and ESR were respectively examined in all patients. The results were as follows. 1. In all patients, regardless of positivity of HB markers, IgG, IgA and IgM levels...
A Clinical and Pathological Study on the Treatment and Course of Purpura Nephritis in Chidren.
Jae Seung Lee, Sang Hak Park, Duk Hi Kim, Pyung Kil Kim, Duk Jin Yun, In Joon Choi
Clin Exp Pediatr. 1981;24(5):466-476.   Published online May 15, 1981
Purpura nephritis, one of the commonly known complications of allergic purpura has variable symptoms ranging from mild transient hematuria to severe nephrotic syndrome leading to renal failure and death. This paper reports on the treatment and course of purpura nephritis with special reference to serum immunoglobulins and immunopathology. These cases were selected among pediatric patients with purpura nephritis admitted to...
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