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Review Article
Neonatal seizures: diagnostic updates based on new definition and classification
Eun-Hee Kim, Jeongmin Shin, Byoung Kook Lee
Clin Exp Pediatr. 2022;65(8):387-397.   Published online April 4, 2022
· Neonatal seizures are often electrographic-only seizures without clinical signs; therefore, the identification of electrical seizure activity on electroencephalography is the gold standard for diagnosis.
· Clinical signs of neonatal seizures are divided into motor or nonmotor seizures, and motor seizures are mostly focal or multifocal.
· Most neonatal seizures are caused by acute symptomatic etiologies, but in cases of intractable seizures, structural, genetic, or metabolic etiologies should be investigated.
Original Article
Neonatology (Perinatology)
Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures
Jae Won Shin, Yun Seob Jung, Kyungsoo Park, Soon Min Lee, Ho Seon Eun, Min Soo Park, Kook In Park, Ran Namgung
Clin Exp Pediatr. 2017;60(2):50-54.   Published online February 27, 2017

The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software NONMEM.


A retrospective analysis of 18 neonatal patients with seizures, who were treated with LEV, including 151 serum samples, was performed. The mean loading dose was 20 mg/kg, followed by...

Clinical Characteristics and Prognosis of Neonatal Seizures
Chang Wu Kim, Chang Hwan Jang, Heng Mi Kim, Byung Ho Choe, Soon Hak Kwon
Clin Exp Pediatr. 2003;46(12):1253-1259.   Published online December 15, 2003
Backgroud : Seizures in the neonate are relatively common and their clinical features are different from those in children and adults. The study aimed to provide the clinical profiles of neonatal seizure in our hospital. Methods : A total of 41 newborns with seizures were enrolled in this study over a period of three years. They were evaluated with special reference...
Case Report
A Case of Incontinentia Pigmenti with Developmental Brain Malformation
Suk Ho Kang, Soon Kim, Seung Hee Jung, Sang Geel Lee
Clin Exp Pediatr. 2002;45(4):535-539.   Published online April 15, 2002
Incontinentia pigmenti is a rare neurocutaneous syndrome characterized by vesiculobullous skin disease in neonates and infants, a noninfectious disease that should be distinguished from infectious diseases with the neonatal seizure or encephalopathy. This disease is X-linked dominant with Xq28 region abnormalities and often associated with developmental defects of the ocular, skeletal, dental, and central nervous system. Central nervous system involvement...
Original Article
Factors Related to the Outcome of Neonatal Seizures
Sung Koo Kim, Ran Lee, In Kyu Lee, Ki Joong Kim, Young Seung Hwang
Clin Exp Pediatr. 2000;43(2):267-273.   Published online February 15, 2000
Purpose : Seizures during the neonatal period may be an important indicator of serious neurologic abnormalities and can cause permanent neurologic sequelae. We attempted to find and analyze the factors related to the outcome of neonatal seizures. Methods : Seventy-six newborns with seizure were reviewed. The outcomes were analyzed according to etiologic diseases, gestational ages, characteristics of seizure, and neuroimaging and...
The Usefulness of Clinical Scoring System as Prognostic Predictor in Neonatal Seizure
Hyunmi Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1996;39(6):829-838.   Published online June 15, 1996
Purpose : Neonatal seizure is usually the presentation of underlying neurologic dysfunction rather than a disease and have high mortality and morbidity as sequalae. Therefore, the parameter predicting the neurologic prognosis is necessary. This study was performed to identify the usefulness of clinical scoring as predictor in neonatal seizure by analyzing outcomes. Methods : From 1982 to 1994, 101 neonates were admitted to Neonatal Intensive...
A clinical study on neonatal seizures.
Bong Sik Kong, Ri Sa Lee, Sang Kyu Park, Ho Jin Park
Clin Exp Pediatr. 1991;34(2):230-239.   Published online February 28, 1991
Clinical observation were made on 57 cases of neonatal seizure who were admitted to the Depart- ment of pediatrics, Seoul Red Cross Hospital during the period of 7 years from Jan. 1983 to Dec. 1989. The results were as follows: 1) According to the type of delivery of neonates which showed neonatal seizure, normal vaginal delivery were 41 cases (71.9%), C-section delivary 11 cases (19.3%)...
Clinical Observation and Electroencephalographic Findings relatee to Prognostic factor in Neonatal Seizure.
Soo Chun Kim, Jung Sam Jeon, Chong Woo Bae, Sa Joon Chung, Chang Il Ahn
Clin Exp Pediatr. 1989;32(6):816-822.   Published online June 30, 1989
To study the clinical prognosis of the neonatal seizure, we carried out a retrospective review on medical records of 40 neonates who were admitted to the Dept. of Pediatrics, Kyung Hee University Hospital between January 1979 and December 1986. The results from the study are summarized as follows 1) Male to female ratio were 1.8:1. In 50.0%(20/40) of newborn infants, neonatal seizure was detected under...
A Clinical Study on Neonatal seizures.
Chong Young Park, Myung Kul Yun, Jung Hwan Choi, Yong Seung Hwang, Chong Ku Yun
Clin Exp Pediatr. 1985;28(3):225-235.   Published online March 31, 1985
Clinical Observations were made on 96 cases of neonatal seizure who were admitted to the Department of Pediatrics, Seoul National University Hospital during the period of 5 years from June, 1979 to May, 1984. The results were as follows: 1)The most frequent cause of neonatal seizure was sepsis with or without meningitis (27.4%), and followed by hypocalcemia(23.4%)> hypoxic-ischemic brain damage(12.9%), hypoglycemia(8.0%), intracranial...
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