|
|
Purpose : Nitric oxide(NO) is a highly reactive messenger molecule that is synthesized by nitric oxide synthase(NOS) in a number of tissues including the brain. Our aim was to examine the possible role of NO on pentylenetetrazole(PTZ)-induced seizure in rats as a proconvulsant or an anticonvulsant.
Methods : Male Sprague-Dawley rats weighing 200-300g were used. PTZ(40mg/kg) was used to induce seizure.... |