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Original Article
The Role of Nitric Oxide in Seizures Induced by Pentylenetetrazole
Jun Ho Kim, Doo Kwun Kim
Clin Exp Pediatr. 2000;43(10):1356-1363.   Published online October 15, 2000
Purpose : Nitric oxide(NO) is a highly reactive messenger molecule that is synthesized by nitric oxide synthase(NOS) in a number of tissues including the brain. Our aim was to examine the possible role of NO on pentylenetetrazole(PTZ)-induced seizure in rats as a proconvulsant or an anticonvulsant. Methods : Male Sprague-Dawley rats weighing 200-300g were used. PTZ(40mg/kg) was used to induce seizure....


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