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Original Article
Gastroenterology
Relationship between nonalcoholic fatty liver disease and hyperandrogenemia in adolescents with polycystic ovary syndrome
Ozlem Kara, Hanife Aysegul Arsoy, Murat Keskin
Clin Exp Pediatr. 2023;66(9):395-402.   Published online June 14, 2023
Question: Is polycystic ovary syndrome (PCOS) a risk factor for nonalcoholic fatty liver disease (NAFLD) in adolescents?
Finding: The frequency of NAFLD did not increase in adolescents with PCOS. However, hyperandrogenemia was a risk factor for NAFLD.
Meaning: Adolescents with PCOS and hyperandrogenemia should be closely monitored for hepatic steatosis.
Endocrinology
Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis
Azam Maleki, Saeid Bashirian, Ali Reza Soltanian, Ensiyeh Jenabi, Abdollah Farhadinasab
Clin Exp Pediatr. 2022;65(2):85-89.   Published online April 15, 2021
Question: Have polycystic ovary syndrome (PCOS) increased risk of having an offspring with attention-deficit/hyperactivity disorder (ADHD)?
Finding: Six articles (3 cohort and 3 case-control studies; 401,413 total ADHD cases) met the study criteria. Maternal PCOS was associated with an increased risk of ADHD in the offspring based on odds ratio (OR) and relative ratio (RR) (OR, 1.42; 95% confidence interval [CI], 1.27–1.57) and (RR, 1.43; 95% CI, 1.35–1.51), respectively.
Meaning: Our study showed that maternal PCOS is a risk factor for ADHD.
Case Report
Oncology
Unusual malignant neoplasms of ovary in children: two cases report
Ali Ghribi, Aicha Bouden, Manef Gasmi, Mourad Hamzaoui
Clin Exp Pediatr. 2016;59(Suppl 1):S107-S111.   Published online November 30, 2016

Sex cord tumors with annular tubules are known to originate from the sex cord of embryonic gonads that synthesize Sertoli cells, Leydig cells, granulosa cells, and theca cells of the ovarian stroma, while ovarian small cell carcinoma of the hypercalcemic type is a type of neuroendocrine tumor. Both these tumors are uncommon, potentially malignant neoplasms in children. We report the...

A sclerosing stromal tumor of the ovary with masculinization in a premenarchal girl
Soo Min Park, Young Nam Kim, Young Jong Woo, Ho Sun Choi, Ji Shin Lee, Suk Hee Heo, Chan Jong Kim
Clin Exp Pediatr. 2011;54(5):224-227.   Published online May 31, 2011

A sclerosing stromal tumor of the ovary is an extremely rare benign tumor; it usually is found during the second and third decades of life. Patients present with pelvic pain or a palpable abdominal mass. Hormonal effects such as masculinization are uncommon. Here, an 11-year old premenarchal girl presented with deepening of the voice. In addition, clitoromegaly and hirsutism with...

Original Article
Effect of genistein on the sexual maturation in immature female rats
Woocheol Lee, Sung-Ho Lee, Ryun-Sup Ahn, Mi Jung Park
Clin Exp Pediatr. 2009;52(1):111-118.   Published online January 15, 2009
Puopose : Exposure to dietary phytoestrogens such as genistein during early childhood is a growing public health concern. We examined the effect of early exposure to genistein on sexual maturation in immature rats. Methods : Weaning (3wk-old) Sprague-Dawley female rats were assigned to three groups (n=6 for each): fed by high dose of genistein (100 mg/kg/d), low dose of genistein...
Case Report
A Case of Juvenile Granulosa Cell Tumor of the Ovary
Jong Ook Kim, Heung Pyo Kong, Wan Seob Kim, Myoung Jin Ju
Clin Exp Pediatr. 1997;40(2):279-283.   Published online February 15, 1997
Juvenile granulosa cell tumor(JGCT) is one of the sex cord stromal tumors of the ovary ocurring in the first two decades of life. These tumors are different from adult granulosa cell tumor(AJCT) with regard to clinical and pathological fetures. Follicles are often irregular, Call-exner bodies are rare, and luteinization is frequent. The tumor may besolid, cystic, orboth. The most common presenting...
A Case of 45, XO/46, XY Mosaicism With Left Inguinal Herniation of The Ovary.
Young Hoon Song, Ha Baik Lee, Chong Moo Park, Yong Giun Baik, Poong Man Jung
Clin Exp Pediatr. 1983;26(6):606-610.   Published online June 30, 1983
In this report, we describsd a 50-days-old female infant who was a case of 45, XO/XY mosaicism with left inguinal herniation of the ovary. The patient manifested the clinical findings of clitorial enlargement and palpable mass in the left inguinal area. The patient was shown by chromosomal analysis of peripheral blood leukocytes to be an 45, XO/46, XY mosaic, shown by operation to be...
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