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- Original Article
- Oligohydramnios affects pulmonary functional/structural abnormalities in school-aged children with bronchopulmonary dysplasia
- Jeong Eun Shin, Soon Min Lee, Mi-Jung Lee, Jungho Han, Joohee Lim, Haerin Jang, Ho Seon Eun, Min Soo Park, Soo Yeon Kim, Myung Hyun Sohn, Ji Ye Jung, Kyung Won Kim
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Question: Is bronchopulmonary dysplasia (BPD) associated with functional/structural abnormalities later in life?
Finding: School-aged children with severe BPD had abnormalities on pulmonary function tests and lung computed tomography despite no subjective respiratory symptoms; however, only prenatal oligohydramnios and prolonged ventilator use were associated with abnormal lung function.
Meaning: Long-term monitoring of preterm infants’ lung health is essential, especially for those with prenatal oligohydramnios or prolonged ventilator use. -
DOI: https://doi.org/10.3345/cep.2023.01053 [Epub ahead of print]
- Review Article
- Neonatology (Perinatology)
- Retinopathy of prematurity: a review of epidemiology and current treatment strategies
- Eun Hee Hong, Yong Un Shin, Heeyoon Cho
- Clin Exp Pediatr. 2022;65(3):115-126. Published online October 12, 2021
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There have been global tri-phasic epidemic periods of retinopathy of prematurity (ROP). In recent years, its incidence has reportedly been 10%–40% depending on country and study population. Current treatment strategies for ROP include laser photocoagulation, surgical treatment, and anti-vascular endothelial growth factor treatment, the role of which has drawn attention in recent years.
- Original Article
- Postnatal weight gain in the first two weeks as a predicting factor of severe retinopathy of prematurity requiring treatment
- Jongmoon Kim, Jang Yong Jin, Sung Shin Kim
- Clin Exp Pediatr. 2015;58(2):52-59. Published online February 28, 2015
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Purpose This study aimed to investigate the relative weight gain at 2-week intervals up to 6 weeks after birth to predict retinopathy of prematurity (ROP) requiring treatment among very low birth weight infants.
Methods A total of 211 preterm infants with birth weights <1,500 g and gestational age <32 weeks were retrospectively reviewed. The main outcome was the development of ROP requiring treatment....
- Case Report
- Transient carnitine transport defect with cholestatic jaundice: report of one case in a premature baby
- Hyun-Seok Cho, Young Kwang Choo, Hong Jin Lee, Hyeon-Soo Lee
- Clin Exp Pediatr. 2012;55(2):58-62. Published online February 14, 2012
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Carnitine (β-hydroxy-γ-trimethylaminobutyric acid) is involved in the transport of long-chain fatty acids into the mitochondrial matrix and the removal of potentially toxic acylcarnitine esters. Transient carnitine transport defect is a rare condition in newborns reported in 1/90,000 live births. In this paper, we describe a case of transient carnitine transport defect found in a premature baby who had prolonged cholestatic...
- Idiopathic severe hypermagnesemia in an extremely low birth weight infant on the first day of life
- Hye Sun Hyun, Hyun Sin Choi, Jin Kyu Kim, So Yoon Ahn, Hey Soo Yoo, Eun Sun Kim, Yun Sil Chang, Won Soon Park
- Clin Exp Pediatr. 2011;54(7):310-312. Published online July 31, 2011
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A preterm female infant born at 27 weeks of gestation with a birth weight of 990 g developed acute hypotonia, apnea, hypotension and bradycardia mimicking septic shock syndrome at 14h after birth. Laboratory tests indicated a severe hypermagnesemia of 45 mg/dL. The renal function, complete blood count and maternal blood concentrations of magnesium were normal, and the blood cultures were...
- Review Article
Ureaplasma infections in pre-term infants: Recent information regarding the role ofUreaplasma species as neonatal pathogens- Tae-Jung Sung
- Clin Exp Pediatr. 2010;53(12):989-993. Published online December 31, 2010
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Although numerous clinical observational studies have been conducted over a period of over 30 years, the clinical significance of
Ureaplasma infection is still under debate. TheUreaplasma speices. is a commensal in the female genital tract and considered to have of low virulence; however,Ureaplasma colonization has been associated with infertility, stillbirth, preterm delivery, histologic chorioamnionitis, and neonatal morbidities, including...
- Original Article
- The relationship between the time from arrival at a hospital to delivery and the occurrence of cerebral palsy in premature infants of less than 34 weeks of gestational age
- Jae Woong Whang, A Lum Heo, Soo Hyun Koo, Hae Jung Lee, Jun Wha Lee, Joo Seok Lee, Kyung Lae Cho
- Clin Exp Pediatr. 2009;52(11):1228-1233. Published online November 15, 2009
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Purpose : This study aimed to evaluate whether a shorter time from the arrival at a hospital to delivery is related to the occurrence of cerebral palsy in premature infants of less than 34 weeks of gestational age. Methods : We studied 142 newborns of less than 34 weeks of gestational age. The time from the arrival at the hospital... -
- The outcomes of retinopathy of prematurity in relation to duration of low dose oxygen therapy
- Pil Sang Lee, Jae Won Choi, Sang Geel Lee
- Clin Exp Pediatr. 2009;52(1):50-55. Published online January 15, 2009
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Purpose : This study aimed to determine the influence of low-dose oxygen (FiO2 <25%) therapy through nasal cannulae on the progress and prognosis of retinopathy of prematurity (ROP) as well as methods of preventing ROP. Methods : Our subjects comprised premature infants (gestation period <37 weeks; birth weight <1,750 g) born in Daegu Fatima Hospital between February 1, 2001 and... -
- Review Article
- Assessment of retinopathy of prematurity (ROP) revisited
- Jeong Hun Kim, Young Suk Yu
- Clin Exp Pediatr. 2009;52(1):22-27. Published online January 15, 2009
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Retinopathy of prematurity (ROP) is a major cause of blindness that affects premature infants. With advances in neonatology, ROP is likely to emerge as the most serious problem of vision loss in children even in developed countries; such a situation could be called the third epidemic of ROP. However, controversy and uncertainty still surround favorable outcomes of ROP. For successfully... -
- Original Article
- Delayed closure effect in preterm infants with patent ductus arteriosus
- Hyun Ju Lee, Gyu Hong Sim, Kyung Eun Jung, Jin A Lee, Chang Won Choi, Ee Kyung Kim, Han Suk Kim, Beyong Il Kim, Jung-Hwan Choi
- Clin Exp Pediatr. 2008;51(10):1065-1070. Published online October 15, 2008
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Purpose : This study aims to determine whether early closure (within 7 d) of significant patent ductus arteriosus (PDA) with indomethacin or ligation reduces neonatal morbidity when compared with delayed closure (after 7 d). Methods : Fifty-eight extremely-low-birth-weight infants admitted to the NICU of Seoul National University Hospital from April 2005 to May 2007 with PDA were studied retrospectively. Results :... -
- Review Article
- Post discharge care of prematurity
- Hye Sun Yoon
- Clin Exp Pediatr. 2007;50(1):14-19. Published online January 15, 2007
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Advances in neonatal care have been responsible for the improved survival of prematurity but have not resulted in decreased morbidity. Once the high-risk infants is discharged from the hospital, his or her many special care needs do not cease. A well-coordinated multidisciplinary approach is essential in the follow-up care of these infants. Special attention must be given to their growth... -
- Original Article
- Evaluation of Perinatal and Management Factors Associated with Improved Survival in Extremely Low Birth Weight Infants
- Sung Eun Park, Ga Won Jeon, Chang Won Choi, Jong Hee Hwang, Soo Hyun Koo, Yu Jin Kim, Chang Hoon Lee, Yun Sil Chang, Won Soon Park
- Clin Exp Pediatr. 2005;48(12):1324-1329. Published online December 15, 2005
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Purpose : The aim of this study was to evaluate recent improvements in the survival rate of extremely low birth weight (ELBW) infants and to identify perinatal and management factors that are associated with improved survival. Methods : Two groups of ELBW infants who were admitted to our neonatal intensive care unit (NICU) during two distinct eras : November 1994-December... -
- Clinical Lecture
- Twins
- Oh Kyung Lee
- Clin Exp Pediatr. 2005;48(7):685-690. Published online July 15, 2005
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Recently, twinning rate increases in Korea since the early 1990s by delayed marriage and prevailing of assisted reproductive technology. But twin and higher-order multiples are at increased risk for perinatal and neonatal mortality over 5 fold despite of dramatic improvement of perinatal and neonatal care. Because twins are born more prematurely and have lower birth weights than singleton. In addition,... -
- Original Article
- Serum Albumin Concentrations and Clinical Disorders by Gestational Ages in Preterm Babies
- Mia Lee, Soo Youn, Baek Keun Lim, Jong Soo Kim
- Clin Exp Pediatr. 2005;48(2):148-153. Published online February 15, 2005
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Purpose : The aim of this study was to determine the reference ranges of serum albumin levels depending on the gestational ages of preterm infants. We also intended to compare the mean serum albumin levels between groups of preterm infants that did not develop clinical disorders later, and groups that did develop clinical disorders such as respiratory distress syndrome, intraventricular... -
- Intrauterine Intraventricular Hemorrhage in Premature Infants
- Hyun-Seung Jin, Kyeng-Ah Park, Hyun-Woo Goo, Jong-Hyun Yoon, Ellen Ai-Rhan Kim, Ki-Soo Kim, Soo-Young Pi
- Clin Exp Pediatr. 2005;48(1):27-33. Published online January 15, 2005
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Purpose : To determine incidence, characteristics and risk factors associated with intrauterine intraventricular hemorrhage(IU-IVH) among premature infants. Methods : The medical records of infants with intraventricular hemorrhage(IVH) admitted to the neonatal intensive care unit of Asan Medical Center from January 1999 to June 2003 were reviewed retrospectively. Infants whose IVH with cystic change were detected within five days of life were... -
- Surfactant Therapy for Neonatal Respiratory Distress Syndrome : Experience in Korea Over 15 Years
- Chong-Woo Bae, Young-Min Kim
- Clin Exp Pediatr. 2004;47(9):940-948. Published online September 15, 2004
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Purpose : Surfactant replacement therapy in neonates with respiratory distress syndrome(RDS) has been used in Korea since 1990. We undertook a collective study of trials from multi-hospitals to evaluate results of neonates with RDS who were treated with surfactant during the past 15 years in Korea(Period I, P-I, 1990-91; Period II, P-II, 1996; Period-III, P-III; 2002). Methods : There were 60... -
- Survival Rate in Very Low Birth Weight Infants
- Jae Ju Cho, Soon Bum Lee, Woo Sung Park, Young Pyo Chang
- Clin Exp Pediatr. 2004;47(5):505-509. Published online May 15, 2004
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Purpose : We observed changes in the outcome of very low birth weight infants(VLBWI) admitted to the neonatal intensive care unit(NICU) of Dankook University Hospital(DKUH) in the last six years. Methods : The distribution of birth weight and gestational age, survival rate, neonatal complications, and causes of death for 228 VLBWI who had been admitted to DKUH from 1st January... -
- A Clinical Characteristics of Systemic Candidiasis in Neonatal Intensive Care Unit : Comparison with Systemic Bacterial Infection
- Jung Hwa Lim, Kyung Pil Park, Jin Kyung Kim, Heng Mi Kim
- Clin Exp Pediatr. 2002;45(7):847-854. Published online July 15, 2002
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Purpose : Long term hospitalized infants in neonatal intensive care units(NICUs) are prone to systemic infection. It is important to differentiate systemic candidiasis from systemic bacterial infection early in the course. Thus, in this study, we have compared clinical characteristics of systemic candidiasis and systemic bacterial infection, in premature low birth weight infants. Methods : Retrospective chart review of the medical... -
- Case Report
- A Case of Partial DiGeorge Syndrome in Prematurity
- Tae Jung Sung, Eun Young Ko, Dal Hyon Kim, Ji Eun Oh, Young Se Kwon, Dae Hyun Lim, Byong Kwan Son
- Clin Exp Pediatr. 2002;45(3):383-389. Published online March 15, 2002
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We experienced a case of partial DiGeorge syndrome in a 35＋5 week premature female infant presented with micrognathia, fish-shaped mouth, beaked nose, nasal regurgitation, obstructive sleep apnea, velopharyngeal insufficiency and late onset hypocalcemic seizures. The chromosome 22q11 microdeletion was found by the FISH method. The lab findings showed serum calcium level of 4.4 mg/dL, ionized calcium level of 0.49 mg/dL,... -
- Original Article
- The Detection of Chlamydia trachomatis Using Nested PCR in Prematurity and Delivery of Low Birth Weight Infant
- Jae Ho Noh, Hye Kyung Lee, Han Jin Kim, Yong Sik Min, Kyeong Bae Park, Joon Soo Park, Young Chang Kim, Sung Ran Cho
- Clin Exp Pediatr. 2001;44(8):875-880. Published online August 15, 2001
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Purpose : Polymerase chain reaction(PCR) has generally been more sensitive than traditional tests for the detection of Chlamydia trachomatis which has been a leading cause of sexually transmitted disease. We performed this study to find out if there is an association between C. trachomatis infection and low birth weight(LBW) or prematurity. Methods : The study included 98 premature or LBW infants... -
- Effect of Parenteral Nutrition Guideline Changes on Neonatal Sepsis in Premature Infants
- Chang-Ryul Kim, Jae-Won Oh, Myung-Kul Yum, Soo-Jee Moon
- Clin Exp Pediatr. 2001;44(6):620-626. Published online June 15, 2001
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Purpose : We hypothesized that decreased parenteral nutrition would lower the incidence of neonatal sepsis in premature infants. Methods : The study involves 223 premature infants who were admitted to the neonatal intensive care unit of Hanyang University Kuri Hospital from July 1995 to January 1999. Infants were divided into two groups based on different parenteral nutrition guidelines : Old... -
- Comparison of Intraventricular Hemorrhagic Findings in Preterm Infants Between Brain Ultrasonogram and Magnetic Resonance Imaging at Discharge
- Yong Kuk Kim, Sung Suk Do, Mi Hyun Cho, Sang Geel Lee
- Clin Exp Pediatr. 2000;43(4):470-476. Published online April 15, 2000
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Purpose : It has been customary to perform brain ultrasonogram(brain US) for the early detection of intraventricular hemorrhage(IVH) during intensive care of neonates. On the other hand magnetic resonance imaging(MRI) has been greatly restrictioned due to its complicated procedures. This study was conducted to identify changes in neonates' brain structure and to gain basic data for the long-term follow-up of... -
- Study on Closing Time after Indomethacin Administration in Prematurity with Patent Ductus Arteriosus
- Wan Cho, Suk Min Choi, Kyu Hyung Lee
- Clin Exp Pediatr. 1999;42(11):1508-1515. Published online November 15, 1999
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Purpose : In the clinical field, the closing time of patent ductus arteriosus(PDA) varies among patients after indomethacin administration. We tried to predict it by analyzing related factors, and also by understanding what affects it. Methods : Among 30 cases of PDA at the NICU, 24 cases(male 14 cases, female 10 cases) were selected. Fifteen cases closed early(within 36 hours) and... -
- Early Onset Hyperkalemia within 72 Hours after Birth in Extremely Preterm Infants
- Young Pyo Chang
- Clin Exp Pediatr. 1999;42(10):1366-1372. Published online October 15, 1999
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Purpose : The incidence of hyperkalemia and the factors contributing the serum potassium level within 72 hours after birth in extremely preterm infants were determined. Methods : The incidence of hyperkalemia and differences of clinical features between hyperkalemic(≥6.5mEq/L) and normokalemic(<6.5mEq/L) groups were determined by reviewing medical records of 53 extremely preterm infants born at less than 28 weeks gestation. Results :... -
- Gastric Emptying Time in Preterm Infents : Comparison between Breast Milk and Formula Milk
- Seong Woo Roh, Seong Sook Jeon, Son Sang Seo, Jeong Mi Kwon
- Clin Exp Pediatr. 1999;42(3):324-331. Published online March 15, 1999
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Purpose : Failure of adequate gastric emptying frequently interferes with successful enteral nutrition in infants. Study of gastric emptying in preterm infants has been hampered by the absence of a suitable and, valid technique, but ultrasonic assessment is well tolerated by infants. The aim of this study is to compare gastric emptying rates of breast milk and formula within preterm... -
- Erythropoietin Levels in Premature Infants Following Prolonged Treatment with Theophylline
- Kug Hwan Kim, Eun Seok Yang, Sang Kee Park
- Clin Exp Pediatr. 1997;40(9):1227-1231. Published online September 15, 1997
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Purpose : Theophylline, an adenosine antagonist commonly used in premature infants to treat apnea, has been shown to decrease erythropoietin levels in adults. We studied the effect of theophylline on serum erythropoietin levels in premature infants with apnea. Methods : Subject were 12 premature infants with apnea who were admitted to the NICU, Chosun University Hospital. The first dose of theophylline was 5mg/kg, given... -
- A Clinical Study for the Time of Development and Risk Factors of Retinopathy of Prematurity
- Eun Ae Park, Gyoung Hee Kim
- Clin Exp Pediatr. 1997;40(7):945-954. Published online July 15, 1997
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- Prophylactic Treatment of Anemia of Prematurity with Recombinant Human Erythropoietin and High Doses of Iron
- Young Ho Lee, Ahn Hong Choi, Soon Yong Lee, Jeong Sook Park, Bong Keun Choi, Hyoung Shim Chang
- Clin Exp Pediatr. 1997;40(3):361-367. Published online March 15, 1997
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Purpose : We conducted randomized study to determine whether high doses(6mg/kg/ day) of iron would exert a more supplemental effect than low doses(3mg/kg/day), and which regimen of recombinant human erythropoietin(rHuEPO) and iron would be more beneficial in the prophylactic treatment of anemia of prematurity. Methods : We randomly assigned 38 sick premature infants who were more likely than symptom-free premature infants requiring erythrocyte transfusions for... -
- Effect of Indomethacin Therapy in Prematurity with Patent Ductus Arteriosus:study of Its Effectiveness in Treatment Modality
- Yun Kyeong Bae, Seong Woo Roh, Min Jeong Kim, Son Sang Seo
- Clin Exp Pediatr. 1996;39(9):1239-1246. Published online September 15, 1996
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Purpose : Conventional indomethacin therapy(0.2mg/kg every 12 hours for three doses) has been used for closure of PDA. The effect of prolonged low dose of indomethacin therapy(0.1mg/kg daily for six days)had been reported in foreign country but, nothing had been reported in our country. So we attempted this study to examine effects of these two methods. Methods : Forty one infants with PDA of... -
- Effect of Recombinant Human Erythropoietin on the Anemia of Premature Infants
- Young Ah Lee, Ki Soo Kim, Young Seo Park, Hyung Nam Moon, Chang Yee Hong
- Clin Exp Pediatr. 1996;39(5):631-640. Published online May 15, 1996
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Purpose : To determine whether the prophylactic treatment with recombinant human erythropoietin(rHuEPO) for the anemia of prematurity would reduce the need for blood transfusions. Methods : We randomly assigned 17 premature infants to therHuEPO group and the control group. For the rHuEPO group (n=9, birth weight=1210¡¾156 g, gestational age=31.7¡¾1.9wk), rHuEPO (400U/kg) was given three times a week for 4 weeks, plus iron (8 mg/kg/day) and vitamin... -
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Impact Factor4.2
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6.52022CiteScore92nd percentilePowered by
