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Original Article
Hematology and Oncology
Lymphocyte-monocyte ratio at day 14 of first cisplatin-doxorubicin chemotherapy is associated with treatment outcome of pediatric patients with localized osteosarcoma
Jun Ah Lee, Hea Lin Oh, Dong Ho Kim, Jung Sub Lim
Clin Exp Pediatr. 2019;62(2):62-67.   Published online October 1, 2018

Purpose: We aimed to determine the prognostic significance of lymphocyte counts and the lymphocytemonocyte ratio (LMR) in pediatric patients with osteosarcoma. Methods: We retrospectively reviewed the medical records of 27 pediatric patients with localized extremity osteosarcoma, treated at the Korea Cancer Center Hospital between May 2002 and March 2016. Leukocyte counts and LMR before treatment and on day 14 (LMR14) of...
Oncology
Metformin displays in vitro and in vivo antitumor effect against osteosarcoma
Yunmi Ko, Aery Choi, Minyoung Lee, Jun Ah Lee
Clin Exp Pediatr. 2016;59(9):374-380.   Published online September 21, 2016
Purpose

Patients with unresectable, relapsed, or refractory osteosarcoma need a novel therapeutic agent. Metformin is a biguanide derivative used in the treatment of type II diabetes, and is recently gaining attention in cancer research.

Methods

We evaluated the effect of metformin against human osteosarcoma. Four osteosarcoma cell lines (KHOS/NP, HOS, MG-63, U-2 OS) were treated with metformin and cell proliferation was evaluated using...

Case Report
Alveolar rhabdomyosarcoma with massive disseminated intravascular coagulopathy treated with systemic chemotherapy
Byung Gyu Yoon, Hee Jo Baek, Burm Seok Oh, Dong Kyun Han, Yoo Duk Choi, Hoon Kook
Clin Exp Pediatr. 2015;58(12):505-508.   Published online December 22, 2015

It is uncommon for pediatric patients with rhabdomyosarcoma to present with clinical and/or laboratory features of disseminated intravascular coagulation (DIC). We report a case of metastatic alveolar rhabdomyosarcoma with severe bleeding because of DIC in a 13-year-old boy. He experienced persistent oozing at the site of a previous operation, gross hematuria, and massive epistaxis. Two weeks after initiating combination chemotherapy...

Review Article
Osteosarcoma in Korean children and adolescents
Jun Ah Lee
Clin Exp Pediatr. 2015;58(4):123-128.   Published online April 22, 2015

Osteosarcoma is the most frequent primary bone tumor. Advances in combination chemotherapy and surgical technique have greatly improved the survival of patients with osteosarcoma. In Korea, improvements in osteosarcoma treatment have been made over the past two decades. The 5-year event-free survival rate of Korean children and adolescents with localized disease is 64.6%, comparable to that of American or European...

Original Article
High-dose chemotherapy and autologous peripheral blood stem cell transplantation in the treatment of children and adolescents with Ewing sarcoma family of tumors
Juhee Seo, Dong Ho Kim, Jung Sub Lim, Jae-Soo Koh, Ji Young Yoo, Chang-Bae Kong, Won Seok Song, Wan Hyeong Cho, Dae-Geun Jeon, Soo-Yong Lee, Jun Ah Lee
Clin Exp Pediatr. 2013;56(9):401-406.   Published online September 30, 2013
Purpose

We performed a pilot study to determine the benefit of high-dose chemotherapy and autologous peripheral blood stem cell transplantation (HDCT/autoPBSCT) for patients with Ewing sarcoma family of tumors.

Methods

We retrospectively analyzed the data of patients who received HDCT/autoPBSCT at Korea Cancer Center Hospital. Patients with relapsed, metastatic, or centrally located tumors were eligible for the study.

Results

A total of 9 patients (3...

Case Report
Candida tropicalis arthritis of the elbow in a patient with Ewing's sarcoma that successfully responded to itraconazole
Seung Youn Kim, Jung Sub Lim, Dong Hwan Kim, Hyeon Jeong Lee, Joong Bum Cho, Jun Ah Lee, Dong Ho Kim
Clin Exp Pediatr. 2011;54(9):385-388.   Published online September 30, 2011

Fungal infections are rarely responsible for arthritis. Few cases of fungal arthritis have been reported, even in immunocompromised hosts susceptible to low-virulence organisms. Herein, the authors report the first case of Candida tropicalis arthritis in a child with a solid tumor. A 13-year-old boy with Ewing's sarcoma developed arthritis in his elbow during the neutropenic period after chemotherapy. Despite treatment...

Original Article
Pulmonary tuberculosis misdiagnosed as lung Metastasis in childhood cancer patients
Hyun Rae KK, Dong Whand Lim, Kang Min, Kyung Duk Park, Jun Ah Lee, Soo Yeon Cho, Yoon Hoh Kook, Hee Youn Kim, Dong Ho Kim
Clin Exp Pediatr. 2009;52(8):904-909.   Published online August 15, 2009

Purpose:The differential diagnosis for a pulmonary nodule is intriguing in cancer patients. Metastasis might be a preferential diagnosis, and yet possibilities of other medical conditions still exist. Pulmonary tuberculosis should be enlisted in the differential diagnosis for a pulmonary nodule in cancer patients in Korea. This study was aimed at analyzing the incidence and clinical features of pulmonary tuberculosis that were misdiagnosed as...
Serum methotrexate level is inversely related to the outcome of osteosarcoma patients
Jun Ah Lee, Min Suk Kim, Jin Kyung Lee, Dong Ho Kim, Young Joon Hong, Won Seok Song, Wan Hyeong Cho, Soo-Yong Lee, Jung Sub Lim, Kyung Duk Park, Dae-Geun Jeon
Clin Exp Pediatr. 2009;52(5):581-587.   Published online May 15, 2009
Purpose : To evaluate the correlation between serum methotrexate (MTX) peak levels and clinical outcome of osteosarcoma, as well as to determine the correlation of these levels with the histologic response and event-free survival (EFS). Methods : To maintain the homogeneity of the study population, we selected 52 patients with localized extremity osteosarcoma who had received two cycles of neoadjuvant...
Iron chelating agent, deferoxamine, induced apoptosis in Saos-2 osteosarcoma cancer cells
Eun Hye Park, Hyo Jung Lee, Soo Yeon Lee, Sun Young Kim, Ho Keun Yi, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2009;52(2):213-219.   Published online February 15, 2009
Purpose : Iron is a critical nutritional element that is essential for a variety of important biological processes, including cell growth and differentiation, electron transfer reactions, and oxygen transport, activation, and detoxification. Iron is also required for neoplastic cell growth due to its catalytic effects on the formation of hydroxyl radicals, suppression of host defense cell activities, and promotion of...
Case Report
Primary leiomyosarcoma of the chest wall in a child : a case report
Jae Hyuk Choi, David Chanwook Chung, Mee Jeong Lee
Clin Exp Pediatr. 2008;51(1):98-101.   Published online January 15, 2008
Leiomyosarcoma is an uncommon soft tissue sarcoma of mesenchymal cell origin, which shows smooth muscle differentiation. Leiomyosarcoma is seldom found in the pediatric population, and accounts for fewer than 2% of all soft tissue sarcomas. Leiomyosarcoma of the chest wall is extremely rare in children. We report here a case of an 8-year-old boy with a primary leiomyosarcoma that was...
Original Article
Outcome after relapse in childhood and adolescent osteosarcoma : single institution experience in Korea
Yun-Jeong Lee, Hyun-Jae Lee, Dong-Ho Kim, Jung-Sub Lim, Jun-Ha Lee, Kyung-Duk Park, Dae-Geun Jeon, Soo-Yong Lee
Clin Exp Pediatr. 2008;51(1):78-83.   Published online January 15, 2008
Purpose : Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. Although survival rate of osteosarcoma patients has markedly improved, about 20-30% of patients still have a relapse. This study was aimed to find factors that influence postrelapse survival of osteosarcoma in childhood and adolescents. Methods : Between 1985 and 2004, of 461 patients who were diagnosed...
Case Report
A case of Rothmund-Thomson syndrome
Seung Hyo Kim, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2006;49(5):565-569.   Published online May 15, 2006
Rothmund-Thomson syndrome (RTS), is a rare autosomal recessive disorder, characterized by : skin photosensitivity, poikiloderma, sparse hair, sparse eyebrows/lashes, short stature, skeletal abnormalities, cataracts, and an increased risk of malignancy. Skeletal abnormalities include : dysplasia, absent or malformed bones, such as absent radii, osteopenia, and delayed bone formation. RTS is thought to result from chromosomal instability, and children with RTS...
Isolated Intracranial Granulocytic Sarcoma as a Relapse Following Unrelated Bone Marrow Transplantation for Myelodysplastic Syndrome in a 1 Year-Old Infant
Kyung Ran Son, Hoon Kook, So Youn Kim, Hee Jo Back, Seok Joo Kim, Ha Young Noh, Mi Jeong Kim, Ic Sun Choi, Shin Jeong, Jong Hee Nam, Tai Ju Hwang
Clin Exp Pediatr. 2004;47(9):1008-1012.   Published online September 15, 2004
Isolated relapse of myeloid leukemia as a granulocytic sarcoma(GS) following allogeneic bone marrow transplantation(BMT) is very rare manifestation, and usually associated with a poor prognosis. We report a case of isolated intracranial GS in an infant with myelodysplastic syndrome(MDS) following unrelated BMT. A 7 month-old girl was diagnosed with refractory anemia with excess blasts (RAEB). During observation for a couple...
Malignant Ectomesenchymoma in a Two-Month-Old Boy
Ji Young Hwang, Ji Hyoun Seo, Jeum-Su Kim, Young-Suk Kim, Sue-Jin Lee, Chan-Hoo Park, Yoo Kyung Kim, Sun Hoo Park, Jung Hee Lee, In Oak Ahn, Ki Hyun Chung, Byung-Kiu Park
Clin Exp Pediatr. 2001;44(8):959-964.   Published online August 15, 2001
Malignant ectomesenchymoma is a rare tumor originating from remnants of migratory neural crest(ectomesenchyme) and composed of neuroectodermal as well as mesenchymal components. Neuroblasts and ganglion cells constitute the neuroectodermal components and rhabdomyosarcoma is the most frequently encountered mesenchymal components. We report a case of malignant ectomesenchymoma in a two-month-old boy who was presented with abdominal pain and urinary difficulty. The...
Original Article
Induction of Apoptosis of Ewing`s Sarcoma Cells by Regulating Fusion Protein Expression
Ho Keun Yi, Ran Ju Kim, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang
Clin Exp Pediatr. 2000;43(7):942-951.   Published online July 15, 2000
Purpose : Fusion genes(EWS-Fli-1 and EWS-erg ) function as transcription activators and are essential for maintaining tumorigenic properties in Ewing`s sarcoma cells. Several reports have noted that Ets family transcription factors bind with CBP(CREB binding protein) in vitro. To understand the interaction of fusion proteins and CBP, we studied the CBP protein in TC135 cells expressing the EWS-Fli-1 gene. We...
A Clinical Study of Childhood Soft Tissue Sarcoma
Hye Lim Jung, Hong Heo Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1993;36(9):1258-1270.   Published online September 15, 1993
Medicine, Seoul, Korea Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea To study the clinical characteristics and treatment results of childhood soft tissue sarcoma, the retrospective study was performed on 67 patients with soft tissue sarcoma, experienced at the Department of Pediatrics, Seoul National University Hospital from January, 1982 to July, 1990. The...
The Treatment Results of Childhood RhaMomyosarcoma
Chuhl-Joo Lyu, Byung Soo Kim, Eui Ho Hwang, Chang Ok Suh, Woo-Hee Cung
Clin Exp Pediatr. 1992;35(11):1520-1527.   Published online November 15, 1992
Rhabdomyosarcoma is a relatively common solid tumor in infants, children and adolescents, according for 4% to 8% of malignant disease in children less than 15 years old. Use of a multimodal approach to treatment has resulted in a dramatic improvement. Yonsei Cancer Center in Korea, since it's establishment in 1975, has been a state of multimodal approach. Thirty-seven cases of childhood...
Osteogenic Sarcoma as Second Malignant Neoplasm After Treatment of Retinoblastoma.
Ja Young Kim, Moon Whan Lee, Ju Hyung Kim, Pyoung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1990;33(12):1735-1740.   Published online December 31, 1990
The improvement in survival for childhood cancer has been achieved through the use of multiple- agent chemotherapy and radiotherapy. However, one of the limitations to quality and length of survival has been the development of second malignant neoplasm. We exprienced a case of second malignant neoplasm in 13-year-old boy who developed osteogenic sarcoma after successful treatment of retinoblastoma. At 3 years of his age,...
Clinical Studies on 10 Cases of Rhabdomyosarcoma in Children.
Wan Soeb Kim, Myung Ho Cho, Young Suk Jang, Myung Ho Lee
Clin Exp Pediatr. 1985;28(11):1112-1117.   Published online November 30, 1985
Clinical records of 10 children under 15 years of age with rhabdomyosarcoma confirmed histopathologically were retrospectively during last 8 years from 1973 through 1981 at Presbyterian Medical Center in Jeon-ju. Age range was from 8 months to 12 years of age, and there was no difference in sexes.The most frequent primary site of rhabdomyosarcoma was head and neck area (5 cases...
Case Report
A case of Rhabdomyosarcoma in the Urinary bladder.
Seung Ki Kim, Young Joo Shu, Man JIn Chung, Ji Sub Oh, Ok Ji Paik
Clin Exp Pediatr. 1985;28(2):197-201.   Published online February 28, 1985
We experienced a case of rhabdomyosarcoma arising from the base of urinary bladder in 20 month old male who presented with palpable abdominal mass, urinary incontinence and dysuria. We diagnosed it through I.V.P., ultrasonography and surgical biopsy. A brief review of the related literature is given.
A Case of Congenital-Fibrosarcoma.
Min Young Cha, Hyek Choul Kwon, Young Il Park, Sang Il Lee, Sang Woo Kim, Sung Sook Kim, Il Hyang Ko
Clin Exp Pediatr. 1984;27(12):1239-1243.   Published online December 31, 1984
We experienced a case of congenital fibrosarcoma in 1-month-old male infant who had a mass in the left back since his birth. Diagnosis was based on ultrasonography, CT Scan and pathalogic pictures obtained by percutaneous needle biopsy. Review of literatures was also attempted briefly.
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