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Purpose : In this study, natural pulmonary surfactant was extracted from bovine lung lavage and
its surface activity was determined. To investigate the usefulness of synthetic peptides reconstituted
with phospholipid as artificial surfactant, truncated peptides from surfactant protein (SP)-B
were synthesized and restored the surface tension lowering activities when appropriately
recombined with phospholipid.
Methods : Crude natural surfactant(CNS) was isolated from lung lavage by centrifugation... |
