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Review Article
Mechanisms of immune tolerance to allergens in children
Umut C. Kucuksezer, Cevdet Ozdemir, Mübeccel Akdis, Cezmi A. Akdis
Clin Exp Pediatr. 2013;56(12):505-513.   Published online December 20, 2013

Because the prevalence of allergic diseases has significantly increased in recent years, understanding the causes and mechanisms of these disorders is of high importance, and intense investigations are ongoing. Current knowledge pinpoints immune tolerance mechanisms as indispensable for healthy immune response to allergens in daily life. It is evident that development and maintenance of allergens-pecific T cell tolerance is of...

Original Article
Factors for persistent growth hormone deficiency in young adults with childhood onset growth hormone deficiency
Young Ah Lee, Hye Rim Chung, Se Min Lee, Jae Hyun Kim, Ji Hyun Kim, Sun Hee Lee, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2009;52(2):227-233.   Published online February 15, 2009
Purpose : Growth hormone (GH) replacement after retesting is necessary because impairment of body composition and cardiovascular health has been more severe in adult patients with persistent GH deficiency (GHD) from childhood to adulthood. This study aimed to investigate the factors for persistent GHD and define a highly probable group of persistent GHD in young adults with childhood-onset GHD. Methods :...
Review Article
Autoimmunity
Joong Gon Kim
Clin Exp Pediatr. 2007;50(12):1165-1172.   Published online December 15, 2007
Self/non-self discrimination and unresponsiveness to self is the fundamental properties of the immune system. Self-tolerance is a state in which the individual is incapable of developing an immune response to an individual's own antigens and it underlies the ability to remain tolerant of individual's own tissue components. Several mechanisms have been postulated to explain the tolerant state. They can be...
Original Article
Affecting Factors of Insulin Resistance in Obese Children and Adolescents
Duk Hee Kim, Ho Seon Eun, In Kyung Choi, Ho Seung Kim, Bong Soo Cha, Dong Kee Kim
Clin Exp Pediatr. 2005;48(10):1076-1081.   Published online October 15, 2005
Purpose : Insulin resistance is the most important risk factor linked to the development of impaired glucose tolerance(IGT), diabetes mellitus and cardiovascular diseases in childhood and adolescent obesity, The purpose of this study was to see whether insulin resistance of obese adolescent is higher than that of obese children. and to analyze gender difference and affecting factors of insulin resistance. Methods...
Clinical Lecture
Food Allergy
Soo-Young Lee
Clin Exp Pediatr. 2004;47(3):240-246.   Published online March 15, 2004
Food allergy is one of the clinical clusters due to food-induced allergic inflammation against dietary proteins which induced by IgE-mediated and/or non-IgE mediated mechanisms. Food allergic reactions are responsible for a variety of clinical symptoms involving the skin, gastrointestinal tract, and respiratory tract. Sometimes the life threatening anaphylactic reactions would be induced, especially by peanuts, tree nuts and buckwheat allergy....
Case Report
A Case of Hereditary Fructose Intolerance
Eun Kyeong Kang, Hye Ran Yang, Jeong Kee Seo, Sun Hoan Bai, Joo Young Jeong, Jae Sung Ko, Il Soo Ha, Jeong Han Song, Kyeong Ae Wi, Yoon Sook Shin
Clin Exp Pediatr. 2002;45(1):120-124.   Published online January 15, 2002
Hereditary fructose intolerance(HFI) is an autosomal recessive disease caused by catalytic deficiency of aldolase B in which affected homozygotes develop hypoglycemia and abdominal symptoms after taking foods containing fructose. Chronic exposure to fructose may lead to progressive hepatic injury, renal injury, growth retardation, and ultimately to liver and kidney failure. Herein, we report a case of HFI with presentation of episodic vomiting, diarrhea, cold...
A Case of Necrotizing Enterocolitis Associated with Cow and Soy Milk Intolerance
Sang Soo Roh, Young Il Park, Sang Il Lee
Clin Exp Pediatr. 1992;35(6):862-866.   Published online June 15, 1992
A case of necrotizing enterocolitis was associated with cow and soy milk intolerance in a term infant. The infant developed symptoms and radiologic findings-pneumatosis intestinalis and portal vein gas-after ingestion of cow and soy milk. Vomiting and diarrhea recurred with reintroduction of either cow or soy milk several times. The infant remained asymptomatic with a good growth rate on breast...
Original Article
Exercise Tolerance Tests in Patients with Tetralogy of Fallot Repaired Earlier : Correlation with 2-Dimensional Echocardiography and Cardiac Catheterization
Jin Yong Lee, Jun Hee Sul, Sung Kyu Lee, Dong Shik Chin, Bum Koo Cho, Soo Kwan Hwang, Dong Soo Yeoun
Clin Exp Pediatr. 1992;35(2):157-167.   Published online February 15, 1992
Exercise tolerance tests were performed using treadmill in 21 patients with tetralogy of Fallot (TOF) repaired earlier (4.8 years in mean) and 10 subjects with small ventricular septal defect or normal heart, aged 8-16 years. Pre and postexercise echocardiography and cardiac catheterization were also performed and the hemodynamic data were compared with exercise parameters. The following results were obtained. 1)...
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