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Review Article
Infection
Global varicella vaccination programs
Young Hwa Lee, Young June Choe, Jia Lee, Eunseong Kim, Jae Young Lee, Kwan Hong, Yoonsun Yoon, Yun-Kyung Kim
Clin Exp Pediatr. 2022;65(12):555-562.   Published online November 2, 2022
It is important to evaluate its effectiveness at the national level and to determine the varicella vaccine schedule based on the evidence generated through the studies.
Case Report
Use of intravenous immunoglobulin in a disseminated varicella infection in an immunocompromised child
Jae Hong Kim, Dae Hyun Kwon, E Young Bae, Seung Beom Han, Jae Wook Lee, Nack Gyun Chung, Dae Chul Jeong, Bin Cho, Jin Han Kang, Hack Ki Kim
Clin Exp Pediatr. 2014;57(8):370-373.   Published online August 25, 2014

Varicella-zoster virus infection can lead to severe illness in immunocompromised patients. Further the mortality rate of disseminated varicella infection is extremely high particularly in immunocompromised children. We report a case of disseminated varicella infection in a child with acute lymphoblastic leukemia who was receiving chemotherapy, but was initially admitted with only for acute abdominal pain. The patient rapidly developed severe...

A case of acute aseptic meningitis associated with herpes zoster
Myong A Kim, Rita Miyoung Yu, Kee Hyuck Kim, Hee Jung Chung
Clin Exp Pediatr. 2009;52(6):705-709.   Published online June 15, 2009
Herpes zoster is caused by the varicella-zoster virus (VZV), which affects nerve ganglions. VZV infection may be associated with neurologic complications, which are usually observed after vesicular exanthem. Acute aseptic meningitis is a rare complication of VZV reactivation. We report the case of a previously healthy 14-year-old boy who suffered from aseptic meningitis that was attributed to reactivated VZV infection...
Herpes zoster complicated by deep vein thrombosis : a case report
Woo-Yeon Cho, Young-Kuk Cho, Jae-Sook Ma
Clin Exp Pediatr. 2009;52(5):607-610.   Published online May 15, 2009
Varicella zoster virus (VZV) causes two diseases: Varicella, a generalized, primary infection, and herpes zoster (zoster), a secondary infection caused by latent VZV reactivation. Zoster can also be caused by latent VZV reactivation after a varicella vaccination. The complications associated with varicella include cutaneous infections, which are the most common, as well as pulmonary and neurological involvement. However, a deep...
A case of acute transverse myelitis following chickenpox
Min Young Kim, Eun Sook Suh
Clin Exp Pediatr. 2009;52(3):380-384.   Published online March 15, 2009
Acute transverse myelitis (ATM) in most patients is characterized by an abrupt onset of progressive weakness and sensory disturbance in the lower extremities with a preceding viral infection such as Epstein-Barr, herpes simplex, influenza, mumps and Varicella-zoster viruses (VZV). Although less frequent, some residual deficits including bladder dysfunction or weakness in the lower extremities may follow ATM, from which recovery...
Review Article
Update in varicella vaccination
Sung Hee Oh
Clin Exp Pediatr. 2006;49(3):229-234.   Published online March 15, 2006
Varicella, which is mostly a benign disease, but also can cause considerable health burden in the community, can be prevented by immunization with live attenuated varicella vaccine. Higher uptake of varicella vaccine by universal immunization in North America has apparently been associated with decline in the number of reported cases of varicella, varicella-related hospitalizations, and the number of deaths caused...
Case Report
A Case of Perinatal Varicella Infection
Jeong A Rho, Young Il Rho, Eun Young Kim, Sang Kee Park
Clin Exp Pediatr. 2003;46(10):1047-1050.   Published online October 15, 2003
Maternal varicella resulting in viremia may transmit the virus to the fetus by either transplacental spread, or by ascending infection from lesion in the birth canal. The characteristic symptoms consist of skin lesions in dermatomal distribution, eye diseases, neurological defects, and limb hypoplasia. Varicella of the newborn is a life-threatening illness that may occur when a newborn is delivered either...
Original Article
A Clinical Study on Varicella zoster Virus Infection, Relating Factors and Treatment in Pediatric Cancer Patients
Yoon Sook Chung, Su Hyun Kim, Ki Joong Kim, Hahng Lee
Clin Exp Pediatr. 2001;44(11):1289-1294.   Published online November 15, 2001
Purpose : We performed this study to contribute to the prevention and treatment of Varicella zoster virus infection in pediatric cancer patients through understanding of VZV infection, acyclovir efficacy and varicella vaccination. Methods : A retrospective study was performed by reviewing chart from January 1988 to January 2001. Results : The diseases among 19 cases were leukemia. 12 cases were solid...
Humoral and Cell Mediated Immune Response After Immunization with Varicella Vaccine(Oka/LG)
Young Mo Sohn, Hye Ok Roh, Mi Lim Goo, Bok Ryeon Park, Joo Hong Park, Gook Jin Lim
Clin Exp Pediatr. 1998;41(2):170-178.   Published online February 15, 1998
Purpose : We evaluated the humoral and cellular immune response to varicella-zoster virus after vaccination with varicella vaccine(Oka/LG strain). Methods : The seroprevalence rate of fluorescent antibody to membrane antigen(FAMA) was evaluated among 178 children and 15 adults. After vaccination, seroconversion rate of FAMA, varicella-zoster virus(VZV) specific IgG and cell mediated immune response to glycoprotein Ⅰwas performed. Results : The seropositive rate...
Epidemiology of Varicella in Korea Based on Pediatrician's Office Practice
Dong Jun Kim, Hyeon Soo Park, Sang Yun Lee, Kee Surk Park, Taik Kill Kim, Young Hoon Song, Jin Choi, Jin Woo Han, Young Suk Song, Tae Jin Park, Hong Kun Kim, Soo Yup Lee, Sun Ho Lee, Hak Won Kim, Sung Hee Oh
Clin Exp Pediatr. 1997;40(5):620-628.   Published online May 15, 1997
Purpose : Although varicella outbreakes have frequently occured, the epidemiology of varicella in Korea has not well been delineated. Furthermore without enough investigation with regard to safety and efficacy of varicella vaccine in Korean population, thevaccine has begun to be used in healthy children. Therefore the authors analized the clinical features of patients diagnosed of varicella to aid in understanding...
Varicella Zoster Virus Spicific IgG Antibody Titer in Vaccinated and Infected Children
Young Eun Lee, Eun Ae Park, Kyung hee Kim
Clin Exp Pediatr. 1996;39(7):934-942.   Published online July 15, 1996
Purpose : Varicella is mild self limited disease with vesicular skin eruption but highly contagious and accompanied many complications. Especially, varicella is fatal in leukemic children and immunocompromised children. The live varicella zoster virus was first developed by Takahashi et al. in the 1974. This vaccine has now been licensed for general use in Europe and the United States as well as in Korea.. The...
Immunogenicity and Safety of Live Attenuated Vaccine(MAV/06srtain) on Healthy Children and Immunocompromised Children
Young Mo Sohn, Chul Joo Yu, Pyung Kil Kim, Kir Young Kim, Chong Young Park, Mi Ran Kim, Woo Kap Jeung, Kyu Kye Hwang, Gyu Jin Woo, Song Yong Park
Clin Exp Pediatr. 1995;38(6):771-777.   Published online June 15, 1995
Purpose : To study the safety and immunogenicity of new live attenuated varicella vaccine (MAV/06strain) in normal healthy children and immunocompromized children in Korea. Methods : Blood samples for fluorescent antibody to membrane antigen(FAMA) assay were taken before the vaccination among seven hundred forth five healthy children and twenty two nine immunocompromised children. One hundred and seventy seven children and twenty...
Varicella-zoster Antibody Titer in Neonates according to Gestational Age
Ji Young Rhou, Eun Yae Park, Kyung Hee Kim
Clin Exp Pediatr. 1995;38(3):311-318.   Published online March 15, 1995
Purpose : Acquisition of varicella by the neonate as a result of congenital varicella-zoster infection or exposure during delivery is well known. And it generaly believed that infants under 6 months of age may acquire varicella more frequently than other viral infections such as measles. However, little if known about immune mechanism of varicella-zoster infection. Transfer maternal antibodies to this...
Safety and Immunogenicity of Live Attenuated Varicella Virus Vaccine(MAV/06 strain)
Young Mo Sohn, Chong Young Park, Kyu Kye Hwang, Gyu Jin Woo, Song Yong Park
Clin Exp Pediatr. 1994;37(10):1405-1413.   Published online October 15, 1994
Immune response induced by live attenuated varicella vaccine(Biken@) in children with acute lymphoblastic leukemia.
Hyo Seop Ahn, Joong Gon Kim
Clin Exp Pediatr. 1991;34(9):1255-1260.   Published online September 30, 1991
To determine the safety and efficacy of varicella vaccine, we studied 10 healthy children and 12 children in remission from acute lymphoblastic leukemia. They were immunized with the Oka strain of live attenuated varicella vaccine (Biken®). All the healthy children and 6 children with leukemia received the vaccine of 1,000 plaque-forming units (PFU), and 6 leukemic children received the vaccine of 500 PFU. The...
A clinical study on varicella zoster virus infection and treatment in children with malignant lymphoproliferative disease.
Hak Won Kim, Jae Won Oh, Sung Hee Oh, Ha Baik Lee, Hahng Lee
Clin Exp Pediatr. 1991;34(9):1246-1254.   Published online September 30, 1991
Vaircella Zoster Virus (VZV) infection is usually a benign disease in normal hosts, but it is known to result in high risk for visceral dissemination and mortality in immunocompromised hosts, as in the children with malignant diseases, especially with malignant lymphoproliferative diseases. Therefore, passive or active immunization and antiviral therapeutic modality have been tried to control visceral dissemination and thus to decrease mortality in...
Case Report
Two Cases of Postvaricella Reye Syndrome.
Won A Park, Sang Keun Chi, In Ho Kim, Churl Young Chung
Clin Exp Pediatr. 1982;25(5):528-532.   Published online May 31, 1982
Authors observed two cases of Reye syndrome in 7 and 8 year old male patients who had begun to vomit after chickenpox. The interval between the onset of varicella rash and encephalopathy of Reye syndrome was 4 days in both these cases. The initial laboratory findings revealed increased serum transaminase and blood ammonia levels which returned to normal on 18...
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