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Original Article
Short term outcomes of topiramate monotherapy as a first-line treatment in newly diagnosed West syndrome
Gyu Min Lee, Kyung Suk Lee, Eun Hye Lee, Sajun Chung
Clin Exp Pediatr. 2011;54(9):380-384.   Published online September 30, 2011
Purpose

To investigate the efficacy of topiramate monotherapy in West syndrome prospectively.

Methods

The study population included 28 patients (15 male and 13 female children aged 2 to 18 months) diagnosed with West syndrome. After a 2-week baseline period for documentation of the frequency of spasms, topiramate was initiated at 2 mg/kg/day. The dose was increased by 2 mg/kg every week to a...

A Case of Lissencephaly with West Syndrome.
Byoung Yul Lim, Ji Ho Song, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1990;33(10):1413-1417.   Published online October 31, 1990
Neuronal migrational disorders of the brain represent abnormalities in the formation of the neocortex caused by faulty migration of the subependimal neuroblasts. Lissencephaly is a rare congenital anomaly representing an arrest of brain development before the third or fourth month of gestaional age. The most common clinical findings were seizure, delayed development, failure to thrive and hydrocephalus. The authors experienced a case of lissencephaly with...
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