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Original Article
Epidemiologic and clinical features in children with acute lower respiratory tract infection caused by human metapneumovirus in 2006-2007
Gwi Ok Park, Ji Hyun Kim, Jae Hee Lee, Jung Ju Lee, Sin Weon Yun, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byoung Hoon Yoo,, Mi Kyung Lee, Soo Ahn Chae
Clin Exp Pediatr. 2009;52(3):330-338.   Published online March 15, 2009
Purpose : The causes of acute lower respiratory tract infection (ALRTI) are mostly attributable to viral infection, including respiratory syncytial virus (RSV), parainfluenza virus (PIV), influenza virus A/B (IFV A/B), or adenovirus (ADV). Several Korean studies reported human metapneumovirus (hMPV) as a common pathogen of ALRTI. However, studies on seasonal distribution and clinical differences relative to other viruses are insufficient,...
Case Report
A case of herpes zoster in a 4-month-old infant
Ji Hyun Kim, Jung Ju Lee, Sin Weon Yun, Soo Ahn Chae, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byoung Hoon Yoo
Clin Exp Pediatr. 2008;51(12):1368-1371.   Published online December 15, 2008
Herpes zoster in infancy is very rare but can be developed following intrauterine or postnatal exposure to varicella zoster virus. We report a case of herpes zoster in a 4-month-old male infant. He had no prior history of primary varicella or varicella vaccination. His mother had no history of varicella infection and no contact history with varicella during pregnancy. He...
Original Article
Clinical significance of serum vascular endothelial growth factor in Kawasaki disease
Ho Seok Lee, Sin Weon Yun, Young Soo Jung, Soo Ahn Chae, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byung Hoon Yoo, Mi Kyung Lee
Clin Exp Pediatr. 2007;50(10):995-1004.   Published online October 15, 2007
Purpose : Kawasaki disease is a systemic vasculitis, leading cause of pediatric acquired heart disease. Vascular endothelial growth factor (VEGF) has functions as vascular permeability factor, plays an important role in coronary artery lesion (CAL). We studied the clinical significance of serum VEGF in Kawasaki disease. Methods : Kawasaki group was 49 patients, and control group was 15 patients. Diagnosis followed...
The Clinical Significance of Soluble Intercellular Adhesion Molecule-1(sICAM-1) and Soluble Vascular Cell Adhesion Molecule-1(sVCAM-1) in Kawasaki Disease
Kang Won Rhee, Sin Weon Yun, Dong Keun Lee, Eung Sang Choi, Byung Hoon Yoo, Mi Kyung Lee
Clin Exp Pediatr. 2005;48(6):640-648.   Published online June 15, 2005
Purpose : Kawasaki disease(KD) is known as an acute multi-systemic vasculitis with various immunologic abnormalities. Adhesion of leukocyte to endothelial cells is a key event in the sequence of inflammatory response. This study was performed to investigate the clinical significance of serum soluble intercellular adhesion molecule-1(sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in acute and subacute stages of typical...
The Significance of Serologic Allergy Tests in Children with Recurrent Pneumonia
Yoon Hee Sim, Sin Weon Yun, Soo Ahn Chae, Dong Keun Lee
Clin Exp Pediatr. 2004;47(6):634-640.   Published online June 15, 2004
Purpose : Pneumonia is one of the most common respiratory diseases in hospitalized children, and often recurs. It has been reported that asthma is one of the significant contributing factors to recurrent pneumonia. On the basis of similarities between asthma and recurrent pneumonia, we intended to evaluate the influence of allergy on recurrent pneumonia. Methods : Seventy one children with...
Comparison of Acute Clinical Features and Coronary Involvement in Patients with Kawasaki Disease between Those Younger and Older than One Year of Age
So Young Kim, Seong Joon Lim, Sin Weon Yun, Dong Keun Lee, Eung Sang Choi
Clin Exp Pediatr. 2002;45(6):773-782.   Published online June 15, 2002
Purpose : To identify the necessity of more reasonable diagnostic criteria and the possibility of early prediction of coronary involvement in the higher risk group, we investigated and compared clinical and laboratory findings in the acute phase and coronary involvements in those younger (n=17) and older(n=53) than one year of age in Kawasaki disease(KD). Methods : Retrospective chart reviews were performed...
Case Report
A Case of Primitive Neuroectodermal Tumor of the Adrenal Gland
Sun Pil Jung, Chong Gwon Oh, In Seok Lim, Dong Keun Lee, Byoung Hoon Yoo
Clin Exp Pediatr. 2001;44(12):1459-1462.   Published online December 15, 2001
Primitive neuroectodermal tumors(PNETs) are a group of small round cell tumors that may arise in the central or peripheral nervous system. In the extracranial location, these neoplasms may occur anywhere and at any age group, but most likely in the bone and soft tissue of children and young adults. The incidence of adrenal gland involvement is very rare. This tumor...
Original Article
Clinical Significance of Serum ECP in Mycoplasma Pneumoniae Pneumonia
Young Ghil Rah, Dong Keun Lee, In Seok Lim, Eung Sang Choi, Soo Ahn Chae
Clin Exp Pediatr. 1999;42(5):672-678.   Published online May 15, 1999
Purpose : Allergic inflammation of the lower respiratory tract is a characteristic clinical feature in asthma patients, in which eosinophils play an important role. The activity of eosinophil may be determined by measuring the level of eosinophil cationic protein(ECP) in sputum or serum as a potential marker of the inflammatory severity. Methods : We measured the serum concentrations of ECP...
MELAS Syndrome Confirmed by Mitochondrial DNA Analysis in Siblings
Young Ghil Rah, Soo Ahn Chae, In Suk Lim, Dong Keun Lee, Byoung Hun Yoo, Tae Sung Ko, Han Wook Yoo
Clin Exp Pediatr. 1999;42(3):412-418.   Published online March 15, 1999
MELAS(mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) syndrome is a major subgroup of mitochondrial myopathy. Recent advances in molecular genetics revealed specific mutations in mitochondrial DNA which cause MELAS. We described here clinical and molecular genetic findings of sister and brother with MELAS syndrome. For molecular genetic studies, DNAs from peripheral blood nucleated cells were used. And the substitution...
Clinical Study of Post-Traumatic Seizure in Childhood and Adolescence
Jang Weon Moon, Soo Ahn Chae, Dong Keun Lee
Clin Exp Pediatr. 1999;42(2):227-232.   Published online February 15, 1999
Purpose : As morbidity and mortality resulting from physical trauma have significantly increased, the importance of trauma concerning medical, legal, and socioeconomic issues has been widely documented. Studies of post-traumatic seizure after head trauma have been reported, but mostly in adults. So this study was performed to analyse clinical findings on head trauma patients under 20 years of age. Methods :...
Case Report
A Case of Idiopathic Long QT Syndrome with 2:1 Atrioventricular Block
Kwang In Lee, Chul Ha Kim, In Seok Lim, Dong Keun Lee, Byoung Hoon Yoo
Clin Exp Pediatr. 1995;38(12):1701-1705.   Published online December 15, 1995
The idiopathic long QT syndrome is a very rare disorder in which affected individuals have an unusual electrocardiographic repolarization abnormality (QT prolongation) and a propensity to syncope and fatal ventricular arrhythmia. Since Jervell and Lange-Nielsen first described this syndrome in 1957, progression has been made in the pathophysiology and in the treatment. Sinus bradycardia may be associated with this syndrome sometimes,...
Pseudoaneurysm after Renal Biopsy; Angigraphic Diagnosis and Treatment by Superselective Embolization
Sin Weon Yun, Keun Seop Jung, In Seok Lim, Chul Ha Kim, Dong Keun Lee, Byeong Heun You, Hyung Jin Shim, Young Ku Kim
Clin Exp Pediatr. 1995;38(3):417-421.   Published online March 15, 1995
The use of superselective embolization was assessed as a treatment for bleeding from arteriovenous fistulas and pseudoaneurysm after renal biopsy procedure. But unless it is sufficiently selective, the procedure results in loss of significant amount of renal parenchyme. We experienced one case of renal arterial pseudoaneurysm, which happened at 5days after percutaneous renal biopsy. Diagnosis of pseudoaneurysm was made by...
A Case of Roberts Syndrome
Young Choi, Yo Han Chung, In Seok Lim, Chul Ha Kim, Dong Keun Lee, Seong Nam Kim, Sang Yong Song, Je Geun Chi
Clin Exp Pediatr. 1993;36(10):1447-1451.   Published online October 15, 1993
Roberts syndrome is an autosomal recessive disorder accompanied by limb defects, craniofacial abnormalities, pre-and postnatal growth retardation. Patients with Roberts syndrome have characteristic premature separation of heterochromatin of many chromosomes and abnormalties in celldivision cycle. We have experienced a case of Roberts syndrome in an immature neonate. The patients showed characteristic clinical features of multiple encephaloceles. Severe facial mid-line clefts, and...
Storage Mite
Dong Keun Lee
Clin Exp Pediatr. 1992;35(10):1323-1327.   Published online October 15, 1992
Original Article
A case of malignant atrophic papulosis (Degos' disease).
Sung Ku Lee, In Seok Lim, Chul Ha Kim, Dong Keun Lee, Eung Sang Choi, Byoung Hoon Yoo, Gae Yong Song
Clin Exp Pediatr. 1991;34(12):1724-1729.   Published online December 31, 1991
Malignant atrophic papulosis (Degos’ disease) is characterized by porcelain-white skin lesions. It has unknown etiology and bad prognosis. Death usually occurs from multiple intestinal perforations weeks to years after onset. We experienced a case of Degos’ disease in a 12-year-old male patient who had porcelain white papules on face, trunk and extremities. Histopathologic studies showed broad epidermal necrobiosis with thrombotic arteriolar occlusion. A brief review of...
A Case of the Malignant Mesenchymoma of the Liver in Childhood.
Byung An Shim, Nak Wan Choe, King Yeob Han, Dong Keun Lee
Clin Exp Pediatr. 1987;30(12):1433-1438.   Published online December 31, 1987
Malignant mesenchymoma of the liver is extremely rare in childhood. It is formed by 2 or more unrelated mesenchymal tissues, chacterized by rapid growth and poor responsiveness to all modes of therapy. We experienced a case of malignant mesenchymoma of the liver in a 11-year-old boy who was admitted because of abdominal pain, anorexia, nausea and vomiting. Radiographic examinations showed a space occupying lesion...
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