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Original Article
Taurine exerts neuroprotective effects via anti-apoptosis in hypoxic-ischemic brain injury in neonatal rats
Ji Eun Jeong, Tae Yeol Kim, Hye Jin Park, Kye Hyang Lee, Kyung Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Eok Su Seo, Woo Taek Kim
Clin Exp Pediatr. 2009;52(12):1337-1347.   Published online December 15, 2009
Purpose : Taurine (2-aminoethanesulfonic acid) is a simple sulfur-containing amino acid. It is abundantly present in tissues such as brain, retina, heart, and skeletal muscles. Current studies have demonstrated the neuroprotective effects of taurine, but limited data are available for such effects during neonatal period. The aim of this study was to determine whether taurine could reduce hypoxic-ischemic (HI) cerebral...
Expression of nitric oxide synthase isoforms and N-methyl-D-aspartate receptor subunits according to transforming growth factor-β1 administration after hypoxic-ischemic brain injury in neonatal rats
Hae Young Go, Eok Su Seo, Woo Taek Kim
Clin Exp Pediatr. 2009;52(5):594-602.   Published online May 15, 2009
Purpose : Transforming growth factor (TGF)-β1 reportedly increases neuronal survival by inhibiting the induction of inducible nitric oxide synthase (NOS) in astrocytes and protecting neurons after excitotoxic injury. However, the neuroprotective mechanism of TGF-β1 on hypoxic-ischemic (HI) brain injury in neonatal rats is not clear. The aim of this study was to determine whether TGF-β1 has neuroprotective effects via a...
Neuroprotective effects of resveratrol via anti-apoptosis on hypoxic-ischemic brain injury in neonatal rats
Jin Young Shin, Min Ae Seo, Eun Jin Choi, Jin Kyung Kim, Eok Su Seo, Jun Hwa Lee, Hai Lee Chung, Woo Taek Kim
Clin Exp Pediatr. 2008;51(10):1102-1111.   Published online October 15, 2008
Purpose : Resveratrol, extracted from red wine and grapes, has an anti-cancer effect, an antiinflammatory effect, and an antioxidative effect mainly in heart disease and also has neuroprotective effects in the adult animal model. No studies for neuroprotective effects during the neonatal periods have been reported. Therefore, we studied the neuroprotective effect of resveratrol on hypoxic-ischemic brain damage in neonatal...
The neuroprotective effect of mycophenolic acid via anti-apoptosis in perinatal hypoxic-ischemic brain injury
Ji Young Kim, Seung Ho Yang, Sun Hwa Cha, Ji Yeun Kim, Young Chae Jang, Kwan Kyu Park, Jin Kyung Kim, Hai Lee Chung, Eok Su Seo, Woo Taek Kim
Clin Exp Pediatr. 2007;50(7):686-693.   Published online July 15, 2007
Purpose : Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), is a potent inhibitor of inosine-monophosphate dehydrogenase (IMPDH), a new immunosuppressive drug used. It was reported that MPA protected neurons after excitotoxic injury, induced apoptosis in microglial cells. However, the effects of MPA on hypoxic-ischemic (HI) brain injury has not been yet evaluated. Therefore, we examined whether MPA...