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Original Article
DNA Methylation Change of IL-4 Gene from T Cell in Allergic Children
Jae Won Oh, Myung Gul Yum, Chang Ryul Kim, In-Joon Seol, Su A Shin, Ha Baik Lee, Se Jin Jang
Clin Exp Pediatr. 2005;48(6):634-639.   Published online June 15, 2005
Purpose : An understanding of the immunological process is required if primary prevention of atopic diseases is to be developed in early childhood. But, it is too hard to distinguish atopy from nonatopy under the age of two clinically, because the expression of phenotype and cytokines is vague in early childhood. We evaluated DNA methylation changes at Th2 interleukin-4 gene...
Elevated Circulating ICAM-1 and Eosinophil Cationic Protein in Children with Chronic Urticaria
You Sun Choi, Su A Shin, Young Dai Kim, Jae Won Oh, Ha Baik Lee
Clin Exp Pediatr. 2004;47(9):986-991.   Published online September 15, 2004
Purpose : Chronic urticaria is characterized by recurrent, itchy, and evanescent wheals over a period of six weeks. The mechanisms of chronic urticaria in children have not been fully elucidated. However, urticaria lesions represent a dynamic inflammatory process involving a complex interplay of various inflammatory mediators, chemokines, adhesion molecules and cellular interaction. The aim of this investigation was to elucidate...
A Nationwide Clinical Study of Acute Respiratory Distress Syndrome in Children
Soo Jung Choi, Do Suck Jeong, Jae Won Oh, Ha Baik Lee, Im Ju Kang, Kwang Woo Kim, Kyu Earn Kim, Ki Bok Kim, Young Ho Rah, Kang Seo Park, Byong Kwan Son, Ki Young Lee, Sang Il Lee, Ji Tai Choung, Young Mi Hong
Clin Exp Pediatr. 1999;42(1):23-31.   Published online January 15, 1999
Purpose : Acute respiratory distress syndrome(ARDS) is the final course of acute lung injury. It results from various etiological origins and pathophysiologic mechanisms, and has a mortality rate of approximately 60-70%. Although the confirmative incidence of ARDS in children is yet unknown, the increasing incidence of ARDS has been reported in Korea. In the present study, we report ARDS diagnosed...
A Study for Causes of Death in Korean Children
Ha Baik Lee, Jun Hee Sul, Young Yull Koh, Jong Wan Kim, Young Jin Hong, Nam Su Kim, Myung Ik Lee
Clin Exp Pediatr. 1998;41(8):1047-1059.   Published online August 15, 1998
Purpose : Analyzing of the causes of childhood death will provide us with the basis to understand prevalent diseases and to make the best possible health plan according to the studies. The National Statistical Office(NSO) of Korea has released an annual report of nationwide death. However, it could have underestimated the death toll of children because of delayed or missing...
Case Report
A Case of Cerebral Infarction Associated with Mycoplasma pneumoniae Infection
Young Jae Koh, Dong Jun Kim, In Joon Seol, Ha Baik Lee, Ki Woong Hong
Clin Exp Pediatr. 1996;39(1):115-119.   Published online January 15, 1996
Mycoplasma pneumoniae has been shown to be of etiologic importance in cases of upper-and lower-respiratory tract infections, especially in children and young adults. It may cause a variety of extrapulmonary manifestations in multiple organ systems, most commonly the central nervous system. The extrapulmonary syndromes include meningitis, cerebral infarction, acute transverse myelitis, psychosis, cerebellar ataxia, Guillain-Barré syndrome and Reye syndrome. Cerebral...
A Case of Non-IgE-mediated Serosal Eosinophilic Gastroenteritis in a Child with Chronic Asthma
Yong Joo Kim, Ha Baik Lee, Hahng Lee, Eun Kyeong Hong, Hyun Chul Rhim
Clin Exp Pediatr. 1995;38(12):1694-1700.   Published online December 15, 1995
Eosinophilic gastroenteritis(EG) is a chronic disorder in which edsinophils constitute the predominant cell type in the inflammatory infiltrates of the gastrointestinaHGD tract. This disease was first described by Kaiiser in 1937. The clinical symptoms and signs are variable according to the extent of the eosinophilic infiltration(diffuse versus cir¡ⓒ cumscribed) and the depth of the eosinophilic reaction (mucosal, muscular, serosal). Some...
Subacute Necrotizing Lymphadenitis (Kikuchi's Disease) in a Child with Atopic Asthma
Dong Jun Kim, Seong Yeoub Moon, Ha Baik Lee, Yeong Hae Koh
Clin Exp Pediatr. 1995;38(8):1141-1145.   Published online August 15, 1995
Subacute necrotizing lymphadenitis (Kikuchi's disease) is an increasingly recognized cause of cervical lymphadenitis since it has been described by Japanese doctors in 1972. It generally follows a benign course, when symptoms and signs of the disease are resolved usually within 1 to 6 months. We experienced a case of subacute necrotizing lymphadenitis in a 12 year-old boy with atopic bronchial asthma...
Original Article
A Clinical Observation in 14 Children with SLE
Jin Nyoung Park, Jai Kyoung Choi, Ha Baik Lee, Hahng Lee
Clin Exp Pediatr. 1994;37(4):510-519.   Published online April 15, 1994
To elucidate the clinical characteristics of childhood onset systemic lupus erythematosus (SLE), we carried out a retrospective reivew on medical records of fourteen patients who were diagnosed as SLE on the base of 뱓he 1982 revised criteria for the SLE?(by american Rheumatism Association) at the Department of pediatrics, Hanyang University Hospital from January 1980 through August 1992. The results were summerized...
Serum Eosinophil Cationic Protien(ECP) in Children with Atopic Astham
Dae Cheol Kim, Ha Baik Lee
Clin Exp Pediatr. 1993;36(6):810-819.   Published online June 15, 1993
Eosinophils play a major role in the airway inflammation in asthma. To werify an association between airway responsiveness of asthmatics and eosinophil and/or ECP, we measured serum ECP in 23 children with atopic asthma during acute attacks and stable, and in 10 normal healthy controls. Peak flows were monitored in 15 children. The data suggest that serum ECP levels were higher...
Clincal Observation on Guillain-Barré Syndrome in Children
In Cheol Park, In Seung Park, Jeh Hoon Shin, In Joon Seol, Ha Baik Lee
Clin Exp Pediatr. 1993;36(5):634-642.   Published online May 15, 1993
Clinical observation was performed on 23 children with Guillain-Barré syndrome which were hospitalized at the Pediatric ward of Han Yang University Hospital, from July 1975 through May 1991. The results were as follows: 1)The ratio of male patient to female was 2.8:1 and 47.8% of total GBS patients were between the ages 1to 5 years. 2)The highest seasonal incidence of GBS was seen...
A Clinical Study of Mycoplasma Pneumonia in Children During Recent 5 Years
In Seung Park, Ha Baik Lee
Clin Exp Pediatr. 1992;35(8):1082-1088.   Published online August 15, 1992
Mycoplasma pneumoniae infections are among the most frequent respiratory diseases of school-aged children, adolescents and young adults. However in preschool children a persistent nonproductive cough, fever and interstitial or lobular infiltrates on the chest radiograph can recently be recognized as presenting features of M. pneumoniae. We studied to find out the recent trends in epidermiologic and clinical variabilities of M. pneumoniae...
A Clinical Study of the Effect of Early(<12 Months) Versus Late(12-24 Months) Onset in Infantile Asthma
Jae Won OH, Ji Yeon Lim, Ha Baik Lee
Clin Exp Pediatr. 1992;35(2):201-210.   Published online February 15, 1992
Asthma in infancy can be confused with a variety of airway diseases, because not all that wheezes is asthma and controversy exists as to the role of age of asthma onset in childhood asthma. This study was designed to examine the role of age and predictive capacity of elevated serum IgE for early asthma doset. We compiled data of asthmatics (n=56)...
A clinical study on varicella zoster virus infection and treatment in children with malignant lymphoproliferative disease.
Hak Won Kim, Jae Won Oh, Sung Hee Oh, Ha Baik Lee, Hahng Lee
Clin Exp Pediatr. 1991;34(9):1246-1254.   Published online September 30, 1991
Vaircella Zoster Virus (VZV) infection is usually a benign disease in normal hosts, but it is known to result in high risk for visceral dissemination and mortality in immunocompromised hosts, as in the children with malignant diseases, especially with malignant lymphoproliferative diseases. Therefore, passive or active immunization and antiviral therapeutic modality have been tried to control visceral dissemination and thus to decrease mortality in...
A case of interstitial pulmonary fibrosis.
Hak Won Kim, Ho Joon Im, In Joon Seol, Ha Baik Lee, Hahng Lee, Seok Chol Jeon, Moon Hyang Park
Clin Exp Pediatr. 1991;34(1):107-114.   Published online January 31, 1991
Interstitial pulmonary fibrosis is a rare, diffuse lug disease which has a tendency to destroy the lung architectures by consequent healing with progressively severe fibrosis. We report with a brief review of literature, one case of a 7-year old female with the typical pictures of interstitial pulmonary fibrosis, histologically on open lung biopsy, and clinically presenting with chronic respiratory difficulty but without definite symptoms...
Comparison between Treatment with Aspirin Alone and the Combined Treatment with Aspirin and Intravenous gamma-Globulin in Kawasaki Disease.
Sang Yoon Ahn, Sun Yang Hong, Nam Soo Kim, Ha Baik Lee, Soo Jee Moon, Hahng Lee
Clin Exp Pediatr. 1990;33(10):1380-1387.   Published online October 31, 1990
Out of a total of 140 children hospitalized with the diagnosis of Kawasaki disease at the Depart- ment of Pediatrics, Hanyang University Hospital during the period of 9 years from July 1980 to July 1989, 68 cases were subjected to echcocardiographic examination at 10 to 15 days after the onset of illness, and these 68 cases were divided into two groups according the...
Orbital Infections in Children.
Hak Won Kim, Young Tae Kim, Sung Hee Oh, Ha Baik Lee
Clin Exp Pediatr. 1990;33(7):932-939.   Published online July 31, 1990
Seven pediatric patients with orbital infections who were managed at the Hanyang University Hospital from April 1981 to June 1988 were reviewed. The summary of the study were as follows. 1) Seven patients were distributed between 3 months to 14 years of age and four were male. 2) Conditions associated with orbital infections were furuncles (eyelid, nasal cavity, finger), upper respiratory tract infections, and extraction of dental...
Clinical and Epidemiologic Studies on Childhood Asthma.
Youn Mo Ahn, Sun Ho Lee, Ha Baik Lee, Hahng Lee
Clin Exp Pediatr. 1990;33(5):632-641.   Published online May 31, 1990
The one-hundred-twenty-seven asthmatic children who were diagnosed and treated either through admission or through clinic visits at the Department of Pediatrics, Hanyang University Hospital from July 1987 to March 1989, were investigated for clinical patterns and epidemiologic correlations. The diagnosis of asthma was made by typical clinical history, physical findings and laboratory examina- tion. The results were as follows: 1) Sixty-three percent of the total population at...
The Clinical Observation on Mucocutaneous Lymph Node Syndrome.
Sang Yun Ahn, Ja Wook Koo, Ha Baik Lee, Soo Jee Moon, Hahng Lee
Clin Exp Pediatr. 1990;33(2):196-204.   Published online February 28, 1990
The one-hundred-forty nine children with mucocutaneous lymph node syndrome who were diagnosed and treated through admission at the Department of Pediatrics, Hanyang University Hospital from July 1977 to January 1989, were investigated for clinical patterns and laboratory , correlations. The results are as follows: 1) Most patients (84.5%) were under 4 years of the age. 2) Boys were more prevalent than girls, as a ratio of 1.9:1. 3) Seasonal incidence...
Hypoplastic Left Heart Syndrome : Report of a Unique Survivor.
Hang Bo Cho, Seong Ho Kim, Ha Baik Lee, Kyu Hwang Rhee, Chong Moo Park
Clin Exp Pediatr. 1988;31(6):790-795.   Published online June 30, 1988
Hypoplastic left heart syndrome is a rare, and fatal congenital heart disease. Most of the patients with this syndrome die within the 1st month of life. Recently we experienced a hypoplastic left heart syndrome in a child who was unusually living without surgical intervention for 3 and half years. The unique clinical course might result from a number of favorable hemodynamic factors and intact...
Allergic Diseases and Immunotherapy.
Ha Baik Lee
Clin Exp Pediatr. 1987;30(11):1189-1195.   Published online November 30, 1987
A Comparative study of Sulbactam/Ampicillin vs Ampicillin/Amikacin in infections of the Pediatric Age Group.
Keun Soo Lee, Ha Baik Lee, Seon Ock Khang, Jung Hee Lee, Tai Yeal Choi, Choon Won Kim
Clin Exp Pediatr. 1986;29(1):1-17.   Published online January 31, 1986
Sulbactam has been shown to be an irreversible inhibitor of bacterial beta.lactamase. The spectrum of Ampicillin is extended hen it is used in combination with Sulbactam to cover Ampicillin resistant organisms. The safety and efficacy of Sulbactamj Ampicillin vs. Ampicillin/Amikacin are compared in the treatment of various disease in pediatric age group Patients are assigned randomly to receive either Sulbactam/...
Clinical Studies on Childhood Bronchial Asthma.
Kwang Nam Kim, Soo Yup Lee, Ha Baik Lee, Kyu Hwan Lee, Woo Gill Lee, Keun Soo Lee
Clin Exp Pediatr. 1985;28(10):997-1006.   Published online October 31, 1985
The results of clinical observation and hematologic findings on 120 cases with bronchial asthma who were admitted to the department of pediatrics, Hanyang University Hospital from Mar. 1984 to Feb. 1985 were as followings: 1)As to the age distribution, 80% of total cases were under 7-year-old and the sex ratio was 2.6 . 1 with male predominance. 2)As to the...
Case Report
A case of Congenital Nephrotic Syndrome.
Kwang Nam Kim, Kwang Hyun Kim, In Joo Seol, Ha Baik Lee, Chong Moo Park
Clin Exp Pediatr. 1985;28(9):931-935.   Published online September 30, 1985
The congenital nephrotic syndrome is characterized by large placenta, low birth weight, early clinical findings, delayed growth and development and resistance to treatment. Authors experienced a case of characteristic of congenital nephrotic syndrome in a girl, who was admitted to the Pediatric Department of HUH at 28 days of age because of generalized edema, abdominal distension with vomiting and diarrhea....
Original Article
So-called 'Septal Aneurysm' in membranous Ventricular Septal defect.
Han Young Lee, In Hee Park, Ha Baik Lee, Heung Jae Lee
Clin Exp Pediatr. 1985;28(9):869-879.   Published online September 30, 1985
During the period of 4 years from October, 1980 to September, 1984, 28 cases with septal aneurysm in membranous ventricular septal defect were observed and evaluated at Hanyaeng University Hospital, and those were confirmed by LV angiogram and/or 2D-echocardiogram. We also correlated the findings of aneurysm of the membranous septum with clinical, electrocardiographic and hemodynamic data for use in noninvasive...
Case Report
A Case of Agenesis of the Corpus Callosum.
Jung Hee Lee, Seong Ryong Hyun, In Joon Seol, Ha Baik Lee, Keun Soo Lee
Clin Exp Pediatr. 1985;28(8):836-840.   Published online August 31, 1985
Agenesis of the corpus callosum is a relatively common malformation that may occur in isolation or in combination with other cerebral malformation. We experienced a case of agenesis of the corpus callosum in a 5/12 year old boy who showed developmental retardation. Cerebral brian CT and sonography demonstrated a typical picture of agenesis of the corpus callosum without any further...
Original Article
A Clinical Study on Reye's Syndrome.
Hye Sun Jung, Seong Ryong Hyon, Ha Baik Lee, Soo Jee Moon, Chong Moo Park
Clin Exp Pediatr. 1985;28(8):783-794.   Published online August 31, 1985
Ninety three cases of Reye's Syndrome were admitted to pediatric ward of Hanyang University Hospital during 6 year period from January 1979 to December 1984. The following results were obtained; 1)The peak age incidence was under 1 year of age. The sex incidence revealed male predominance with sex ratio 1.6 to 1(M : F). 2)The peak seasonal incidence was noted in...
Clinical Studies of Anaphylactoid Purpura in Childhood.
Kwang Hyun Kim, Kwang Nam Kim, Ha Baik Lee, Hang Lee
Clin Exp Pediatr. 1985;28(6):545-554.   Published online June 30, 1985
Anaphylactoid purpura or Henoch-Schonlein purpura is a common pediatric disease presenting most frequently with purpura, and occasionally with gastrointestinal and joint manifestations, and has been known to present pathologically with diffuse vasculitis involving small blood vessles in many organs. Clinical manifestations and laboratory findings were observed and analyzed in 110 cases with anaphylactoid purpura hospitalized at Hanyang University Hospital during...
Case Report
A Case of Acute Megakaryoblastic Leukemia.
Hye Sun Jung, Ha Baik Lee, Hahng Lee, Chong Moo Park
Clin Exp Pediatr. 1985;28(4):390-395.   Published online April 30, 1985
Acute megakaryoblastic leukemia in a very rare type of leukemia characterized by megakaryoblatic proliferation and organ infiltration without proliferation of other marrow elements. The authors experienced a case of acute megakaryoblastic leukemia in a 3 9/12 year-old female patient on admission. Acute leukemia was suspected because blast cells were found in peripheral blood smear, and there was hepatosplenomegaly. Bone marrow...
Original Article
Clinical Study of Cerebrospinal Fluid Lactate Levels in Children with Menigitis.
Sang Hee Cho, Ha Baik Lee, Keun Soo Lee
Clin Exp Pediatr. 1984;27(5):475-482.   Published online May 31, 1984
Cerebrospinal fluid lactate level and C-reactive protein(CRP) reactions were studied in 131 children who were hospitalized to the Department of Pediatrics, Hanyang University Hospital between February 1983 and August 1983. Among 131 hospitalized children, 68 were meningitis cases as for study group and the rest 63 were non-meningitis cases as for control group. These two groups were statistically well matched....
Case Report
A Case of Bartter'S Syndrome.
Yung Suk Song, Moon Ho Chung, Ha Baik Lee, Chong Moo Park
Clin Exp Pediatr. 1983;26(6):611-615.   Published online June 30, 1983
Bartter’s syndrome is rare disease which is characterised by hypokalemic, hypochloremic metabolic alkalosis, hyperreninemia, secondary aldosteronism, hyperplasia of juxtaglomerular apparatus without hypertension. We had experienced a case of Barker's syndrome in 4 months old girl. The diagnosis was made by clinical, hematologic, and biochemical studies. Literatures are reviewed briefly
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