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Review Article
Metabolic complications of obesity in children and adolescents
Hyunjin Park, Jung Eun Choi, Seunghee Jun, Hyelim Lee, Hae Soon Kim, Hye Ah Lee, Hyesook Park
Early-onset obesity, which carries a high risk of metabolic complications, may contribute to a lower age at the onset of cardiovascular disease. As metabolic diseases such as diabetes, dyslipidemia, and nonalcoholic fatty liver disease observed in adulthood are increasingly recognized in the pediatric population, there is an emphasis on moving disease susceptibility assessments from adulthood to childhood to enable early...
DOI: https://doi.org/10.3345/cep.2023.00892    [Epub ahead of print]
Editorial
Endocrinology
Simple universal cutoff point of waist-height ratio for metabolic risk in Korean children and adolescents
Hae Soon Kim
Clin Exp Pediatr. 2019;62(7):257-258.   Published online March 28, 2019
Original Article
Endocrinology
The serum level of 25-hydroxyvitamin D for maximal suppression of parathyroid hormone in children: the relationship between 25-hydroxyvitamin D and parathyroid hormone
Jung In Kang, Yoon Suk Lee, Ye Jin Han, Kyoung Ae Kong, Hae Soon Kim
Clin Exp Pediatr. 2017;60(2):45-49.   Published online February 27, 2017
Purpose

Serum level of 25-hydroxyvitamin D (25-OHD) is considered as the most appropriate marker of vitamin D status. However, only a few studies have investigated the relationship between 25-OHD and parathyroid hormone (PTH) in children. To this end, this study was aimed at evaluating the lowest 25-OHD level that suppresses the production of parathyroid hormone in children.

Methods

A retrospective record review was...

Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease
Han Seul Choi, Seul Bee Lee, Jung Hyun Kwon, Hae Soon Kim, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2015;58(10):374-379.   Published online October 21, 2015
Purpose

Incomplete Kawasaki disease (KD) is frequently associated with delayed diagnosis and treatment. Delayed diagnosis leads to increasing risk of coronary artery aneurysm. Anterior uveitis is an important ocular sign of KD. The purpose of this study was to assess differences in laboratory findings, including echocardiographic measurements, clinical characteristics such as fever duration and treatment responses between KD patients with and...

Clinical characteristics and serum N-terminal pro-brain natriuretic peptide as a diagnostic marker of Kawasaki disease in infants younger than 3 months of age
Hyun Kyung Bae, Do Kyung Lee, Jung Hyun Kwon, Hae Soon Kim, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2014;57(8):357-362.   Published online August 25, 2014
Purpose

The incidence of Kawasaki disease (KD) is rare in young infants (less than 3 months of age), who present with only a few symptoms that fulfill the clinical diagnostic criteria. The diagnosis for KD can therefore be delayed, leading to a high risk of cardiac complications. We examined the clinical characteristics and measured the serum levels of N-terminal pro-brain natriuretic...

An inhibitory effect of tumor necrosis factor-alpha antagonist to gene expression in monocrotaline-induced pulmonary hypertensive rats model
Jung Hyun Kwon, Kwan Chang Kim, Min-Sun Cho, Hae Soon Kim, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2013;56(3):116-124.   Published online March 18, 2013
Purpose

Tumor necrosis factor (TNF)-α is thought to contribute to pulmonary hypertension. We aimed to investigate the effect of infliximab (TNF-α antagonist) treatment on pathologic findings and gene expression in a monocrotaline-induced pulmonary hypertension rat model.

Methods

Six-week-old male Sprague-Dawley rats were allocated to 3 groups: control (C), single subcutaneous injection of normal saline (0.1 mL/kg); monocrotaline (M), single subcutaneous injection of monocrotaline...

Clinical characteristics of obese boys and girls in a high school: focused on abdominal fat indices, fatty liver and carotid intima-media thickness
Jung Eun Oh, Jiyoung Jung, Hae Soon Kim, Young Mi Hong, Jung Hyun Yoo, Young Whan Song, Jo Won Jung, Nam Su Kim, Chung Il Noh
Clin Exp Pediatr. 2011;54(7):292-297.   Published online July 31, 2011
Purpose

Our study aimed to evaluated sex differences in clinical features of obese high school students.

Methods

One hundred three obese high school students (body mass index [BMI]≥85th percentile) and 51 control students (BMI<85th percentile) were enrolled in this study. Anthropometric measurements were performed. Fasting serum glucose, insulin, aspartate aminotransferase, alanine aminotransferase, total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C),...

Mycoplasma pneumoniae infection in patients with Kawasaki disease
Mi Na Lee, Jie Hae Cha, Hye Mi Ahn, Jeong Hyun Yoo, Hae Soon Kim, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2011;54(3):123-127.   Published online March 31, 2011
Purpose

Kawasaki disease (KD) is the main cause of acquired heart disease in children. In addition to cardiovascular involvement, many complications have been recognized in KD. However, respiratory complications have been rarely reported. We investigated the differences in clinical characteristics, laboratory findings, radiography findings, and echocardiography findings of Mycoplasma pneumoniae infection and other types of pneumonia in KD patients.

Methods

Among 358 patients...

Enterovirus 71-associated hand, foot and mouth diseases with neurologic symptoms, a university hospital experience in Korea, 2009
Hye Kyung Cho, Na Yong Lee, Hyunju Lee, Hae Soon Kim, Jeong Wan Seo, Young Mi Hong, Seung Joo Lee, Sun Wha Lee, Doo Sung Cheon, Ji Young Hong, Byung Hak Kang, Jong-Hyun Kim, Kyung-Hyo Kim
Clin Exp Pediatr. 2010;53(5):639-643.   Published online May 31, 2010
Purpose

Hand-foot-mouth disease (HFMD) is a common viral illness in children, which is usually mild and self-limiting. However, in recent epidemics of HFMD in Asia, enterovirus 71 (EV71) has been recognized as a causative agent with severe neurological symptoms with or without cardiopulmonary involvement. HFMD was epidemic in Korea in the spring of 2009. Severe cases with complications including death have...

Effects of a 12-week, school-based obesity management program on obese primary school children
Han Gyu Kim, Goh-woon Lim, Hae Soon Kim, Young Mi Hong,
Clin Exp Pediatr. 2010;53(3):335-340.   Published online March 15, 2010

Purpose:This study was designed to determine the effects of a school-based obesity-management program on obese primary school children. Methods:A total of 995 children (6–12 years old) in a primary school were screened in March 2008, and of those, 101 obese students (44 boys and 57 girls, body mass index (BMI) ≥95 percentile) were enrolled for a study group. The school-...
Metabolic syndrome in the overweight and obese adolescents and the impact of obesity on the cardiovascular system
Yong Mi Hong, Young Young Song, Hae Soon Kim, Hae Sook Park, Jung Hae Min, Jo Won Jung, Nam Soo Park, Chung Il Noh
Clin Exp Pediatr. 2009;52(10):1109-1118.   Published online October 15, 2009
Purpose : Metabolic syndrome (MS), characterized by obesity and insulin resistance, elicits risk factors such as hyperlipidemia, hypertension, and glucose intolerance with additive effects on atherosclerosis, leading to cardiovascular diseases. The purposes of this study were to evaluate the prevalence of MS among overweight and obese adolescents and to investigate the impact of obesity on the cardiovascular system. Methods : In...
Low T3 syndrome in Kawasaki disease: Relation to serum levels of tumor necrosis factor-α, interleukin-6 and NT-proBNP
Hye Kyung Cho, Jin A Sohn, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2009;52(2):234-241.   Published online February 15, 2009
Purpose : We investigated the relationship between thyroid hormone and serum tumor necrosis factor (TNF-α), interleukin (IL-6) and N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) in patients with Kawasaki disease (KD). Methods : Serum levels of thyroid hormone, TNF-α, IL-6, and NT-proBNP were measured in 52 KD patients in the acute and subacute phase and 10 patients with acute...
Bacterial meningitis in children experienced at a university hospital, 1993-2006
Sung Yoon Cho, Tae Yeon Kim, Hyunju Lee, Kyung Hyo Kim, Eun Sun Yoo, Hae Soon Kim, Eun Ae Park, Kyung Ha Ryu, Jeong Wan Seo, Sejung Sohn, Seung Joo Lee
Clin Exp Pediatr. 2008;51(10):1077-1084.   Published online October 15, 2008
Purpose : Despite the seriousness of bacterial meningitis in children, there is little information on the incidence, causative organisms, mortality rate and age distribution. We studied the frequency by age group and causal pathogens, and clinical characteristics in children with bacterial meningitis in the private sector in Korea. Methods : The medical records containing the data on bacterial meningitis patients...
Case Report
Kawasaki disease presenting as retropharyngeal abscess
Sung Yoon Cho, Hye Kyung Cho, Ky Young Cho, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2008;51(9):1023-1027.   Published online September 15, 2008
A group of patients with Kawasaki disease (KD) initially present with cervical lymphadenitis or deep neck infection. These unusual KD presentations lead to unnecessary antibiotic therapy or surgical intervention, thereby delaying intravenous immunoglobulin treatment and increasing the risk of coronary artery damage. We present four KD patients whose initial presentations mimicked a retropharyngeal abscess. Nonsuppurative cervical lymphadenitis or suspected neck...
Original Article
Clinical fetures of kawasaki disease in school-aged children
Eun Young Park, Ji Hye Kim, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2007;50(3):292-297.   Published online March 15, 2007
Purpose : Kawasaki disease (KD) rarely occurs in school-aged children. We clarified the characteristics of KD in this age group to provide tips for a high index of suspicion. Methods : Features of 38 patients with KD who were 7 years of age or older were retrospectively reviewed. Results : The incidence of the KD patients ≥7 years was 4.9 percent. The...
Review Article
Calcium and phosphate metabolism and disorders in the newborn
Hae Soon Kim
Clin Exp Pediatr. 2007;50(3):230-235.   Published online March 15, 2007
In the early neonatal period, the neonate is challenged by the loss of the placental calcium transport and manifests a quick transition, from an environment in which PTHrP plays an important role to a PTH- and 1,25-dihydroxyvitamin D-controlled neonatal milieu. Disturbances in mineral homeostasis are common in the neonatal period, especially in premature infants and infants who are hospitalized in...
Original Article
NT-pro BNP : A new diagnostic screening tool for Kawasaki disease
Hyunju Lee, Heejung Kim, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2006;49(5):539-544.   Published online May 15, 2006
Purpose : The purpose of this study was to determine whether N-terminal fragment of B-type natriuretic peptide(NT-proBNP) may be used to differentiate acute Kawasaki disease(KD) from other clinically similar diseases. Methods : Using electrochemiluminescence immunoassay, NT-proBNP concentrations were measured in the acute phase within 10 days after the onset of KD(n=58) and in the convalescent phase, 60 to 81 days after...
Benign Transient Hyperphosphatasemia of Infancy and Childhood
Jung Hyun Kwon, Ji Hye Park, Hae Soon Kim, Seung Joo Lee, Mi Ae Lee
Clin Exp Pediatr. 2005;48(3):306-309.   Published online March 15, 2005
Purpose : The aim of study is to investigate the clinical manifestations and the etiology of markedly-elevated serum alkaline phosphatase(ALP) levels in children without accompanying liver or bone disease. Methods : The serum ALP and other biochemical laboratory data of 4,989 patients attending the pediatric department of Ewha Womans University Mokdong Hospital between January 2002 to December 2002 were studied. The...
Clinical Characteristics of Recurrent Kawasaki Disease
Hyun Ji Lee, Ae Ra Cho, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2004;47(8):879-883.   Published online August 15, 2004
Purpose : The purpose of this study is to investigate the clinical manifestations and the risk factors of recurrent Kawasaki disease(KD). Methods : From March 1995 to June 2003, 14 children with recurrent KD in Ewha Womans University Hospital were retrospectively evaluated by reviewing their admission reports. The clinical characteristics, laboratory findings, treatment and complications of the recurrent KD group were...
Methylenetetrahydrofolate Reductase(MTHFR) Gene Expression in Kawasaki Disease
Hye Ryung Choi, Ae Ra Joo, Hae Soon Kim, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2004;47(7):774-778.   Published online July 15, 2004
Purpose : Hyperhomocysteinemia is known as an independent risk factor for cardiovascular diseases such as atherosclesosis and myocardiac infarct. A common mutation in 5, 10-methylenetetrahydrofolate reductase(MTHFR) gene results in a valine for alanine substitution, which makes enzyme thermolabile and reduces enzymal activity. We examined the relation of MTHFR genetic mutation and Kawasaki disease. Methods : We extracted DNA from the peripheral...
Safety and Efficacy of Early Treatment with Intravenous Immunoglobulin in Patients with Kawasaki Disease
Hyun Jin Kim, Hae Won Yom, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2003;46(10):1019-1023.   Published online October 15, 2003
Purpose : To determine the differences in clinical characteristics, blood chemistry and coronary artery complications between patients with Kawasaki disease who received intravenous immunoglobulin (IVIG) within the fourth day of illness and after the fifth day of illness. Methods : A retrospective chart review was conducted of all children with Kawasaki disease who were admitted to Ewha Mokdong Hospital between January...
A Follow-up Survey of Mothers' Antenatal Breast-feeding Plans
Hae Soon Kim, Jeong Wan Seo, Yong Joo Kim, Kee Hyoung Lee, Jae Young Kim, Jae Sung Ko, Sun Hwan Bae, Hye Sook Park
Clin Exp Pediatr. 2003;46(7):635-641.   Published online July 15, 2003
Purpose : To investigate the success rate and factors that influence breast-feeding among women having antenatal breast-feeding plans. Methods : Questionnaires included items on success in breast-feeding, reasons for failure and perinatal factors. It was done by telephone calls to 152 randomly selected women having antenatal breast-feeding plans at 4 months after delivery. The questionnaires were analysed by bivariate χ2-...
Clinical Characteristics of Kawasaki Disease in Infants Younger than 3 Months of Age
Soo Jeong Lee, So Jung Kim, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2003;46(6):591-596.   Published online June 15, 2003
Purpose : Kawasaki disease(KD) is rare in infants <3 months of age. In this younger group, the diagnosis may be delayed due to lack of most of the clinical criteria, resulting in a high risk of cardiac complications. We examined clinical characteristics in these patients for early recognition and treatment. Methods : We conducted a retrospective study on the infants...
Prognostic Value of Repeated Cerebrospinal Latex Agglutination Testing in Bacterial Meningitis
Soo Jeong Lee, So Hyun Ahn, Su Jin Cho, Hae Soon Kim, Seung Joo Lee
Clin Exp Pediatr. 2003;46(4):345-350.   Published online April 15, 2003
Purpose : Bacterial meningitis is a serious infection of childhood associated with a significant morbidity and mortality. Repeated cerebrospinal fluid(CSF) examination is a useful prognostic indicator and a delayed sterilization is associated with a higher incidence of neurologic abnormalities. In this study we tried to determine the prognostic value of repeated CSF latex agglutination testing. Methods : We retrospectively evaluated 19...
High-dose Intravenous Immune Globulin Retreatment in Kawasaki Disease
So Yun Shim, Mi Young Heo, Hae Soon Kim, Sejung Sonh
Clin Exp Pediatr. 2002;45(10):1273-1277.   Published online October 15, 2002
Purpose : To determine clinical features, laboratory findings and cardiac abnormalities of highdose immune globulin(IVIG) retreatment in patients with Kawasaki disease, and to report effectiveness of retreatment. Methods : Retrospective study of 174 children diagnosed with Kawasaki disease at Ewha Mokdong hospital from March, 1999 to July, 2001. Results : Twenty(11.5%) of 174 patients were retreated with high-dose IVIG. After this, only two patients(1.1%) did not...
A Survey on the Understanding of Breast-feeding in Pregnant Woman
Jeong Wan Seo, Yong Joo Kim, Kee Hyoung Lee, Jae Young Kim, Jay G Sim, Hae Soon Kim, Jae Sung Ko, Sun Hwan Bae, Hye Sook Park, Beom Soo Park
Clin Exp Pediatr. 2002;45(5):575-587.   Published online May 15, 2002
Purpose : To investigate the understanding of breast-feeding in pregnant woman and the proper way of encouraging breast-feeding. Methods : Each questionnaire included items about demographic characteristics and the understanding of breast-feeding. The questionnaires were filled up by pregnant women visiting obstetric clinics in Seoul and its vicinities, Busan, Choongjoo and Chungjoo from July 2001 to August 2001. One thousand, two...
A Clinical Manifestation of Meckel's Diverticulum
Jin Beom Lee, Yong Soon Lee, Eun Sun Yoo, Hae Soon Kim, Se Jeong Son, Eun Ae Park, Seung Joo Lee, Sun Hee Sung, Jeong Wan Seo
Clin Exp Pediatr. 2002;45(4):466-472.   Published online April 15, 2002
Purpose : The diagnosis of Meckel's diverticulum is difficult and delayed because it presents with various clinical symptoms. We evaluated clinical, imaging and pathologic findings of Meckel's diverticulum to facilitate detection of Meckel's diverticulum in children. Methods : Review of clinical, imaging, surgical and pathological findings in 10 children aged 7 days to 14 years with Meckel's diverticulum during an 8-year...
Case Report
A Case of Bilateral Spontaneous Tension Pneumothorax Associated with Mycoplasma pneumoniae Infection
Jae Won Lee, Mi Young Heo, Hae Soon Kim, Seung Joo Lee
Clin Exp Pediatr. 2002;45(3):401-405.   Published online March 15, 2002
Mycoplasma pneumoniae(M. pneumoniae) is the leading cause of pneumonia in school-age children and young adults. The clinical courses are usually mild but recently, severe cases were reported such as lung abscess, Swyer-James syndrome and adult respiratory distress syndrome. Spontaneous pneumothorax associated with M. pneumoniae infection is rare. Carlisle reported a 6-year-old patient with bilateral spontaneous pneumothorax associated with M. pneumoniae...
Original Article
Clinical Features of Atypical Kawasaki Disease
Mi Young Heo, Su Jung Choi, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2002;45(3):376-382.   Published online March 15, 2002
Purpose : To identify clinical and laboratory features of atypical Kawasaki disease(KD), and to develop criteria for early diagnosis of atypical KD patients. Methods : All patients with KD treated at our hospital from January 1998 to June 2000 were reviewed retrospectively. Results : Among a total of 167 patients, 28(16.8%) were atypical KD of which seven(25%) were infants. Among the...
Oscillometric Blood Pressure of Upper and Lower Extremities and Aortic Blood Flow Velocity in Neonates
Sang Young Bae, Hae Soon Kim, Se Jung Sohn, Young Mi Hong
Clin Exp Pediatr. 2000;43(4):484-488.   Published online April 15, 2000
Purpose : We studied the blood pressure difference between the upper and lower extremities in healthy newborn infants and the effect of isthmic narrowing of the aorta on making a possible difference. Methods : The blood pressure was measured with an oscillometric blood pressure device from four extremities of 62 healthy infants aged 1-15 days. A Doppler echocardiography was performed for...
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