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Case Report
PHACE association with intracranial, oropharyngeal hemangiomas, and an atypical patent ductus arteriosus arising from the tortuous left subclavian artery in a premature infant
Do-Hyun Kim, Jang Hwan Choi, Jung Ha Lee, Hee Sup Kim
Clin Exp Pediatr. 2012;55(1):29-33.   Published online January 31, 2012

PHACE association is a rare neurocutaneous condition in which facial hemangiomas associate with a spectrum of posterior fossa malformations, arterial cerebrovascular anomalies, cardiovascular anomalies, and eye anomalies. We reported a case of PHACE association in a premature infant showing facial, intracranial, and oropharyngeal hemangiomas with evidence of the Dandy-Walker variant and complicated cardiovascular anomalies, including a right-sided aortic arch and...

Original Article
Influence of histologic chorioamnionitis and funisitis on the level of peripheral blood C-reactive protein at birth in preterm infants
Do-Hyun Kim, Heun Ji Lee, Hee Sup Kim, Byoung Hoon Yoo
Clin Exp Pediatr. 2010;53(1):33-40.   Published online January 15, 2010
Purpose : The objective of this study is to determine the change of C-reactive protein (CRP) levels in the peripheral blood of preterm infants at birth according to the stage of intrauterine inflammation. Methods : A total of 187 infants (<32 weeks of gestation) were divided into a “no histologic chorioamnionitis” [HCAM (-), n=85] group and a “histologic chorioamnionitis” [HCAM...
Difference in the Transcriptional Activity of the Interleukin-4 Promoter Haplotypes
Eun Hwa Choi, Hee Sup Kim, Stephen J. Chanock, Hoan Jong Lee
Clin Exp Pediatr. 2005;48(5):495-499.   Published online May 15, 2005
Purpose : Interleukin-4(IL-4) is a critical component of the Th2 cytokine pathway and contributes to severity of respiratory syncytial virus(RSV) bronchiolitis. Previous studies observed an association between severe RSV bronchiolitis in Korean children with a common haplotype of the IL4 promoter. This study was performed to investigate functional differences of the variant IL4 promoter haplotypes. Methods : Genomic DNA was obtained...
Clinical and Endoscopic Findings in Children with Duodenal Ulcer due to Helicobacter pylori Infection
Hwa Jung Kim, Hae Jeong Han, Sang Gil An, Ji Sook Yoo, Hee Sup Kim, Hann Tchah, Ho Jin Park, Mi Kyoung Shin
Clin Exp Pediatr. 1999;42(1):69-76.   Published online January 15, 1999
Purpose : Recently, a wide application of gastrofiberoscopy in pediatrics has revealed that the incidence of peptic ulcer has increased in the past years, and various results were reported about the relationship between duodenal ulcer and H. pylori. The aim of this retrospective study is to investigate the role of H. pylori in duodenal ulcers in children and to help diagnose and treat duodenal...
Case Report
A Case of Alagille Syndrome
Eun Kyung Hwang, Gwang Hoon Lee, Eell Ryoo, Kang Ho Cho, Gil Hyun Kim, Hak Soo Lee, Ji Hye Kim, Sung Hae Park, Hee Sup Kim
Clin Exp Pediatr. 1998;41(3):410-414.   Published online March 15, 1998
Alagille syndrome is characterized by chronic cholestasis, posterior embryotoxon, skeletal abnormalities, cardiovascular abnormalities, and a typical face with prominent forehead and pointed chin. Its histological feature includes paucity of interlobular bile ducts. We experienced a 49-day-old female infant presenting with frequent upper respiratory tract infection and persistent jaundice. She had a typical face and chronic cholestasis. Echocardiograms revealed peripheral pulmonary...
Original Article
Endoscopic Removal of Foreign Bodies in Upper GI Tract in Children
Hae Jung Han, Sang Gil An, Yong Min Chung, Hee Sup Kim, Hann Tchah, Ho Jin Park
Clin Exp Pediatr. 1997;40(11):1552-1558.   Published online November 15, 1997
Purpose : The foreing bodies in the upper GI tract are chiefly caused by accidental swallowing and rarely provoke symptoms. It is recommended to remove the foreign bodies if they produce symptoms or remain in GI tract for long duration or complications are expected to bring about. Nowadays the development of pediatric therapeutic endoscopy enables the removal of the foreign bodies in upper GI tract...
Measles Hepatitis in Children
Sang Gil An, Ji Eun Wuon, Ki Moon Cha, Yong Min Chung, Hee Sup Kim, Hann Tchah, Ho Jin Park
Clin Exp Pediatr. 1996;39(10):1371-1377.   Published online October 15, 1996
Purpose : Measlesinfection in children hasbeen known to havemany complications including hepatitis. But there has been no appropriate study about measles hepatitis in children. So we studied to facilitate the understanding of measles hepatitis in children by analyzing their clinical features and laboratory findings. Methods : We investigated 164 patients who were admitted to the Department of Pediatrics, Seoul Red Cross Hospital due to measles...
Prospective, Controlled Trial with Dipheny1-dimethy1-dicarboxylate in Children with Chronic Liver Diseses : The Effect on Lowering Serum Aminotransferase Levels
Ji Eun Wunon, Sang Gil An, Ki Moon Cha, Yong Min Chung, Hee Sup Kim, Hann Tchah, Ho Jin Park
Clin Exp Pediatr. 1995;38(10):1378-1383.   Published online October 15, 1995
Purpose : The prospective cotrolled study was performed to identify the effect of the dipheny1-dimethy1-dicarboxylate(PMC) on lowering serum transaminases in children with chronic liver diseases. Methods : The twenty patients were paticipated in this study who were followed up in the Department of Pediatrics of the Seoul Red Cross Hospital because of the elevated levels of serum alaine aminotransferase(ALT) and aspartate...
Doxapram in the Treatment of Idiopathic Apnea of Prematurity Unresponsive to Aminophylline
Jung Hoon Park, Hee Sup Kim, Sang Hee Kim, Gil Hyun Kim, Hak Soo Lee
Clin Exp Pediatr. 1995;38(8):1046-1053.   Published online August 15, 1995
Purpose : Recurrent apnea of prematurity is a very common and troublesome problem despite treatment with aminophylline, and is often associated with a poor developmental outcome. Recently doxapram, a potent respiratory stimulant in adults, has been used to overcome idiopathic apnea of prematurity. This study was to evaluate the efficacy, safety and optimal dosage of doxapram in idiopathic apnea refractory to aminophylline. Methods...
Periventricular-Intraventricular Hemorrhage in the Full-term Infant
Hee Sup Kim, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun, In One Kim
Clin Exp Pediatr. 1994;37(5):642-648.   Published online May 15, 1994
Intraventricular hemorrhage (IVH) is common in the premature infants and occurs mainly in subependymal germinal matrix. In contrast, IVH in the term infants is rare and different in pathogenesis and bleeding sites from those of the premature infants. Most studies of IVH in term infants have been studied by computerized tomography and postmortem examination. Brain ultrasonography which has become a...
Comparison between Preterm and Fullterm infants in Neonatal Sepsis
Sung Hee Kim, Kum Hee Hur, Hee Sup Kim, Myoung Jae Chey, Kil Hyoun Kim, Hak Soo Lee
Clin Exp Pediatr. 1993;36(11):1542-1554.   Published online November 15, 1993
We retrospectively evaluated datas on 61 cases of neonatal sepsis confirmed by clinical symptoms and blood cultures at the NICU of Gil General Hospital From Mar. 1989, to Reb. 1992. The result obtained were as follows : 1) The mean gestational age was 32.7±2.6 weeks in preterm infants, and 39±1.5weeks on term infants. The mean birth weight was 1,701.4±422.4g in preterm infants,...
Case Report
Transfusion-Acquired Cytomegalovirus Infections in Two Premature Infants
Dong Wook Kim, Kyung Un No, Mi Jung Kim, Soon Mee Park, Hee Sup Kim, Young Pyo Chang, Hoan Jong Lee, Jung-Hwan Choi, Chong Ku Yun, Je Geun Chi
Clin Exp Pediatr. 1992;35(8):1141-1147.   Published online August 15, 1992
Transfusion-acquired perinatal cytomegalovirus (CMV) infection can cause significant morbidity and mortality, particularly in premature infants with a birth wight of less than 1,500 gm. This recognizable syndrome consisted of deterioration of respiratory function, hepatosplenogaly, unusual gray pallor with disturbing septic appearance, lymphocytosis, thrombocytopenia and hemolytic anemia. We experienced transfusion-acquired CMV infections in 2 premature infants with a birth weight of...
Original Article
An Experience of High Dose Intravenous Immunoglobulin Therapy in Refractory Evans Syndrome.
Hee Sup Kim, Won Sup Shin, Sang Il Lee, Sang Woo Kim
Clin Exp Pediatr. 1990;33(5):701-707.   Published online May 31, 1990
Evans syndrome, a combination of autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura, relapses freguently and is refractory to conventional treatment such as corticosteroid, immunosuppressive agents, splenectomy and plasma exchange. Recently Oda et al applied high dose immunoglobulin (400/kg/day for 4 days repeated 2 weeks later) to 5 month-old infant with refractory Evans syndrome, and was successful in maintaining remission for five years and nine...
The Effect of Infantile Eczema on the Development of Allergic Diseases.
Hee Sup Kim, Chang Sung Lee, Sung Hwan Kim, Sang Il Lee, Sung Jae Suh, Pyung Nam Kim
Clin Exp Pediatr. 1989;32(6):834-838.   Published online June 30, 1989
For the evaluation of the correlation between infantile eczema and other allergic disorders in childhood, we performed the study which included questionnaire and allergic skin test, in July through August, 1987. Eight hundred and thirty three students were selected randomly from the middle class in Seoul. All the materials were grouped into four; early primary school group (6-8 years of age; EPSG), late primary...
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