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Original Article
Change of coronary artery indices according to coronary dominance pattern in early childhood
Yoon jin Lee, Kyoung Soo Park, Hong Ryang Kil
Clin Exp Pediatr. 2019;62(6):240-243.   Published online November 22, 2018

Purpose: Coronary arterial lesion assessment in children can be difficult, depending on the coronary dominance pattern. Although it is easier to determine coronary dominance with echocardiography in children than in adults, it is still difficult. This study aimed to examine the coronary dominance pattern according to the objective coronary artery (CA) indices. Methods: The CA diameter, aortic valve annulus, and abdominal...
The outcome of short-term low-dose aspirin treatment in Kawasaki disease based on inflammatory markers
Jae Won Yoo, Ji Mok Kim, Hong Ryang Kil
Clin Exp Pediatr. 2017;60(1):24-29.   Published online January 24, 2017

Previously, Kawasaki disease (KD) treatment with low-dose aspirin was administered for 6–8 weeks after the acute phase. However, inflammatory marker levels normalize before 6–8 weeks. In this study, we aimed to investigate the clinical outcome of short-term low-dose aspirin treatment based on inflammatory and thrombotic marker levels.


We performed a retrospective review of the medical records of patients with KD who...

Clinical outcome of patients with refractory Kawasaki disease based on treatment modalities
Hyun Jung Kim, Hyo Eun Lee, Jae Won Yu, Hong Ryang Kil
Clin Exp Pediatr. 2016;59(8):328-334.   Published online August 24, 2016

Although a significant number of reports on new therapeutic options for refractory Kawasaki disease (KD) such as steroid, infliximab, or repeated intravenous immunoglobulin (IVIG) are available, their effectiveness in reducing the prevalence of coronary artery lesions (CAL) remains controversial. This study aimed to define the clinical characteristics of patients with refractory KD and to assess the effects of adjuvant therapy...

Correlation between the morning hypertension on ambulatory blood pressure monitoring and the left ventricular mass in children
Hyun Jung Kim, Kyung Hee Kim, Hong Ryang Kil
Clin Exp Pediatr. 2014;57(9):403-409.   Published online September 30, 2014

Although high morning blood pressure (BP) is known to be associated with the onset of cardiovascular events in adults, data on its effects in children with hypertension are limited. Our retrospective study aimed to define the clinical characteristics of children with morning hypertension (MH) and to determine its associated factors.


We reviewed 31 consecutive patients with hypertension, confirmed by the ambulatory...

Cardiovascular risk factors of early atherosclerosis in school-aged children after Kawasaki disease
Hyun Jeong Cho, Soo In Yang, Kyung Hee Kim, Jee Na Kim, Hong Ryang Kil
Clin Exp Pediatr. 2014;57(5):217-221.   Published online May 31, 2014

The aim of this study was to determine whether school-aged children with Kawasaki disease (KD) have an increased risk for early atherosclerosis.


The study included 98 children. The children were divided into the following groups: group A (n=19), KD with coronary arterial lesions that persisted or regressed; group B (n=49), KD without coronary arterial lesions; and group C (n=30), healthy children....

Changes of clinical characteristics and outcomes in patients with Kawasaki disease over the past 7 years in a single center study
Hye Jin Kang, Gee Na Kim, Hong Ryang Kil
Clin Exp Pediatr. 2013;56(9):389-395.   Published online September 30, 2013

This single-center study was conducted to assess the changes in epidemiological and clinical characteristics and outcomes of patients with Kawasaki disease (KD) over the past 7 years.


This retrospective study included 135 children with KD, admitted to Chungnam National University Hospital, Daejeon, between 2004 and 2005 (group A, n=53) and between 2011 and 2012 (group B, n=82). Medical records were reviewed...

Clinical outcome of acute myocarditis in children according to treatment modalities
Hyun Jung Kim, Gyeong-Hee Yoo, Hong Ryang Kil
Clin Exp Pediatr. 2010;53(7):745-752.   Published online July 31, 2010

There is currently little evidence to support intravenous immune globulin (IVIG) therapy for pediatric myocarditis. The purpose of our retrospective study was to assess the effects of IVIG therapy in patients with presumed myocarditis on survival and recovery of ventricular function and to determine the factors associated with its poor outcome.


We reviewed all consecutive cases of patients with myocarditis with...

Clinical significance of the mechanical properties of the abdominal aorta in Kawasaki disease
Mi Jin Kim, Mi Jin Kim, Sang Yun Lee, Sang Yun Lee, Yong Bum Kim, Yong Bum Kim, Hong Ryang Kil, Hong Ryang Kil
Clin Exp Pediatr. 2008;51(9):1012-1017.   Published online September 15, 2008
Purpose : This study aimed to assess the mechanical properties of the abdominal aorta in school-aged patients treated for Kawasaki disease and in normal, healthy children. Methods : This study examined 28 children with Kawasaki disease who had been followed up on and 30 healthy subjects of the same age and gender. We recorded systolic (Ps) and diastolic (Pd) blood pressure...
Change of hemostatic markers according to the clinical state in Kawasaki disease
Yong Beom Kim, You Sook Yoon, Sang Yun Lee, Hong Ryang Kil
Clin Exp Pediatr. 2007;50(12):1247-1251.   Published online December 15, 2007
Purpose : Pathologically, Kawasaki disease (KD) is associated with widespread vascular endothelial damage in the acute phase. The vasculitis induced endothelial injury leads to coagulation abnormalities. Abnormalities of endothelial function, platelet activation, and fibrinolysis are present during acute phase and long after the onset of KD. The aim of study is to evaluate the change of hemostatic markers in the...
Review Article
The myocarditis and cardiomyopathy in children
Hong Ryang Kil
Clin Exp Pediatr. 2007;50(11):1049-1054.   Published online November 15, 2007
Myocarditis represent an important condition encountered by general pediatricians & general practitioners. Its presentation is varied, and therefore a high index of suspicion must be maintained when the possibility of myocarditis is raised. A progression from viral myocarditis to dilated cardiomyopathy has long been hypothesized. Treatment is initially aimed at achieving hemodynamic stability and is largely supportive. There is currently...
Original Article
Prenatal diagnosis and clinical course of restrictive foramen ovale in otherwise normal heart
Ji Joung Lee, Min A Lee, Yun ee Rhee, Mea Young Chang, Hong Ryang Kil
Clin Exp Pediatr. 2007;50(3):268-271.   Published online March 15, 2007
Purpose : Premature narrowing of the foramen ovale is rare but serious clinical entity. Prenatal narrowing or obstruction of the foramen ovale shows symptoms such as right heart failure, fetal hydrops, triscupid regurgitation, left heart obstructive disease, and supraventricular tachycardia. This study aimed to assess the prenatal diagnosis and postnatal clinical course of restrictive foramen ovale in utero in otherwise...
Case Report
Intervention with Balloon Valvuloplasty followed by Patent Ductus Arteriosus Stent in a Patient with Pulmonary Atresia with Intact Ventricular Septum
Han Hyuk Lim, Young Deuk Kim, Jae Hwan Lee, Mea Young Chang, Hong Ryang Kil
Clin Exp Pediatr. 2005;48(11):1256-1259.   Published online November 15, 2005
Pulmonary atresia with intact ventricular septum (PAIVS) is rare, less than 1% of congenital heart disease. It needs a therapeutic approach according to its individual morphologic feature. Surgical treatment of valvotomy and modified Blalock-Taussig shunt or non-surgical interventional catheter balloon valvuloplasty can be used for mild to moderate hypoplasia of right ventricle. Fontan operation can be considered for less optimum...
Transcatheter Closure of a Residual Shunt after Surgical Repair of Traumatic Ventricular Septal Defect
Hee Jeong Jeong, Han Hyuk Lim, Jae Hyun Yu, Jae Hwan Lee, Hong Ryang Kil
Clin Exp Pediatr. 2005;48(10):1143-1147.   Published online October 15, 2005
The traumatic ventricular septal defect (VSD) is a rare but potentially life threatening complication of chest wall injury. The traumatic VSD occurs in up to 4.5% of penetrating cardiac trauma. Most of the patients are usually operated on because of heart failure and/or significant left-to-right shunt. The feasibility of surgical repair under cardiopulmonary bypass may be affected by coexisting pulmonary,...
Original Article
Clinical Characteristics of Infant Kawasaki Disease
Yeun Keun Choi, Jung Min Hong, Su Mi Ihn, Hae Kyeung Lim, Hong Ryang Kil
Clin Exp Pediatr. 2002;45(1):109-113.   Published online January 15, 2002
Purpose : To assess the incidence of coronary artery lesion(CAL) and the efficacy of intravenously administered immune globulin(IVGG) and aspirin therapy, identify risk factors for CAL, and analyze clinical characteristics in infants less than 12 months of age with Kawasaki disease. Methods : Retrospective chart review of children less than 12 months of age with Kawasaki disease between 1994 and 1998, diagnosed at Chungnam...
Case Report
Two Cases of Growth Hormone Therapy in Idiopathic Dilated Cardiomyopath
Jeong Won Shin, Hong Ryang Kil, Jae Hong Yu
Clin Exp Pediatr. 2001;44(8):942-947.   Published online August 15, 2001
Growth hormone receptor gene is expressed in the myocardium and growth hormone(GH) administration has been shown to increase cardiac insulin-like growth factor-I(IGF-1) contents. The cardiac myocyte express IGF-I receptors and IGF-I promotes cardiac hypertrophy. Furthermore GH therapy has been reported to have beneficial effects in the treatment of dilated cardiomyopathy in adults. We have studied the effect of short term...
Original Article
22q11 Microdeletion and Clinico-Genetic Correlation in CATCH 22 Syndrome
Hong Ryang Kil, Young Ha Lee, Yong Hun Chung, Yong Hun Chung
Clin Exp Pediatr. 2000;43(12):1536-1544.   Published online December 15, 2000
Purpose : Deletion of chromosome 22q11 is associated with DiGeorge syndrome, velocardiofacial syndrome, and conotruncal anomaly face syndrome. This study was performed to determine the criteria of clinical phenotype as recognizable syndrome and to research the loss of heterozygosity in CATCH 22 patients and their family. Methods : An evaluation of the clinical and genetic profiles of 30 persons of CATCH...
Immunologic Characteristics of CATCH 22 Syndrome
Hye Young Ryu, Eun Kyung Jo, Eun Jung Cheon, Hong Ryang Kil, Jae Ho Lee
Clin Exp Pediatr. 2000;43(11):1423-1429.   Published online November 15, 2000
Purpose : Microdeletion of chromosome 22q11.2 are associated with DiGeorge syndrome(DGS), velocardiofacial syndrome(VCFS) and conotruncal anomaly face syndrome(CTAFS). DGS was originally described as an immunodeficiency disorder secondary to impaired T cell production due to thymic aplasia or hypoplasia. But the frequency & severity of immunodeficiency of other clinical syndromes associated with the chromosome 22q11 deletion has not been investigated. This...
Selective Gamma Globulin Treatment in Kawasaki Disease : The Comparison between Single 1g/kg and 2g/kg
Su Mi Ihn, Ren Zhe Ann, Hong Ryang Kil, Young Hun Chung
Clin Exp Pediatr. 2000;43(7):920-925.   Published online July 15, 2000
Purpose : Treatment of Kawasaki disease with intravenous gamma globulin(IVGG), together with aspirin, has been demonstrated to be safe and effective in preventing coronary artery lesion and systemic inflammation, but optimal IVGG dosage and administration method are still controversial. We compared the therapeutic efficacy and clinical response of single IVGG 1g/kg to that of IVGG 2g/kg for comparable risk group of Kawasaki disease. Methods :...
Intermediate Term Follow-up Results of Hypertrophic Cardiomyopathy in Children
Eun Jung Cheon, Chung Il Noh, Jae Young Lee, Sun Sung Park, Myung Ja Yun, Hong Ryang Kil, Ho Sung Kim, Jung Yun Choi, Yong Soo Yun
Clin Exp Pediatr. 1997;40(5):641-649.   Published online May 15, 1997
Purpose : Hypertrophic cardiomyopathy(HCMP) is a primary cardiac muscular disease with high risk of sudden cardiac death. This study is performed to understand the clinical features of children with HCMP. Methods : Retrospective analysis of the medical records of the patients diagnosed at Seoul National University Children's Hospital between October 1985 and June 1996 was done. Excluded the patients who had...
A Study on Clinical Application of Harada's Scoring Method to Kawasaki Disease - Suggesting the revision of the criteria for IVGG treatment of KD in Korea -
Byoung Kil Han, Hyong Shin Lee, Hong Ryang Kil, Heon-Seok Han, Jae Ho Lee, Young Hun Chung
Clin Exp Pediatr. 1997;40(4):539-548.   Published online April 15, 1997
Purpose : We performed a study on clinical benefits of Harada's scoring method, problems of present criteria and requirement of the revision of that criteria for intrvenos γ-globulin(IVGG) treatment of Kawasaki disease(KD) in Korea. Methods : The patients of 104 cases who visited to Department of Pediatrics of Chungnam National University Hospital and diagnosed as KD were objective group. We classified the...
A Study on Red Cell Distribution Width of Iron Deficiency Anemia in Childhood.
Hong Ryang Kil, Young Hun Chung
Clin Exp Pediatr. 1988;31(10):1321-1327.   Published online October 31, 1988
A hematologic study was undertaken on 60 cases of control group and 53 cases of iron deficiency anemia group who visited the outpatient department of Pediatrics, Chungnam National University Hospital from January, 1984 to July, 1987 The results were as follows: 1) In 60 cases of control group between 1 to 15 year, hemoglobin was 12.5±1.7 gm/dl, MCV 82.4± 3.8 fl, and RDW 13.1 ±1.1% and...
A Case of Mediastinal Gastroenteric Cyst.
Hong Ryang kil, Hye Suk Hong, Yang Won Lee, Jong Jin Seo, Young hun Chung, Seung Pyung Lim
Clin Exp Pediatr. 1988;31(7):924-929.   Published online July 31, 1988
Among heterogenous group of developmental anomalies known as enteric duplication, mediastinal gastroenteric cysts are rare and of outstanding diagnostic importance, because without definitive treatment they can be fatal. Unlike other mediastinal cysts they are almost never asymtomatic. The authors experienced a case of mediastinal gastroenteric cyst in 1 year 7 month-old female patient with chief complaint of abnormal mass density in chest X-ray. The...
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