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Review Article
The role of cytokines in seizures: interleukin (IL)-1β, IL-1Ra, IL-8, and IL-10
Youngah Youn, In Kyung Sung, In Goo Lee
Clin Exp Pediatr. 2013;56(7):271-274.   Published online July 19, 2013

Brain insults, including neurotrauma, infection, and perinatal injuries such as hypoxic ischemic encephalopathy, generate inflammation in the brain. These inflammatory cascades induce a wide spectrum of cytokines, which can cause neuron degeneration, have neurotoxic effects on brain tissue, and lead to the development of seizures, even if they are subclinical and occur at birth. Cytokines are secreted by the glial...

Original Article
Parental concerns about their premature infants' health after discharge from the neonatal intensive care unit: a questionnaire survey for anticipated guidance in a neonatal follow-up clinic
Ji-Yun Cho, Juyoung Lee, Young Ah Youn, Soon Ju Kim, So Young Kim, In Kyung Sung
Clin Exp Pediatr. 2012;55(8):272-279.   Published online August 23, 2012

The aim of this study was to develop an appropriate nursing information guideline according to corrected age, after investigating parents' concerns about the growth, development, and diseases of their premature infants after discharge from the neonatal intensive care unit (NICU).


The parents of premature infants (birth weight, <2,500 g; gestational age, <37 weeks) who went to a neonatal follow-up clinic after...

The current child and adolescent health screening system: an assessment and proposal for an early and periodic check-up program
Baik-Lin Eun, Jin Soo Moon, So-Hee Eun, Hea Kyoung Lee, Son Moon Shin, In Kyung Sung, Hee Jung Chung
Clin Exp Pediatr. 2010;53(3):300-306.   Published online March 15, 2010
Purpose : Recent changes in the population structure of Korea, such as rapid decline in birth rate and exponential increase in old-aged people, prompted us to prepare a new health improvement program in children and adolescents. Methods : We reviewed current health screenings applied for children and adolescents in Korea and other developed countries. We collected and reviewed population-based data...
Review Article
Neurodevelopmental outcomes of very low birth weight infants and extremely low birth weight infants in Korea, 1984-2008
In Kyung Sung
Clin Exp Pediatr. 2009;52(1):14-21.   Published online January 15, 2009
Neurodevelopmental outcomes of very low birth weight infants (VLBWI) and extremely low birth weight infants (ELBWI) in Korea on 14 reports from 1984 to 2008 were analyzed. Follow-up rates were varied from 42.9% to 90.2%. Duration of follow-up ranged from 4 months to 5 years. The prevalence of cerebral palsy (CP) of VLBWI was as follows: 4.3-5.3% in 1980s, 7.1-9.1...
Pediatric approach to early detection of learning disabilities
In Kyung Sung
Clin Exp Pediatr. 2008;51(9):911-921.   Published online September 15, 2008
Learning disabilities (LD) are heterogeneous group of disorders with evidences of genetic or familial trait, intrinsic to the individual and presume to be due to central nervous dysfunction. Learning disabilities and attention deficit hyperactivity disorder (ADHD) are the two of the most common disorders in the population of school-age children. Typically academic achievements in children with learning disabilities are significantly...
Overview of the national health screening program for infant and children
Baik-Lin Eun, Seong Woo Kim, Young Key Kim, Jung Wook Kim, Jin Soo Moon, Su Kyung Park, In Kyung Sung, Son Moon Shin, Sun Mi Yoo, So Hee Eun, Hea Kyoung Lee, Hyun Taek Lim, Hee Jung Chung
Clin Exp Pediatr. 2008;51(3):225-232.   Published online March 15, 2008
The mission of National Health Screening Program for Infant and Children is to promote and improve the health, education, and well-being of infants, children, families, and communities. Although the term 'diagnosis' usually relates to pathology, a similar diagnostic approach applies to the child seen primarily for health supervision. In the case of health, diagnosis determines the selection of appropriate health...
Original Article
The ages and stages questionnaire: screening for developmental delay in the setting of a pediatric outpatient clinic
Eun Young Kim, In Kyung Sung
Clin Exp Pediatr. 2007;50(11):1061-1066.   Published online November 15, 2007
Purpose : Early identification of developmental disabilities allows intervention at the earliest possible point to improve the developmental potential. The Ages and Stages Questionnaire (ASQ), a parent- completed questionnaire, can be used as a substitute for formal screening tests. The purpose of this study was to evaluate the validity of the Korean version of the ASQ (K-ASQ) as a screening...
A review of the contents about childhood health care in middle & high school textbooks
Jung Hun Kim, Sung Won Park, Son Moon Shin, In Kyung Sung, Mi Jung Park, Yoo Mi Chung, Jeong Hun Ha
Clin Exp Pediatr. 2007;50(4):340-347.   Published online April 15, 2007
Purpose : The purpose of this study is to investigate the material in middle school and high school textbooks covering child care and children's health for medically inaccurate content and to make sure that the correct information is given to students. Methods : We have examined 47 kinds of textbooks on the subjects 'Home economics' and 'Technology and home economics' published...
Effects of Insulin-like Growth Factor-I and 1,25-(OH)2 Vitamin D3 Concentration on Intrauterine Growth of Newborns from Mothers with Preeclampsia
In Sook Yang, Jung Hyun Lee, Hyung Shin Lee, So Young Kim, Sung Dong Choi, In Kyung Sung, Chung Sik Chun
Clin Exp Pediatr. 2004;47(5):527-531.   Published online May 15, 2004
Purpose : This study was undertaken to observe the blood levels of IGF-I and 1,25-(OH)2 Vit. D3 in maternal and neonatal compartments and the effects of IGF-I concentration on intrauterine fetal growth and 1,25-(OH)2 Vit. D3 metabolism in the presence of preeclampsia. Methods : Thirty-four full-term pregnant women with preeclampsia and their newborns(preeclampsia group) and 10 normotensive full-term pregnant women and...
A Clinical Study on Mental Retardation of Preschool Children Diagnosed in Pediatric Developmental Clinic
Young Yeui Kim, In Kyung Sung
Clin Exp Pediatr. 2004;47(2):157-163.   Published online February 15, 2004
Purpose : Mental retardation, which can be defined as subnormal cognitive ability with markedly decreased ability to adapt to one's environment, is a common developmental disorder. But the diagnosis of mental retardation in young children is frequently missed in pediatric clinics. The purpose of this study is to increase the rate of early diagnosis and intervention by providing clinical information...
Plasma L-Arginine Concentration, Oxygenation Index and Pulmonary Artery Pressure in Premature Infants with Respiratory Distress Syndrome
Kyong Ah Jeong, Soon Ju Lee, In Kyung Sung, Chung Sik Chun
Clin Exp Pediatr. 2003;46(12):1207-1211.   Published online December 15, 2003
Purpose : This study was performed to observe the relationship of plasma L-arginine level and the severity of disease and pulmonary artery pressure in respiratory distress syndrome of premature infants. Methods : Peripheral blood samples were obtained at 1st, 3rd and 7th day from 21 premature infants with respiratory distress syndrome to analyze the L-arginine concentration. Oxygenation index (OI), an indicator...
Clinical Lecture
Developmental Test in Children
Sa Jun Chung, In Kyung Sung, Hee Ju Kim, Young Joung Woo, Mun Hyang Lee, Son Moon Shin
Clin Exp Pediatr. 2002;45(7):817-821.   Published online July 15, 2002
Case Report
Two Cases of Hydrometrocolpos in Neonate
Min Young Park, Bo Ra Son, So Young Kim, Young You Kim, Hyun Hee Kim, Won-Bae Lee, In Kyung Sung, Chung Sik Chun, Su Aa Lim
Clin Exp Pediatr. 2002;45(2):278-283.   Published online February 15, 2002
Imperforated hymen, vaginal atresia or high transverse vaginal septum are caused by incomplete vaginal canalization. The infant may be present with distention of the vagina and the uterus with glandular secretions stimulated by maternal estrogens, known as hydrometrocolpos. We report two cases of hydrometrocolpos. In the first case, distal vaginal atresia with cystovaginal fistula was revealed by a contrast fluoroscope...
Original Article
The Effect of the Maternal Hypertension on the Lipid Peroxidation and Antioxidant Status in the Newborn Rat Lung
You Jin Jung, So-Young Kim, In Kyung Sung, Chung Sik Chun
Clin Exp Pediatr. 2001;44(5):545-551.   Published online May 15, 2001
Purpose : The aim of this study was to investigate the effect of the maternal hypertension on the lipid peroxidation and antioxidant status of the newborn rat lung. Methods : We used adult female SHR(essential hypertension, 1b, A, 6-8 weeks), Sprague-Dawley white rats as a model of hypertensive dams. Breeding was accomplished by allowing female and male rats to cohabit overnight....
Neuro-developmental Assessment of Patients with Transposition of the Great Arteries by Localized 1H-Magnetic Resonance Spectroscopy
Ki-Soo Kim, Jee-Yeon Min, So Young Yoon, Young Hwue Kim, Jae Kon Ko, In Sook Park, Ki-Soo Kim, Dong Man Seo, Sang-Tae Kim, Jung Hee Lee, In Kyung Sung
Clin Exp Pediatr. 2001;44(5):533-544.   Published online May 15, 2001
Purpose : The purpose of this study was to evaluate the hemodynamic effect of transposition of the great arteries(TGA) on neuro-development by measuring the cerebral metabolites before and 1 year after open heart surgery(OHS) by localized in vivo 1H-magnetic resonance spectroscopy(1H- MRS) along with Bayley scales of infants development II(BSID II). Methods : Full-term newborns(N=13) with TGA and intact ventricular septum...
Neonatal Cord Blood Leptin : Its Relationship to Birth Weight
Byung Churl Lee, In Kyung Sung, Byung Kyu Suh, Moon Young Song
Clin Exp Pediatr. 1999;42(5):637-643.   Published online May 15, 1999
Purpose : The purpose of this study was to correlate birth weight, skinfold thickness, gestational age, BMI and ponderal index of neonates and maternal status with cord serum leptin concentration. Methods : Sixty newborns were enrolled in this study. Standard growth curves were used to categorize infants as appropriate(AGA), large(LGA), or small for gestational age(SGA). Gestational age, birth weight, length, skinfold...
Case Report
A Case of von Gierke Disease
Young A Joe, Moon Young Song, Bin Cho, Soon Ju Lee, In Kyung Sung, Kyong Su Lee
Clin Exp Pediatr. 1997;40(12):1756-1760.   Published online December 15, 1997
von Gierke disease(type Ia glycogen storage disease) is an inherited disease associated with accumulation of glycogen in the liver, kidney, intestine and erythrocytes due to the defect of glucose-6-phosphatase activity. Hepatomegaly, doll face, anemia, bleeding tendency and increased susceptability to infection are common features observed during infancy. Hypoglycemia especially fasting hypoglycemia is typical metabolic derangement in this disease, followed by metabolic acidosis, lactic acidemia, hyperlipidemia, hyperuricemia,...
A Case of Pena-Shokeir Phenotype in Trisomy 18 Syndrome
Ki Hun Song, Jee Yeon Song, In Kyung Sung, Kyong Su Lee
Clin Exp Pediatr. 1997;40(9):1303-1308.   Published online September 15, 1997
Pena-Shokeir syndrome is a rare, often lethal disease, characterized by intrauterine growth retardation, craniofacial anomalies, limb ankylosis, polyhydramnios and pulmonary hypoplasia. This autosomal recessive disease should be differentiated from trisomy 18, which the second most common multiple congenital malformation syndrome. It is therefore clear that the two syndromes have certain features in common, the most consistent being craniofacial and limb abnormalities and intrathoracic pathology. Therefore,...
A Case of McKusick-Kaufman Syndrome
Han Joo Kong, Young Mi Jee, In Kyung Sung, Byung Churl Lee
Clin Exp Pediatr. 1992;35(6):829-833.   Published online June 15, 1992
We experienced a case of Mckusick-Kaufman syndrome in a 14 day-old female neonate. She had hydrometrocolpos with vaginal atresia and polydactyly of feet associated with bilateral hydronephrosis and umbilical hernia. Hydronetrocolpos with vaginal atresia was corrected by abdominoperineal-vaginal pull through operation on 21st day of life. A brief review of related literatures was made.
A Case of Cloacal Deformity
Young Mi Jee, Seung Jin Lee, In Kyung Sung, Byung Churl Lee
Clin Exp Pediatr. 1992;35(5):667-670.   Published online May 15, 1992
We experienced a case of cloacal deformity. This one day-old female neonate had hydrometrocolpos with vaginal atresia, imperforated anus, cloaca associated with hemivertebrae, left renal agenesis and right hydronephrosis. A brief review of related literature was made.
Original Article
Clinical Obervation in 40 Cases with Neonatal Sepsis.
Jung Hee Lee, Jae Jin Park, In Kyung Sung, Byung Churl Lee
Clin Exp Pediatr. 1990;33(11):1489-1494.   Published online November 30, 1990
Sepsis is still one of major causes of mortality and morbidity in neonatal period and early diagnosis and appropriate treatment for neonatal sepsis is difficult due to its vague clinical manifestation and rapid progress. An analysis of 40 cases of neonatal sepsis confirmed by clinical manifestation and blood cultures from Jan. 1986 to Dec. 1989 at nursery of St. Mary’s Hospital of Catholic University...
Clinical Studies on Congenital Heart Diseases.
Hee Young Chun, Dae Churl Chung, In Kyung Sung, Kyong Su Lee, Du Bong Lee
Clin Exp Pediatr. 1990;33(1):66-74.   Published online January 31, 1990
A retrospective study of 10 years* experience with surgical treatment of congenital heart disease in the St. Mary’s Hospital from 1978 to 1987 was made. Data were analyzed on 188 children with congenital heart disease who had received corrective heart surgery under the age of 18 years. The results were as follows: 1) Out of 188 patients, ventricular septal defect(54.2% of all) was the most...
Mechanical Ventilation in Newborn Infants.
Young Back Hahm, Jong Ho Sung, In Kyung Sung, Byung Churl Lee, Du Bong Lee
Clin Exp Pediatr. 1990;33(1):10-21.   Published online January 31, 1990
Clinical analysis of 5 years* experience with mechanical ventilation of 68 neonates in NICU of St. Mary’s Hospital, from Jan. 1983 to June 1988, was done. The results were as follows; 1) Indications for mechanical ventilation were hyaline membrane disease(51.5%), postasphyxia syndrome(19.1%), apnea of prematurity (5.9%), sepsis (5.9%), intracranial hemorrhage (5.9%) and others. 2) Number of male patients was 33(48.5%》and of female was 35(51.5%), and male to female...
Statistical Analysis of Pediatric Diseases in Korea(1987).
Kyong Su Lee, Ki Sup Chung, Ki Yang Ryoo, Woo Gill Lee, Sang Bum Lee, Se Jin Kang, In Kyung Sung
Clin Exp Pediatr. 1989;32(7):885-896.   Published online July 31, 1989
The Korean pediatric association is conducting the analysis of disease patterns of children by the body organ system. For the purpose of assessing the disease patterns in patients of the pediatric age in Korea, we performed a statistical analysis of diseases of patients admitted to the department of pediatrics in 36 hospitals having pediatric residency programs in 1987. The results obtained were as follows, 1) Total...
A Case of Chondrodysplasia Punctata of the Rhizomelic Type.
Ki Sik Min, Bo Kyung Cho, In Kyung Sung, Byung Churl Lee
Clin Exp Pediatr. 1989;32(1):87-91.   Published online January 31, 1989
Chondrodysplasia punctata is a rare familial disorder of bone, characterized by punctate calcifica- tion in the epiphyseal regions. We experienced a case of the rhizomelic type of chondrodysplasia punctata in an one day old female. She had symmetrical shortening of the proximal limbs, flexion contracture of both hip joints, cataracts and ichthyotic skin lesion. Radiologic findings showed multiple stippled calcified densities in most joints and...
Clinical Analysis of Congenital Malformations in the Newborn Infant.
Hoon Chang, Chae Hwa Lee, In Kyung Sung, Byung Churl Lee, Sung Hoon Cho
Clin Exp Pediatr. 1988;31(1):72-77.   Published online January 31, 1988
Congenital malformations are still one of the leading problems of neonatal death and illness. But, we have only a few data for about it, because of difficulty in the exact analysis of the incidence and etiologic factors. During the period of 6 years, between January 1980 and December 1985, a clinical study about the general incidence of congenital malformations was done on 50, 979...
Case Report
A Case of Poland Syndrome.
Jong Deok Kim, Hyung Kook Ki, In Kyung Sung, Byung Churl Lee
Clin Exp Pediatr. 1987;30(1):99-101.   Published online January 31, 1987
The Poland syndrome consists of congenital unilateral absence of the pectoralis major muscle and ipsilateral anomalies of the hand, typically syndactyly. It may be combined with many other anomalies. Recently, we experienced an 8 days old boy, who had the total absence of the metacarpals and phalanges of left hand and defect of the pectoralis muscle on the same side. A brief review of the...
A Case of Acute Lymphocytic Leukemia Successfully Treated with Allogeneic Bone Marrow Transplantaion.
In Kyung Sung, Byung Churl Lee, Kyong Su Lee, Du Bong Lee, Chong Won Park, Chun Choo Kim, Dong Jip Kim
Clin Exp Pediatr. 1985;28(8):805-811.   Published online August 31, 1985
A 8-year old boy with acute lymphocytic leukemia who had shown resistance to repeated combination chemotherapies, was successfully grafted with bone marrow from his HLA- matched sister. He was in the third partial remission at the time of bone marrow transplantation. He was conditioned with cyclophosphamide 60 mg/kg/day on two consecutive days, followed by 800 rads total body irradiation. Marrow...
A Case of Neurofibromatosis.
In Kyung Sung, Sung Won Kang, Ik Jun Lee, Sung Hoon Cho
Clin Exp Pediatr. 1983;26(1):97-101.   Published online January 31, 1983
Neurofibromatosis, first described by Von Recklinghausen in 1882, is characterized by multiple areas of pigmentation in association with tissue overgrowth of nerve sheath and fibrous tissue elements. We experienced a case of neurofibromatosis with megalencephaly in a 12-years old boy. A brief review of the related literature is given.
A Case Of Choledochal Cyst In A Neonate.
Jong Man Lee, In Kyung Sung, Jong Seung Kim, Chang Kyu Oh
Clin Exp Pediatr. 1982;25(10):1068-1072.   Published online October 31, 1982
Congenital choledochal cyst is a rare disease, especially in fetal life and early infancy age. Our case was a 66 days old female baby who had the symptoms of jaundice, clay-colored stool, intermittent vomiting since birth and abdominal distension. Final diagnosis was choledochal cyst with neonatal hepatitis. An early accurate preoperative diagnosis has been associated with a marked decrease in the mortality. Roux-en-Y choledochocystojejunostomy was done. We...
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