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Original Article
Clinical and laboratory profiles of hospitalized children with acute respiratory virus infection
Eunjin Choi, Kee-Soo Ha, Dae Jin Song, Jung Hwa Lee, Kwang Chul Lee
Clin Exp Pediatr. 2018;61(6):180-186.   Published online June 25, 2018

Despite the availability of molecular methods, identification of the causative virus in children with acute respiratory infections (ARIs) has proven difficult as the same viruses are often detected in asymptomatic children.


Multiplex reverse transcription polymerase chain reaction assays were performed to detect 15 common respiratory viruses in children under 15 years of age who were hospitalized with ARI between January 2013...

Case Report
Familial Mediterranean fever presenting as fever of unknown origin in Korea
Jun Hee Lee, Jong Hyun Kim, Jung Ok Shim, Kwang Chul Lee, Joo Won Lee, Jung Hwa Lee, Jae Jin Chae
Clin Exp Pediatr. 2016;59(Suppl 1):S53-S56.   Published online November 30, 2016

Familial Mediterranean fever (FMF) is the most common Mendelian autoinflammatory disease, characterized by uncontrolled activation of the innate immune system that manifests as recurrent brief fever and polyserositis (e.g., peritonitis, pleuritic, and arthritis). FMF is caused by autosomal recessive mutations of the Mediterranean fever gene, MEFV which encodes the pyrin protein. Although FMF predominantly affects people from Mediterranean and Middle...

Idiopathic acute eosinophilic pneumonia in a 14-month-old girl
Ha Neul Park, Bo Hyun Chung, Jung Eun Pyun, Kwang Chul Lee, Ji Tae Choung, Choon Hak Lim, Young Yoo
Clin Exp Pediatr. 2013;56(1):37-41.   Published online January 29, 2013

Idiopathic acute eosinophilic pneumonia (IAEP), characterized by acute febrile respiratory failure associated with diffuse radiographic infiltrates and pulmonary eosinophilia, is rarely reported in children. Diagnosis is based on an association of characteristic features including acute respiratory failure with fever, bilateral infiltrates on the chest X-ray, severe hypoxemia and bronchoalveolar lavage fluid >25% eosinophils or a predominant eosinophilic infiltrate in lung...

Original Article
Alteration of CD4+CD25+Foxp3+ T cell level in Kawasaki disease
Su Ye Sohn, Young Wooh Song, Yun Ku Yeo, Yun Kyung Kim, Gi Young Jang, Chan Wook Woo, Jung Hwa Lee, Kwang Chul Lee
Clin Exp Pediatr. 2011;54(4):157-162.   Published online April 30, 2011

Exaggerated pro-inflammatory reactions during the acute phase of Kawasaki disease (KD) suggest the role of immune dysregulation in the pathogenesis of KD. We investigated the profiles of T regulatory cells and their correlation with the clinical course of KD.


Peripheral blood mononuclear cells were collected from 17 KD patients during acute febrile and subacute afebrile phases. T cells expressing CD4, CD25,...

Direct detection of hemophilia B F9 gene mutation using multiplex PCR and conformation sensitive gel electrophoresis
Ki Young Yoo, Hee Jin Kim, Kwang Chul Lee
Clin Exp Pediatr. 2010;53(3):397-407.   Published online March 15, 2010
Purpose : The F9 gene is known to be the causative gene for hemophilia B, but unfortunately the detection rate for restriction fragment length polymorphism-based linkage analysis is only 55.6%. Direct DNA sequencing can detect 98% of mutations, but this alternative procedure is very costly. Here, we conducted multiplex polymerase chain reactions (PCRs) and conformation sensitive gel electrophoresis (CSGE) to...
Comparison of predicted adult heights measured by Bayley-Pinneau and Tanner-Whitehouse 3 methods in normal children, those with precocious puberty and with constitutional growth delay
Yeon Joung Oh, Byung Keun Yu, Jung Yeon Shin, Kee-Hyoung Lee, Kwang Chul Lee, Chang Sung Son
Clin Exp Pediatr. 2009;52(3):351-355.   Published online March 15, 2009
Purpose : This study compared bone ages measured by the Greulich-Pyle (GP) and Tanner-Whitehouse 3 (TW3) methods and investigated the differences in predicted adult heights measured by Bayley-Pinneau (BP) and TW3 methods. Methods : Bone ages were assessed from left-wrist radiographs by two investigators, one for each GP and TW3 methods in 85 normal children, 30 precocious puberty girls, and...
Weaning food practice in children with iron deficiency anemia
Joo Hee Chang, Woo Sik Cheong, Yong Hoon Jun, Soon Ki Kim, Hung Sik Kim, Sang Kyu Park, Kyung Ha Ryu, Eun Sun Yoo, Chuhl Joo Lyu, Kun soo Lee, Kwang Chul Lee, Jae Young Lim, Du Young Choi, Byung Kyu Choe, Eun Jin Choi, Bong Soon Choi
Clin Exp Pediatr. 2009;52(2):159-166.   Published online February 15, 2009
Purpose : Iron deficiency anemia (IDA) is one of the most common nutritional deficiencies in children on a weaning diet. We investigated weaning practices in infants and children, as well as their mothers' knowledge about weaning. Methods : We investigated 129 children with IDA and 166 without IDA (aged 6-36 months) who had visited 10 university hospitals between March 2006...
Case Report
Three cases of pulmonary and/or intestinal tuberculosis in adolescents
Jung Hye Byeon, Yoon Lee, Jin Chul Lee, Young Yoo, Kee Hyoung Lee, Kwang Chul Lee, Ji Tae Choung, Soo Youn Ham, Chul Whan Kim
Clin Exp Pediatr. 2007;50(11):1134-1138.   Published online November 15, 2007
Since the tuberculosis (TB) in adolescents has unique clinical characteristics, special attention should be paid to this age group. Adolescents are more susceptible to developing TB disease and more likely to have cavitary pulmonary disease. Also, adolescent patients with TB more frequently present with extrapulmonary disease. We report three adolescents with active pulmonary and/or intestinal TB: one had pulmonary and...
Original Article
Carotid artery intima media thickness in obese children : relation with cardiovascular risk factors
Jin Lee, Hyo Jin Kwon, Moon Ho Park, Ki Young Jang, Kee-Hyoung Lee, Kwang Chul Lee, Chang Sung Son, Joo Won Lee
Clin Exp Pediatr. 2007;50(11):1091-1096.   Published online November 15, 2007
Purpose : The of common carotid artery intima media thickness (IMT) is an acknowledged noninvasive marker for early atherosclerotic changes. We investigate whether common carotid IMT is different between obese and normal-weight children and also evaluate the relationships IMT with cardiovascular risk factors. Methods : We collected the clinical data (age, sex, pubertal stage, body mass index) and measured blood...
Clinical application of D-dimer in Kawasaki Disease
Jae Joon Han, Hong Ki Ko, Young Yoo, JungHwa Lee, Kwang Chul Lee, Chang Sung Son, Joo Won Lee
Clin Exp Pediatr. 2007;50(2):205-208.   Published online February 15, 2007
Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea Purpose : Vascular endothelial cell damage and alteration of a fibrinolytic system was suggested to play a role in the development of coronary artery abnormalities in Kawasaki disease (KD). D-dimer is one of the markers of endothelial damage and fibrinolysis. We evaluated the clinical usefulness of D- dimer to differentiate KD...
Case Report
A case of Kikuchi's disease with skin involvement
Ji Min Jang, Chul Hee Woo, Jung Woo Choi, Dae Jin Song, Young Yoo, Kwang Chul Lee, Chang Sung Son
Clin Exp Pediatr. 2006;49(1):103-106.   Published online January 15, 2006
Histiocytic necrotizing lymphadenitis, which is also commonly referred to as Kikuchi's disease (KD), is a self-limiting disease of unknown etiology. It affects individuals of all ages, although it is usually seen in young women. However, only a few descriptions of this disease are available in the pediatric literature. KD is clinically characterized by cervical lymphadenopathy, high fever, myalgia, neutropenia and,...
Wilms' tumor with polydipsia, polyuria, hyponatremic hypertension and congestive heart failure : a case report
Chul Hee Woo, Ji Min Jang, Chan Wook Woo, Ki Hyung Lee, Kwang Chul Lee
Clin Exp Pediatr. 2006;49(1):99-102.   Published online January 15, 2006
A 3-year-old girl presented with polydipsia, polyuria, hyponatremia, hypertension and congestive heart failure. Her polyuria was unresponsive to water restriction and vasopressin challenge tests, and her blood pressure was not effectively controlled by antihypertensive drugs. Radiologic examinations revealed a Wilms' tumor in the right kidney. Her plasma renin activity and aldosterone concentration were greatly increased. After surgical removal of the...
Two Cases of Kabuki Make-up Syndrome Including One Case Associated with Xq Isochromosome
Ki Hea Cho, Jung Hwa Lee, Kee Hyoung Lee, Kwang Chul Lee, Ji Tae Choung, Chang Sung Son, Young Chang Tockgo
Clin Exp Pediatr. 2000;43(8):1111-1115.   Published online August 15, 2000
Kabuki make-up syndrome(KMS) is characterized by mental and developmental retardation and peculiar facial features including long palpebral fissures with eversion of the lateral portion of lower eyelid and arching of eyebrows, resembling the actors in Japanese Kabuki. In addition, dermatoglyphic and skeletal abnormalities are commonly associated. Although most karyotypes of KMS are shown to be normal, there have been some...
A Case of Factor Ⅶ Deficiency Presenting as Hemarthroses
Han Seong Ko, Kee Hwan Yoo, Kwang Chul Lee, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 2000;43(3):428-431.   Published online March 15, 2000
Factor Ⅶ deficiency has an estimated incidence of 1/500,000 in the general population and autosomal recessive pattern of inheritance. Factor Ⅶ deficiency is characterized by prolonged prothrombin time(PT), and normal activated partial thromboplastin time(aPTT) and bleeding time(BT). Definite diagnosis of this condition requires a specific Factor Ⅶ assay. The clinical features are variable and do not always correlate with the...
Original Article
Clinical Manifestations and Hematologic Complications of Epstein-Barr Virus Infection in Korean Children
Seong Hoi Jeon, Chan Wook Woo, Jung Hwa Lee, Kwang Chul Lee, Young Chang Tocko
Clin Exp Pediatr. 1998;41(9):1216-1223.   Published online September 15, 1998
Purpose : Epstein-Barr virus(EBV) is associated with various diseases and complications caused by the host's immune reactions. This study focuses on various clinical findings and hematologic complications in childhood EBV infection. Methods : The study group was thirty-eight EBV infected children(Anti-EBV VCA IgM; positive) who were admitted to the Department of Pediatrics, Korea University from January 1996 to July 1997. Patients...
Medical Lecture Course
Bone Marrow Transplantation in Children
Kwang Chul Lee
Clin Exp Pediatr. 1996;39(9):1193-1200.   Published online September 15, 1996
Original Article
Plasma Fibronectin Concentration in the Neonate
Young Yoo, Kwang Chul Lee, Young Chang Tockgo
Clin Exp Pediatr. 1996;39(3):319-325.   Published online March 15, 1996
Purpose : Plasma fibronectin is thought to have important role in the inflammatory response and host defense. We performed this study to evaluate concentration in the full-term, healthy preterm, asphyxia and respiratory distress syndrome and how that correlated with gestational age and birth weight. Methods : We evaluate 51 neonates who were delivered at Korea University Hospital from Jan. 1992 to...
Study on Iron Deficient State in the Female Adolescent Athletes
Pil Seob Shim, Ja Hyun Park, Dong Gun Park, Kwang Chul Lee, Young Chang Tockgo
Clin Exp Pediatr. 1994;37(7):953-960.   Published online July 15, 1994
Iron deficient state occurs commonly in the athlets, and the cause may be cause may be inadequate iron intake, loss of iron from sweat, blood loss of gastrointestinal tract, and hematuria. The age of the athletes ranged from 11 to 17 years old. I messured red blood cell count, hemoglobin, hematocrit, and related hematologic factors in the 32 adolescent female...
Case Report
A Case of Congenital Hypoprothrombinemia
Jong Kwang Lee, Hae Won Cheon, Jung Hwa Lee, Kwang Chul Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(3):422-429.   Published online March 15, 1994
Congenital hypoprothrombinemia is a rare congenital coagulation defect. The clinical signs are manifestation of generalized bleeding tendency such as; mucosal bleeding, hypermenorrhea and post tooth extraction hemorrage. It is associated with prolongation of PT and PTT with normal thrombin time and decreased serum prothrombin level. A case with congenital hypoprothrombinemia was experienced by the authors. A 36 days old male baby...
Original Article
A Clinical Observation of Neonatal Hyperbilirubinemia Due to ABO imcompatibility
Kang Woo Lee, Young Guk Kim, Dong Gun Park, Kee Hwan Yoo, Kwang Chul Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(1):54-60.   Published online January 15, 1994
A clinical and statistical study was performed on 213 neonates of hyperbilirubinemia who were admitted to department of pediatrics of Korea University Hospital from Jan. 1989 to Jun. 1991. And we studied the difference between ABO compatible group and incompatible group, such as, day of appe5rance of hyperbilirubinemia, tendency of bilirubin concentration change, reticulocyte, hemoglobin and duration of hyperbilirubinemia. The following...
Case Report
A Case of Solid and Papilary Tumor of Pancreas
Kyoung Bum Kim, Hae Won Cheon, Ji Hee Park, Kee Hyoung Lee, Kwang Chul Lee, Young Chang Tockgo
Clin Exp Pediatr. 1993;36(12):1765-1769.   Published online December 15, 1993
We report a cases of solid and papillary neoplasm of the pancreas, which is a rare pancreatic tumor. We described clinical characteristics, sonographic, computed tomographic and pathologic finding. The tumors had a smooth, enhanced capsule and variable internal architecture. The tumor was distributed tail of pancreas without local invasion. The origin of the tumor is probably from a multipotential stem...
Original Article
A Cause of Transient Systolic Murmur in Neonates Physiologic Pulmonary Artery Stenosis
Hyun Joo Kwak, Phil Seob Sim, Kwang Chul Lee, Chang Sung Sohn, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1992;35(12):1696-1701.   Published online December 15, 1992
A transient heart murmur is frequently heard in normal newborn who has no congenital heart disease. The cause of this murmur remains unclear but was speculated as hypoplasia of the pulmonary arterial branches or unusual alignment of the main pulmonary artery with its branches. Pulsed Doppler and two-dimensional echocardiographic studies were undertaken in 19 newborn infants with a transient murmur and...
Clinical Evaluation of Reactive Thrombocytosis in Childhood
Yoon Suck Suh, Young Yoo, Kwang Chul Lee, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1992;35(5):607-613.   Published online May 15, 1992
The platelet coiunt has not been part of routine hematologic profiles until recently, when the newer electronic blood cell counters began to include platelet count with all other blood cell counts. With the widespread use of newer generation electronic blood cell counters, elevated platelets coiunts are being encountered more ofter in pediatric practice. We reviewed all cases of marked thrombocytosis to...
A Scientific Analysis of Changes in Hemostatic Parameters Following Cardiopulmonary
Hyoung Won Lee, You In Park, Kwang Chul Lee, Ju Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1992;35(1):34-43.   Published online January 15, 1992
Despite the scientific advances made in medical science, the potential for serious hemorrhagic complications remain an important problem in patients undergoing open heart surgery with extracorporeal circultation (OHSEC). Hematologic abnormalities that have been reported in association with OHSEC and that may lead to a hemorrhagic tendency include thrombocytopenia, alteration of coagulation factors, advanced fibrinolysis and inadequate neutralization of heparin. We investigated...
Clinical Investigation of Chlamydia Pneumonia in Infants.
Jong Hoon Park, Se Geon Park, Kwang Chul Lee, Young Sook Hong, Young Chang vTockgo
Clin Exp Pediatr. 1990;33(8):1065-1073.   Published online August 31, 1990
We performed chlamydia antigen test by enzyme immunoassay in 322 infants who were admitted because of pneumonia. Clinical investigation and statistical analysis were done between chlamydia antigen positive group and negative group. The results obtain were as follows 1) Chlamydia antigen positive were resulted in 42 cases (13.04%) among 322 cases. 2) The mean age of Chlamydia positive and negative group were 14.2±6.2 weeks and 11.5±5. 7weeks respectively. 3) Afebrile...
A case of Endobronchial Metastatic Malignant Melanoma.
Sang Hee Kim, Young Kyoo Shin, Kwang Chul Lee, Chang Sung Son, Pyung Hwa Choe
Clin Exp Pediatr. 1990;33(4):573-578.   Published online April 30, 1990
Metastatic malignant melanoma is a rare neoplasm in child. We experienced a case of endobron- chial metastatic malignant melanoma developed in a 5 year-8month-old boy, who was admitted because of dyspnea and productive cough. Diagnosis was made by endobrochia 1 biopsy and histopathologic findings. He was treated with radiation as a palliative therapy. The result was good. Tumor size decreased and symptoms im- proved. The...
A case of Distal Renal Tubular Acidosis.
Seong Gyoo Park, Gyung Min Ann, Sang Hee Park, Kwang Chul Lee, Chang Sung Son, Pyung Hwa Choi
Clin Exp Pediatr. 1990;33(4):539-543.   Published online April 30, 1990
Distal Renal Tubular Acidosis is rare disease which is characterized by impaired renal acidification at distal renal tubule and collecting duct. The urinary pH cannot be reduced below 5.8 despite severe systemic acidosis. A 6 months old boy was admitted to Ped. Dept, of Korea University Hospital due to fever and tachypnea. IVP and abdominal sonography were normal. Laboratory data showed hyperchloremia and metabolic acidosis....
Serum LDH and Isoenzyme Activity in Children with Respiratory Diseases.
Kyoung Min Ann, Young Kyoo Shin, Kwang Chul Lee, Ji Tae Choung, Young Chang Tockgo, Pyung Hwa Choe
Clin Exp Pediatr. 1989;32(8):1051-1056.   Published online August 31, 1989
LDH which are widely distributed in mammalian tissues, being rich in myocardium, kidney, liver and muscle, and which is well known to catalyzes the reversible oxidation of lactate to pyruvate. We investigated serum LDH & Isoenzyme changes in 317 cases of children with respiratory disease and in 117 cases of healthy children as control. The objectives of this study were to ascertain whether serum...
A Case of Methylmalonic Acidemia.
Jong Hoon Park, Si Houn Hahn, Kee Hwan Yoo, Kwang Chul Lee, Chang Sung Sohn, Pyung Hwa Choe
Clin Exp Pediatr. 1989;32(7):984-989.   Published online July 31, 1989
Methylmalonic acidemia is an inborn error of metabolism, which is characterized by excretion of large amount of methylmalonate, and is transmitted as an autosomal recessive traits. The clinical symptoms begin in early life and are recurrent vomiting, lethargy, dehydration, failure to thrive. Laboratory findings show ketosis, metabolic acidosis, methymalonic aciduria with normal serum cobalamin level, hyperammonemia, pancytopenia. Two treatment regi- mens exist and should...
A case of Evans Syndrome Associated with A-V Malformation.
Keun Haeng Cho, Min Young Lee, Kwang Chul Lee, Young Sook Hong, Soon Kyum Kim
Clin Exp Pediatr. 1989;32(6):839-844.   Published online June 30, 1989
In 1951, Evans and associates first described a group of patients with primary thrombocytopenic purpura for a diagnosis of Evans syndrome, The criteria for a diagnosis of Evans syndrome were(l) hemolytic anemia with a positive direct coombs’ test and thrombocytopenia occuring either simultaneously or in succession and(2) the absence of any known underlying etiology. We experienced a case of Evans syndrome associated with...
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